N. Beard

发表

Novel regulators of RyR Ca2+ release channels: insight into molecular changes in genetically-linked myopathies

A. Dulhunty, N. Beard, P. Pouliquin, 2006, Journal of Muscle Research & Cell Motility.

Multiple Actions of the Anthracycline Daunorubicin on Cardiac Ryanodine Receptors

Amy D. Hanna, A. Dulhunty, N. Beard, 2011, Molecular Pharmacology.

Triadin Binding to the C-Terminal Luminal Loop of the Ryanodine Receptor is Important for Skeletal Muscle Excitation–Contraction Coupling

I. Marty, A. Dulhunty, N. Beard, 2007, The Journal of general physiology.

Quantification of calsequestrin 2 (CSQ2) in sheep cardiac muscle and Ca2+-binding protein changes in CSQ2 knockout mice.

G. Lamb, B. Knollmann, N. Beard, 2011, American journal of physiology. Heart and circulatory physiology.

Junctin and triadin each activate skeletal ryanodine receptors but junctin alone mediates functional interactions with calsequestrin.

A. Dulhunty, N. Beard, E. Gallant, 2009, The international journal of biochemistry & cell biology.

A Skeletal Muscle Ryanodine Receptor Interaction Domain in Triadin

A. Dulhunty, N. Beard, E. Wium, 2012, PloS one.

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease

Amy D. Hanna, A. Dulhunty, N. Beard, 2012, The Journal of general physiology.

AuPS/ASB Meeting - Adelaide 2010 Symposium: Stress, disease and Ca2+ management: the cardiovascular challenge. Chair: Lea

A. Dulhunty, N. Beard, D. Laver, 2010 .

CSQ2 knockout mice -binding protein changes in 2+ cardiac muscle and Ca Quantification of calsequestrin 2 (CSQ2) in sheep

G. Lamb, B. Knollmann, N. Beard, 2011 .

Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity.

A. Dulhunty, N. Beard, E. Gallant, 2008, The international journal of biochemistry & cell biology.

Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis.

C. Svensson, S. Ajeganova, A. Cheng, 2019, JCI insight.

A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction.

A. Dulhunty, N. Beard, S. Pace, 2007, The Biochemical journal.

C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition

A. Dulhunty, N. Beard, 2015, Skeletal Muscle.

The ryanodine receptor: a pivotal Ca2+ regulatory protein and potential therapeutic drug target.

M. Casarotto, A. Dulhunty, N. Beard, 2011, Current drug targets.

Short-Term Very High Carbohydrate Diet and Gut-Training Have Minor Effects on Gastrointestinal Status and Performance in Highly Trained Endurance Athletes

Avish P. Sharma, N. Etxebarria, P. Saunders, 2022, Nutrients.

Three residues in the luminal domain of triadin impact on Trisk 95 activation of skeletal muscle ryanodine receptors

A. Dulhunty, N. Beard, E. Wium, 2016, Pflügers Archiv - European Journal of Physiology.

CONTROL OF MUSCLE RYANODINE RECEPTOR CALCIUM RELEASE CHANNELS BY PROTEINS IN THE SARCOPLASMIC RETICULUM LUMEN

A. Dulhunty, N. Beard, Lan Wei, 2009, Clinical and experimental pharmacology & physiology.

Interventions for the long-term prevention of hereditary angioedema attacks

N. Beard, C. Katelaris, Michael Frese, 2019, Cochrane Database of Systematic Reviews.

CARDIOTONIC STEROIDS: CORRELATION OF SODIUM‐POTASSIUM ADENOSINE TRIPHOSPHATE INHIBITION AND ION TRANSPORT in vitro WITH INOTROPIC ACTIVITY AND TOXICITY IN DOGS

N. Beard, A. R. Somerville, W. Rouse, 1975, British journal of pharmacology.

Effects of omecamtiv mecarbil on failing human ventricular trabeculae and interaction with (−)‐noradrenaline

P. Molenaar, N. Beard, K. Hay, 2021, Pharmacology research & perspectives.

Skeletal muscle excitation-contraction coupling: who are the dancing partners?

