Y. Angulo

发表

Isolation of an acidic phospholipase A2 from the venom of the snake Bothrops asper of Costa Rica: biochemical and toxicological characterization.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Biochimie.

Structural and functional characterization of myotoxin I, a Lys49 phospholipase A(2) homologue from Bothrops moojeni (Caissaca) snake venom.

R. Arni, J. Gutiérrez, B. Lomonte, 2000, Archives of biochemistry and biophysics.

Myotoxic phospholipases A(2) in bothrops snake venoms: effect of chemical modifications on the enzymatic and pharmacological properties of bothropstoxins from Bothrops jararacussu.

J. Gutiérrez, B. Lomonte, A. Soares, 2000, Biochimie.

Comparative study of synthetic peptides corresponding to region 115-129 in Lys49 myotoxic phospholipases A2 from snake venoms.

C. Santamaria, B. Lomonte, Y. Angulo, 2003, Toxicon : official journal of the International Society on Toxinology.

Synthetic peptides derived from the C-terminal region of Lys49 phospholipase A2 homologues from viperidae snake venoms: biomimetic activities and potential applications.

B. Lomonte, E. Moreno, Y. Angulo, 2010, Current pharmaceutical design.

Skeletal muscle necrosis and regeneration after injection of Thalassophryne nattereri (niquim) fish venom in mice

J. Gutiérrez, B. Lomonte, A. Rucavado, 2001, International journal of experimental pathology.

Isolation of bothrasperin, a disintegrin with potent platelet aggregation inhibitory activity, from the venom of the snake Bothrops asper.

B. Lomonte, Y. Angulo, A. Pinto, 2003, Revista de biologia tropical.

Antivenomics of Atropoides mexicanus and Atropoides picadoi snake venoms: Relationship to the neutralization of toxic and enzymatic activities

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of venom research.

Clinical and laboratory alterations in horses during immunization with snake venoms for the production of polyvalent (Crotalinae) antivenom.

J. Gutiérrez, Y. Angulo, R. Estrada, 1997, Toxicon : official journal of the International Society on Toxinology.

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability on snakebite management.

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteomics.

Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region.

Edgardo Moreno, Bruno Lomonte, C. Santamaria, 2005, Toxicon : official journal of the International Society on Toxinology.

Membrane cholesterol modulates the cytolytic mechanism of myotoxin II, a Lys49 phospholipase A2 homologue from the venom of Bothrops asper

J. Gutiérrez, B. Lomonte, Y. Angulo, 2011, Cell biochemistry and function.

Biochemistry and toxicology of toxins purified from the venom of the snake Bothrops asper.

B. Lomonte, Y. Angulo, 2009, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of a myotoxic phospholipase A2 from the venom of the arboreal snake Bothriechis (Bothrops) schlegelii from Costa Rica.

J. Gutiérrez, B. Lomonte, A. Rucavado, 1997, Archives of biochemistry and biophysics.

Tyr-->Trp-substituted peptide 115-129 of a Lys49 phospholipase A(2) expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect.

B. Lomonte, E. Moreno, J. Gorvel, 1999, Biochimica et biophysica acta.

Comparative study of the cytolytic activity of myotoxic phospholipases A2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro.

J. Gutiérrez, B. Lomonte, W. Cho, 1999, Toxicon : official journal of the International Society on Toxinology.

Profiling the venom gland transcriptomes of Costa Rican snakes by 454 pyrosequencing

A. Conesa, J. Dopazo, J. Calvete, 2011, BMC Genomics.

Identification of the myotoxic site of the Lys49 phospholipase A(2) from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities.

B. Lomonte, C. E. Núñez, Y. Angulo, 2001, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of the Lesser Antillean pit vipers Bothrops caribbaeus and Bothrops lanceolatus: correlation with toxicological activities and immunoreactivity of a heterologous antivenom.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteome research.

Venomic and antivenomic analyses of the Central American coral snake, Micrurus nigrocinctus (Elapidae).

