M. Sofia

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Chapter 12. Novel Approaches to Anti-Inflammatory Agents as Therapeutics for Pulmonary Disease

M. Sofia, S. Silbaugh, 1993 .

Review Nucleotide prodrugs for HCV therapy

M. Sofia, 2011 .

M. Sofia, 2011, Antiviral chemistry & chemotherapy.

Efficient synthesis of a stereochemically defined carbohydrate scaffold: carboxymethyl 2-acetamido-6-azido-4-O-benzyl-2-deoxy-alpha-D-glucopyranoside.

R. Kakarla, M. Sofia, M. Ghosh, 2000, The Journal of organic chemistry.

Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

Mindy I. Davis, D. Baker, D. Hazuda, 2021, The Journal of infectious diseases.

Discovery of novel disaccharide antibacterial agents using a combinatorial library approach.

F. Chi, H. Wang, H. Axelrod, 1999, Journal of medicinal chemistry.

Nucleotide prodrugs for the treatment of HCV infection.

M. Sofia, 2013, Advances in pharmacology.

Stereoselective synthesis of PSI-352938: a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyl-3',5'-cyclic phosphate nucleotide prodrug for the treatment of HCV.

M. Sofia, B. Ross, P. G. Reddy, 2011, The Journal of organic chemistry.

Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection.

M. Otto, C. Espiritu, A. Lam, 2011, ACS medicinal chemistry letters.

Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein.

A. Lee, S. Majeski, A. Cuconati, 2021, Antiviral research.

Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation

Quanxin Long, N. Snead, A. Lee, 2018, Antimicrobial Agents and Chemotherapy.

The Discovery of Sofosbuvir: A Liver-Targeted Nucleotide Prodrug for the Treatment and Cure of HCV

M. Sofia, P. Furman, 2019, Topics in Medicinal Chemistry.

Harvoni: A Combination Therapy for Curing HCV

M. Sofia, J. Link, 2017 .

Beyond sofosbuvir: what opportunity exists for a better nucleoside/nucleotide to treat hepatitis C?

M. Sofia, 2014, Antiviral research.

Curing Hepatitis C with Direct‐Acting Antiviral Therapy

M. Sofia, 2021, New Drug Development for Known and Emerging Viruses.

Sofosbuvir: The Discovery of a Curative Therapy for the Treatment of Hepatitis C Virus

M. Sofia, 2016 .

Chapter Fifteen - Nucleosides and Nucleotides for the Treatment of Viral Diseases

M. Sofia, 2014 .

PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication

M. Otto, D. Smee, C. Espiritu, 2010, Antimicrobial Agents and Chemotherapy.

The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class.

W. Jackson, M. Sofia, S. Silbaugh, 1997, Advances in experimental medicine and biology.

Solid phase synthesis of peptidoglycan monomers for the generation of a combinatorial library

M. Sofia, T. Chan, N. Allanson, 1996 .

Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY293111: in vivo pulmonary studies

A. Bendele, W. Jackson, M. Sofia, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

Aerosolized LTB4 produces delayed onset increases in pulmonary gas trapping.

A. Bendele, W. Jackson, M. Sofia, 1996, Prostaglandins, leukotrienes, and essential fatty acids.

Host RNA quality control as a hepatitis B antiviral target.

J. Young, M. Sofia, T. Block, 2020, Antiviral research.

QSAR study of ortho-phenylphenol leukotriene B4 receptor antagonists

J. Wikel, K. Bemis, M. Sofia, 1994 .

Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies.

R. J. Boyd, R. Schultz, W. Jackson, 1999, The Journal of pharmacology and experimental therapeutics.

Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients

R. Rijnbrand, M. Sofia, S. Kottilil, 2020, Scientific Reports.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine

M. Otto, C. Espiritu, A. Lam, 2011, Antimicrobial Agents and Chemotherapy.

Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) - (cid:3) -Fluoro-2 (cid:2) - (cid:1) - C -Methylguanosine (cid:1) †

M. Otto, C. Espiritu, A. Lam, 2011 .

Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR).

