M. Yogavel

发表

Crystal structures of the free and anisic acid bound triple mutant of phospholipase A2.

D. Velmurugan, A. Jeyaprakash, M. Tsai, 2003, Journal of molecular biology.

A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

A. Bougdour, Y. Couté, M. Hakimi, 2013, The Journal of experimental medicine.

Structural and Functional Highlights of Vacuolar Soluble Protein 1 from Pathogen Trypanosoma brucei brucei*

C. Venien-Bryan, A. Round, L. Bannwarth, 2015, The Journal of Biological Chemistry.

SAD phasing of a structure based on cocrystallized iodides using an in-house Cu Kalpha X-ray source: effects of data redundancy and completeness on structure solution.

M. Yogavel, Amit Sharma, P. Mishra, 2007, Acta crystallographica. Section D, Biological crystallography.

Iodide-SAD, SIR and SIRAS phasing for structure solution of a nucleosome assembly protein.

M. Yogavel, Amit Sharma, J. Gill, 2009, Acta crystallographica. Section D, Biological crystallography.

Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis

Arvind Sharma, M. Yogavel, Manmohan Sharma, 2016, PLoS neglected tropical diseases.

An Appended Domain Results in an Unusual Architecture for Malaria Parasite Tryptophanyl-tRNA Synthetase

Arvind Sharma, M. Yogavel, Amit Sharma, 2013, PloS one.

2-Benzoyl-3-cyclohexyl-4-(p-methoxyphenyl)-5-phenylpyrrolidine-3-spiro-3′-chroman-4′-one

D. Velmurugan, H. Fun, M. Yogavel, 2003 .

Engagement Rules That Underpin DBL-DARC Interactions for Ingress of Plasmodium knowlesi and Plasmodium vivax Into Human Erythrocytes

M. Yogavel, Jyoti Chhibber-Goel, Amit Sharma, 2017, bioRxiv.

A single amino acid substitution alters activity and specificity in Plasmodium falciparum aspartyl & asparaginyl-tRNA synthetases.

M. Yogavel, Jyoti Chhibber-Goel, Amit Sharma, 2022, Molecular and biochemical parasitology.

Structure of a superoxide dismutase and implications for copper-ion chelation.

S. Dutt, P. Ahuja, Sanjay Kumar, 2008, Acta crystallographica. Section D, Biological crystallography.

Structure–Function Analysis of Liver Flavin Monooxygenase 3 that Drives Trimethylaminuria in Humans

M. Yogavel, Anamika Gaur, Jyoti Chhibber-Goel, 2017, Proceedings of the National Academy of Sciences, India Section B: Biological Sciences.

Structural delineation of histone post-translation modifications in histone-nucleosome assembly protein complex.

M. Yogavel, Amit Sharma, Anuj Kumar, 2012, Journal of structural biology.

Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite.

Dhanasekaran Shanmugam, K. Harlos, N. Malhotra, 2018, Journal of medicinal chemistry.

3,4:9,10‐Dibenzo‐1,12‐diformyl‐5,8‐dioxododecane

P. G. Aravindan, Devadasan Velmurugan, M. Thirumavalavan, 2003 .

Conformational heterogeneity in apo and drug-bound structures of Toxoplasma gondii prolyl-tRNA synthetase.

N. Malhotra, H. Kikuchi, M. Yogavel, 2019, Acta crystallographica. Section F, Structural biology communications.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.

K. Harlos, F. Tacchini-Cottier, M. Matsumoto, 2017, Structure.

Structure of Prolyl-tRNA Synthetase-Halofuginone Complex Provides Basis for Development of Drugs against Malaria and Toxoplasmosis.

