X. Wan

发表

Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall.

D. Rosenbaum, Maria Strom, X. Wan, 2010, American journal of physiology. Heart and circulatory physiology.

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

David S. Rosenbaum, Jeffrey Robbins, Saptarsi M. Haldar, 2012, Nature.

Hysteresis Effect Implicates Calcium Cycling as a Mechanism of Repolarization Alternans

D. Rosenbaum, G. Kirsch, X. Wan, 2003, Circulation.

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine

W. Wenzel, H. Katus, Dierk Thomas, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

Myocardial KChIP2 Expression in Guinea Pig Resolves an Expanded Electrophysiologic Role

D. Nassal, I. Deschênes, X. Wan, 2016, PloS one.

Electrotonic load triggers remodeling of repolarizing current Ito in ventricle.

D. Rosenbaum, X. Wan, I. Libbus, 2004, American journal of physiology. Heart and circulatory physiology.

KChIP2 regulates the cardiac Ca2+ transient and myocyte contractility by targeting ryanodine receptor activity

D. Nassal, I. Deschênes, X. Wan, 2017, PloS one.

Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway.

Prasongchai Sattayaprasert, D. Nassal, I. Deschênes, 2016, Journal of molecular and cellular cardiology.

Molecular correlates of repolarization alternans in cardiac myocytes.

D. Rosenbaum, X. Wan, K. Laurita, 2005, Journal of molecular and cellular cardiology.

A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1–Induced Activation of Pacemaker Current

Ronald A. Li, I. Deschênes, X. Wan, 2017, Stem Cell Reviews and Reports.

Phosphorylation at Connexin43 Serine‐368 Is Necessary for Myocardial Conduction During Metabolic Stress

D. Rosenbaum, A. Werdich, I. Deschênes, 2016, Journal of cardiovascular electrophysiology.

Atrial SERCA2a Overexpression Has No Affect on Cardiac Alternans but Promotes Arrhythmogenic SR Ca2+ Triggers

M. Cutler, X. Wan, K. Laurita, 2015, PloS one.

Intracellular Potassium Stabilizes Human Ether-à-go-go-Related Gene Channels for Export from Endoplasmic Reticulum

T. Hébert, X. Wan, E. Ficker, 2009, Molecular Pharmacology.

Aberrant S-nitrosylation mediates calcium-triggered ventricular arrhythmia in the intact heart

J. Stamler, M. Cutler, D. Rosenbaum, 2012, Proceedings of the National Academy of Sciences.

Targeted Sarcoplasmic Reticulum Ca2+ ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart

M. Cutler, D. Rosenbaum, R. Hajjar, 2012, Circulation.

Targeted SERCA2a Gene Delivery to Restore Electrical Stability in the Failing Heart

M. Cutler, D. Rosenbaum, R. Hajjar, 2012 .

Heart Failure Targeted Sarcoplasmic Reticulum Ca ATPase 2a Gene Delivery to Restore Electrical Stability in the Failing Heart

M. Cutler, D. Rosenbaum, R. Hajjar, 2012 .

Sarcomere-based genetic enhancement of systolic cardiac function in a murine model of dilated cardiomyopathy.

I. Deschênes, X. Wan, R. Mamidi, 2018, International journal of cardiology.

Impaired contractile function due to decreased cardiac myosin binding protein C content in the sarcomere.

M. Chandler, Y. Cheng, D. Rosenbaum, 2013, American journal of physiology. Heart and circulatory physiology.

Antimony-Based Antileishmanial Compounds Prolong the Cardiac Action Potential by an Increase in Cardiac Calcium Currents

Y. Kuryshev, B. Wible, X. Wan, 2006, Molecular Pharmacology.

Ionic bases for electrical remodeling of the canine cardiac ventricle.

Y. Rudy, D. Jeyaraj, D. Rosenbaum, 2013, American journal of physiology. Heart and circulatory physiology.

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

James W. Smyth, J. Gorelik, I. Deschênes, 2018, eLife.

Mechanisms by which SCN5A mutation N1325S causes cardiac arrhythmias and sudden death in vivo.

