D. Isbrandt

发表

Contribution of N‐ and C‐terminal channel domains to Kv channel interacting proteins in a mammalian cell line

O. Pongs, B. Callsen, D. Isbrandt, 2005 .

A novel long-QT 5 gene mutation in the C-terminus (V109I) is associated with a mild phenotype

G. Breithardt, W. Haverkamp, E. Schulze-Bahr, 2001, Journal of Molecular Medicine.

Hippocampal network patterns in Kv 7 / M-current deficient mice ( Mus musculus , Linnaeus 1758 )

E. Diekhof, C. Lohr, D. Isbrandt, 2017 .

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice – a one year longitudinal MRI study

J. Bell, S. Neubauer, J. Schneider, 2008, Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance.

Genetics of Sinus Node Disease

G. Breithardt, E. Schulze-Bahr, H. Wedekind, 2004 .

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

R. D'Hooge, S. Stroobants, B. de Strooper, 2013, The Journal of Neuroscience.

Disturbed Prefrontal Cortex Activity in the Absence of Schizophrenia-Like Behavioral Dysfunction in Arc/Arg3.1 Deficient Mice

Dietmar Kuhl, M. Muhia, M. Kneussel, 2019, The Journal of Neuroscience.

Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks

Dietmar Kuhl, O. Ohana, S. Graf, 2018, Proceedings of the National Academy of Sciences.

Glycine Amidinotransferase (GATM), Renal Fanconi Syndrome, and Kidney Failure.

Johann M B Simbürger, P. Oefner, A. Hammers, 2018, Journal of the American Society of Nephrology : JASN.

Creatine uptake in mouse hearts with genetically altered creatine levels

S. Neubauer, D. Isbrandt, C. Lygate, 2008, Journal of molecular and cellular cardiology.

Phosphorylated guanidinoacetate partly compensates for the lack of phosphocreatine in skeletal muscle of mice lacking guanidinoacetate methyltransferase

A. Heerschap, H. Kan, D. Isbrandt, 2004, The Journal of physiology.

Impaired cardiac contractile function in arginine:glycine amidinotransferase knockout mice devoid of creatine is rescued by homoarginine but not creatine

S. Neubauer, S. Zervou, B. Casadei, 2017, Cardiovascular research.

Cloning and sequence analysis of human guanidinoacetate N-methyltransferase cDNA.

K. von Figura, D. Isbrandt, 1995, Biochimica et biophysica acta.

Reduced Inotropic Reserve and Increased Susceptibility to Cardiac Ischemia/Reperfusion Injury in Phosphocreatine-Deficient Guanidinoacetate-N-Methyltransferase–Knockout Mice

S. Neubauer, K. Clarke, H. Watkins, 2005, Circulation.

Differential regulation of AMPK activation in leptin‐and creatine‐deficient mice

D. Isbrandt, K. Sauter, C. Choe, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency.

Stefan Neubauer, Arend Heerschap, Dirk Isbrandt, 2004, Human molecular genetics.

Creatine, guanidinoacetate and homoarginine in statin-induced myopathy

C. Gerloff, E. Schwedhelm, D. Isbrandt, 2020, Amino Acids.

Functional roles of Ca(v)1.3, Ca(v)3.1 and HCN channels in automaticity of mouse atrioventricular cells: insights into the atrioventricular pacemaker mechanism.

H. Ehmke, P. Fontanaud, Hee-Sup Shin, 2011, Channels.

Mutations in classical late infantile neuronal ceroid lipofuscinosis disrupt transport of tripeptidyl-peptidase I to lysosomes.

J. Gärtner, D. Isbrandt, R. Steinfeld, 2004, Human molecular genetics.

UM 9(5)h and UM 9(5)p, human and porcine noncoding transcripts with preferential expression in the cerebellum.

P. Rieckmann, D. Isbrandt, U. Michel, 2002, RNA.

Effective long‐term control of cardiac events with β‐blockers in a family with a common LQT1 mutation

G. Breithardt, W. Haverkamp, E. Schulze-Bahr, 2004, Clinical genetics.

Homoarginine supplementation improves blood glucose in diet-induced obese mice

E. Schwedhelm, D. Isbrandt, R. Böger, 2015, Amino Acids.

Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

O. Pongs, D. Isbrandt, K. Sauter, 2000, Genomics.

Kv4 Voltage Gated Potassium Channel

O. Pongs, D. Isbrandt, R. Bähring, 2008 .

Local anaesthetic sensitivities of cloned HERG channels from human heart: comparison with HERG/MiRP1 and HERG/MiRP1 T8A.

D. Isbrandt, A. Solth, P. Friederich, 2004, British journal of anaesthesia.

A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior

Ricardo M. Neves, K. Holthoff, S. Kiebel, 2021, Proceedings of the National Academy of Sciences.

Intraneuronal chloride accumulation via NKCC1 is not essential for hippocampal network development in vivo

Ricardo M. Neves, K. Holthoff, S. Kiebel, 2020, bioRxiv.

