I. Lotan

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Rearrangements in the Relative Orientation of Cytoplasmic Domains Induced by a Membrane-anchored Protein Mediate Modulations in Kv Channel Gating*

Shai Berlin, A. Lvov, Dafna Greitzer, 2009, The Journal of Biological Chemistry.

VAMP2 interacts directly with the N terminus of Kv2.1 to enhance channel inactivation

A. Lvov, D. Chikvashvili, I. Lotan, 2008, Pflügers Archiv - European Journal of Physiology.

Voltage‐gated Potassium Channel as a Facilitator of Exocytosis

U. Ashery, I. Lotan, Lori Feinshreiber, 2009, Annals of the New York Academy of Sciences.

Non-conducting function of the Kv2.1 channel enables it to recruit vesicles for release in neuroendocrine and nerve cells

O. Yizhar, U. Matti, U. Ashery, 2010, Journal of Cell Science.

Molecular mechanism of protein kinase C modulation of sodium channel α‐subunits expressed in Xenopus oocytes

N. Dascal, I. Lotan, M. Wallner, 1991, FEBS letters.

Adenosine-induced slow ionic currents in the Xenopus oocyte

N. Dascal, I. Lotan, Sasson Cohen, 1982, Nature.

Evidence for the existence of a cardiac specific isoform of the α1 subunit of the voltage dependent calcium channel

G. Váradi, N. Dascal, I. Lotan, 1989, FEBS letters.

A potential site of functional modulation by protein kinase A in the cardiac Ca2+ channel α 1C subunit

N. Dascal, I. Lotan, E. Shistik, 1996, FEBS letters.

The Dual Function of the Polybasic Juxtamembrane Region of Syntaxin 1A in Clamping Spontaneous Release and Stimulating Ca2+-Triggered Release in Neuroendocrine Cells

I. Lotan, I. Michaelevski, A. Sheinin, 2017, The Journal of Neuroscience.

CK2 Phosphorylation Is Required for Regulation of Syntaxin 1A Activity in Ca2+-Triggered Release in Neuroendocrine Cells

D. Chikvashvili, I. Lotan, D. Singer‐Lahat, 2020, bioRxiv.

Domain 2 of Drosophila Para Voltage-Gated Sodium Channel Confers Insect Properties to a Rat Brain Channel

D. Gordon, I. Shichor, E. Zlotkin, 2002, The Journal of Neuroscience.

A Scorpion α-Like Toxin That Is Active on Insects and Mammals Reveals an Unexpected Specificity and Distribution of Sodium Channel Subtypes in Rat Brain Neurons

D. Bertrand, D. Gordon, I. Shichor, 1999, The Journal of Neuroscience.

Modal behavior of the Kv1.1 channel conferred by the Kvβ1.1 subunit and its regulation by dephosphorylation of Kv1.1

N. Dascal, I. Lotan, D. Singer‐Lahat, 1999, Pflügers Archiv.

Scorpion toxins differentiating among neuronal sodium channel subtypes: Nature's guide for design of selective drugs

D. Bertrand, S. Heinemann, M. Gurevitz, 2002 .

Synaptosome-associated protein of 25 kilodaltons modulates Kv2.1 voltage-dependent K(+) channels in neuroendocrine islet beta-cells through an interaction with the channel N terminus.

P. MacDonald, M. Wheeler, J. Lakey, 2002, Molecular endocrinology.

The voltage-dependent potassium channel subunit Kv2.1 regulates insulin secretion from rodent and human islets independently of its electrical function

P. MacDonald, X. Dai, C. Hajmrle, 2012, Diabetologia.

Expression of Exogenous Ion Channels and Neurotransmitter Receptors in RNA-Injected Xenopus Oocytes

N. Dascal, I. Lotan, 1992 .

Cardiac calcium channels expressed in Xenopus oocytes are modulated by dephosphorylation but not by cAMP-dependent phosphorylation.

M. Biel, F. Hofmann, V. Flockerzi, 1994, Receptors & channels.

Expression of Voltage‐Dependent Ca Channels from Skeletal Muscle in Xenopus Oocytes

N. Dascal, I. Lotan, A. Gigi, 1989, Annals of the New York Academy of Sciences.

Specific block of calcium channel expression by a fragment of dihydropyridine receptor cDNA.

N. Dascal, I. Lotan, P. Goelet, 1989, Science.

Adenosine-induced K+ current in Xenopus oocyte and the role of adenosine 3',5'-monophosphate.