J. Calvete, L. Sanz, J. Gutiérrez, 2011, Journal of proteome research.

Venoms, venomics, antivenomics

J. Calvete, L. Sanz, J. Gutiérrez, 2009, FEBS letters.

Comparative proteomic analysis of the venom of the taipan snake, Oxyuranus scutellatus, from Papua New Guinea and Australia: role of neurotoxic and procoagulant effects in venom toxicity.

David J. Williams, J. Calvete, J. Gutiérrez, 2012, Journal of proteomics.

Snake venomics and antivenomics: Proteomic tools in the design and control of antivenoms for the treatment of snakebite envenoming.

J. Calvete, L. Sanz, J. Gutiérrez, 2009, Journal of proteomics.

Comparative study of the cytolytic activity of snake venoms from African spitting cobras (Naja spp., Elapidae) and its neutralization by a polyspecific antivenom.

J. Calvete, J. Gutiérrez, B. Lomonte, 2011, Toxicon : official journal of the International Society on Toxinology.

Snake venomics of the pit vipers Porthidium nasutum, Porthidium ophryomegas, and Cerrophidion godmani from Costa Rica: toxicological and taxonomical insights.

J. Calvete, J. Gutiérrez, B. Lomonte, 2012, Journal of proteomics.

Role of enzymatic activity in muscle damage and cytotoxicity induced by Bothrops asper Asp49 phospholipase A2 myotoxins: are there additional effector mechanisms involved?

J. Gutiérrez, B. Lomonte, Y. Angulo, 2014, PeerJ.

Venomous snakes of Costa Rica: biological and medical implications of their venom proteomic profiles analyzed through the strategy of snake venomics.

J. Calvete, L. Sanz, J. Gutiérrez, 2014, Journal of proteomics.

Isolation and characterization of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a new Lys49 phospholipase A2 homologue.

B. Lomonte, L. Possani, Y. Angulo, 2000, The international journal of biochemistry & cell biology.

Snake venomics of Bothriechis nigroviridis reveals extreme variability among palm pitviper venoms: different evolutionary solutions for the same trophic purpose.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of proteome research.

Snake venomics of the Central American rattlesnake Crotalus simus and the South American Crotalus durissus complex points to neurotoxicity as an adaptive paedomorphic trend along Crotalus dispersal in South America.

J. Calvete, L. Sanz, J. Gutiérrez, 2010, Journal of proteome research.

Crystallization of the Lys49 PLA2 homologue, myotoxin II, from the venom of Atropoides nummifer.

L. M. Gava, R. Arni, B. Lomonte, 2004, Biochimica et biophysica acta.

Neutralization of Bothrops asper venom by antibodies, natural products and synthetic drugs: contributions to understanding snakebite envenomings and their treatment.

B. Lomonte, A. Rucavado, Y. Angulo, 2009, Toxicon : official journal of the International Society on Toxinology.

Ability of fucoidan to prevent muscle necrosis induced by snake venom myotoxins: comparison of high- and low-molecular weight fractions.

B. Lomonte, Y. Angulo, Karol Azofeifa, 2008, Toxicon : official journal of the International Society on Toxinology.

Inhibitory effect of fucoidan on the activities of crotaline snake venom myotoxic phospholipases A(2).

B. Lomonte, Y. Angulo, 2003, Biochemical pharmacology.

Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop.

J. Gutiérrez, Y. Angulo, H. W. Fan, 2009, Toxicon : official journal of the International Society on Toxinology.

Trends in snakebite envenomation therapy: scientific, technological and public health considerations.

J. Gutiérrez, B. Lomonte, A. Rucavado, 2007, Current pharmaceutical design.

Myotoxic and cytolytic activities of dimeric Lys49 phospholipase A2 homologues are reduced, but not abolished, by a pH-induced dissociation.

J. Gutiérrez, B. Lomonte, W. Cho, 2005, Toxicon : official journal of the International Society on Toxinology.

Comparative study of the efficacy and safety of two polyvalent, caprylic acid fractionated [IgG and F(ab')2] antivenoms, in Bothrops asper bites in Colombia.