Homoarginine supplementation improves blood glucose in diet-induced obese mice

E. Schwedhelm, D. Isbrandt, R. Böger, 2015, Amino Acids.

Transcriptomic and metabolic analyses reveal salvage pathways in creatine-deficient AGAT−/− mice

K. Kharbanda, D. Isbrandt, K. Sauter, 2016, Amino Acids.

Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior

Dirk Isbrandt, Hua Hu, Olaf Pongs, 2005, Nature Neuroscience.

GABAergic Transmission during Brain Development: Multiple Effects at Multiple Stages

K. Holthoff, O. Witte, C. Hübner, 2018, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

Small area, low power neural recording integrated circuit in 130 nm CMOS technology for small mammalians

Dietmar Schroeder, Wolfgang H. Krautschneider, Andreas Bahr, 2016, 2016 28th International Conference on Microelectronics (ICM).

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice

W. Huttner, J. Roeper, A. Tresch, 2021, Proceedings of the National Academy of Sciences of the United States of America.

Treatment during a vulnerable developmental period rescues a genetic epilepsy

Christophe Bernard, Dirk Isbrandt, Fabio Morellini, 2015, Nature Medicine.

Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain Development in Mice

C. Métin, C. Müller, Â. R. Tomé, 2013, Science Translational Medicine.

Silva Development in Mice Adenosine Receptor Antagonists Including Caffeine Alter Fetal Brain

C. Métin, C. Müller, Â. R. Tomé, 2013 .

Guanidinoacetate methyltransferase deficiency: the first inborn error of creatine metabolism in man.

F. Hanefeld, K. von Figura, K. Figura, 1996, American journal of human genetics.

Homoarginine Levels Are Regulated by L-Arginine: Glycine Amidinotransferase and Affect Stroke Outcome Results From Human and Murine Studies

C. Gerloff, S. Blankenberg, A. Heerschap, 2013, Circulation.

Disturbances of novel object exploration and recognition in a chronic ketamine mouse model of schizophrenia

J. Roeper, D. Isbrandt, Maria Jelena Hauser, 2017, Behavioural Brain Research.

Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome): six unique arylsulfatase B gene alleles causing variable disease phenotypes.

C. Peters, K. von Figura, K. Figura, 1994, American journal of human genetics.

Stable isotope dilution microquantification of creatine metabolites in plasma, whole blood and dried blood spots for pharmacological studies in mouse models of creatine deficiency.

A. Schulze, M. Yazdanpanah, D. Isbrandt, 2014, Clinica chimica acta; international journal of clinical chemistry.

Contribution of N- and C-terminal Kv4.2 channel domains to KChIP interaction [corrected].

O. Pongs, B. Callsen, D. Isbrandt, 2005, The Journal of physiology.

N-type inactivation features of Kv4.2 channel gating.

O. Pongs, B. Callsen, D. Isbrandt, 2004, Biophysical journal.

Conserved Kv4 N-terminal Domain Critical for Effects of Kv Channel-interacting Protein 2.2 on Channel Expression and Gating*

J. Sweatt, O. Pongs, J. W. Hinson, 2001, The Journal of Biological Chemistry.

Pacemaker channel dysfunction in a patient with sinus node disease.

G. Breithardt, E. Schulze-Bahr, O. Pongs, 2003, The Journal of clinical investigation.

C-terminal HERG ( LQT 2 ) mutations disrupt

S. Priori, G. Mönnig, E. Schulze-Bahr, 2006 .

C-terminal HERG ( LQT2 ) mutations disrupt I Kr channel regulation through 14-3-3 e

S. Priori, G. Mönnig, E. Schulze-Bahr, 2006 .

L-arginine:glycine amidinotransferase deficiency protects from metabolic syndrome.

A. Heerschap, F. Morellini, D. Isbrandt, 2013, Human molecular genetics.

Four novel mutant alleles of the arylsulfatase B gene in two patients with intermediate form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome)

C. Peters, K. Figura, D. Isbrandt, 1994, Human Genetics.

Juvenile form of mucopolysaccharidosis VI (Maroteaux-Lamy syndrome). A C-terminal extension causes instability but increases catalytic efficiency of arylsulfatase B.

C. Peters, K. von Figura, D. Brooks, 1994, The Journal of biological chemistry.

Dentate Gyrus Sharp Waves, a Local Field Potential Correlate of Learning in the Dentate Gyrus of Mice

S. Marguet, F. Morellini, D. Isbrandt, 2020, The Journal of Neuroscience.

Coexpression of the KCNA3B Gene Product with Kv1.5 Leads to a Novel A-type Potassium Channel*

O. Pongs, D. Isbrandt, R. Bähring, 1998, The Journal of Biological Chemistry.

A mechanistic link between glia and neuronal excitability in acute neuroinflammation

D. Isbrandt, 2017, Journal of Physiology.

Control of heart rate by cAMP sensitivity of HCN channels

H. Ehmke, D. Isbrandt, M. Mangoni, 2009, Proceedings of the National Academy of Sciences.

Pacemaker activity and ionic currents in mouse atrioventricular node cells

S. Dübel, H. Ehmke, P. Fontanaud, 2011, Channels.

Identification and functional characterization of a novel KCNE2 (MiRP1) mutation that alters HERG channel kinetics

G. Breithardt, W. Haverkamp, M. Borggrefe, 2002, Journal of Molecular Medicine.

Cardiac arrhythmia induced by genetic silencing of “funny” (f) channels is rescued by GIRK4 inactivation

H. Ehmke, Anne Fernandez, D. Isbrandt, 2014, Nature Communications.

Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia

F. Charpentier, M. Ronjat, D. Isbrandt, 2020, Scientific Reports.

Abolishing cAMP sensitivity in HCN2 pacemaker channels induces generalized seizures.

