I. Deschênes

发表

Diversity and functional roles of K + channels in cardiac repolarization : from single cell to whole organ levels

Jamie, J. Nerbonne, J. Weiss, 2016 .

Membrane Potential Depolarization as a Triggering Mechanism for Vpu-Mediated HIV-1 Release

E. Marbán, I. Deschênes, K. Hsu, 2010, Biophysical Journal.

Structure–Function Relations of Heterotrimetric Complexes of Sodium Channel α- and β-Subunits

I. Deschênes, 2018 .

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

J. Nerbonne, J. Weiss, M. Sanguinetti, 2017, The Journal of physiology.

Molecular Determinants of Pentamidine-Induced hERG Trafficking Inhibition

D. Nassal, I. Deschênes, E. Ficker, 2012, Molecular Pharmacology.

Strategically targeting calcium: Altering activation sequence to reverse remodel the failing ventricle.

I. Deschênes, L. Wilson, 2018, Heart rhythm.

Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role

D. Nassal, I. Deschênes, X. Wan, 2016, PloS one.

Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito.

Antonis A Armoundas, Steven R Houser, Isabelle Deschenes, 2004, American journal of physiology. Heart and circulatory physiology.

Inhibition of CREB-CBP Signaling Improves Fibroblast Plasticity for Direct Cardiac Reprogramming

I. Deschênes, Ji-Dong Fu, A. Dennis, 2021, Cells.

KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity

D. Nassal, I. Deschênes, X. Wan, 2017, PloS one.

Phosphoinositide Binding Differentially Regulates NHE1 Na+/H+ Exchanger-dependent Proximal Tubule Cell Survival*

S. N. Naga Prasad, M. Mohan, J. Schelling, 2011, The Journal of Biological Chemistry.

Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway.

Prasongchai Sattayaprasert, D. Nassal, I. Deschênes, 2016, Journal of molecular and cellular cardiology.

Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Na(v)1.5 α-subunits.

P. Guicheney, S. Maugenre, N. Neyroud, 2012, Cardiovascular research.

A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1–Induced Activation of Pacemaker Current

Ronald A. Li, I. Deschênes, X. Wan, 2017, Stem Cell Reviews and Reports.

Phosphorylation at Connexin43 Serine‐368 Is Necessary for Myocardial Conduction During Metabolic Stress

D. Rosenbaum, A. Werdich, I. Deschênes, 2016, Journal of cardiovascular electrophysiology.

Lipotoxic disruption of NHE1 interaction with PI(4,5)P2 expedites proximal tubule apoptosis.

R. Harris, M. D. Parker, J. Schelling, 2014, The Journal of clinical investigation.

Electrophysiological characterization of SCN5A mutations causing long QT (E1784K) and Brugada (R1512W and R1432G) syndromes.

P. Guicheney, I. Barde, I. Denjoy, 2000, Cardiovascular research.

S-phase Synchronization Facilitates the Early Progression of Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit

Satoru Takahashi, I. Deschênes, Ji-Dong Fu, 2018, International journal of molecular sciences.

1 S-Phase Synchronization Facilitates the Early Progression of 2 Induced-Cardiomyocyte Reprogramming through Enhanced Cell-Cycle Exit 3 4

Satoru Takahashi, I. Deschênes, Ji-Dong Fu, 2018 .

A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation.

S. Duchatelet, P. Guicheney, N. Neyroud, 2014, Heart rhythm.

Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa.

P. Guicheney, N. Neyroud, I. Deschênes, 2022, Frontiers in bioscience.

A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope.

I. Deschênes, E. Ficker, G. Christé, 2008, Heart rhythm.

Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart

J. Stamler, M. Cutler, D. Rosenbaum, 2012, Proceedings of the National Academy of Sciences.

Targeted Sarcoplasmic Reticulum Ca2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart

M. Cutler, D. Rosenbaum, R. Hajjar, 2012, Circulation.

Targeted SERCA2a Gene Delivery to Restore Electrical Stability in the Failing Heart

M. Cutler, D. Rosenbaum, R. Hajjar, 2012 .

Heart Failure Targeted Sarcoplasmic Reticulum Ca ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart

M. Cutler, D. Rosenbaum, R. Hajjar, 2012 .

Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy.

I. Deschênes, X. Wan, R. Mamidi, 2018, International journal of cardiology.

Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes.

Wanchun Tang, M. Jiang, G. Tseng, 2019, Journal of molecular and cellular cardiology.

Ionic bases for electrical remodeling of the canine cardiac ventricle.

Y. Rudy, D. Jeyaraj, D. Rosenbaum, 2013, American journal of physiology. Heart and circulatory physiology.

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

James W. Smyth, J. Gorelik, I. Deschênes, 2018, eLife.

