Ku-Chung Chen

发表

The structural and functional contribution of N‐terminal region and His‐47 on Taiwan cobra phospholipase A2

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2008, Journal of peptide science : an official publication of the European Peptide Society.

p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells.

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2008, Toxicology letters.

Panobinostat sensitizes KRAS‐mutant non‐small‐cell lung cancer to gefitinib by targeting TAZ

Wen-ying Lee, Ku-Chung Chen, Yen-Hua Huang, 2017, International journal of cancer.

Inhibition of RNA transportation induces glioma cell apoptosis via downregulation of RanGAP1 expression.

Chien-Ju Lin, C. Shih, Ku-Chung Chen, 2015, Chemico-biological interactions.

Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells.

C. Shih, W. Chiu, Ku-Chung Chen, 2013, Chemico-biological interactions.

TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Jau-Song Yu, Jau-Song Yu, K. Tsai, 2019, Scientific Reports.

Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction

Cheng-Ying Chu, Ku-Chung Chen, C. Kandaswami, 2018, Journal of food and drug analysis.

Interleukin-28B genetic variants in identification of hepatitis C virus genotype 1 patients responding to 24 weeks peginterferon/ribavirin.

S. Juo, H. Kuo, Ming‐Lung Yu, 2012, Journal of hepatology.

Taiwan cobra phospholipase A2‐elicited JNK activation is responsible for autocrine fas‐mediated cell death and modulating Bcl‐2 and Bax protein expression in human leukemia K562 cells

Long-Sen Chang, Ku-Chung Chen, Wen-Hsin Liu, 2009, Journal of cellular biochemistry.

Suppression of ERK signaling evokes autocrine Fas‐mediated death in arachidonic acid‐treated human chronic myeloid leukemia K562 cells

Long-Sen Chang, Ku-Chung Chen, Wen-Hsin Liu, 2009, Journal of cellular physiology.

Taiwan cobra cardiotoxins induce apoptotic death of human neuroblastoma SK-N-SH cells mediated by reactive oxygen species generation and mitochondrial depolarization.

Long-Sen Chang, Shinne‐ren Lin, Yi-Ling Chiou, 2008, Toxicon : official journal of the International Society on Toxinology.

The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide.

Wen-ying Lee, C. Shih, Ku-Chung Chen, 2014, Toxicology and applied pharmacology.

RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin

C. Chou, G. Lai, Ku-Chung Chen, 2015 .

Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells

Cheng-Ying Chu, T. Ko, Ku-Chung Chen, 2019, International journal of oncology.

Activation of fibroblasts by nicotine promotes the epithelial‐mesenchymal transition and motility of breast cancer cells

Wen-ying Lee, Ku-Chung Chen, Chia-Hsiung Cheng, 2018, Journal of cellular physiology.

Divergence of genes encoding B chains of β-bungarotoxins

Long-Sen Chang, Yun-Ching Cheng, Ku-Chung Chen, 2006 .

Notexin upregulates Fas and FasL protein expression of human neuroblastoma SK-N-SH cells through p38 MAPK/ATF-2 and JNK/c-Jun pathways.

Long-Sen Chang, Ku-Chung Chen, 2010, Toxicon : official journal of the International Society on Toxinology.

Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells.

S. Juo, Ku-Chung Chen, Chung-Ling Liang, 2012, Cellular immunology.

miR-328-3p Affects Axial Length Via Multiple Routes and Anti-miR-328-3p Possesses a Potential to Control Myopia Progression

S. Juo, E. Hsi, Ku-Chung Chen, 2022, Investigative ophthalmology & visual science.

Taiwan cobra phospholipase A2 suppresses ERK-mediated ADAM17 maturation, thus reducing secreted TNF-α production in human leukemia U937 cells.

Ying-Jung Chen, Long-Sen Chang, Shinne‐ren Lin, 2014, Toxicon : official journal of the International Society on Toxinology.

