S. Serrano

发表

A novel phospholipase A2, BJ-PLA2, from the venom of the snake Bothrops jararaca: purification, primary structure analysis, and its characterization as a platelet-aggregation-inhibiting factor.

E. Auerswald, M. L. Santoro, S. Serrano, 1999, Archives of biochemistry and biophysics.

Functional Variability of Snake Venom Metalloproteinases: Adaptive Advantages in Targeting Different Prey and Implications for Human Envenomation

S. Serrano, J. L. Bernardoni, L. F. Sousa, 2014, PloS one.

Insights into the Mechanisms Involved in Strong Hemorrhage and Dermonecrosis Induced by Atroxlysin-Ia, a PI-Class Snake Venom Metalloproteinase

S. Serrano, A. Moura-da-Silva, M. Lopes-Ferreira, 2017, Toxins.

Snake Venom Metalloproteinases

J. Fox, S. Serrano, 2009 .

Timeline of key events in snake venom metalloproteinase research.

J. Fox, S. Serrano, 2009, Journal of proteomics.

N-glycome profiling of Bothrops jararaca newborn and adult venoms.

V. Reinhold, S. Serrano, A. Zelanis, 2012, Journal of proteomics.

The long road of research on snake venom serine proteinases.

S. Serrano, 2013, Toxicon : official journal of the International Society on Toxinology.

Molecular cloning of serine proteinases from Bothrops jararaca venom gland.

S. Serrano, A. Camargo, S. Higuchi, 2005, Toxicon : official journal of the International Society on Toxinology.

Purification, characterization, and amino acid sequence of a serine proteinase, PA-BJ, with platelet-aggregating activity from the venom of Bothrops jararaca.

S. Serrano, R. Mentele, C. Sampaio, 1995, Biochemistry.

Proteomic and Glycoproteomic Profilings Reveal That Post-translational Modifications of Toxins Contribute to Venom Phenotype in Snakes.

S. Serrano, A. S. Lopes, M. Reis, 2016, Journal of proteome research.

The Novel Leptospiral Surface Adhesin Lsa20 Binds Laminin and Human Plasminogen and Is Probably Expressed during Infection

A. L. Nascimento, S. Serrano, S. Vasconcellos, 2011, Infection and Immunity.

Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of Batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species.

M. Nishiyama, S. Serrano, L. F. Sousa, 2015, Biochimie.

Insights into the local pathogenesis induced by fish toxins: role of natterins and nattectin in the disruption of cell-cell and cell-extracellular matrix interactions and modulation of cell migration.

A. D. Ramos, S. Serrano, Evilin N. Komegae, 2011, Toxicon : official journal of the International Society on Toxinology.

Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases.

J. Fox, S. Serrano, 2005, Toxicon : official journal of the International Society on Toxinology.

Tissue distribution in mice of BPP 10c, a potent proline-rich anti-hypertensive peptide of Bothrops jararaca.

S. Serrano, A. Camargo, N. Nascimento, 2008, Toxicon : official journal of the International Society on Toxinology.

Signatures of protein expression revealed by secretome analyses of cancer associated fibroblasts and melanoma cell lines.

S. Serrano, A. Zelanis, Eduardo S Kitano, 2018, Journal of proteomics.

Bradykinin-potentiating peptides: beyond captopril.

S. Serrano, A. Camargo, D. Ianzer, 2012, Toxicon : official journal of the International Society on Toxinology.

A proteomics-MM/PBSA dual approach for the analysis of SARS-CoV-2 main protease substrate peptide specificity

G. Gallo, C. Coelho, L. Hardy, 2022, Peptides.

Plasmin cleaves fibrinogen and the human complement proteins C3b and C5 in the presence of Leptospira interrogans proteins: A new role of LigA and LigB in invasion and complement immune evasion.

S. Serrano, A. Barbosa, L. Isaac, 2016, Immunobiology.

Profilings of subproteomes of lectin-binding proteins of nine Bothrops venoms reveal variability driven by different glycan types.

