P. Kühnen

发表

Modulation of monocarboxylate transporter 8 oligomerization by specific pathogenic mutations.

A. Grüters, H. Biebermann, H. Krude, 2014, Journal of molecular endocrinology.

Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity

S. Wiegand, H. Krude, P. Kühnen, 2022, International Journal of Obesity.

Role of 68Ga somatostatin receptor PET/CT in the detection of endogenous hyperinsulinaemic focus: an explorative study

V. Prasad, M. Pavel, A. Pascher, 2016, European Journal of Nuclear Medicine and Molecular Imaging.

A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway

K. Clément, S. Wiegand, I. Farooqi, 2021, Skin Pharmacology and Physiology.

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.

K. Clément, A. Grüters, S. Wiegand, 2016, The New England journal of medicine.

An Integrated Understanding of the Molecular Mechanisms of How Adipose Tissue Metabolism Affects Long-term Body Weight Maintenance

N. Hübner, S. Wiegand, H. Krude, 2018, Diabetes.

Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.

W. Chung, K. Clément, I. Farooqi, 2020, The lancet. Diabetes & endocrinology.

Tissue Sodium Content and Arterial Hypertension in Obese Adolescents

M. Kelm, A. Hennemuth, T. Kuehne, 2019, Journal of clinical medicine.

Long-term outcomes of bariatric surgery in patients with bi-allelic mutations in the POMC, LEPR, and MC4R genes.

K. Clément, F. Pattou, S. Wiegand, 2021, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

Natural History of Obesity Due to POMC, PCSK1, and LEPR Deficiency and the Impact of Setmelanotide

N. Bratina, S. Farooqi, M. Stewart, 2022, Journal of the Endocrine Society.

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

M. Lohse, P. Annibale, H. Biebermann, 2020, International journal of molecular sciences.

Melanocortin-4 Receptor Signalling: Importance for Weight Regulation and Obesity Treatment.

H. Biebermann, H. Krude, P. Kühnen, 2019, Trends in molecular medicine.

[Obesity is rarely curable: individual concepts and therapy programs for children and adolescents].

S. Wiegand, P. Kühnen, Peter Kühnen, 2020, Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz.

Cardiac phenotype and tissue sodium content in adolescents with defects in the melanocortin system.

M. Kelm, R. Cone, T. Kuehne, 2021, The Journal of clinical endocrinology and metabolism.

Pharmacological treatment strategies for patients with monogenic obesity

H. Biebermann, S. Wiegand, P. Kühnen, 2020, Journal of pediatric endocrinology & metabolism : JPEM.

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

M. Laakso, J. Toppari, H. Biebermann, 2016, Thyroid : official journal of the American Thyroid Association.

Melanocortin 4 receptor mutations become common.

H. Biebermann, H. Krude, P. Kühnen, 2021, Cell metabolism.

Positive correlation of thyroid hormones and serum copper in children with congenital hypothyroidism.

L. Schomburg, P. Kühnen, O. Blankenstein, 2016, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Understanding the Patient Experience of Hunger and Improved Quality of Life with Setmelanotide Treatment in POMC and LEPR Deficiencies

S. Fehnel, P. Kühnen, M. Wabitsch, 2022, Advances in Therapy.

Design and Characterization of a Fluorescent Reporter Enabling Live-cell Monitoring of MCT8 Expression.

H. Biebermann, R. Opitz, P. Kühnen, 2021, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.

Two Novel GATA6 Mutations Cause Childhood-Onset Diabetes Mellitus, Pancreas Malformation and Congenital Heart Disease

N. Hübner, F. Spagnoli, K. Hussain, 2013, Hormone Research in Paediatrics.

Generation of integration free induced pluripotent stem cells from fibrodysplasia ossificans progressiva (FOP) patients from urine samples.

M. Gossen, P. Reinke, A. Kurtz, 2016, Stem cell research.

A Setmelanotide-like Effect at MC4R Is Achieved by MC4R Dimer Separation

H. Biebermann, P. Scheerer, P. Kühnen, 2022, Biomolecules.

Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength

C. Schwiebert, S. Wiegand, L. Schomburg, 2020, International journal of molecular sciences.

Long-Term Lanreotide Treatment in Six Patients with Congenital Hyperinsulinism

T. Meissner, K. Raile, P. Kühnen, 2012, Hormone Research in Paediatrics.

Natural Autoimmunity to the Thyroid Hormone Monocarboxylate Transporters MCT8 and MCT10

L. Schomburg, P. Kühnen, Jörg Johannes, 2021, Biomedicines.

Glucose-Dependent Insulinotropic Polypeptide Reduces Fat-Specific Expression and Activity of 11β-Hydroxysteroid Dehydrogenase Type 1 and Inhibits Release of Free Fatty Acids

A. Pfeiffer, H. Krude, U. Kintscher, 2012, Diabetes.

DB100902 292..300

A. Pfeiffer, H. Krude, U. Kintscher, 2012 .

Spatiotemporal Changes of Cerebral Monocarboxylate Transporter 8 Expression.