Dietary Flavonoids Luteolin and Quercetin Inhibit Migration and Invasion of Squamous Carcinoma through Reduction of Src/Stat3/S100A7 Signaling

T. Ko, Ku-Chung Chen, Mau-Sun Chang, 2019, Antioxidants.

JNK1/c‐Jun and p38α MAPK/ATF‐2 pathways are responsible for upregulation of Fas/FasL in human chronic myeloid leukemia K562 cells upon exposure to Taiwan cobra phospholipase A2

Long-Sen Chang, Yi-Ling Chiou, Ku-Chung Chen, 2009, Journal of cellular biochemistry.

Upregulation of Fas and FasL in Taiwan cobra phospholipase A2‐treated human neuroblastoma SK‐N‐SH cells through ROS‐ and Ca2+‐mediated p38 MAPK activation

Long-Sen Chang, Shinne‐ren Lin, Pei-Hsiu Kao, 2009, Journal of cellular biochemistry.

A functional polymorphism of PON1 interferes with microRNA binding to increase the risk of ischemic stroke and carotid atherosclerosis.

S. Juo, Hsiu-Fen Lin, R. Lin, 2013, Atherosclerosis.

MicroRNA-328 may influence myopia development by mediating the PAX6 gene.

S. Juo, E. Hsi, Ku-Chung Chen, 2012, Investigative ophthalmology & visual science.

Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.

Ku-Chung Chen, Mei-Hsiang Lin, Chia-Hsiung Cheng, 2014, Chemico-biological interactions.

Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling.

I. Tsai, G. Chang, Ku-Chung Chen, 2017, Food & function.

Residue dynamics and risk assessment of pyraclostrobin in rice, plants, hulls, field soil, and paddy water

Xiangji Kong, Ku-Chung Chen, Z. Shan, 2017 .

Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions.

Ku-Chung Chen, Yen-Chou Chen, Chia-Hsiung Cheng, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Glycolysis-associated lncRNAs identify a subgroup of cancer patients with poor prognoses and a high-infiltration immune microenvironment

C. Shih, Ku-Chung Chen, Tzu-Wen Huang, 2021, BMC Medicine.

MicroRNA-195 regulates vascular smooth muscle cell phenotype and prevents neointimal formation.

P. Tsai, S. Juo, R. Lin, 2012, Cardiovascular research.

miR‐4725‐3p targeting stromal interacting molecule 1 signaling is involved in xanthohumol inhibition of glioma cell invasion

Wei-Chiao Chang, Ku-Chung Chen, C. Chang, 2018, Journal of neurochemistry.

Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.

J. Liao, Ku-Chung Chen, F. Mi, 2017, Journal of agricultural and food chemistry.

miR-140 targeting CTSB signaling suppresses the mesenchymal transition and enhances temozolomide cytotoxicity in glioblastoma multiforme.

C. Shih, C. Chou, Ku-Chung Chen, 2019, Pharmacological research.

Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210

S. Juo, Jaw-Yuan Wang, Y. Liao, 2015, Oncotarget.

Calcium‐stimulated mitogen‐activated protein kinase activation elicits Bcl‐xL downregulation and Bak upregulation in notexin‐treated human neuroblastoma SK‐N‐SH cells

Pei-Hsiu Kao, Ku-Chung Chen, L. Chang, 2010, Journal of cellular physiology.

Involvement of mitochondrial alteration and reactive oxygen species generation in Taiwan cobra cardiotoxin-induced apoptotic death of human neuroblastoma SK-N-SH cells.

Long-Sen Chang, Shinne‐ren Lin, Ku-Chung Chen, 2008, Toxicon : official journal of the International Society on Toxinology.

microRNA-199a/b-5p enhance imatinib efficacy via repressing WNT2 signaling-mediated protective autophagy in imatinib-resistant chronic myeloid leukemia cells.

C. Shih, Ku-Chung Chen, Yi-Ting Lee, 2018, Chemico-biological interactions.

MicroRNA-1301-Mediated RanGAP1 Downregulation Induces BCR-ABL Nuclear Entrapment to Enhance Imatinib Efficacy in Chronic Myeloid Leukemia Cells

C. Shih, Ku-Chung Chen, Kun-Li Wang, 2016, PLoS ONE.

Cancer Essential Genes Stratified Lung Adenocarcinoma Patients with Distinct Survival Outcomes and Identified a Subgroup from the Terminal Respiratory Unit Type with Different Proliferative Signatures in Multiple Cohorts

C. Shih, Ku-Chung Chen, Tzu-Wen Huang, 2021, Cancers.

MicroRNAs in atherosclerosis

Ku-Chung Chen, Suh-Hang Hank Juo, S. H. Juo, 2012, The Kaohsiung journal of medical sciences.