S. Serrano, Daniela Cajado-Carvalho, Débora Andrade-Silva, 2022, Biochimica et biophysica acta. Proteins and proteomics.

Snake venomics of the Brazilian pitvipers Bothrops cotiara and Bothrops fonsecai. Identification of taxonomy markers.

J. Calvete, L. Sanz, S. Serrano, 2008, Journal of proteomics.

Rapid purification of serine proteinases from Bothrops alternatus and Bothrops moojeni venoms.

R. Arni, P. Spencer, S. Serrano, 2013, Toxicon : official journal of the International Society on Toxinology.

Proteomic profiling of the proteolytic events in the secretome of the transformed phenotype of melanocyte-derived cells using Terminal Amine Isotopic Labeling of Substrates.

R. Chammas, S. Serrano, A. Zelanis, 2019, Journal of proteomics.

High-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venom

S. Serrano, L. Troncone, A. Zelanis, 2016, Amino Acids.

Hemorrhagic activity of HF3, a snake venom metalloproteinase: insights from the proteomic analysis of mouse skin and blood plasma.

J. Fox, N. Sherman, A. F. Paes Leme, 2012, Journal of proteome research.

"Insularin, a disintegrin from Bothrops insularis venom: inhibition of platelet aggregation and endothelial cell adhesion by the native and recombinant GST-insularin proteins".

P. Ho, S. Serrano, I. Junqueira-de-Azevedo, 2011, Toxicon : official journal of the International Society on Toxinology.

Comparison of indirect and direct approaches using ion-trap and Fourier transform ion cyclotron resonance mass spectrometry for exploring viperid venom proteomes.

J. Fox, N. Sherman, K. Nelson, 2006, Toxicon : official journal of the International Society on Toxinology.

Amblyomin-X having a Kunitz-type homologous domain, is a noncompetitive inhibitor of FXa and induces anticoagulation in vitro and in vivo.

A. Iqbal, S. Serrano, L. Iwai, 2016, Biochimica et biophysica acta.

Mass spectrometric analysis of the individual variability of Bothrops jararaca venom peptide fraction. Evidence for sex-based variation among the bradykinin-potentiating peptides.

S. Serrano, A. Camargo, B. Prezoto, 2007, Rapid communications in mass spectrometry : RCM.

Analysis of the Snake Venom Peptidome.

S. Serrano, A. Zelanis, Eduardo S Kitano, 2018, Methods in molecular biology.

Antivenomic characterization of two antivenoms against the venom of the taipan, Oxyuranus scutellatus, from Papua New Guinea and Australia.

David J. Williams, J. Gutiérrez, S. Serrano, 2014, The American journal of tropical medicine and hygiene.

Biochemical characterization of venom from Pseudoboa neuwiedii (Neuwied's false boa; Xenodontinae; Pseudoboini).

S. Serrano, S. Hyslop, Débora Andrade-Silva, 2018, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Sialic acid-containing glycans play a role in the activity of snake venom proteases.

S. Serrano, D. Trevisan-Silva, Daniela Cajado-Carvalho, 2022, Biochimie.

Immunological comparison of hemorrhagic principles present in venoms of the Crotalinae and Viperinae subfamilies.

S. Serrano, M. Assakura, F. Mandelbaum, 1989, Toxicon : official journal of the International Society on Toxinology.

Snake venom serine proteinases: sequence homology vs. substrate specificity, a paradox to be solved.

R. Maroun, S. Serrano, 2005, Toxicon : official journal of the International Society on Toxinology.

Basic proteinases from Bothrops moojeni (caissaca) venom--II. Isolation of the metalloproteinase MPB. Comparison of the proteolytic activity on natural substrates by MPB, MSP 1 and MSP 2.

S. Serrano, C. Sampaio, F. Mandelbaum, 1993, Toxicon : official journal of the International Society on Toxinology.

NPP-BJ, a nucleotide pyrophosphatase/phosphodiesterase from Bothrops jararaca snake venom, inhibits platelet aggregation.