J. Gómez, J. Gutiérrez, Y. Angulo, 2012, Toxicon : official journal of the International Society on Toxinology.

Isolation and characterization of four medium-size disintegrins from the venoms of Central American viperid snakes of the genera Atropoides, Bothrops, Cerrophidion and Crotalus.

J. Calvete, J. Gutiérrez, B. Lomonte, 2014, Biochimie.

Differential susceptibility of C2C12 myoblasts and myotubes to group II phospholipase A2 myotoxins from crotalid snake venoms

B. Lomonte, Y. Angulo, 2005, Cell biochemistry and function.

Snake venomics and antivenomics of Protobothrops mucrosquamatus and Viridovipera stejnegeri from Taiwan: keys to understand the variable immune response in horses.

J. Calvete, L. Sanz, J. Gutiérrez, 2012, Journal of proteomics.

Antivenoms for snakebite envenomings.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2011, Inflammation & allergy drug targets.

Preclinical assessment of a polyspecific antivenom against the venoms of Cerrophidion sasai, Porthidium nasutum and Porthidium ophryomegas: Insights from combined antivenomics and neutralization assays.

J. Calvete, L. Sanz, J. Gutiérrez, 2013, Toxicon : official journal of the International Society on Toxinology.

Purification of IgG and albumin from human plasma by aqueous two phase system fractionation

J. Gutiérrez, Y. Angulo, T. Burnouf, 2012, Biotechnology progress.

Epidemiology of rapes in Costa Rica: characterization of victims, perpetrators and circumstances surrounding forced intercourse.

Y. Angulo, M. Espinoza, Aarón Gómez, 2014, Forensic science international.

Isolation, characterization and molecular cloning of AnMIP, a new alpha-type phospholipase A2 myotoxin inhibitor from the plasma of the snake Atropoides nummifer (Viperidae: Crotalinae).

Bruno Lomonte, B. Lomonte, A. Alape-Girón, 2007, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Integrated “omics” profiling indicates that miRNAs are modulators of the ontogenetic venom composition shift in the Central American rattlesnake, Crotalus simus simus

J. Calvete, L. Sanz, J. Gutiérrez, 2013, BMC Genomics.

The phospholipase A2 homologues of snake venoms: biological activities and their possible adaptive roles.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2009, Protein and peptide letters.

Venom of the crotaline snake Atropoides nummifer (jumping viper) from Guatemala and Honduras: comparative toxicological characterization, isolation of a myotoxic phospholipase A(2) homologue and neutralization by two antivenoms.

J. J. Chavez, J. Gutiérrez, B. Lomonte, 2001, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Snake venomics and antivenomics of Bothrops atrox venoms from Colombia and the Amazon regions of Brazil, Perú and Ecuador suggest the occurrence of geographic variation of venom phenotype by a trend towards paedomorphism.

J. Calvete, L. Sanz, J. Gutiérrez, 2009, Journal of proteomics.

Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.

J. Calvete, J. Gutiérrez, B. Lomonte, 2012, Toxicon : official journal of the International Society on Toxinology.

Snake venomics and antivenomics of the arboreal neotropical pitvipers Bothriechis lateralis and Bothriechis schlegelii.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteome research.

Snake venomics of the South and Central American Bushmasters. Comparison of the toxin composition of Lachesis muta gathered from proteomic versus transcriptomic analysis.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteomics.

An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action.

B. Lomonte, Y. Angulo, L. Calderón, 2003, Toxicon : official journal of the International Society on Toxinology.

VENOM DIVERSITY IN THE NEOTROPICAL SCORPION GENUS TITYUS: IMPLICATIONS FOR ANTIVENOM DESIGN EMERGING FROM MOLECULAR AND IMMUNOCHEMICAL ANALYSES ACROSS ENDEMIC AREAS OF SCORPIONISM.

Roberto J. Miranda, J. Gómez, J. Pascale, 2020, Acta tropica.

Hemostatic effects induced by Thalassophryne nattereri fish venom: a model of endothelium-mediated blood flow impairment.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2002, Toxicon.