The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA

C. Shih, Ku-Chung Chen, K. Cheng, 2017, PloS one.

Hypoxia‐inducible lncRNA MIR210HG interacting with OCT1 is involved in glioblastoma multiforme malignancy

C. Shih, Ku-Chung Chen, Ann-Jeng Liu, 2021, Cancer science.

MicroRNA‐302b‐inhibited E2F3 transcription factor is related to all trans retinoic acid‐induced glioma cell apoptosis

C. Shih, Wei-Chiao Chang, Ku-Chung Chen, 2014, Journal of neurochemistry.

Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells.

M. Hou, Wei-Chiao Chang, Chien-Chih Chiu, 2011, Biochimica et biophysica acta.

microRNA let‐7g suppresses PDGF‐induced conversion of vascular smooth muscle cell into the synthetic phenotype

S. Juo, Hsiu-Fen Lin, Y. Liao, 2017, Journal of cellular and molecular medicine.

Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells.

Long-Sen Chang, Ku-Chung Chen, Wen-Min Chou, 2010, Toxicon : official journal of the International Society on Toxinology.

miR-4286 is Involved in Connections Between IGF-1 and TGF-β Signaling for the Mesenchymal Transition and Invasion by Glioblastomas

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2020, Cellular and Molecular Neurobiology.

miR-4286 is Involved in Connections Between IGF-1 and TGF-β Signaling for the Mesenchymal Transition and Invasion by Glioblastomas

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2020, Cellular and molecular neurobiology.

Functional roles of EF-hands in human potassium channel-interacting protein 2.2.

Ku-Chung Chen, L. Chang, Liya Lee, 2009, Protein and peptide letters.

A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2020, Neurotherapeutics.

A Key Role of DNA Damage-Inducible Transcript 4 (DDIT4) Connects Autophagy and GLUT3-Mediated Stemness To Desensitize Temozolomide Efficacy in Glioblastomas

C. Shih, C. Chou, Ku-Chung Chen, 2020, Neurotherapeutics.

Guanabenz Sensitizes Glioblastoma Cells to Sunitinib by Inhibiting GADD34-Mediated Autophagic Signaling

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2021, Neurotherapeutics.

BRAP Activates Inflammatory Cascades and Increases the Risk for Carotid Atherosclerosis

Toshihiro Tanaka, K. Ozaki, S. Juo, 2011, Molecular medicine.

Taiwan cobra phospholipase A2 elicits posttranscriptional up‐regulation of ADAM17 in human neuroblastoma SK‐N‐SH cells

Long-Sen Chang, Shinne‐ren Lin, Yi-Ling Chiou, 2010, Journal of cellular biochemistry.

MicroRNA-93 inhibits tumor growth and early relapse of human colorectal cancer by affecting genes involved in the cell cycle.

Ming-Feng Hou, Szu-Wei Huang, P. Tsai, 2012, Carcinogenesis.

Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1

Wen-ying Lee, C. Chou, Ku-Chung Chen, 2015, Oncotarget.

OxLDL up‐regulates microRNA‐29b, leading to epigenetic modifications of MMP‐2/MMP‐9 genes: a novel mechanism for cardiovascular diseases

Chia-Yen Dai, S. Juo, Y. Liao, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2017, Neuropharmacology.

Xanthohumol regulates miR-4749-5p-inhibited RFC2 signaling in enhancing temozolomide cytotoxicity to glioblastoma.

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2020, Life sciences.

microRNA-152 Mediates DNMT1-Regulated DNA Methylation in the Estrogen Receptor α Gene

S. Juo, R. Lin, Ku-Chung Chen, 2012, PloS one.

Arachidonic acid-induced apoptosis of human neuroblastoma SK-N-SH cells is mediated through mitochondrial alteration elicited by ROS and Ca(2+)-evoked activation of p38alpha MAPK and JNK1.