A. F. Paes Leme, M. L. Santoro, S. Serrano, 2009, Toxicon : official journal of the International Society on Toxinology.

Development of a cell‐free protein synthesis protocol to rapidly screen L‐asparaginase proteoforms by enzymatic activity

S. Serrano, G. Monteiro, I. Costa, 2021 .

A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies.

S. Serrano, A. Zelanis, Eduardo S Kitano, 2019, Comparative biochemistry and physiology. Part D, Genomics & proteomics.

High-resolution proteomic profiling of spider venom: expanding the toxin diversity of Phoneutria nigriventer venom

S. Serrano, L. Troncone, A. Zelanis, 2016, Amino Acids.

Individual variability in the venom proteome of juvenile Bothrops jararaca specimens.

S. Serrano, A. Zelanis, Eduardo S Kitano, 2013, Journal of proteome research.

Proteome-derived peptide library for the elucidation of the cleavage specificity of HF3, a snake venom metalloproteinase

S. Serrano, A. Zelanis, Ana K Oliveira, 2016, Amino Acids.

BJ-PI2, a non-hemorrhagic metalloproteinase from Bothrops jararaca snake venom.

S. Serrano, S. Hyslop, A. Zelanis, 2012, Biochimica et biophysica acta.

Proteomic identification of gender molecular markers in Bothrops jararaca venom.

J. Fox, N. Sherman, P. Ho, 2016, Journal of proteomics.

Ontogenetic Variation in Biological Activities of Venoms from Hybrids between Bothrops erythromelas and Bothrops neuwiedi Snakes

M. L. Santoro, S. Serrano, K. Barbaro, 2015, PloS one.

Exploring potential virulence regulators in Paracoccidioides brasiliensis isolates of varying virulence through quantitative proteomics.

S. Serrano, A. Zelanis, P. Xander, 2014, Journal of proteome research.

Early response of C2C12 myotubes to a sub-cytotoxic dose of hemorrhagic metalloproteinase HF3 from Bothrops jararaca venom.

M. Nishiyama, S. Serrano, A. Zelanis, 2019, Journal of proteomics.

Structures of N-Glycans of Bothrops Venoms Revealed as Molecular Signatures that Contribute to Venom Phenotype in Viperid Snakes *

D. Ashline, V. Reinhold, S. Serrano, 2018, Molecular & Cellular Proteomics.

Dynamic Rearrangement in Snake Venom Gland Proteome: Insights into Bothrops jararaca Intraspecific Venom Variation.

S. Serrano, D. R. Stuginski, A. Zelanis, 2016, Journal of proteome research.

Interaction of the cysteine‐rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site‐specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor‐mediated platelet aggregation

J. Fox, R. Polanowska-Grabowska, S. Serrano, 2007, The FEBS journal.

Approaching the golden age of natural product pharmaceuticals from venom libraries: an overview of toxins and toxin-derivatives currently involved in therapeutic or diagnostic applications.

Jay W Fox, J. Fox, S. Serrano, 2007, Current pharmaceutical design.

Purification and characterization of a kinin-releasing and fibrinogen-clotting serine proteinase (KN-BJ) from the venom of Bothrops jararaca, and molecular cloning and sequence analysis of its cDNA.

S. Serrano, R. Mentele, C. Sampaio, 1998, European journal of biochemistry.

Activation of alpha(M)beta(2)-mediated phagocytosis by HF3, a P-III class metalloproteinase isolated from the venom of Bothrops jararaca.

C. Teixeira, S. Serrano, R. Mentele, 2004, Biochemical and biophysical research communications.

The unusual high molecular mass of Bothrops protease A, a trypsin-like serine peptidase from the venom of Bothrops jararaca, is due to its high carbohydrate content.