R. Stoffel, S. Gerritz, D. Gordon, 2008, Bioorganic & medicinal chemistry letters.

alkoxyphenol leukotriene B4 receptor antagonists

W. Jackson, M. Sofia, S. Silbaugh, 1992 .

Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production.

R. Schultz, M. Sofia, D. K. Herron, 1991, Prostaglandins, leukotrienes, and essential fatty acids.

Flow cytometric evaluation of the effects of leukotriene B4 receptor antagonists (LY255283 and SC-41930) on calcium mobilization and integrin expression of activated human neutrophils.

R. Schultz, M. Sofia, D. K. Herron, 1992, Prostaglandins, leukotrienes, and essential fatty acids.

-alkoxyphenol leukotriene B4 receptor antagonists: effect of a chroman carboxylic acid.

W. Jackson, M. Sofia, S. Silbaugh, 1992 .

Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA

A. Lee, A. Lam, D. Gotchev, 2021, bioRxiv.

HBsAg mRNA degradation induced by a dihydroquinolizinone compound depends on the HBV posttranscriptional regulatory element

A. Lee, D. Gotchev, R. Rijnbrand, 2018, Antiviral research.

PSI-7851, a Pronucleotide of (cid:1) - D -2 (cid:2) -Deoxy-2 (cid:2) -Fluoro-2 (cid:2) - C -Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication (cid:1)

M. Otto, D. Smee, C. Espiritu, 2010 .

Hepatitis C Virus-From Discovery to Cure: The 2016 Lasker-DeBakey Clinical Medical Research Award.

C. Rice, R. Bartenschlager, M. Sofia, 2016, JAMA.

Acid unit modifications of 1,2,4,5-substituted hydroxyacetophenones and the effect on in vitro and in vivo LTB4 receptor antagonism

W. Jackson, M. Sofia, S. Silbaugh, 1993 .

Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates.

M. Sofia, R. Mosley, Haiying Bao, 2011, Journal of medicinal chemistry.

Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis

A. Lam, Jinhong Chang, A. Cuconati, 2022, Journal of virology.

Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977

M. Otto, C. Espiritu, A. Lam, 2010, The Journal of Biological Chemistry.

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

W. Stec, M. Sofia, B. Ross, 2009, The Journal of organic chemistry.

Synthesis of diastereomerically pure nucleotide phosphoramidates.

M. Sofia, B. Ross, P. G. Reddy, 2011, The Journal of organic chemistry.

2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938.

M. Otto, C. Espiritu, A. Lam, 2010, Bioorganic & medicinal chemistry letters.

Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661.

M. Otto, C. Espiritu, A. Lam, 2011, Antiviral research.

A liquid chromatography-tandem mass spectrometry method for the quantitative determination of diastereomers of a phosphoramidate nucleotide prodrug (PSI-7851) in human plasma.

M. Sofia, B. Ross, Donghui Bao, 2012, Biomedical chromatography : BMC.

Solid-phase synthesis of a library based on biphenyl-containing trypsin-like serine protease inhibitors.

D. Cheney, S. Gerritz, M. Sofia, 2009, Bioorganic & medicinal chemistry letters.

Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics.

M. Otto, A. Lam, M. Sofia, 2012, Bioorganic & medicinal chemistry letters.

Stereospecific reductive methylation via a radical cyclization-desilylation process

M. Sofia, G. Stork, 1986 .

Solid phase synthesis of 1,5-disubstituted pyrazole-4-hydroxamic acids and pyrazole-4-carboxamides via direct amidation of β-ketoesters

S. Gerritz, M. Sofia, W. Zhai, 2012 .

Phenylpropenamide derivatives: anti-hepatitis B virus activity of the Z isomer, SAR and the search for novel analogs.

M. Otto, M. Sofia, R. Mosley, 2011, Bioorganic & medicinal chemistry letters.

Analysis of the interaction of haloenol lactone suicide substrates with .alpha.-chymotrypsin using computer graphics and molecular mechanics

G. Marshall, J. Katzenellenbogen, S. Daniels, 1985 .

Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.

