D. Hart

发表

Treatment regimens and outcomes in severe and moderate haemophilia A in the UK: The THUNDER study

M. Scott, H. Xiang, D. Hart, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

nonsevere hemophilia A ) mutation and risk of inhibitor development in F8 Factor VIII gene (

J. Astermark, R. Keenan, J. Oldenburg, 2014 .

GENERAL INTRODUCTION AND OUTLINE OF THE THESIS

J. Astermark, R. Keenan, J. Oldenburg, 2012 .

THROMBOSIS AND HEMOSTASIS Factor VIII gene ( F 8 ) mutation and risk of inhibitor development in nonsevere hemophilia A

J. Astermark, R. Keenan, J. Oldenburg, 2013 .

Computational prediction of phenotype in haemophilia A

P. Batty, D. Hart, Daniel P. Hart, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders.

Sri V. V. Deevi, W. Ouwehand, A. Attwood, 2016, Blood.

Comprehensive Cancer-Predisposition Gene Testing in an Adult Multiple Primary Tumor Series Shows a Broad Range of Deleterious Variants and Atypical Tumor Phenotypes

William J. Astle, Dorothy A. Thompson, Sri V. V. Deevi, 2018, American journal of human genetics.

The incidence and magnitude of fibrinolytic activation in trauma patients

S. Stanworth, K. Pasi, K. Brohi, 2013, Journal of thrombosis and haemostasis : JTH.

Development of a Wilms’ tumor antigen-specific T-cell receptor for clinical trials: engineered patient’s T cells can eliminate autologous leukemia blasts in NOD/SCID mice

D. Hart, S. Xue, E. Morris, 2010, Haematologica.

Optimizing language for effective communication of gene therapy concepts with hemophilia patients: a qualitative study

C. Négrier, D. Hart, R. Sidonio, 2021, Orphanet Journal of Rare Diseases.

Perioperative laboratory monitoring in congenital haemophilia patients with inhibitors: a systematic literature review.

M. Makris, R. Liesner, D. Hart, 2019, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

B. Engels, W. Uckert, A. Thrasher, 2005 .

transduced human T cells Elimination of human leukemia cells in NOD/SCID mice by WT1-TCR gene

B. Engels, A. Thrasher, D. Hart, 2013 .

Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer

M. Collins, M. Perro, D. Hart, 2010, Gene Therapy.

WT1-targeted immunotherapy of leukaemia.

D. Hart, S. Xue, E. Morris, 2004, Blood cells, molecules & diseases.

LMP2-specific TCR gene therapy for Hodgkin's lymphoma

Emma Morris, Daniel P. Hart, Sharyn Thomas, 2008 .

FVIII Immunogenicity—Bioinformatic Approaches to Evaluate Inhibitor Risk in Non-severe Hemophilia A

D. Hart, 2020, Frontiers in Immunology.

Computational modelling and inhibitor risk: predicting the future?

D. Hart, 2014, Haemophilia : the official journal of the World Federation of Hemophilia.

Whole genome sequencing of a sporadic primary immunodeficiency cohort

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2018, Nature.

Lupus Anticoagulant and Abnormal Coagulation Tests in Patients with Covid-19

S. Sivapalaratnam, K. Pasi, D. Hart, 2020, The New England journal of medicine.

New challenges for an expanding generation of older persons with haemophilia

D. Hart, J. O’Hara, S. Chaplin, 2022, The Journal of Haemophilia Practice.

Haemophilia

V. Blanchette, K. Fischer, A. Shapiro, 1937, Nature Reviews Disease Primers.

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

William J. Astle, Sri V. V. Deevi, Matthew C. Sims, 2020, medRxiv.

Performing and interpreting individual pharmacokinetic profiles in patients with Hemophilia A or B: Rationale and general considerations

E. Neufeld, A. Iorio, J. Blatny, 2018, Research and practice in thrombosis and haemostasis.

Lentiviral Vectors for TCR Gene Transfer: Improved Function of TCR-Transduced T Cells After Non-Activating Cytokine-Mediated Transduction

Emma Morris, Daniel P. Hart, Hans J. Stauss, 2010 .

Letter in response to: Coagulation markers are independent predictors of increased oxygen requirements and thrombosis in COVID‐19

D. Hart, P. Bhogal, O. Jaffer, 2020, Journal of Thrombosis and Haemostasis.

Gene Modified Human T Cells Tetramer Binding but Not the Function of TCR Gene Transfer: TCR Variants Improve Targeting the Wilms Tumor Antigen 1 by

B. Alarcón, V. Wong, R. Debets, 2007 .

Novel manifestations of immune dysregulation and granule defects in gray platelet syndrome

William J. Astle, Sri V. V. Deevi, Matthew C. Sims, 2020, medRxiv.