S. Serrano, R. Mentele, A. Camargo, 2003, Biochimica et biophysica acta.

A Novel Fibrinogen-clotting Enzyme, TL-BJ, from the Venom of the Snake Bothrops jararaca: Purification and Characterization

S. Serrano, R. Mentele, C. Sampaio, 2000, Thrombosis and Haemostasis.

Peptidomics of Three Bothrops Snake Venoms: Insights Into the Molecular Diversification of Proteomes and Peptidomes*

A. C. Schenberg, S. Serrano, A. Camargo, 2012, Molecular & Cellular Proteomics.

Bothrops protease A, a unique highly glycosylated serine proteinase, is a potent, specific fibrinogenolytic agent

A. F. Paes Leme, S. Serrano, A. Camargo, 2008, Journal of thrombosis and haemostasis : JTH.

Cleavage of proteoglycans, plasma proteins and the platelet-derived growth factor receptor in the hemorrhagic process induced by snake venom metalloproteinases

S. Serrano, D. Trevisan-Silva, A. Zelanis, 2020, Scientific Reports.

Generation of a Chinese Hamster Ovary Cell Line Producing Recombinant Human Glucocerebrosidase

A. F. Paes Leme, P. Ho, S. Serrano, 2012, Journal of biomedicine & biotechnology.

Phosphosite-specific regulation of the oxidative-stress response of Paracoccidioides brasiliensis: a shotgun phosphoproteomic analysis.

S. Serrano, W. L. Batista, Ana K Oliveira, 2017, Microbes and infection.

AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility

G. Goldberg, S. Serrano, M. Cruz, 2016, Oncotarget.

A multifaceted analysis of viperid snake venoms by two‐dimensional gel electrophoresis: An approach to understanding venom proteomics

J. Fox, S. Serrano, J. Shannon, 2005, Proteomics.

Comparative analysis of the high molecular mass subproteomes of eight Bothrops snake venoms.

S. Serrano, E. Gren, M. Reis, 2019, Comparative biochemistry and physiology. Part D, Genomics & proteomics.

Argininosuccinate Synthetase Is a Functional Target for a Snake Venom Anti-hypertensive Peptide

J. Fox, C. Lameu, O. Augusto, 2009, The Journal of Biological Chemistry.

Analysis of the ontogenetic variation in the venom proteome/peptidome of Bothrops jararaca reveals different strategies to deal with prey.

P. Ho, S. Serrano, A. Camargo, 2010, Journal of proteome research.

Bothrops jararaca venom proteome rearrangement upon neonate to adult transition

J. Fox, N. Sherman, P. Ho, 2011, Proteomics.

Naja annulifera Snake: New insights into the venom components and pathogenesis of envenomation

D. Tambourgi, S. Serrano, B. Cogliati, 2019, PLoS neglected tropical diseases.

Insights into and speculations about snake venom metalloproteinase (SVMP) synthesis, folding and disulfide bond formation and their contribution to venom complexity

J. Fox, S. Serrano, 2008, The FEBS journal.

New insights into the structural elements involved in the skin haemorrhage induced by snake venom metalloproteinases

J. Fox, S. Serrano, A. Camargo, 2010, Thrombosis and Haemostasis.

Venomics profiling of Thamnodynastes strigatus unveils matrix metalloproteinases and other novel proteins recruited to the toxin arsenal of rear-fanged snakes.

P. Ho, S. Serrano, J. Perales, 2012, Journal of proteome research.

New proline-rich oligopeptides from the venom of African adders: Insights into the hypotensive effect of the venoms.

D. Tambourgi, S. Serrano, A. K. Kuniyoshi, 2015, Biochimica et biophysica acta.

Angiostatin-like molecules are generated by snake venom metalloproteinases.

P. Ho, S. Serrano, R. Mentele, 2002, Biochemical and biophysical research communications.

P-I Snake Venom Metalloproteinase Is Able to Activate the Complement System by Direct Cleavage of Central Components of the Cascade

D. Tambourgi, S. Serrano, A. S. Lopes, 2013, PLoS neglected tropical diseases.

Basic proteinases from Bothrops moojeni (caissaca) venom--I. Isolation and activity of two serine proteinases, MSP 1 and MSP 2, on synthetic substrates and on platelet aggregation.

S. Serrano, C. Sampaio, M. Matos, 1993, Toxicon : official journal of the International Society on Toxinology.

Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability.

