J. Mitcheson

发表

Insight into the mechanism of inactivation and pH sensitivity in potassium channels from molecular dynamics simulations.

M. Sutcliffe, M. Sansom, A. Grottesi, 2008, Biochemistry.

Drug block of the hERG potassium channel: Insight from modeling

M. Sutcliffe, P. Stansfeld, P. Gedeck, 2007, Proteins.

Computational design and discovery of "minimally structured" hERG blockers.

A. Cavalli, M. Recanatini, R. Buonfiglio, 2012, Journal of medicinal chemistry.

hERG potassium channels and the structural basis of drug-induced arrhythmias.

J. Mitcheson, 2008, Chemical research in toxicology.

A structural basis for drug-induced long QT syndrome.

Jun Chen, John S. Mitcheson, M. Sanguinetti, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structural Determinants of HERG Channel Block by Clofilium and Ibutilide

Michael C Sanguinetti, Martin Tristani-Firouzi, Derek Leishman, 2004, Molecular Pharmacology.

Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs

Michael J Sutcliffe, Claire Wood, Phillip J Stansfeld, 2006, Molecular Pharmacology.

Molecular Determinants of hERG Channel Block

Kaichiro Kamiya, Michael C Sanguinetti, John S Mitcheson, 2006, Molecular Pharmacology.

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome

Michael J Sutcliffe, Phillip J Stansfeld, John S Mitcheson, 2006, Expert opinion on drug metabolism & toxicology.

Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

Michael C Sanguinetti, John S Mitcheson, M. Sanguinetti, 2005, Trends in pharmacological sciences.

A structural basis for drug-induced long QT syndrome.

M. Sanguinetti, C. Culberson, J. Mitcheson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The Low-Potency, Voltage-Dependent HERG Blocker Propafenone—Molecular Determinants and Drug Trapping

Jules C Hancox, Richard B Sessions, Harry J Witchel, 2004, Molecular Pharmacology.

Drug binding to HERG channels: evidence for a ‘non‐aromatic’ binding site for fluvoxamine

J. Mitcheson, 2003, British journal of pharmacology.

Trapping of a Methanesulfonanilide by Closure of the Herg Potassium Channel Activation Gate

John S. Mitcheson, M. Sanguinetti, J. Mitcheson, 2000, The Journal of general physiology.

Open channel block of HERG K(+) channels by vesnarinone.

I Kodama, M. Sanguinetti, K. Kamiya, 2001, Molecular pharmacology.

Molecular determinants of high-affinity drug binding to HERG channels.

J. Mitcheson, M. Perry, 2003, Current opinion in drug discovery & development.

Molecular biology of K(+) channels and their role in cardiac arrhythmias.

M. Sanguinetti, M. Tristani-Firouzi, J. Mitcheson, 2001, The American journal of medicine.

Functional Roles of Charged Residues in the Putative Voltage Sensor of the HCN2 Pacemaker Channel*

M. Sanguinetti, J. Mitcheson, Jun Chen, 2000, The Journal of Biological Chemistry.

Comparative Pharmacology of Guinea Pig Cardiac Myocyte and Cloned hERG (IKr) Channel

Chris Pollard, N. Standen, J. Mitcheson, 2004, Journal of cardiovascular electrophysiology.

New Pyrimido-Indole Compound CD-160130 Preferentially Inhibits the KV11.1B Isoform and Produces Antileukemic Effects without Cardiotoxicity

G. Basso, A. Becchetti, A. Arcangeli, 2015, Molecular Pharmacology.

Mechanistic Insight into Human ether-à-go-go-related Gene (hERG) K+ Channel Deactivation Gating from the Solution Structure of the EAG Domain

S. Thomson, F. Muskett, P. Stansfeld, 2010, The Journal of Biological Chemistry.

hERG potassium channel inhibition by ivabradine may contribute to QT prolongation and risk of torsades de pointes

J. Hancox, C. Dempsey, J. Mitcheson, 2015, Therapeutic advances in drug safety.

Inhibition of L‐type calcium current by propafenone in single myocytes isolated from the rabbit atrioventricular node

J. Hancox, J. Mitcheson, 1997, British journal of pharmacology.

A heme-binding domain controls regulation of ATP-dependent potassium channels

N. Davies, R. Schmid, T. Chernova, 2016, Proceedings of the National Academy of Sciences.

Direct block of hERG potassium channels by caffeine

J. Mitcheson, S. Cockerill, 2005 .

Drug binding interactions in the inner cavity of hERG: Molecular insights from structure-activity relationships of clofilium and ibutilide analogues

M. Sutcliffe, P. Stansfeld, J. Mitcheson, 2005 .

hERG Potassium Channel Blockade by the HCN Channel Inhibitor Bradycardic Agent Ivabradine

Jules C. Hancox, Christopher E. Dempsey, John S. Mitcheson, 2015, Journal of the American Heart Association.

Characteristics of a transient outward current (sensitive to 4-aminopyridine) in Ca2+-tolerant myocytes isolated from the rabbit atrioventricular node

John S. Mitcheson, J. Hancox, J. Mitcheson, 1999, Pflügers Archiv.

Cultured adult cardiac myocytes: future applications, culture methods, morphological and electrophysiological properties.