Immature platelet fraction measurement: a future guide to platelet transfusion requirement after haematopoietic stem cell transplantation

D. Hart, S. Machin, C. Briggs, 2006, Transfusion medicine.

Assessment of an immature platelet fraction (IPF) in peripheral thrombocytopenia

D. Hart, S. Machin, C. Briggs, 2004, British journal of haematology.

Diagnosis and treatment of factor VIII and IX inhibitors in congenital haemophilia: (4th edition)

R. Liesner, D. Hart, P. Collins, 2013, British journal of haematology.

Factor VIII brand and the incidence of factor VIII inhibitors in previously untreated UK children with severe hemophilia A, 2000-2011.

R. Liesner, D. Hart, B. Palmer, 2014, Blood.

Diagnosis and management of acquired coagulation inhibitors: a guideline from UKHCDO

R. Liesner, D. Hart, S. Rangarajan, 2013, British journal of haematology.

The incidence and treatment of bleeding episodes in non-severe haemophilia A patients with inhibitors

M. Nijziel, K. Hamulýak, J. G. van der Bom, 2015, Thrombosis and Haemostasis.

Anti-fibrinolytic agents in bleeding disorders – A clinical perspective

D. Hart, Saket Badle, 2016 .

A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

Ania, Eleanor, Dewhurst, 2018 .

Dose-escalated donor lymphocyte infusions following reduced intensity transplantation: toxicity, chimerism, and disease responses.

S. Mackinnon, K. Peggs, D. Linch, 2004, Blood.

Von Willebrand factor.

D. Hart, P. Bhogal, O. Jaffer, 2020, Clinical medicine.

Current Status of Allogeneic Stem Cell Transplantation for Treatment of Hematologic Malignancies

D. Hart, K. Peggs, D. Hart, 2007, Clinical pharmacology and therapeutics.

Human immunodeficiency virus associated thrombotic thrombocytopenic purpura – favourable outcome with plasma exchange and prompt initiation of highly active antiretroviral therapy

T. Baglin, D. Hart, Robert F Miller, 2011, British journal of haematology.

Diagnosis and management of acquired coagulation inhibitors : a guideline from UKHCDO A United Kingdom Haemophilia Centre Doctors ’ Organization ( UKHCDO ) guideline approved by the British Committee for Standards in Haematology

R. Liesner, D. Hart, P. Collins, 2013 .

Wilate use in 47 children with von Willebrand disease: the North London paediatric haemophilia network experience

K. Khair, Y.-H. Chen, R. Liesner, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

The factor VIII treatment history of non‐severe hemophilia A

C. Santoro, K. Fischer, M. Kruip, 2020, Journal of Thrombosis and Haemostasis.

International consensus recommendations on the management of people with haemophilia B

J. Astermark, C. Hermans, V. Jiménez‐Yuste, 2022, Therapeutic advances in hematology.

Common themes and challenges in hemophilia care: a multinational perspective

K. Batt, R. Wu, M. Mancuso, 2018, Hematology.

Treatment of bleeding episodes in haemophilia A complicated by a factor VIII inhibitor in patients receiving Emicizumab. Interim guidance from UKHCDO Inhibitor Working Party and Executive Committee

M. Makris, D. Hart, P. Collins, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

The incidence of factor VIII inhibitors in severe haemophilia A following a major switch from full‐length to B‐domain‐deleted factor VIII: a prospective cohort comparison

R. Liesner, D. Hart, B. Palmer, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Individualized PK‐based prophylaxis in severe haemophilia

S. Meunier, P. Mismetti, D. Hart, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany

L. Mantovani, J. Blatny, D. Perry, 2017, European journal of haematology.

Adherence to Prophylaxis in Adolescents and Young Adults with Severe Haemophilia: A Quantitative Study with Patients

N. Troop, D. Hart, S. van Os, 2017, PloS one.

Population pharmacokinetics of factor IX in hemophilia B patients undergoing surgery

F. Leebeek, R. Mathôt, M. Cnossen, 2018, Journal of thrombosis and haemostasis : JTH.

Partnering to change the world for people with haemophilia: 6th Haemophilia Global Summit, Prague, Czech Republic, 24–26th September 2015

J. Astermark, J. Blatny, C. Hermans, 2016, European journal of haematology.

Perioperative replacement therapy in haemophilia B: An appeal to “B” more precise

F. Leebeek, R. Mathôt, M. Cnossen, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

PERSEPT 3: A phase 3 clinical trial to evaluate the haemostatic efficacy of eptacog beta (recombinant human FVIIa) in perioperative care in subjects with haemophilia A or B with inhibitors