J. Fox, S. Serrano, M. Assakura, 2003, Archives of biochemistry and biophysics.

Surface Protein Dispersin of Enteroaggregative Escherichia coli Binds Plasminogen That Is Converted Into Active Plasmin

R. Piazza, M. Morone, S. Serrano, 2020, Frontiers in Microbiology.

Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome

Michael Broe, P. Ho, S. Serrano, 2021, Proceedings of the National Academy of Sciences.

Functional and proteomic comparison of Bothrops jararaca venom from captive specimens and the Brazilian Bothropic Reference Venom.

S. Serrano, A. Tanaka-Azevedo, Débora Andrade-Silva, 2018, Journal of proteomics.

Peptidomics of Acanthoscurria gomesiana spider venom reveals new toxins with potential antimicrobial activity.

U. C. Oliveira, M. Nishiyama, S. Serrano, 2017, Journal of proteomics.

Deep profiling of the cleavage specificity and human substrates of snake venom metalloprotease HF3 by PICS using proteome derived peptide libraries and TAILS N-terminomics.

Pitter F. Huesgen, C. Overall, A. Prudova, 2019, Journal of proteome research.

High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry.

J. Fox, J. Gutiérrez, T. Escalante, 2011, Journal of proteomics.

Use of microarrays for investigating the subtoxic effects of snake venoms: insights into venom-induced apoptosis in human umbilical vein endothelial cells.

J. Fox, S. Serrano, R. Theakston, 2003, Toxicon : official journal of the International Society on Toxinology.

Community-based network analyses reveal emerging connectivity patterns of protein-protein interactions in murine melanoma secretome.

R. Chammas, S. Serrano, M. C. Nascimento, 2020, Journal of proteomics.

The distinct N-terminomes of Bothrops jararaca newborn and adult venoms.

M. Nishiyama, S. Serrano, D. R. Stuginski, 2021, Biochimica et biophysica acta. Proteins and proteomics.

The proteinase-rich proteome of Bothrops jararaca venom

S. Serrano, A. Zelanis, Ana K Oliveira, 2014 .

Proteoforms of the platelet-aggregating enzyme PA-BJ, a serine proteinase from Bothrops jararaca venom.

S. Serrano, Eduardo S Kitano, I. Junqueira-de-Azevedo, 2014, Biochimica et biophysica acta.

A Transcriptomic View of the Proteome Variability of Newborn and Adult Bothrops jararaca Snake Venoms

P. Ho, S. Serrano, A. Zelanis, 2012, PLoS neglected tropical diseases.

Analysis of the subproteomes of proteinases and heparin‐binding toxins of eight Bothrops venoms

J. Fox, P. Ho, S. Serrano, 2009, Proteomics.

Sex-based individual variation of snake venom proteome among eighteen Bothrops jararaca siblings.

S. Serrano, A. Camargo, M. Furtado, 2006, Toxicon : official journal of the International Society on Toxinology.

Systemic Effects of Hemorrhagic Snake Venom Metalloproteinases: Untargeted Peptidomics to Explore the Pathodegradome of Plasma Proteins

S. Serrano, A. Zelanis, A. Asega, 2021, Toxins.

Inflammatory Reaction Induced by Two Metalloproteinases Isolated from Bothrops atrox Venom and by Fragments Generated from the Hydrolysis of Basement Membrane Components

S. Gimenes, S. Serrano, A. Moura-da-Silva, 2020, Toxins.

Interaction of Bothrops jararaca venom metalloproteinases with protein inhibitors.

S. Serrano, A. Neves-Ferreira, A. Asega, 2014, Toxicon : official journal of the International Society on Toxinology.

Simplified procedures for the isolation of HF3, bothropasin, disintegrin-like/cysteine-rich protein and a novel P-I metalloproteinase from Bothrops jararaca venom.