Y. Oron, N. Dascal, I. Lotan, 1985, Molecular pharmacology.

Mechanism of modulation of single sodium channels from skeletal muscle by the β1-subunit from rat brain

I. Lotan, M. Wallner, W. Schreibmayer, 1994, Pflügers Archiv.

Inactivation of a voltage-dependent K+ channel by β subunit: Modulation by a phosphorylation-dependent interaction between the distal C-terminus of a subunit and cytoskeleton

D. Chikvashvili, I. Lotan, W. Thornhill, 1997, Neuroscience Letters.

Imaging plasma membrane proteins in large membrane patches of Xenopus oocytes

N. Dascal, L. Mittelman, I. Lotan, 2000, Pflügers Archiv.

Direct Interaction of Target SNAREs with the Kv2.1 Channel

M. Linial, D. Chikvashvili, Sharon Tsuk, 2003, Journal of Biological Chemistry.

Syntaxin‐binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents

I. Lotan, E. Aizenman, J. Horn, 2014, The Journal of physiology.

MODAL REGULATION OF CHANNEL ACTIVATION AND INACTIVATION GATING

M. Linial, D. Chikvashvili, Sharon Tsuk, 2003 .

Protein kinase A reduces voltage-dependent Na+ current in Xenopus oocytes

E. Gershon, N. Dascal, I. Lotan, 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Modulation of a Brain Voltage-gated K+ Channel by Syntaxin 1A Requires the Physical Interaction of Gβγ with the Channel*

M. Lohse, D. Chikvashvili, Sharon Tsuk, 2002, The Journal of Biological Chemistry.

Direct Interaction of a Brain Voltage-Gated K+Channel with Syntaxin 1A: Functional Impact on Channel Gating

M. Linial, D. Chikvashvili, I. Lotan, 2001, The Journal of Neuroscience.

Phosphorylation by protein kinase A of RCK1 K+ channels expressed in Xenopus oocytes.

N. Dascal, I. Lotan, W. Thornhill, 1994, Biochemistry.

K+ Channel Facilitation of Exocytosis by Dynamic Interaction with Syntaxin

M. Benveniste, U. Ashery, E. Levitan, 2007, The Journal of Neuroscience.

Dissociation of acetylcholine- and cyclic GMP-induced currents inXenopu oocytes

N. Dascal, I. Lotan, Y. Lass, 1987, Pflügers Archiv.

Acetylcholine and phorbol esters inhibit potassium currents evoked by adenosine and cAMP in Xenopus oocytes.

N. Dascal, I. Lotan, H. Lester, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Selective elimination of mRNAs in vivo: complementary oligodeoxynucleotides promote RNA degradation by an RNase H-like activity.

E R Kandel, E. Kandel, P. Dash, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Hybrid arrest technique to test for functional roles of cloned cDNAs and to identify homologies among ion channel genes.

I. Lotan, 1992, Methods in Enzymology.

Calcium channel currents in Xenopus oocytes injected with rat skeletal muscle RNA.

N. Dascal, I. Lotan, A. Gigi, 1992, The Journal of physiology.

Blockade of ion channel expression in xenopus oocytes with complementary DNA probes to Na+ and K+ channel mRNAs

P. Dash, S. Siegelbaum, A. Volterra, 1988, Neuron.

Modulation of the skeletal muscle sodium channel α‐subunit by the β1 ‐subunit

I. Lotan, P. Meera, M. Wallner, 1993 .

Activation of protein kinase C alters voltage dependence of a Na+ channel

N. Dascal, I. Lotan, 1991, Neuron.

Syntaxin 1A Binds to the Cytoplasmic C Terminus of Kv2.1 to Regulate Channel Gating and Trafficking*

Sharon Tsuk, I. Lotan, Y. Leung, 2003, The Journal of Biological Chemistry.

ATP-evoked membrane responses inXenopus oocytes

N. Dascal, I. Lotan, Sasson Cohen, 1986, Pflügers Archiv.

pH Dependence of the Acetylcholine Receptor Channel

B. Gavish, I. Lotan, E. M. Landau, 1981 .

The roles of the subunits in the function of the calcium channel.

M. Biel, F. Hofmann, V. Flockerzi, 1991, Science.

GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networks

Edden Slomowitz, Boaz Styr, I. Vertkin, 2015, Proceedings of the National Academy of Sciences.

Inactivation of a Voltagedependent K+ Channel by β Subunit

D. Chikvashvili, I. Lotan, W. Thornhill, 1997, The Journal of Biological Chemistry.

Deletion of the N-terminus of a K+ channel brings about short-term modulation by cAMP and β1-adrenergic receptor activation

I. Lotan, G. Levin, J. Jing, 2007, Journal of Molecular Neuroscience.

Fast inactivation of a brain K+ channel composed of Kv1.1 and Kvβ1.1 subunits modulated by G protein βγ subunits

D. Chikvashvili, I. Lotan, E. Reuveny, 1999, The EMBO journal.

Phosphorylation of a K+ channel alpha subunit modulates the inactivation conferred by a beta subunit. Involvement of cytoskeleton.