Expression defect of the rare variant/Brugada mutation R1512W depends upon the SCN5A splice variant background and can be rescued by mexiletine and the common polymorphism H558R

D. Tester, M. Ackerman, J. Makielski, 2021, Channels.

iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

M. Boutjdir, J. Puymirat, I. Deschênes, 2021, Scientific Reports.

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells.

I. Deschênes, X. Wan, Ming-Tao Zhao, 2021, Journal of visualized experiments : JoVE.

Calmodulin Regulation of NaV1.4 Current: Role of Binding to the Carboxyl Terminus

G. Tomaselli, D. Disilvestre, I. Deschênes, 2008, The Journal of general physiology.

Increase in the proliferative capacity of human myoblasts by using the T antigen under the vimentin promoter control

J. Tremblay, J. Puymirat, I. Deschênes, 1997, Muscle & nerve.

A common SCN5A polymorphism modulates the biophysical defects of SCN5A mutations.

E. Kaufman, I. Deschênes, E. Ficker, 2011, Heart rhythm.

Cysteine scanning analysis of the IFM cluster in the inactivation gate of a human heart sodium channel.

I. Deschênes, M. Chahine, E. Trottier, 1999, Cardiovascular research.

Restoration of fast inactivation in an inactivation-defective human heart sodium channel by the cysteine modifying reagent benzyl-MTS: analysis of IFM-ICM mutation.

R. Kallen, I. Deschênes, M. Chahine, 1997, Biochemical and biophysical research communications.

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels

H. Katus, S. Chai, Christina Mayer, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

Regulation of Kv4.3 Current by KChIP2 Splice Variants: A Component of Native Cardiac Ito?

G. Tomaselli, D. Disilvestre, I. Deschênes, 2002, Circulation.

Antidepressant-induced Ubiquitination and Degradation of the Cardiac Potassium Channel hERG*

D. Nassal, Dierk Thomas, I. Deschênes, 2011, The Journal of Biological Chemistry.

Long QT syndrome – Bench to bedside

Daniela Ponce-Balbuena, I. Deschênes, 2021, Heart rhythm O2.

SCN5A Polymorphism Restores Trafficking of a Brugada Syndrome Mutation on a Separate Gene

Mohamed Chahine, Sandro Sorrentino, Steven Poelzing, 2006, Circulation.

Na+ channel function, regulation, structure, trafficking and sequestration

Jon T. Sack, R. Aldrich, W. Catterall, 2015, The Journal of physiology.

KChIP2 is a core transcriptional regulator of cardiac excitability

D. Nassal, I. Deschênes, X. Wan, 2017, eLife.

Multilayer control of cardiac electrophysiology by microRNAs.

I. Deschênes, Ji-Dong Fu, Dandan Yang, 2022, Journal of molecular and cellular cardiology.

Precision medicine for long QT syndrome: patient-specific iPSCs take the lead

I. Deschênes, Ming-Tao Zhao, Yang Yu, 2023, Expert Reviews in Molecular Medicine.

Contribution of two-pore K+ channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes.

S. Chai, D. Nassal, I. Deschênes, 2017, American journal of physiology. Heart and circulatory physiology.

Mechanoelectrical Feedback as Novel Mechanism of Cardiac Electrical Remodeling

David S. Rosenbaum, Chris Flask, Jeffrey E. Saffitz, 2007, Circulation.

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

P. Mohler, T. Hund, I. Deschênes, 2021, Circulation.

Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency

Joe Z. Zhang, V. Garg, I. Deschênes, 2022, Circulation research.

Modulation of Kv4.3 current by accessory subunits

G. Tomaselli, I. Deschênes, 2002, FEBS letters.

Mechanisms of zolpidem‐induced long QT syndrome: acute inhibition of recombinant hERG K+ channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells

H. Katus, C. Schmidt, I. Deschênes, 2013, British journal of pharmacology.

Maintenance of intercellular coupling by the antiarrhythmic peptide rotigaptide suppresses arrhythmogenic discordant alternans.

D. Rosenbaum, I. Deschênes, B. Eloff, 2008, American journal of physiology. Heart and circulatory physiology.

Alteration of tyrosine kinase signaling: another player in the arrhythmogenesis of atrial fibrillation?

I. Deschênes, K. Shinlapawittayatorn, 2010, Heart rhythm.

Materials and Methods Transfections of HEK 293 and C 2 C 12 Cell Lines

G. Tomaselli, E. Marbán, D. T. Yue, 2002 .

Implication of the C-Terminal Region of the α-Subunit of Voltage-gated Sodium Channels in Fast Inactivation

I. Deschênes, M. Chahine, E. Trottier, 2001, The Journal of Membrane Biology.

Electrophysiological Study of Chimeric Sodium Channels from Heart and Skeletal Muscle

R. Kallen, I. Deschênes, M. Chahine, 1998, The Journal of Membrane Biology.

Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents.