A J Levi, J. Hancox, J. Mitcheson, 1998, Cardiovascular research.

Role of Intracellular Sodium Overload in the Genesis of Cardiac Arrhythmias

A J Levi, S J Evans, J. Hancox, 1997, Journal of cardiovascular electrophysiology.

Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture

J. Hancox, J. Mitcheson, A. Levi, 1996, Pflügers Archiv.

Action potentials, ion channel currents and transverse tubule density in adult rabbit ventricular myocytes maintained for 6 days in cell culture

J. Hancox, J. Mitcheson, A. Levi, 2006, Pflügers Archiv.

Physicochemical basis for binding and voltage-dependent block of hERG channels by structurally diverse drugs.

M. Sanguinetti, K. Kamiya, J. Mitcheson, 2005, Novartis Foundation symposium.

Ion channel and exchange currents in single myocytes isolated from the rabbit atrioventricular node.

J. Hancox, J. Mitcheson, 1997, The Canadian journal of cardiology.

Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes.

Jules C Hancox, Harry J Witchel, James T Milnes, 2002, Journal of pharmacological and toxicological methods.

A mechanism for CO regulation of ion channels

N. Davies, R. Schmid, P. Moody, 2018, Nature Communications.

An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes

J. Hancox, J. Mitcheson, J. C. Hancox, 1999, Pflügers Archiv.

Modulation of hERG potassium currents in HEK‐293 cells by protein kinase C. Evidence for direct phosphorylation of pore forming subunits

N. Standen, I. Torrecilla, J. Mitcheson, 2007, The Journal of physiology.

The S4–S5 linker couples voltage sensing and activation of pacemaker channels

Jun Chen, John S. Mitcheson, Martin Tristani-Firouzi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Mechanism for Calmodulin-Dependent Inactivation of Transient Receptor Potential Vanilloid 6.

G. W. Vuister, B. Goult, N. Bate, 2018, Biochemistry.

Long-Term Channel Block Is Required to Inhibit Cellular Transformation by Human Ether-à-Go-Go–Related Gene (hERG1) Potassium Channels

C. Pritchard, S. Giblett, J. Mitcheson, 2014, Molecular Pharmacology.

SYMPOSIUM REVIEW: Revealing the structural basis of action of hERG potassium channel activators and blockers

M. Sanguinetti, J. Mitcheson, M. Perry, 2010, The Journal of physiology.

Progress and Gaps in Understanding the Electrophysiological Properties of Morphologically Normal Cells from the Cardiac atrioventricular Node

Jules C. Hancox, Kathryn H. Yuill, John S. Mitcheson, 2003, Int. J. Bifurc. Chaos.

hERG potassium channel inhibition by ivabradine requires channel gating.

J. Hancox, C. Dempsey, A. El Harchi, 2015, Journal of molecular and cellular cardiology.

Biophysical Properties and Molecular Basis of Cardiac Rapid and Slow Delayed Rectifier Potassium Channels

M. Sanguinetti, J. Mitcheson, J.S. Mitcheson, 1999, Cellular Physiology and Biochemistry.

Structural determinants for high-affinity block of hERG potassium channels.

Michael C Sanguinetti, Harry Witchel, J. Hancox, 2005, Novartis Foundation symposium.

Author Correction: A mechanism for CO regulation of ion channels

N. Davies, R. Schmid, P. Moody, 2018, Nature Communications.

hERG Channel Physiology and Drug‐Binding Structure–Activity Relationships

S. Dalibalta, J. Mitcheson, 2008 .

Calmodulin Regulates Human Ether à Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain*

N. Davies, F. Muskett, P. Stansfeld, 2016, The Journal of Biological Chemistry.

Voltage dependence of the Fura-2 transient in rabbit left atrial myocytes at 37°C

J. Hancox, J. Mitcheson, A. Levi, 1997, Pflügers Archiv.

The effect of internal sodium and caesium on phasic contraction of patch‐clamped rabbit ventricular myocytes.

J. Hancox, J. Mitcheson, A. Levi, 1996, The Journal of physiology.

Comparison of Na(+)/Ca(2+) exchanger current and of its response to isoproterenol between acutely isolated and short-term cultured adult ventricular myocytes.

J. Hancox, J. Mitcheson, Y. H. Zhang, 2002, Biochemical and biophysical research communications.

Activation Gating of hERG Potassium Channels

M. Sutcliffe, P. Stansfeld, S. Dalibalta, 2007, Journal of Biological Chemistry.

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum

J. L. Smalley, G M Cohen, T W Gant, 2012, Cell Death and Differentiation.

Discovery of a heme-binding domain in a neuronal voltage-gated potassium channel

Samuel L. Freeman, N. Davies, R. Schmid, 2020, Journal of Biological Chemistry.

Cultured Adult Rabbit Myocytes:

J. Hancox, J. Mitcheson, A. Levi, 1997, Journal of cardiovascular electrophysiology.

A heme-binding domain controls regulation of ATP-dependent potassium channels

N. Davies, R. Schmid, T. Chernova, 2016, Proceedings of the National Academy of Sciences.

Computational design and discovery of "minimally structured" hERG blockers.

A. Cavalli, M. Recanatini, R. Buonfiglio, 2012, Journal of medicinal chemistry.