M. Hakimi, H. Kikuchi, Y. Oshima, 2015, Structure.

Structural and functional analysis of the anti-malarial drug target prolyl-tRNA synthetase

H. Kikuchi, Y. Oshima, M. Yogavel, 2014, Journal of Structural and Functional Genomics.

3-Acetyl-2-hydroxy-2-methylchromene

D. Velmurugan, R. Peschar, H. Schenk, 2003 .

3-benzoyl-2-hydroxy-2-methylchromene

D. Velmurugan, R. Peschar, H. Schenk, 2003 .

2-Methoxybenzaldehyde thiosemicarbazone

D. Velmurugan, H. Fun, M. Yogavel, 2002 .

2‐Hydroxy‐4,4‐dimethyl‐N‐(4‐methylphenyl‐6‐oxocyclohexanylacetamide

D. Velmurugan, H. Fun, M. Yogavel, 2003 .

N,N‐Dimethyl‐N'‐phenylformamidinium perchlorate

P. G. Aravindan, D. Velmurugan, M. Yogavel, 2003 .

Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses.

Anmol Chandele, Sameena Khan, Tarun Kumar Bhatt, 2011, Nature communications.

Suggestive evidence for the involvement of the second calcium and surface loop in interfacial binding: monoclinic and trigonal crystal structures of a quadruple mutant of phospholipase A2.

D. Velmurugan, Z. Dauter, M. Tsai, 2006, Acta crystallographica. Section D, Biological crystallography.

Observation of additional calcium ion in the crystal structure of the triple mutant K56,120,121M of bovine pancreatic phospholipase A2.

J Jeyakanthan, Ming-Daw Tsai, D Velmurugan, 2002, Journal of molecular biology.

Utility of anion and cation combinations for phasing of protein structures

Amit Kumar Sharma, M. Yogavel, Ashwani Sharma, 2012, Journal of Structural and Functional Genomics.

Crystal Structure of Malaria Parasite Nucleosome Assembly Protein

S. Jain, S. Jain, M. Rug, 2009, Journal of Biological Chemistry.

6a,14a-cis-6,6a,7,14a-Tetrahydrochromeno[4′,3′:3,4]pyrano[3,2-c]coumarin

P. G. Aravindan, D. Velmurugan, H. Fun, 2003 .

Atomic resolution crystal structure of glutaredoxin 1 from Plasmodium falciparum and comparison with other glutaredoxins.

S. Rahlfs, K. Becker, H. Belrhali, 2014, Acta crystallographica. Section D, Biological crystallography.

Characterization of Plasmodium falciparum Calcium-dependent Protein Kinase 1 (PfCDPK1) and Its Role in Microneme Secretion during Erythrocyte Invasion*

C. Chitnis, A. Bansal, M. Yogavel, 2012, The Journal of Biological Chemistry.

3-[2-(2,4-Dichlorophenyl)vinyl]-2-methyl-1-phenylsulfonyl-1H-indole

D. Velmurugan, M. Yogavel, S. S. Raj, 2003 .

Structural Analysis of ABC-family Periplasmic Zinc Binding Protein Provides New Insights Into Mechanism of Ligand Uptake and Release

M. Yogavel, Amit Sharma, B. R. Chandra, 2007, Journal of molecular biology.

Dimerization of Arginyl-tRNA Synthetase by Free Heme Drives Its Inactivation in Plasmodium falciparum.

M. Yogavel, Amit Sharma, V. Jain, 2016, Structure.

Crystal Structure of Soluble Domain of Malaria Sporozoite Protein UIS3 in Complex with Lipid

Amit Kumar Sharma, M. Yogavel, R. Akhouri, 2008, Journal of Biological Chemistry.

Structural and functional attributes of malaria parasite diadenosine tetraphosphate hydrolase

M. Yogavel, Amit Sharma, Arvind Sharma, 2016, Scientific Reports.

Structural and Biochemical Characterization of Apicomplexan Inorganic Pyrophosphatases

S. Jain, M. Abdin, M. Yogavel, 2017, Scientific Reports.

Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein.

K. Harlos, M. Yogavel, S. Parvez, 2020, Acta crystallographica. Section D, Structural biology.

Atomic resolution structure of the double mutant (K53,56M) of bovine pancreatic phospholipase A2.

D. Velmurugan, Z. Dauter, M. Tsai, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Characterization of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) and its role in microneme secretion during erythrocyte invasion.