D. Chikvashvili, I. Lotan, W. Thornhill, 1996, The Journal of biological chemistry.

Modulation of vertebrate brain Na+ and K+ channels by subtypes of protein kinase C

N. Dascal, Z. Naor, I. Lotan, 1990, FEBS letters.

Activation of a Metabotropic Glutamate Receptor and Protein Kinase C Reduce the Extent of Inactivation of the K+Channel Kv1.1/Kvβ1.1 via Dephosphorylation of Kv1.1*

D. Chikvashvili, I. Lotan, W. Thornhill, 1998, The Journal of Biological Chemistry.

Agonist-independent inactivation and agonist-induced desensitization of the G protein-activated K+ channel (GIRK) in Xenopus oocytes

N. Dascal, I. Lotan, G. Levin, 1998, Pflügers Archiv.

Selective Interaction of Syntaxin 1A with KCNQ2: Possible Implications for Specific Modulation of Presynaptic Activity

A. Korngreen, B. Attali, N. Regev, 2009, PloS one.

Regulation of RCK1 Currents with a cAMP Analog via Enhanced Protein Synthesis and Direct Channel Phosphorylation (*)

D. Chikvashvili, I. Lotan, W. Thornhill, 1995, The Journal of Biological Chemistry.

Modulation of cardiac Ca2+ channels in Xenopus oocytes by protein kinase C

M. Biel, F. Hofmann, R. Hullin, 1992, FEBS letters.

The 25-kDa Synaptosome-associated Protein (SNAP-25) Binds and Inhibits Delayed Rectifier Potassium Channels in Secretory Cells*

N. Diamant, W. Trimble, A. Salapatek, 2002, The Journal of Biological Chemistry.

Tracking Ca2+-dependent and Ca2+-independent conformational transitions in syntaxin 1A during exocytosis in neuroendocrine cells

Y. Oron, Shai Berlin, D. Chikvashvili, 2013, Journal of Cell Science.

Formation of the full SNARE complex eliminates interactions of its individual protein components with the Kv2.1 channel.

A. Lvov, D. Chikvashvili, Sharon Tsuk, 2008, Biochemistry.

Direct Interaction of Endogenous Kv Channels with Syntaxin Enhances Exocytosis by Neuroendocrine Cells

D. Chikvashvili, I. Lotan, D. Singer‐Lahat, 2008, PloS one.

Target Soluble N-Ethylmaleimide-Sensitive Factor Attachment Protein Receptors (t-SNAREs) Differently Regulate Activation and Inactivation Gating of Kv2.2 and Kv2.1: Implications on Pancreatic Islet Cell Kv Channels

D. Chikvashvili, I. Lotan, I. Michaelevski, 2006, Molecular Pharmacology.

Kv2.1 Channel Activation and Inactivation Is Influenced by Physical Interactions of Both Syntaxin 1A and the Syntaxin 1A/Soluble N-Ethylmaleimide-Sensitive Factor-25 (t-SNARE) Complex with the C Terminus of the Channel

R. Joho, D. Chikvashvili, Sharon Tsuk, 2005, Molecular Pharmacology.

Modulation of a brain voltage-gated K+ channel by syntaxin 1A requires the physical interaction of Gbetagamma with the channel.

M. Lohse, D. Chikvashvili, Sharon Tsuk, 2002, The Journal of biological chemistry.

Regulation of the neuronal KCNQ2 channel by Src – a dual rearrangement of the cytosolic termini underlies bidirectional regulation of gating

D. Chikvashvili, I. Lotan, V. Tsemakhovich, 2015, Journal of Cell Science.

pH dependence of the acetylcholine receptor channel: a species variation

B. Gavish, I. Lotan, E. M. Landau, 1981, The Journal of general physiology.

Phosphorylation of SPICK2, an AKT2 channel homologue from Samanea motor cells.

M. Moshelion, R. Hedrich, Ling Yu, 2006, Journal of experimental botany.

Evidence for the existence of RNA of Ca2+-channel α2/δ subunit in Xenopus oocytes

N. Dascal, I. Lotan, K. Itagaki, 1992 .

Regulation of Neuronal M-Channel Gating in an Isoform-Specific Manner: Functional Interplay between Calmodulin and Syntaxin 1A

J. Hirsch, N. Regev, I. Lotan, 2011, The Journal of Neuroscience.

Level of expression controls modes of gating of a K+ channel

N. Dascal, I. Lotan, W. Schreibmayer, 1992, FEBS letters.

Phosphorylation of a K+ Channel α Subunit Modulates the Inactivation Conferred by a β Subunit

D. Chikvashvili, I. Lotan, W. Thornhill, 1996, The Journal of Biological Chemistry.

Modulation by protein kinase C activation of rat brain delayed‐rectifier K+ channel expressed in Xenopus oocytes

D. Chikvashvili, I. Lotan, W. Thornhill, 1996, FEBS letters.

Modulation of a Shaker potassium A‐channel by protein kinase C activation

N. Dascal, I. Lotan, O. Moran, 1991, FEBS letters.

pH dependence of the acetylcholine receptor channel: a species variation

B. Gavish, I. Lotan, E. M. Landau, 1981, The Journal of general physiology.

Syntaxin modulates Kv1.1 through dual action on channel surface expression and conductance.

D. Chikvashvili, I. Lotan, I. Michaelevski, 2009, Biochemistry.

Evidence for the existence of RNA of Ca(2+)-channel alpha 2/delta subunit in Xenopus oocytes.

N. Dascal, I. Lotan, K. Itagaki, 1992, Biochimica et biophysica acta.

Modulation of the skeletal muscle sodium channel alpha-subunit by the beta 1-subunit.

I. Lotan, P. Meera, M. Wallner, 1993, FEBS letters.