A. Konnerth, C. Wahl-Schott, M. Biel, 2019, JCI insight.

Measurement of Brain Creatine Metabolism In Vivo: Magnetic Resonance Spectroscopy Studies of Transgenic Animals

A. Heerschap, H. Kan, B. Wieringa, 2012 .

In vivo magnetic resonance spectroscopy of transgenic mice with altered expression of guanidinoacetate methyltransferase and creatine kinase isoenzymes.

A. Heerschap, H. Kan, B. Wieringa, 2007, Sub-cellular biochemistry.

In vivo cardiac 1H‐MRS in the mouse

S. Neubauer, K. Clarke, H. Watkins, 2004, Magnetic resonance in medicine.

Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure

C. Gerloff, E. Schwedhelm, D. Isbrandt, 2019, Amino Acids.

Disturbed energy metabolism and muscular dystrophy caused by pure creatine deficiency are reversible by creatine intake

A. Heerschap, R. Rodenburg, H. Kan, 2013, The Journal of physiology.

Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis.

H. Lerche, D. Isbrandt, M. Friese, 2016, JCI insight.

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy

Tobias Bock, S. Siegelbaum, F. Leroy, 2021, bioRxiv.

Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice.

A. de Haan, A. Heerschap, H. Kan, 2005, American journal of physiology. Cell physiology.

Creatine uptake in brain and skeletal muscle of mice lacking guanidinoacetate methyltransferase assessed by magnetic resonance spectroscopy.

A. Heerschap, E. Meeuwissen, H. Kan, 2007, Journal of applied physiology.

MR spectroscopy of muscle and brain in guanidinoacetate methyltransferase (GAMT)‐deficient mice: Validation of an animal model to study creatine deficiency

A. Heerschap, F. Oerlemans, B. Wieringa, 2003, Magnetic resonance in medicine.

Characterization of human Kv4.2 mediating a rapidly-inactivating transient voltage-sensitive K+ current.

O. Pongs, D. Isbrandt, A. Wulf, 1999, Receptors & channels.

A Mouse Model of Creatine Transporter Deficiency Reveals Impaired Motor Function and Muscle Energy Metabolism

A. Heerschap, D. Isbrandt, I. Hermans-Borgmeyer, 2018, Front. Physiol..

Activation of GABAA Receptors by Guanidinoacetate: A Novel Pathophysiological Mechanism

Jochen Roeper, Dirk Isbrandt, Gerhard Trube, 2002, Neurobiology of Disease.

The funny current in genetically modified mice.

M. L. DiFrancesco, D. Isbrandt, M. Mangoni, 2021, Progress in biophysics and molecular biology.

Two novel frameshift mutations causing premature stop codons in a patient with the severe form of Maroteaux‐Lamy syndrome

K. von Figura, J. Hopwood, D. Isbrandt, 1996, Human mutation.

Early-life exposure to caffeine affects the construction and activity of cortical networks in mice

S. Marguet, C. Bernard, M. Esclapez, 2017, Experimental Neurology.

Functional roles of Cav1.3, Cav3.1 and HCN channels in automaticity of mouse atrioventricular cells

S. Dübel, H. Ehmke, P. Fontanaud, 2011 .

Activity of Na V 1 . 2 promotes neurodegeneration in an animal model of multiple sclerosis

H. Lerche, D. Isbrandt, M. Friese, 2018 .

A homozygous SCN5A mutation in a severe, recessive type of cardiac conduction disease

Dirk Isbrandt, Matthias Paul, Eric Schulze-Bahr, 2010, Human mutation.

Upregulation of respiratory chain enzymes in guanidinoacetate methyltransferase deficiency

D. Isbrandt, A. Das, K. Ullrich, 2000, Journal of Inherited Metabolic Disease.

Activity of NaV 1 . 2 promotes neurodegeneration in an animal model of multiple sclerosis

H. Lerche, D. Isbrandt, M. Friese, 2016 .

The Na+/H+ Exchanger Nhe1 Modulates Network Excitability via GABA Release.

R. Jahn, M. Kessels, B. Qualmann, 2018, Cerebral cortex.

C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon.

Dirk Isbrandt, Colleen E Clancy, Eric Schulze-Bahr, 2006, Human molecular genetics.

Autophagy regulates neuronal excitability by controlling cAMP/protein kinase A signaling at the synapse

P. Kloppenburg, V. Nikoletopoulou, J. Tutas, 2022, bioRxiv.