M. Chung, P. Tchou, D. V. Van Wagoner, 2004, Cardiovascular research.

Generation and Expansion of Human Cardiomyocytes from Patient Peripheral Blood Mononuclear Cells.

I. Deschênes, X. Wan, Ming-Tao Zhao, 2021, Journal of visualized experiments : JoVE.

Pharmacological Modulation of Cardiac Gap Junctions to Enhance Cardiac Conduction: Evidence Supporting a Novel Target for Antiarrhythmic Therapy

D. Rosenbaum, E. Gilat, X. Wan, 2003, Circulation.

hERG channel trafficking: novel targets in drug-induced long QT syndrome.

X. Wan, E. Ficker, E Ficker, 2007, Biochemical Society transactions.

Abstract 1083: Targeted SERCA2a Gene Overexpression Identifies Mechanism and Potential Therapy for Arrhythmogenic Cardiac Alternans

M. Cutler, D. Rosenbaum, R. Hajjar, 2007 .

Targeted SERCA2a Gene Expression Identifies Molecular Mechanism and Therapeutic Target for Arrhythmogenic Cardiac Alternans

Roger J Hajjar, M. Cutler, D. Rosenbaum, 2009, Circulation. Arrhythmia and electrophysiology.

Transmural Heterogeneity of Calcium Handling in Canine

Kenneth R. Laurita, B. Wible, X. Wan, 2003, Circulation research.

KChIP2 is a core transcriptional regulator of cardiac excitability

D. Nassal, I. Deschênes, X. Wan, 2017, eLife.

Contribution of two-pore K+ channels to cardiac ventricular action potential revealed using human iPSC-derived cardiomyocytes.

S. Chai, D. Nassal, I. Deschênes, 2017, American journal of physiology. Heart and circulatory physiology.

MicroRNA Biophysically Modulates Cardiac Action Potential by Direct Binding to Ion Channel

P. Mohler, T. Hund, I. Deschênes, 2021, Circulation.

Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency

Joe Z. Zhang, V. Garg, I. Deschênes, 2022, Circulation research.

Mechanisms of zolpidem‐induced long QT syndrome: acute inhibition of recombinant hERG K+ channels and action potential prolongation in human cardiomyocytes derived from induced pluripotent stem cells

H. Katus, C. Schmidt, I. Deschênes, 2013, British journal of pharmacology.

Brassinosteroids Positively Regulate Plant Immunity via BRI1-EMS-SUPPRESSOR 1-Mediated GLUCAN SYNTHASE-LIKE 8 Transcription

F. Yang, X. Wan, Xiumei Xu, 2022, Frontiers in Plant Science.

Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar

X. Wan, I. Greener, J. K. Donahue, 2022, Nature Communications.

Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction.

D. Rosenbaum, Maria Strom, J. K. Donahue, 2012, Journal of the American College of Cardiology.

Cardiac Glycosides as Novel Inhibitors of Human Ether-a-go-go-Related Gene Channel Trafficking

B. Wible, X. Wan, E. Ficker, 2007, Journal of Pharmacology and Experimental Therapeutics.

The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart.

D. Jeyaraj, D. Rosenbaum, A. Werdich, 2012, Progress in biophysics and molecular biology.

Cellular Alternans

D. Rosenbaum, L. Wilson, X. Wan, 2006, Annals of the New York Academy of Sciences.

Heart failure enhances susceptibility to arrhythmogenic cardiac alternans.

Matthew Gittinger, D. Jeyaraj, D. Rosenbaum, 2009, Heart rhythm.

Arrhythmogenic Delayed Afterdepolarizations Are Promoted by Severe Hypothermia But Not Therapeutic Hypothermia.