M. Casarotto, A. Dulhunty, N. Beard, 2014, The international journal of biochemistry & cell biology.

Interventions for the treatment of acute hereditary angioedema attacks

N. Beard, C. Katelaris, Michael Frese, 2019, Cochrane Database of Systematic Reviews.

Characterising the effect of heat strain and exercise intensity on gut permeability in well-trained male runners

D. Pyne, N. Etxebarria, P. Saunders, 2018, Journal of Science and Medicine in Sport.

Calsequestrin and the calcium release channel of skeletal and cardiac muscle.

A. Dulhunty, N. Beard, D. Laver, 2004, Progress in biophysics and molecular biology.

C-terminal residues of skeletal muscle calsequestrin are essential for calcium binding and for skeletal ryanodine receptor inhibition

A. Dulhunty, N. Beard, 2015, Skeletal Muscle.

Study of serum antibodies against three eye muscle antigens and the connective tissue antigen collagen XIII in patients with Graves' disease with and without ophthalmopathy: correlation with clinical features.

N. Beard, B. Gopinath, J. Wall, 2006, Thyroid : official journal of the American Thyroid Association.

Antibodies targeting the calcium binding skeletal muscle protein calsequestrin are specific markers of ophthalmopathy and sensitive indicators of ocular myopathy in patients with Graves’ disease

N. Beard, B. Gopinath, J. Wall, 2006, Clinical and experimental immunology.

ß-Adrenergic Stimulation Increases RyR2 Activity via Intracellular Ca2+ and Mg2+ Regulation

Derek R. Laver, Mohammad S. Imtiaz, Nicole A. Beard, 2013, PloS one.

The β(1a) subunit of the skeletal DHPR binds to skeletal RyR1 and activates the channel via its 35-residue C-terminal tail.

M. Casarotto, A. Dulhunty, N. Beard, 2011, Biophysical journal.

Ion channel gating in cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse

A. Dulhunty, N. Beard, E. Gallant, 2019, Journal of Cell Science.

Understanding How Phosphorylation and Redox Modifications Regulate Cardiac Ryanodine Receptor Type 2 Activity to Produce an Arrhythmogenic Phenotype in Advanced Heart Failure.

P. Molenaar, N. Beard, H. Haqqani, 2020, ACS pharmacology & translational science.

Junctin – the quiet achiever

A. Dulhunty, N. Beard, Lan Wei, 2009, The Journal of physiology.

The conformation of calsequestrin determines its ability to regulate skeletal ryanodine receptors.

M. Varsányi, A. Dulhunty, N. Beard, 2006, Biophysical journal.

Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels.

A. Dulhunty, N. Beard, D. Laver, 2002, Biophysical journal.

Calsequestrin content and SERCA determine normal and maximal Ca2+ storage levels in sarcoplasmic reticulum of fast‐ and slow‐twitch fibres of rat

G. Lamb, N. Beard, R. Murphy, 2009, The Journal of physiology.

The Anthracycline Metabolite Doxorubicinol Abolishes RyR2 Sensitivity to Physiological Changes in Luminal Ca2+ through an Interaction with Calsequestrin

Amy D. Hanna, A. Dulhunty, N. Beard, 2017, Molecular Pharmacology.

Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle.

Amy D. Hanna, A. Dulhunty, N. Beard, 2009, Cell calcium.

Phosphorylation of skeletal muscle calsequestrin enhances its Ca2+ binding capacity and promotes its association with junctin.

M. Varsányi, A. Dulhunty, N. Beard, 2008, Cell calcium.

Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation.

M. Varsányi, M. Casarotto, A. Dulhunty, 2005, Biophysical journal.

A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels

A. Dulhunty, N. Beard, S. Pace, 2015, Journal of Cell Science.

Agonists and antagonists of the cardiac ryanodine receptor: potential therapeutic agents?

M. Casarotto, A. Dulhunty, N. Beard, 2007, Pharmacology & therapeutics.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

M. Casarotto, A. Dulhunty, N. Beard, 2015, Skeletal Muscle.

Sarcoplasmic reticulum calcium mishandling: central tenet in heart failure?