N. Meanwell, Zeyu Lin, S. Gerritz, 2010, Journal of combinatorial chemistry.

Synthesis of five-membered halo enol lactone analogs of .alpha.-amino acids: potential protease suicide substrates

J. Katzenellenbogen, M. Sofia, P. Chakravarty, 1983 .

Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate.

J. Katzenellenbogen, M. Sofia, 1986, Journal of medicinal chemistry.

3-(Acylamido)-4-phenyl-6(E)-(iodomethylidene)tetrahydro-2-pyranones. Synthesis of novel amino acid analogues

J. Katzenellenbogen, M. Sofia, 1985 .

Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives.

A. Lam, M. Sofia, R. Mosley, 2014, Journal of medicinal chemistry.

Phosphoramidate Prodrugs of (−)-β-D-(2R,4R)-dioxolane-thymine (DOT) as Potent Anti-HIV Agents

M. Otto, Véronique Zennou, M. Sofia, 2012, Antiviral chemistry & chemotherapy.

Carbohydrate-based combinatorial libraries

M. Sofia, 1997, Molecular Diversity.

Generation of oligosaccharide and glycoconjugate libraries for drug discovery

M. Sofia, 1996 .

Expeditious route to F unit building block of moenomycin A

M. Sofia, R. Kakarla, M. Ghosh, 1999 .

Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin.

J. Katzenellenbogen, S. Daniels, M. Sofia, 1983, The Journal of biological chemistry.

Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.

E. Gordon, T. Harrity, M. Sofia, 1990, Journal of medicinal chemistry.

Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.

Wonsuk Chang, M. Sofia, R. Mosley, 2012, Journal of medicinal chemistry.

Synthesis OF differentially protected phenyl d-thioglucopyranosides and 1-phenyl d-thioglucopyranosiduronic acids

M. Sofia, R. Chen, D. Liu, 1998 .

Novel carbohydrate scaffolds. Assembly of a uridine–mannose scaffold based on tunicamycin

M. Sofia, Domingos J. Silva, 2000 .

Carbohydrate-Based Small-Molecule Scaffolds for the Construction of Universal Pharmacophore Mapping Libraries

M. Sofia, D. Gange, R. Dulina, 1998 .

Rapid differentiation of nucleotide phosphoramidate diastereomers by electrospray ionization tandem mass spectrometry.

M. Sofia, B. Ross, P. G. Reddy, 2012, Rapid communications in mass spectrometry : RCM.

Diastereofacial selection in the 1,2-addition of MeMgX and McLi to 4-oxo sugar:Efficient synthesis of 4-C-methyl-l-S-β-D-gluco- and galactopyranoside building blocks of moenomycin

M. Sofia, R. Kakarla, M. Ghosh, 1999 .

Stereospecific Solution- and Solid-Phase Glycosylations. Synthesis of β-Linked Saccharides and Construction of Disaccharide Libraries Using Phenylsulfenyl 2-Deoxy-2-Trifluoroacetamido Glycopyranosides as Glycosyl Donors1

R. Jain, M. Sofia, N. Allanson, 1999 .

Simple and Efficient Method for the Oxidation of Sulfides to Sulfoxides: Application to the Preparation of Glycosyl Sulfoxides.

M. Sofia, R. Kakarla, N. Hatzenbuhler, 1996, The Journal of organic chemistry.

3-Azido-3-deoxy-glycopyranoside derivatives as scaffolds for the synthesis of carbohydrate-based universal pharmacophore mapping libraries.

