R. Liesner

发表

Risk Factors for the Progression from Low to High Titres in 260 Children with Severe Haemophilia A and Newly Developed Inhibitors

J. Oldenburg, R. Ljung, E. Santagostino, 2017, Thrombosis and Haemostasis.

Rituximab and immune tolerance in severe hemophilia A: a consecutive national cohort

R. Keenan, D. Perry, M. Laffan, 2009, Journal of thrombosis and haemostasis : JTH.

Early factor VIII exposure and subsequent inhibitor development in children with severe haemophilia A

D. Stirling, R. Liesner, Angela E. Thomas, 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

Quality of life in a large multinational haemophilia B cohort (The B‐Natural study) – Unmet needs remain

J. Astermark, C. Kempton, M. Witkop, 2022, Haemophilia : the official journal of the World Federation of Hemophilia.

ABC of clinical haematology: Platelet disorders

R. Liesner, S. Machin, 1997, BMJ.

Deep compartment models: A deep learning approach for the reliable prediction of time‐series data in pharmacokinetic modeling

A. Janssen, M. Kruip, R. Mathôt, 2022, CPT: pharmacometrics & systems pharmacology.

Thrombophilia and first arterial ischaemic stroke: a systematic review

V. Ganesan, R. Liesner, S. Haywood, 2005, Archives of Disease in Childhood.

Performance of the platelet function analyser PFA-100 in testing abnormalities of primary haemostasis.

R. Liesner, R. Liesner, I. Mackie, 1999, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

The PFA-100: a potential rapid screening tool for the assessment of platelet dysfunction.

Paul J. Harrison, K. Khair, H. Cohen, 2002, Clinical and laboratory haematology.

How to achieve full prophylaxis in young boys with severe haemophilia A: different regimens and their effect on early bleeding and venous access

R. Ljung, K. Fischer, K. Kurnik, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Efficacy and safety of simoctocog alfa (Nuwiq®) in patients with severe hemophilia A: a review of clinical trial data from the GENA program

J. Oldenburg, C. Kessler, R. Klamroth, 2019, Therapeutic advances in hematology.

Long‐term consequences of intracranial haemorrhage in children with haemophilia

K. Khair, R. Liesner, R. Liesner, 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

Von Willebrand factor--cleaving protease activity in congenital thrombotic thrombocytopenic purpura.

R. Liesner, I. Mackie, P. Harrison, 2000 .

von Willebrand factor‐cleaving protease activity in congenital thrombotic thrombocytopenic purpura

R. Liesner, I. Mackie, S. Machin, 2000, British journal of haematology.

Immunogenicity, efficacy and safety of Nuwiq® (human‐cl rhFVIII) in previously untreated patients with severe haemophilia A—Interim results from the NuProtect Study

E. Neufeld, T. Lambert, M. Carcao, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Using routine Haemophilia Joint Health Score for international comparisons of haemophilia outcome: standardization is needed

B. Bartels, K. Fischer, K. Kurnik, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

Factors affecting the Haemophilia Joint Health Score in children with severe haemophilia

K. Khair, R. Liesner, E. Main, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Plasma and albumin‐free recombinant factor VIII: pharmacokinetics, efficacy and safety in previously treated pediatric patients

G. Spotts, V. Blanchette, I. Warrier, 2008, Journal of thrombosis and haemostasis : JTH.

Treatment of bleeding episodes in haemophilia A complicated by a factor VIII inhibitor in patients receiving Emicizumab. Interim guidance from UKHCDO Inhibitor Working Party and Executive Committee

M. Makris, D. Hart, P. Collins, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Clinical haemophilia Long-term safety and efficacy of recombinant factor VIII Fc fusion protein ( rFVIIIFc ) in subjects with haemophilia

D. Perry, B. Konkle, K. Pasi, 2016 .

Safety and efficacy of investigator‐prescribed BeneFIX® prophylaxis in children less than 6 years of age with severe haemophilia B

P. Monahan, R. Liesner, D. Roth, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Final results of the PUPs B-LONG study: evaluating safety and efficacy of rFIXFc in previously untreated patients with hemophilia B.

M. Recht, A. Rauch, K. Fischer, 2021, Blood advances.

Post hoc analysis to evaluate the effect of recombinant factor IX Fc fusion protein (rFIXFc) prophylaxis in adults and adolescents with target joints and hemophilia B

K. Pasi, R. Liesner, N. Jain, 2016 .

Experience of Advate rAHF-PFM in previously untreated patients and minimally treated patients with haemophilia A

M. Recht, A. Thompson, R. Liesner, 2012, Thrombosis and Haemostasis.

The incidence, risk and functional outcomes of intracranial haemorrhage in children with inherited bleeding disorders at one haemophilia center

K. Khair, R. Liesner, E. Main, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

The haemtrack home therapy reporting system: Design, implementation, strengths and weaknesses: A report from UK Haemophilia Centre Doctors Organisation

G. Dolan, M. Scott, H. Xiang, 2017, Haemophilia : the official journal of the World Federation of Hemophilia.

Characterization of the Pharmacokinetics of rFVIII in Young Pre-School Children with Hemophilia, Including an Analysis of the Influence of Age and Body Weight.