P. Molenaar, N. Beard, A. Dashwood, 2020, Biophysical Reviews.

Adverse Effects of Doxorubicin and Its Metabolic Product on Cardiac RyR2 and SERCA2A

Amy D. Hanna, A. Dulhunty, N. Beard, 2014, Molecular Pharmacology.

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling

M. Casarotto, A. Dulhunty, N. Beard, 2018, F1000Research.

Calmodulin inhibition of human RyR2 channels requires phosphorylation of RyR2-S2808 or RyR2-S2814.

C. D. dos Remedios, R. Cornea, B. Knollmann, 2019, Journal of molecular and cellular cardiology.

Ca2+ signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin

A. Dulhunty, N. Beard, Lan Wei, 2009, European Biophysics Journal.

Core skeletal muscle ryanodine receptor calcium release complex

M. Casarotto, A. Dulhunty, N. Beard, 2017, Clinical and experimental pharmacology & physiology.

Physiology and Pharmacology of Ryanodine Receptor Calcium Release Channels.

M. Casarotto, A. Dulhunty, N. Beard, 2017, Advances in pharmacology.

FKBP12 binds to the cardiac ryanodine receptor with negative cooperativity: implications for heart muscle physiology in health and disease

A. Dulhunty, N. Beard, M. G. Casarotto, 2023, Philosophical Transactions of the Royal Society B.

Dietary Intake and Gastrointestinal Integrity in Runners Undertaking High-Intensity Exercise in the Heat.

D. Pyne, N. Etxebarria, K. Pumpa, 2021, International journal of sport nutrition and exercise metabolism.

Running at Increasing Intensities in the Heat Induces Transient Gut Perturbations.

D. Pyne, N. Etxebarria, P. Saunders, 2020, International journal of sports physiology and performance.

Dantrolene inhibition of ryanodine channels (RyR2) in artificial lipid bilayers depends on FKBP12.6

D. V. van Helden, N. Beard, D. Laver, 2023, The Journal of general physiology.

Association of FK506 binding proteins with RyR channels – effect of CLIC2 binding on sub-conductance opening and FKBP binding

C. Schwartz, M. Casarotto, A. Dulhunty, 2017, Journal of Cell Science.

Ryanodine receptor modification and regulation by intracellular Ca2+ and Mg2+ in healthy and failing human hearts.

C. D. dos Remedios, P. Molenaar, D. V. van Helden, 2017, Journal of molecular and cellular cardiology.

Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output

Amy D. Hanna, A. Dulhunty, N. Beard, 2012, Clinical and experimental pharmacology & physiology.

A novel cytoplasmic interaction between junctin and ryanodine receptor calcium release channels

A. Dulhunty, N. Beard, S. Pace, 2014 .

Ryanodine receptor Ca2+ release channel post-translational modification: Central player in cardiac and skeletal muscle disease.

A. Dulhunty, N. Beard, A. Denniss, 2018, The international journal of biochemistry & cell biology.

Differences in the regulation of RyR2 from human, sheep, and rat by Ca2+ and Mg2+ in the cytoplasm and in the lumen of the sarcoplasmic reticulum

C. D. dos Remedios, P. Molenaar, D. V. van Helden, 2014, The Journal of general physiology.

Correction: Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment

Amy D. Hanna, A. Dulhunty, N. Beard, 2016, Journal of Cell Science.

Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment

Amy D. Hanna, A. Dulhunty, N. Beard, 2014, Journal of Cell Science.

Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit

M. Casarotto, A. Dulhunty, N. Beard, 2015, Skeletal Muscle.

Multiple actions of φ-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins

I. Vetter, Jennifer J. Smith, J. Tytgat, 2013, Proceedings of the National Academy of Sciences of the United States of America.

Oxidative hotspots on actin promote skeletal muscle weakness in rheumatoid arthritis.

C. Svensson, S. Ajeganova, A. Cheng, 2019, JCI insight.

Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity.

A. Dulhunty, N. Beard, E. Gallant, 2008, The international journal of biochemistry & cell biology.

Ryanodine receptor phosphorylation in human heart failure

P. Molenaar, A. Dulhunty, N. Beard, 2010 .