J. Luck, A. al‐Sabbagh, C. Hermans, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

Re-personalization and stratification of hemophilia care in an evolving treatment landscape

C. Kessler, L. Aledort, D. Hart, 2019, Hematology.

Adherence to prophylaxis in adolescents and young adults with severe haemophilia A, a qualitative study with patients

N. Troop, D. Hart, S. van Os, 2018, Health psychology and behavioral medicine.

Adherence to prophylaxis in adolescents and young adults with severe haemophilia: a qualitative study with healthcare professionals

N. Troop, D. Hart, S. van Os, 2020, Health psychology and behavioral medicine.

The first recombinant FVIII produced in human cells – an update on its clinical development programme

L. Valentino, C. Négrier, R. Liesner, 2014, Haemophilia : the official journal of the World Federation of Hemophilia.

Treatment burden, haemostatic strategies and real world inhibitor screening practice in non‐severe haemophilia A

K. Khair, P. Batty, D. Hart, 2017, British journal of haematology.

The first Team Haemophilia Education meeting, 2015, Amsterdam, The Netherlands

P. Giangrande, D. Perry, A. Miners, 2016, European journal of haematology.

Vaccination against COVID‐19: Rationale, modalities and precautions for patients with haemophilia and other inherited bleeding disorders

C. Hermans, M. Makris, T. Sannié, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

Inhibitors in nonsevere haemophilia A: outcome and eradication strategies

V. Jiménez‐Yuste, K. Khair, F. Smiers, 2015, Thrombosis and Haemostasis.

First‐line immune tolerance induction for children with severe haemophilia A: A protocol from the UK Haemophilia Centre Doctors' Organisation Inhibitor and Paediatric Working Parties

M. Makris, R. Liesner, D. Hart, 2017, Haemophilia : the official journal of the World Federation of Hemophilia.

Diagnostic accuracy study of a factor VIII ELISA for detection of factor VIII antibodies in congenital and acquired haemophilia A

K. Pasi, P. Batty, D. Hart, 2015, Thrombosis and Haemostasis.

Pre‐analytical heat treatment and a FVIII ELISA improve Factor VIII antibody detection in acquired haemophilia A

K. Pasi, P. Batty, D. Hart, 2014, British journal of haematology.

Factor VIII/IX inhibitor testing practices in the United Kingdom: Results of a UKHCDO and UKNEQAS national survey

P. Batty, D. Hart, S. Kitchen, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

A large‐scale computational study of inhibitor risk in non‐severe haemophilia A

D. Moss, A. Shepherd, C. Sansom, 2015, British journal of haematology.

Commentary on “Development of a novel fully functional coagulation factor VIII with reduced immunogenicity utilizing an in silico prediction and deimmunization approach” ‐ Will we ever be able to avoid inhibitor formation in hemophilia A?

D. Hart, 2021, Journal of thrombosis and haemostasis : JTH.

Immune tolerance induction in severe haemophilia A: A UKHCDO inhibitor and paediatric working party consensus update

M. Makris, R. Liesner, J. Motwani, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

A computer‐based model to assess costs associated with the use of factor VIII and factor IX one‐stage and chromogenic activity assays

D. Perry, K. Friedman, R. Ko, 2016, Journal of thrombosis and haemostasis : JTH.

Rare variants in GP1BB are responsible for autosomal dominant macrothrombocytopenia.

William J. Astle, Suthesh Sivapalaratnam, Kathleen Stirrups, 2017, Blood.

Recombinant factor VIII products and inhibitor development in previously untreated patients with severe haemophilia A: Combined analysis of three studies

P. Volkers, R. Ljung, E. Santagostino, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

The factor VIII treatment history of non‐severe hemophilia A—Response from original authors Abdi et al

K. Fijnvandraat, Fabienne R Kloosterman, A. Abdi, 2021, Journal of thrombosis and haemostasis : JTH.

Validation of a perioperative population factor VIII pharmacokinetic model with a large cohort of pediatric hemophilia a patients

F. Leebeek, R. Mathôt, M. Cnossen, 2021, British journal of clinical pharmacology.

J. Oldenburg, C. Hermans, G. Castaman, 2021, Journal of thrombosis and haemostasis : JTH.

Gene therapy of hemophilia: Hub centres should be haemophilia centres: A joint publication of EAHAD and EHC

V. Jiménez‐Yuste, M. Makris, F. Baghaei, 2022, Haemophilia : the official journal of the World Federation of Hemophilia.

Delivery of AAV‐based gene therapy through haemophilia centres—A need for re‐evaluation of infrastructure and comprehensive care: A Joint publication of EAHAD and EHC

V. Jiménez‐Yuste, M. Makris, R. Klamroth, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

Safety and efficacy of a von Willebrand factor/factor VIII concentrate (Wilate®): a single centre experience

K. Pasi, P. Batty, D. Hart, 2014, Haemophilia : the official journal of the World Federation of Hemophilia.

Optimization of pre‐analytical heat treatment for inhibitor detection in haemophilia A

P. Batty, D. Hart, S. Platton, 2018, International journal of laboratory hematology.

Functional definition and characterization of acute traumatic coagulopathy

Karim Brohi, Rupert Pearse, Daniel Hart, 2011, Critical care medicine.