J. Fox, S. Serrano, A. Camargo, 2009, Toxicon : official journal of the International Society on Toxinology.

Activation of leukocyte rolling by the cysteine‐rich domain and the hyper‐variable region of HF3, a snake venom hemorrhagic metalloproteinase

J. Fox, S. Serrano, M. Lopes-Ferreira, 2008, FEBS letters.

The Cysteine-rich Domain of Snake Venom Metalloproteinases Is a Ligand for von Willebrand Factor A Domains

Deyu Wang, Jay W. Fox, John D. Shannon, 2006, Journal of Biological Chemistry.

Function of the cysteine-rich domain of the haemorrhagic metalloproteinase atrolysin A: targeting adhesion proteins collagen I and von Willebrand factor.

Deyu Wang, Jay W Fox, J. Fox, 2005, The Biochemical journal.

Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin.

C. Moskaluk, J. Fox, J. Gutiérrez, 2005, Archives of biochemistry and biophysics.

Trends in the Evolution of Snake Toxins Underscored by an Integrative Omics Approach to Profile the Venom of the Colubrid Phalotris mertensi

S. Serrano, A. Zelanis, Débora Andrade-Silva, 2016, Genome biology and evolution.

Recombinant expression of the precursor of the hemorrhagic metalloproteinase HF3 and its non-catalytic domains using a cell-free synthesis system

T. Vernet, S. Serrano, Eduardo S Kitano, 2016, Amino Acids.

Cotiarinase is a novel prothrombin activator from the venom of Bothrops cotiara.

S. Serrano, A. Zelanis, Eduardo S Kitano, 2013, Biochimie.

Heterotypic signaling between dermal fibroblasts and melanoma cells induces phenotypic plasticity and proteome rearrangement in malignant cells.

S. Serrano, A. Zelanis, Débora Andrade-Silva, 2020, Biochimica et biophysica acta. Proteins and proteomics.

Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

Pitter F. Huesgen, C. Overall, S. Serrano, 2015, Journal of proteomics.

Molecular cloning and expression of structural domains of bothropasin, a P-III metalloproteinase from the venom of Bothrops jararaca.

S. Serrano, R. Mentele, A. Camargo, 2003, Toxicon : official journal of the International Society on Toxinology.

Philodryas Venom Metalloproteinases

S. Serrano, A. P. Reichl, M. Assakura, 2004 .

Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome

P. Ho, S. Serrano, Daniel Carvalho Pimenta, 2006, FEBS letters.

Interaction of viper venom serine peptidases with thrombin receptors on human platelets

S. Serrano, A. Kuliopulos, S. Niewiarowski, 2000, FEBS letters.

Disintegrin-like/cysteine-rich domains of the reprolysin HF3: Site-directed mutagenesis reveals essential role of specific residues.

S. Serrano, M. Lopes-Ferreira, A. Balan, 2011, Biochimie.

A Comparative Study of the Outer Membrane Proteome from an Atypical and a Typical Enteropathogenic Escherichia coli

S. Serrano, M. Martinez, R. Piazza, 2011, The open microbiology journal.

Molecular cloning, functional expression, and molecular modeling of bothrostatin, a new highly active disintegrin from Bothrops jararaca venom.

S. Serrano, A. Camargo, M. Assakura, 2005, Biochemical and biophysical research communications.

Crystallization and preliminary crystallographic studies of a phospholipase A2 from the venom of the Brazilian snake Bothrops moojeni.

G. Oliva, M. Nonato, Y. Mascarenhas, 2001, Acta crystallographica. Section D, Biological crystallography.

Corrigendum to “Some aspects of the venom proteome of the Colubridae snake Philodryas olfersii revealed from a Duvernoy's (venom) gland transcriptome” [FEBS Lett. 580 (2006) 4417–4422]

P. Ho, S. Serrano, Daniel Carvalho Pimenta, 2006 .

Identification of the substrate‐binding exosites of two snake venom serine proteinases: molecular basis for the partition of two essential functions of thrombin

R. Maroun, S. Serrano, 2004, Journal of molecular recognition : JMR.

Platelet-Aggregating Endopeptidase of Bothrops jararaca Venom

S. Serrano, 2013 .