Long-Sen Chang, Ku-Chung Chen, L. Chang, 2009, Toxicology.

The mechanism of cytotoxicity by Naja naja atra cardiotoxin 3 is physically distant from its membrane-damaging effect.

Shinne‐ren Lin, Pei-Hsiu Kao, Ku-Chung Chen, 2007, Toxicon : official journal of the International Society on Toxinology.

Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis

C. Shih, Wei-Chiao Chang, E. Hsi, 2017, Scientific Reports.

Negative feedback regulation between microRNA let-7g and the oxLDL receptor LOX-1

S. Juo, E. Hsi, Ku-Chung Chen, 2011, Journal of Cell Science.

A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity.

C. Shih, Ku-Chung Chen, Tzu-Wen Huang, 2021, Life sciences.

Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set

C. Shih, Ku-Chung Chen, Tzu-Wen Huang, 2018, PloS one.

Phthalate plasticizer di(2‐ethyl‐hexyl) phthalate induces cyclooxygenase‐2 expression in gastric adenocarcinoma cells

Wei-Chiao Chang, Ku-Chung Chen, Che-Mai Chang, 2019, Environmental toxicology.

The role of SIRT1/AKT/ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells.

Jaw-Yuan Wang, Ku-Chung Chen, Yung-Song Wang, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

The role of SIRT 1 / AKT / ERK pathway in ultraviolet B induced damage on human retinal pigment epithelial cells

S. Juo, Jaw-Yuan Wang, Ku-Chung Chen, 2013 .

The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2016, Neuropharmacology.

The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling Involves in Temozolomide-Induced Glioma Cell Apoptotic Death

C. Shih, Ku-Chung Chen, Chia-Hsiung Cheng, 2016, PloS one.

Piperlongumine-inhibited TRIM14 signaling sensitizes glioblastoma cells to temozolomide treatment.

C. Shih, Ku-Chung Chen, Ann-Jeng Liu, 2022, Life sciences.

OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: novel mechanisms for cardiovascular diseases.

S. Juo, Y. Liao, Ku-Chung Chen, 2012, Journal of molecular and cellular cardiology.

A functional polymorphism at 3'UTR of the PAX6 gene may confer risk for extreme myopia in the Chinese.

S. Juo, E. Hsi, Ku-Chung Chen, 2011, Investigative ophthalmology & visual science.

IGF-1-enhanced miR-513a-5p signaling desensitizes glioma cells to temozolomide by targeting the NEDD4L-inhibited Wnt/β-catenin pathway

C. Shih, C. Chou, Ku-Chung Chen, 2019, PloS one.

A functional polymorphism at the FGF10 gene is associated with extreme myopia.

S. Juo, Ming‐Lung Yu, E. Hsi, 2013, Investigative ophthalmology & visual science.

Functional role of EF-hands 3 and 4 in membrane-binding of KChIP1

Long-Sen Chang, Ku-Chung Chen, Yanling Liao, 2009, Journal of Biosciences.

TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers

Jau-Song Yu, K. Tsai, Ting-Wen Chen, 2019, Scientific Reports.

Corrigendum to "Evodiamine, a plant alkaloid, induces calcium/JNK-mediated autophagy and calcium/mitochondria-mediated apoptosis in human glioblastoma cells" [Chem. Biol. Interact. 205 (1) (2013 Sep 5) 20-28].

C. Shih, W. Chiu, Ku-Chung Chen, 2017, Chemico-biological interactions.

Podocalyxin-Like Protein 1 Regulates TAZ Signaling and Stemness Properties in Colon Cancer

Wen-ying Lee, Ku-Chung Chen, Chia-Hsiung Cheng, 2017, International journal of molecular sciences.

Population-based 5-year follow-up study in Taiwan of osteoporosis and risk of periodontitis.

W. Chiu, Ku-Chung Chen, Mei-Shin Wu, 2014, Journal of periodontology.