Safety and efficacy of emicizumab and other novel agents in newborns and infants

D. Hart, R. Kaczmarek, G. Pierce, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

The importance of developing world haematology

F. Cotter, D. Hart, I. Bates, 2011, British Journal of Haematology.

De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures

Henning Gall, Fengyuan Hu, Kevin Rue-Albrecht, 2018, American journal of human genetics.

Whole-genome sequencing of patients with rare diseases in a national health system

Keith W. Muir, William J. Astle, Mark I. McCarthy, 2020, Nature.

The effect of low-dose aciclovir on reactivation of varicella zoster virus after allogeneic haemopoietic stem cell transplantation

S. Mackinnon, D. Hart, K. Peggs, 2005, Bone Marrow Transplantation.

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

W. Ouwehand, K. Downes, J. Stephens, 2020, Haematologica.

Whole-genome sequencing of a sporadic primary immunodeficiency cohort

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2020, Nature.

Generation of tumor-specific T-cell therapies.

D. Hart, S. Xue, E. Morris, 2006, Blood reviews.

Monoclonal T-cell receptors: new reagents for cancer therapy.

A. Little, M. Perro, D. Hart, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

An unusual cause of bleeding in an elderly patient.

P. Batty, D. Hart, J. Pasi, 2012, Clinical medicine.

Gene Therapy with Etranacogene Dezaparvovec for Hemophilia B.

R. Dolmetsch, J. Astermark, C. Hermans, 2023, The New England journal of medicine.

Whole-genome sequencing of patients with rare diseases in a national health system

William J. Astle, Sri V. V. Deevi, Kenneth G. C. Smith, 2020, Nature.

A comprehensive high-throughput sequencing test for the diagnosis of inherited bleeding , thrombotic and platelet disorders

Sri V. V. Deevi, W. Ouwehand, J. Jolley, 2015 .

Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells

D. Hart, S. Xue, E. Morris, 2008, Gene Therapy.

WT1-specific T cell receptor gene therapy: improving TCR function in transduced T cells.

M. Perro, D. Hart, S. Xue, 2008, Blood cells, molecules & diseases.

Targeting the Wilms Tumor Antigen 1 by TCR Gene Transfer: TCR Variants Improve Tetramer Binding but Not the Function of Gene Modified Human T Cells1

B. Alarcón, V. Wong, R. Debets, 2007, The Journal of Immunology.

T-cell receptor gene therapy for cancer: the progress to date and future objectives

D. Hart, S. Xue, H. Stauss, 2007, Expert opinion on biological therapy.

Phenotypic Characterization of EIF2AK4 Mutation Carriers in a Large Cohort of Patients Diagnosed Clinically With Pulmonary Arterial Hypertension

Fengyuan Hu, Kevin Rue-Albrecht, Patrick Deegan, 2017, Circulation.

Ongoing risk of thrombosis with factor XI concentrate: 5 years experience in two centres

K. Pasi, P. Batty, D. Hart, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Emicizumab prophylaxis in haemophilia A with inhibitors: Three years follow‐up from the UK Haemophilia Centre Doctors’ Organisation (UKHCDO)

H. Xiang, D. Hart, B. Palmer, 2023, Haemophilia : the official journal of the World Federation of Hemophilia.

Considerations for shared decision management in previously untreated patients with hemophilia A or B

C. Königs, J. Astermark, C. Hermans, 2023, Therapeutic advances in hematology.

A HaemSTAR is born; a trainee-led, UK-wide research network in haematology.

D. Hart, T. Biss, C. Toh, 2019, Clinical medicine.

A national survey of immunosuppression strategies for acquired haemophilia A

R. Liesner, P. Batty, D. Hart, 2015, Haemophilia.

Factor VIII cross-matches to the human proteome reduce the predicted inhibitor risk in missense mutation hemophilia A

D. Moss, A. Shepherd, D. Hart, 2018, Haematologica.

THROMBOSIS AND HEMOSTASIS A high-throughput sequencing test for diagnosing inherited bleeding, thrombotic, and platelet disorders