R. Jain, M. Sofia, Chunguang Wang, 2003, Bioorganic & Medicinal Chemistry Letters.

Synthesis of phenyl 1-thioglycopyranosiduronic acids using a sonicated jones oxidation

F. Chi, R. Jain, M. Sofia, 1998 .

Intestinal Transport of Gentamicin with a Novel, Glycosteroid Drug Transport Agent

S. Choe, G. Amidon, H. Axelrod, 1998, Pharmaceutical Research.

The Efficient Synthesis of a Bis-glycosylated Steroid Drug Transport Reagent: Methyl 3-β-Amino-7α-, 12α-Di(1′α-glucosyl)-5β-cholate (TC002).

T. Wagler, M. Sofia, R. Kakarla, 1998 .

Attachment of unreactive amines to the solid support: synthesis of phenyl-substituted anilines, 2-aminopyridines, and 2-aminopyrimidines.

S. Gerritz, M. Sofia, Shirong Zhu, 2003, Journal of combinatorial chemistry.

Inhibition of HBV replication by N‐hydroxyisoquinolinedione and N‐hydroxypyridinedione ribonuclease H inhibitors

J. Tavis, R. Rijnbrand, M. Sofia, 2019, Antiviral research.

Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938

C. Espiritu, M. Sofia, B. Ross, 2011, Nucleosides, nucleotides & nucleic acids.

Accessing carbohydrate-based combinatorial libraries through solid phase and solution phase approaches

M. Sofia, 1999 .

Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus.

M. Otto, C. Espiritu, A. Lam, 2010, Journal of medicinal chemistry.

Use of 2'-spirocyclic ethers in HCV nucleoside design.

C. Espiritu, A. Lam, M. Sofia, 2014, Journal of medicinal chemistry.

Discovery of a β-D-2 0-Deoxy-2 0-r-fluoro-2 0-β-C-methyluridine Nucleotide Prodrug ( PSI-7977 ) for the Treatment of Hepatitis C Virus

M. Otto, C. Espiritu, A. Lam, 2010 .

Synthesis and anti-HCV activity of 3',4'-oxetane nucleosides.

M. Otto, M. Sofia, B. Ross, 2010, Bioorganic & medicinal chemistry letters.

Structural basis for RNA replication by the hepatitis C virus polymerase

M. Mcgrath, T. Appleby, S. Swaminathan, 2015, Science.

A 2′-Deoxy-2′-Fluoro-2′-C-Methyl Uridine Cyclopentyl Carbocyclic Analog and Its Phosphoramidate Prodrug as Inhibitors of HCV NS5B Polymerase

C. Espiritu, M. Sofia, Jian Liu, 2012, Nucleosides, nucleotides & nucleic acids.

β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study.

M. Otto, C. Espiritu, A. Lam, 2012, Bioorganic & medicinal chemistry letters.

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

M. Otto, A. Lam, M. Sofia, 2012, Journal of Virology.

Discovery and Development of PSI‐6130/RG7128

M. Otto, M. Sofia, P. Furman, 2011 .

Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin.

Y. Shu, K. S. Lam, S. Gerritz, 2005, Bioorganic & medicinal chemistry letters.

Safety, pharmacokinetics, and antiviral activity of the capsid inhibitor AB‐506 from Phase 1 studies in healthy subjects and those with hepatitis B

Bhavna S. Paratala, M. Yuen, P. Tangkijvanich, 2022, Hepatology communications.

HCV: The Journey from Discovery to a Cure: Volume II

C. Coburn, G. Dore, M. Sofia, 2019, Topics in Medicinal Chemistry.

HBsAg and Immune Competency; is HBsAg a Mere Biomarker or a Therapeutic Target for Chronic Hepatitis B?

Bhavna S. Paratala, R. Rijnbrand, M. Sofia, 2022, Journal of Immunological Sciences.

Metabolic Activation of the Anti-Hepatitis C Virus Nucleotide Prodrug PSI-352938

M. Otto, A. Lam, M. Sofia, 2012, Antimicrobial Agents and Chemotherapy.

Molecular and Structural Basis for the Roles of Hepatitis C Virus Polymerase NS5B Amino Acids 15, 223, and 321 in Viral Replication and Drug Resistance

M. Otto, A. Lam, M. Sofia, 2014, Antimicrobial Agents and Chemotherapy.

ARB-1740, a RNA Interference Therapeutic for Chronic Hepatitis B Infection.