Antonis A Armoundas, Steven P Jones, A. A. Armoundas, 2008, Journal of molecular and cellular cardiology.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

Alfred L George, E. Kaufman, A. George, 2018, The Journal of clinical investigation.

T-Wave Morphology Analysis to Detect High Risk in Long-QT Syndrome.

E. Kaufman, I. Deschênes, 2017, Circulation. Arrhythmia and electrophysiology.

Voltage-gated sodium channels assemble and gate as dimers

T. Ha, Céline Marionneau, I. Deschênes, 2017, Nature Communications.

Isoform-Specific Modulation of Voltage-Gated Na+ Channels by Calmodulin

Eduardo Marbán, Deborah DiSilvestre, G. Tomaselli, 2002, Circulation research.

Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function.

S. Weinberg, I. Deschênes, X. Wan, 2020, Biophysical journal.

The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation

Indra D Sahu, S. Chakrapani, I. Sahu, 2018, The Journal of general physiology.

Brugada Syndrome Disease Phenotype Explained in Apparently Benign Sodium Channel Mutations

S. Chai, I. Deschênes, X. Wan, 2014, Circulation. Cardiovascular genetics.

EXTRACELLULAR PERINEXAL SEPARATION IS A PRINCIPAL DETERMINANT OF CARDIAC CONDUCTION

James W. Smyth, R. Davalos, I. Deschênes, 2023, bioRxiv.

Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function.

I. Deschênes, L. Wilson, X. Wan, 2017, American journal of physiology. Heart and circulatory physiology.

A Novel Strategy Using Cardiac Sodium Channel Polymorphic Fragments To Rescue Trafficking-Deficient SCN5A Mutations

I. Deschênes, S. Poelzing, E. Ficker, 2011, Circulation. Cardiovascular genetics.

STORM and TEM Identify the Cardiac Ephapse: An Intercalated Disk Nanodomain with Previously Unanticipated Functions in Cardiac Conduction

James W. Smyth, J. Gorelik, I. Deschênes, 2017, Microscopy and Microanalysis.

Protein 14-3-3 Influences the Response of the Cardiac Sodium Channel Nav1.5 to Antiarrhythmic Drugs

I. Deschênes, Yang Zheng, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Somatic Gene Transfer of Tagged K+ Channel Fragments to Probe Trafficking and Electrical Function in Epithelial Cells and Cardiac Myocytes

E. Marbán, M. Akao, N. Neyroud, 2002, The Journal of Membrane Biology.

Mutant voltage-gated Na+ channels can exert a dominant negative effect through coupled gating.

Céline Marionneau, I. Deschênes, K. Laurita, 2018, American journal of physiology. Heart and circulatory physiology.

A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

I. Deschênes, X. Wan, Ji-Dong Fu, 2021, Frontiers in Physiology.

Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics

J. Nerbonne, J. Weiss, M. Sanguinetti, 2017, The Journal of physiology.

Antidepressant-induced Ubiquitination and Degradation of the Cardiac Potassium Channel hERG*

D. Nassal, Dierk Thomas, I. Deschênes, 2011, The Journal of Biological Chemistry.

How can a single mutation cause such arrhythmic havoc?

I. Deschênes, K. Laurita, 2007, Heart rhythm.

Cardiovascular pharmacology of K2P17.1 (TASK-4, TALK-2) two-pore-domain K+ channels

H. Katus, Christina Mayer, Dierk Thomas, 2018, Naunyn-Schmiedeberg's Archives of Pharmacology.

A new C-terminal hERG mutation A915fs+47X associated with symptomatic LQT2 and auditory-trigger syncope.

I. Deschênes, E. Ficker, G. Christé, 2008, Heart rhythm.

Regulation of Kv4.3 Current by KChIP2 Splice Variants: A Component of Native Cardiac Ito?

D. Disilvestre, I. Deschênes, Richard Wu, 2002, Circulation.

Na+ channel regulation, structure, trafficking and sequestration

Jon T. Sack, R. Aldrich, W. Catterall, 2015 .

Phosphoinositide Binding Differentially Regulates NHE1 Na+/H+ Exchanger-dependent Proximal Tubule Cell Survival*

S. N. Naga Prasad, M. Mohan, J. Schelling, 2011, The Journal of Biological Chemistry.

Targeted Antioxidant Treatment Decreases Cardiac Alternans Associated With Chronic Myocardial Infarction

I. Deschênes, X. Wan, K. Laurita, 2015, Circulation. Arrhythmia and electrophysiology.

Stretch the heart: get memory.

D. Jeyaraj, I. Deschênes, L. Wilson, 2008, Heart rhythm.