C. Chitnis, A. Bansal, M. Yogavel, 2013, The Journal of Biological Chemistry.

10‐[2‐(4‐Acetylpiperzin‐1‐yl)ethyl]‐9‐(4‐chlorophenyl)‐3,3,6,6‐tetramethyl‐3,4,6,7,9,10‐hexahydro‐2H,5H‐acridine‐1,8‐dione

P. R. Seshadri, D. Velmurugan, M. Yogavel, 2003 .

3-Phenyl-4a,5-dihydro-1,2,4-triazolo[3,4-b][1,3]benzothiazine

P. G. Aravindan, D. Velmurugan, M. Yogavel, 2003 .

5‐Amino‐4‐(4‐dimethylaminophenyl)‐2‐(4‐methoxyphenyl)‐7‐(pyrrolidin‐1‐yl)‐1,6‐naphthyridine‐8‐carbonitrile

D. Velmurugan, M. Yogavel, R. Krishna, 2003 .

1,4-Bis{2-hydroxy-3-[N-(2-hydroxyethyl)imino]-5-methylbenzyl}piperazine

Hoong-Kun Fun, Devadasan Velmurugan, S. Selvanayagam, 2003 .

Crystal and Molecular Structure of an Acridinedione

D. Velmurugan, K. Sekar, J. Jeyakanthan, 2002 .

Inhibition of Protein Synthesis and Malaria Parasite Development by Drug Targeting of Methionyl-tRNA Synthetases

M. Yogavel, Amit Sharma, T. Hussain, 2015, Antimicrobial Agents and Chemotherapy.

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

A. Bougdour, K. Harlos, N. Malhotra, 2023, PLoS pathogens.

Structure-Based Targeting of Orthologous Pathogen Proteins Accelerates Antiparasitic Drug Discovery.

M. Yogavel, G. Singh, Amit Sharma, 2017, ACS infectious diseases.

Structure–Function Analysis of Liver Flavin Monooxygenase 3 that Drives Trimethylaminuria in Humans

M. Yogavel, Anamika Gaur, Jyoti Chhibber-Goel, 2018, Proceedings of the National Academy of Sciences, India Section B: Biological Sciences.

Structural analyses of the malaria parasite aminoacyl‐tRNA synthetases provide new avenues for antimalarial drug discovery

M. Yogavel, Jyoti Chhibber-Goel, Amit Sharma, 2021, Protein science : a publication of the Protein Society.

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines

S. Schreiber, K. Harlos, B. Melillo, 2021, Nature communications.

Structure, localization and histone binding properties of nuclear-associated nucleosome assembly protein from Plasmodium falciparum

M. Rug, A. Maier, H. Belrhali, 2010, Malaria Journal.

Structural and functional analysis of Glutaminyl-tRNA synthetase (TtGlnRS) from Thermus thermophilus HB8 and its complexes.

J. Jeyakanthan, M. Yogavel, Amit Sharma, 2018, International journal of biological macromolecules.

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase–dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance

Amit Kumar Sharma, K. Harlos, J. Nettleship, 2018, The Journal of Biological Chemistry.

1,2,3,4,4a,12a‐Hexahydro‐2,5,5‐trimethyl‐1H‐[2]benzopyrano[3,2‐c]coumarin

D. Velmurugan, M. Yogavel, R. Raghunathan, 2003 .

Structural basis of malaria parasite lysyl-tRNA synthetase inhibition by cladosporin

H. Belrhali, M. Yogavel, Amit Sharma, 2014, Journal of Structural and Functional Genomics.

Malaria parasite tyrosyl-tRNA synthetase secretion triggers pro-inflammatory responses.

A. Craig, Arvind Sharma, A. Maier, 2011, Nature communications.

Ligand-bound Structures Provide Atomic Snapshots for the Catalytic Mechanism of d-Amino Acid Deacylase*

M. Yogavel, Amit Sharma, T. Bhatt, 2009, The Journal of Biological Chemistry.