I. Bechmann, H. Biebermann, H. Krude, 2020, Thyroid : official journal of the American Thyroid Association.

Evaluation of Pharmacological Rescue of Melanocortin-4 Receptor Nonsense Mutations by Aminoglycoside

P. Annibale, H. Biebermann, P. Scheerer, 2022, Life.

Trace element and cytokine concentrations in patients with Fibrodysplasia Ossificans Progressiva (FOP): A case control study.

T. Gaber, L. Schomburg, P. Kühnen, 2017, Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements.

Generation of human induced pluripotent stem cell lines from 2 patients with MIRAGE syndrome.

P. Kühnen, H. Stachelscheid, K. Fischer, 2021, Stem cell research.

Treatment of congenital thyroid dysfunction: Achievements and challenges.

H. Biebermann, H. Krude, P. Kühnen, 2015, Best practice & research. Clinical endocrinology & metabolism.

Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans

G. Kokai, A. Grüters, M. Wlodarski, 2017, The Journal of clinical investigation.

Pharmacotherapy in Childhood Obesity

H. Biebermann, S. Wiegand, P. Kühnen, 2021, Hormone Research in Paediatrics.

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

K. Clément, A. Grüters, H. Biebermann, 2018, Nature Medicine.

Signal Transduction and Pathogenic Modifications at the Melanocortin-4 Receptor: A Structural Perspective

H. Biebermann, H. Krude, M. Szczepek, 2019, Front. Endocrinol..

Recessive Mutations in PCBD1 Cause a New Type of Early-Onset Diabetes

N. Hübner, F. Spagnoli, N. Blau, 2014, Diabetes.

Sleep Timing in Patients with Precocious and Delayed Pubertal Development

S. Wiegand, H. Krude, C. Vetter, 2019, Clocks & sleep.

Identification of PENDRIN (SLC26A4) mutations in patients with congenital hypothyroidism and "apparent" thyroid dysgenesis.

A. Grüters, H. Biebermann, H. Krude, 2014, The Journal of clinical endocrinology and metabolism.

Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease

A. Prentice, M. Silver, P. Kühnen, 2019, Frontiers in Neuroendocrinology.

The neuroendocrine circuitry controlled by POMC, MSH, and AGRP.

H. Biebermann, H. Krude, G. Kleinau, 2012, Handbook of experimental pharmacology.

Occurrence of giant focal forms of congenital hyperinsulinism with incorrect visualization by 18F DOPA‐PET/CT scanning

K. Hussain, K. Raile, P. Kühnen, 2014, Clinical endocrinology.

Twin and family studies on epigenetics and obesity

A. Prentice, M. Silver, P. Kühnen, 2021, Twin and Family Studies of Epigenetics.

Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity.

P. Dominguez-Salas, A. Prentice, F. Heppner, 2016, Cell metabolism.

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity

E. Zeggini, N. W. Rayner, T. Schöneberg, 2022, Nature Metabolism.

A missense KCNQ1 Mutation Impairs Insulin Secretion in Neonatal Diabetes

Z. Izsvák, Zhimin Zhou, M. Sander, 2021, bioRxiv.

Mean High-Dose L-Thyroxine Treatment Is Efficient and Safe to Achieve a Normal IQ in Young Adult Patients With Congenital Hypothyroidism

A. Grüters, H. Krude, M. Craig, 2018, The Journal of clinical endocrinology and metabolism.

Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

B. Kobilka, T. Mielke, C. Spahn, 2021, Cell Research.

Long-Term MC4R Agonist Treatment in POMC-Deficient Patients.

P. Kühnen, Karine Clément, 2022, The New England journal of medicine.

Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency

K. Clément, A. Gnanasakthy, C. Poitou, 2022, Orphanet Journal of Rare Diseases.

68Ga-NODAGA-Exendin-4 PET/CT Improves the Detection of Focal Congenital Hyperinsulinism

W. Brenner, C. Rottenburger, P. Nuutila, 2021, The Journal of Nuclear Medicine.

New pathogenic thyrotropin receptor mutations decipher differentiated activity switching at a conserved helix 6 motif of family A GPCR.

A. Grüters, B. Wiesner, H. Biebermann, 2012, The Journal of clinical endocrinology and metabolism.

Investigation of Naturally Occurring Single-Nucleotide Variants in Human TAAR1

H. Völzke, G. Homuth, A. Teumer, 2017, Front. Pharmacol..

Primary sulphonylurea therapy in a newborn with transient neonatal diabetes attributable to a paternal uniparental disomy 6q24 (UPD6)

K. Raile, P. Kühnen, C. Bührer, 2018, Diabetes, obesity & metabolism.

Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment

B. Obermayer, A. Prentice, K. Jöckel, 2023, Science Translational Medicine.

Recessive mutations in PCBD 1 cause a new type of early-onset diabetes Short title : PCBD 1 mutations cause diabetes

N. Hübner, F. Spagnoli, N. Blau, 2014 .