B. Dumotier

发表

Analysis of Unipolar Electrograms in Rabbit Heart Demonstrated the Key Role of Ventricular Apicobasal Dispersion in Arrhythmogenicity

N. Guérard, P. Jordaan, B. Dumotier, 2014, Cardiovascular Toxicology.

Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart.

G. Helmlinger, R. Penland, A. Stamps, 2006, Progress in biophysics and molecular biology.

Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.

S. Whitebread, L. Urban, B. Dumotier, 2016, Drug discovery today.

Drug-Induced QTC Prolongation Dangerously Underestimates Proarrhythmic Potential: Lessons From Terfenadine

B. Dumotier, P. Hoffmann, L. Hondeghem, 2011, Journal of cardiovascular pharmacology.

Pharmacological Characterization of a Novel 5-Hydroxybenzothiazolone-Derived β2-Adrenoceptor Agonist with Functional Selectivity for Anabolic Effects on Skeletal Muscle Resulting in a Wider Cardiovascular Safety Window in Preclinical Studies

S. Hatakeyama, T. Ullrich, D. Glass, 2019, The Journal of Pharmacology and Experimental Therapeutics.

A straightforward guide to the basic science behind arrhythmogenesis

B. Dumotier, 2014, Heart.

Republished: A straightforward guide to the basic science behind arrhythmogenesis

B. Dumotier, 2014, Postgraduate Medical Journal.

Antimalarial drugs: QT prolongation and cardiac arrhythmias

B. Dumotier, M. Traebert, 2005, Expert opinion on drug safety.

Preclinical cardio-safety assessment of torsadogenic risk and alternative methods to animal experimentation: The inseparable twins

B. Dumotier, B. M. Dumotier, A. V. Georgieva, 2007, Cell Biology and Toxicology.

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: a database review and analysis.

M. Deurinck, B. Dumotier, M. Traebert, 2008, Pharmacology & therapeutics.

Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart.

N. Guérard, B. Dumotier, M. Traebert, 2008, Journal of pharmacological and toxicological methods.

Ultrafast sodium channel block by dietary fish oil prevents dofetilide-induced ventricular arrhythmias in rabbit hearts.

B. Dumotier, L. Hondeghem, K. Dujardin, 2008, American journal of physiology. Heart and circulatory physiology.

Chronic Amiodarone Effects on Epicardial Conduction and Repolarization in the Isolated Porcine Heart

D. Lacroix, B. Dumotier, B. Dupuis, 2000, Pacing and clinical electrophysiology : PACE.

"Use-dependent" effects of cisapride on postrest action potentials in rabbit ventricular myocardium.

B. Dumotier, M. Bastide, M. Adamantidis, 2001, European journal of pharmacology.

Repercussions of pharmacologic reduction in ionic currents on action potential configuration in rabbit Purkinje fibers: Are they indicative of proarrhythmic potential?

F. Puisieux, B. Dumotier, B. Dupuis, 1999 .

Oscillations of cardiac wave length and proarrhythmia

B. Dumotier, M. Traebert, L. Hondeghem, 2010, Naunyn-Schmiedeberg's Archives of Pharmacology.

Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824).

P. Atadja, E. Francotte, W. Shao, 2010, Journal of medicinal chemistry.

Safety Aspects of the Cav1.2 Channel

B. Dumotier, M. Traebert, 2015 .

Report and Recommendations of the Workshop of the European Centre for the Validation of Alternative Methods for Drug-Induced Cardiotoxicity

Carl-Fredrik Mandenius, Mario Beilmann, Susanne Bremer, 2009, Cardiovascular Toxicology.

Modeling and simulation of preclinical cardiac safety: towards an integrative framework.

Anna Georgieva, Antoine Soubret, Ruben Bibas, 2009, Drug metabolism and pharmacokinetics.

Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells.

Martin Traebert, B. Dumotier, M. Traebert, 2004, European journal of pharmacology.

Cardiotoxic Potential of Hydroxychloroquine, Chloroquine and Azithromycin in Adult Human Primary Cardiomyocytes.

Paul E. Miller, L. Urban, P. Jordaan, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae

Torsten Christ, Thomas Eschenhagen, Arne Hansen, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver

A. Zell, H. Ellinger-Ziegelbauer, M. Schwarz, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors

P. Furet, P. Chène, T. Schmelzle, 2023, ChemMedChem.

Cisapride‐induced prolongation of cardiac action potential and early afterdepolarizations in rabbit Purkinje fibres

B. Dumotier, B. Dupuis, M. Adamantidis, 1996, British journal of pharmacology.

Analysis of Unipolar Electrograms in Rabbit Heart Demonstrated the Key Role of Ventricular Apicobasal Dispersion in Arrhythmogenicity

N. Guérard, P. Jordaan, B. Dumotier, 2014, Cardiovascular Toxicology.

Antimalarial drugs: QT prolongation and cardiac arrhythmias.

B. Dumotier, M. Traebert, 2005 .

Secondary pharmacology: screening and interpretation of off-target activities - focus on translation.

S. Whitebread, L. Urban, B. Dumotier, 2016, Drug discovery today.