Snake venomics of Central American pitvipers: clues for rationalizing the distinct envenomation profiles of Atropoides nummifer and Atropoides picadoi.

J. Calvete, L. Sanz, J. Gutiérrez, 2008, Journal of proteome research.

Structural characterization and phylogenetic relationships of myotoxin II from Atropoides (Bothrops) nummifer snake venom, a Lys49 phospholipase A(2) homologue.

B. Lomonte, A. Alape-Girón, L. Possani, 2002, The international journal of biochemistry & cell biology.

Tissue pathology induced by snake venoms: how to understand a complex pattern of alterations from a systems biology perspective?

J. Fox, J. Gutiérrez, B. Lomonte, 2010, Toxicon : official journal of the International Society on Toxinology.

Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain

G. Carmignoto, J. Gutiérrez, A. Chiavegato, 2010, Proceedings of the National Academy of Sciences.

The C-terminal region of a Lys49 myotoxin mediates Ca2+ influx in C2C12 myotubes.

J. Gutiérrez, B. Lomonte, C. Montecucco, 2010, Toxicon : official journal of the International Society on Toxinology.

Cytotoxicity induced in myotubes by a Lys49 phospholipase A2 homologue from the venom of the snake Bothrops asper: evidence of rapid plasma membrane damage and a dual role for extracellular calcium.

J. Gutiérrez, B. Lomonte, Y. Angulo, 2007, Toxicology in vitro : an international journal published in association with BIBRA.

Two phospholipase A2 inhibitors from the plasma of Cerrophidion (Bothrops) godmani which selectively inhibit two different group-II phospholipase A2 myotoxins from its own venom: isolation, molecular cloning and biological properties.

M. Lazdunski, J. Fox, J. Gutiérrez, 2000, The Biochemical journal.

Effects of bleeding in horses iÍnmunized with snake venoms for antivenom production

J. Gutiérrez, Y. Angulo, R. Estrada, 1997 .

Screening for target toxins of the antiophidic protein DM64 through a gel-based interactomics approach.

B. Lomonte, G. Domont, Y. Angulo, 2017, Journal of proteomics.

Characterization of a basic phospholipase A2-homologeu myotoxin isolated from the venom of the snake Bothrops neuwiedii (yarará chica) from Argentina.

B. Lomonte, Y. Angulo, A. Cangelosi, 1999, Toxicon : official journal of the International Society on Toxinology.

Isolation of two basic phospholipases A2 from Bothrops diporus snake venom: Comparative characterization and synergism between Asp49 and Lys49 variants.

B. Lomonte, Stephanie Chaves-Araya, Julián Fernández, 2019, Toxicon : official journal of the International Society on Toxinology.

Phospholipase A(2) enhances the endothelial cell detachment effect of a snake venom metalloproteinase in the absence of catalysis.

J. Gutiérrez, B. Lomonte, O. Acosta, 2015, Chemico-biological interactions.

Immunochemical properties of the N-terminal helix of myotoxin II, a lysine-49 phospholipase A(2) from Bothrops asper snake venom.

B. Lomonte, C. E. Núñez, A. Soares, 2001, Toxicon : official journal of the International Society on Toxinology.

Two phospholipase A 2 inhibitors from the plasma of Cerrophidion ( Bothrops ) godmani which selectively inhibit two different group-II phospholipase A 2 myotoxins from its own venom : isolation , molecular cloning and biological properties

Ge, M. Lazdunski, J. Fox, 2022 .

Structure of myotoxin II, a catalytically inactive Lys49 phospholipase A2 homologue from Atropoides nummifer venom.

R. Arni, M. Murakami, B. Lomonte, 2006, Acta crystallographica. Section F, Structural biology and crystallization communications.

Snake venomics and toxicological profiling of the arboreal pitviper Bothriechis supraciliaris from Costa Rica.

J. Calvete, J. Gutiérrez, B. Lomonte, 2012, Toxicon : official journal of the International Society on Toxinology.