N. Snead, X. Ye, A. Cuconati, 2018, ACS infectious diseases.

Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase.

M J Sofia, M. Sofia, A. Branstrom, 2000, Microbiology.

Potent, Rationally Designed Inhibitors of Squalene Synthase

J. Abt, E. Gordon, T. Harrity, 1992 .

The first potent inhibitor of squalene synthase : a profound contribution of an ether oxygen to inhibitor-enzyme interaction

E. Gordon, T. Harrity, M. Sofia, 1991 .

HCV: The Journey from Discovery to a Cure: Volume I

R. Bartenschlager, M. Sofia, H. Alter, 2019 .

Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1

Bhavna S. Paratala, R. Rijnbrand, M. Sofia, 2021, Nature Communications.

Hepatitis B Virus Therapeutic Agent ARB-1740 Has Inhibitory Effect on Hepatitis Delta Virus in a New Dually-Infected Humanized Mouse Model.

N. Snead, X. Ye, T. Shimada, 2019, ACS infectious diseases.

The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA

Fei Liu, R. Rijnbrand, M. Sofia, 2020, Antimicrobial Agents and Chemotherapy.

High throughput on-bead monitoring of solid phase reactions by Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS)

Brian C. Smith, Michael J. Sofia, M. Sofia, 1997 .

Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists.

M. Sofia, S. Silbaugh, J. S. Sawyer, 1993, Journal of Medicinal Chemistry.

Synthetic and Structure-Activity Studies on Acid-Substituted 2- Arylphenols: Discovery of 2-(2-Propyl-3-(3-(2-ethyl-4-(4-fluorophenyl)- 5-hydroxyphenoxy)propoxy)phenoxy)benzoic Acid, a High-Affinity Leukotriene B4 Receptor Antagonist.

W. Jackson, M. Sofia, S. Silbaugh, 1996 .

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. Part 1. 4-((2- Arylethyl)hydroxyphosphinyl)-3-hydroxybutanoic Acids: A New Class of Cell-Selective Inhibitors of Cholesterol Biosynthesis.

E. Gordon, T. Harrity, M. Sofia, 1991 .

An Empirical Process for the Design of High-Throughput Screening Deck Filters

Andrew C. Good, David A. Stock, Bradley C. Pearce, 2006, J. Chem. Inf. Model..

Circulating serum HBsAg level is a biomarker for HBV-specific T and B cell responses in chronic hepatitis B patients

R. Rijnbrand, M. Sofia, S. Kottilil, 2020, Scientific Reports.

Enter Sofosbuvir: The Path to Curing HCV

M. Sofia, 2016, Cell.

Acyl guanidine inhibitors of β-secretase (BACE-1): optimization of a micromolar hit to a nanomolar lead via iterative solid- and solution-phase library synthesis.

Ramesh Padmanabha, A. Good, J. Macor, 2012, Journal of medicinal chemistry.

Preclinical antiviral drug combination studies utilizing novel orally bioavailable investigational agents for chronic hepatitis B infection: AB-506, a next generation HBV capsid inhibitor, and AB-452, a HBV RNA destabilizer

K. Mcclintock, S. Majeski, D. Gotchev, 2018 .

Synthesis of diastereomerically pure nucleotide phosphoramidates.

M. Sofia, B. Ross, P. G. Reddy, 2011, The Journal of organic chemistry.

Design of compounds that increase the absorption of polar molecules.

S. Choe, G. Amidon, P. Venkatesan, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Structure of Hepatitis C Virus Polymerase in Complex with Primer-Template RNA

M. Otto, A. Lam, M. Sofia, 2012, Journal of Virology.

Nucleotide Prodrugs for HCV Therapy

M. Sofia, 2011, Antiviral chemistry & chemotherapy.

An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase.

W. Stec, M. Sofia, B. Ross, 2009, The Journal of organic chemistry.