L. Wilson, X. Wan, K. Laurita, 2017, Circulation journal : official journal of the Japanese Circulation Society.

Oxidative Inactivation of the Lipid Phosphatase Phosphatase and Tensin Homolog on Chromosome Ten (PTEN) as a Novel Mechanism of Acquired Long QT Syndrome*

C. Obejero-Paz, X. Wan, E. Ficker, 2010, The Journal of Biological Chemistry.

A topographical study of mechanical and electrical properties of single myocytes isolated from normal guinea‐pig ventricular muscle

S. Bryant, X. Wan, G. Hart, 2003, Journal of anatomy.

The Effects of [K+]O on Regional Differences in Electrical Characteristics of Ventricular Myocytes in Guinea‐Pig

S. Bryant, X. Wan, G. Hart, 2000, Experimental physiology.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity

Alfred L George, E. Kaufman, A. George, 2018, The Journal of clinical investigation.

Voltage-gated sodium channels assemble and gate as dimers

T. Ha, Céline Marionneau, I. Deschênes, 2017, Nature Communications.

Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function.

S. Weinberg, I. Deschênes, X. Wan, 2020, Biophysical journal.

The voltage-gated sodium channel pore exhibits conformational flexibility during slow inactivation

Indra D Sahu, S. Chakrapani, I. Sahu, 2018, The Journal of general physiology.

Brugada Syndrome Disease Phenotype Explained in Apparently Benign Sodium Channel Mutations

S. Chai, I. Deschênes, X. Wan, 2014, Circulation. Cardiovascular genetics.

Heterogeneous repolarization creates ventricular tachycardia circuits in healed myocardial infarction scar

S. Parajuli, J. K. Donahue, X. Wan, 2022, Nature communications.

Spontaneous calcium oscillations during diastole in the whole heart: the influence of ryanodine reception function and gap junction coupling.

M. Cutler, X. Wan, K. Laurita, 2011, American journal of physiology. Heart and circulatory physiology.

EXTRACELLULAR PERINEXAL SEPARATION IS A PRINCIPAL DETERMINANT OF CARDIAC CONDUCTION

James W. Smyth, R. Davalos, I. Deschênes, 2023, bioRxiv.

Mild hypothermia preserves myocardial conduction during ischemia by maintaining gap junction intracellular communication and Na+ channel function.

I. Deschênes, L. Wilson, X. Wan, 2017, American journal of physiology. Heart and circulatory physiology.

New experimental evidence for mechanism of arrhythmogenic membrane potential alternans based on balance of electrogenic I(NCX)/I(Ca) currents.

Michael Cutler, Zhen Song, Alain Karma, 2012, Heart rhythm.

STORM and TEM Identify the Cardiac Ephapse: An Intercalated Disk Nanodomain with Previously Unanticipated Functions in Cardiac Conduction

James W. Smyth, J. Gorelik, I. Deschênes, 2017, Microscopy and Microanalysis.

Arrhythmogenic cardiac alternans in heart failure is suppressed by late sodium current blockade by ranolazine.

D. Rosenbaum, L. Wilson, X. Wan, 2019, Heart rhythm.

Functional suppression of sodium channels by beta(1)-subunits as a molecular mechanism of idiopathic ventricular fibrillation.

Q. Wang, G. Kirsch, X. Wan, 2000, Journal of molecular and cellular cardiology.

Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation.

G. Kirsch, X. Wan, Shenghan Chen, 2001, American journal of physiology. Heart and circulatory physiology.

A Heart Failure-Associated SCN5A Splice Variant Leads to a Reduction in Sodium Current Through Coupled-Gating With the Wild-Type Channel

I. Deschênes, X. Wan, Ji-Dong Fu, 2021, Frontiers in Physiology.

Intracellular Potassium Stabilizes Human Ether-à-go-go-Related Gene Channels for Export from Endoplasmic Reticulum

X. Wan, E. Ficker, A. Dennis, 2009, Molecular Pharmacology.

Gap junction heterogeneity as mechanism for electrophysiologically distinct properties across the ventricular wall.

D. Rosenbaum, Maria Strom, X. Wan, 2010, American journal of physiology. Heart and circulatory physiology.

Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals.

Jiajie Yan, X. Wan, M. Fill, 2024, The Journal of membrane biology.

Fusion of Anthopleurin-B to AAV2 increases specificity of cardiac gene transfer.

X. Wan, J. E. Finet, J. K. Donahue, 2018, Virology.