G. Spotts, V. Blanchette, A. Shapiro, 2004 .

Management of coagulation disorders in children

R. Liesner, 2002 .

Long‐term safety and efficacy of recombinant factor VIII Fc fusion protein (rFVIIIFc) in subjects with haemophilia A

D. Perry, B. Konkle, K. Pasi, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

Management of neonates with inherited bleeding disorders – a survey of current UK practice

K. Pasi, R. Liesner, M. Williams, 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

Factor XIII – an under diagnosed deficiency – are we using the right assays?

L. Green, F. Peyvandi, R. Liesner, 2010, Journal of thrombosis and haemostasis : JTH.

Transient lupus anticoagulant: an unusual cause of bruising in children

R. Liesner, U. Mohan, A. Anderson, 2003, Emergency medicine journal : EMJ.

Coagulation disorders in children

R. Liesner, 1995 .

Prophylactic treatment of bleeding episodes in children <12 years with moderate to severe hereditary factor X deficiency (FXD): Efficacy and safety of a high‐purity plasma‐derived factor X (pdFX) concentrate

R. Liesner, J. Payne, M. Norton, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Safety, Efficacy, and Pharmacokinetics of Recombinant Factor VIII FC Fusion Protein (RFVIIIFC) in Previously Treated Paediatric Subjects with Severe Haemophilia A (Kids A-LONG)

J. Mahlangu, B. Nolan, G. Young, 2013 .

Interim Analysis Of The ASPIRE Study Evaluating Long-term Safety And Efficacy Of Recombinant Factor VIII FC (RFVIIIFC) In Children With Severe Haemophilia A

J. Mahlangu, B. Nolan, G. Young, 2015 .

Efficacy, Immunogenicity, Pharmacokinetics, and Safety Of Human-cl rhFVIII – a GCP Study In Children With Severe Haemophilia A

A. Klukowska, V. Vdovin, T. Szczepański, 2013 .

Safety, Efficacy, and Pharmacokinetics of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously-Treated Children with Severe Hemophilia a (Kids-ALONG)

J. Mahlangu, B. Nolan, G. Young, 2014 .

Application of SHAP values for inferring the optimal functional form of covariates in pharmacokinetic modeling

M. Hoogendoorn, A. Janssen, F. Leebeek, 2022, CPT: pharmacometrics & systems pharmacology.

Inherited prothrombotic states and ischaemic stroke in childhood

F. Kirkham, V. Ganesan, R. Liesner, 1998, Journal of neurology, neurosurgery, and psychiatry.

Use of central venous catheters in children with severe congenital coagulopathy

A. Vora, R. Liesner, R. Liesner, 1995, British journal of haematology.

A phenotype–genotype correlation of ADAMTS13 mutations in congenital thrombotic thrombocytopenic purpura patients treated in the United Kingdom

R. Liesner, M. Scully, I. Mackie, 2012, Journal of thrombosis and haemostasis : JTH.

The impact of prophylactic treatment on children with severe haemophilia

K. Khair, R. Liesner, R. Liesner, 1996, British journal of haematology.

Regular ArticleThe management of coagulation disorders in children

R. Liesner, 2002 .

Increased anticardiolipin antibody IgG titers do not predict recurrent stroke or TIA in children

F. Kirkham, G. deVeber, E. Atenafu, 2004, Neurology.

Homozygous thermolabile variant of the methylenetetrahy‐drofolate reductase gene: a potential risk factor for hyperhomo‐cysteinaemia, CVD, and stroke in childhood

F. Kirkham, R. Surtees, R. Liesner, 2001, Developmental medicine and child neurology.

Cerebral venous sinus thrombosis in children: risk factors, presentation, diagnosis and outcome.

A. Wade, F. Kirkham, D. Saunders, 2005, Brain : a journal of neurology.

Prothrombotic changes in children with sickle cell disease: relationships to cerebrovascular disease and transfusion

Hann, McDonald, Mackie, 1998, British journal of haematology.

Long‐term tolerability, immunogenicity and efficacy of Nuwiq® (human‐cl rhFVIII) in children with severe haemophilia A

R. Liesner, A. Klukowska, V. Vdovin, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Prospective observational cohort studies for studying rare diseases: the European PedNet Haemophilia Registry

R. Ljung, K. Fischer, R. Liesner, 2014, Haemophilia : the official journal of the World Federation of Hemophilia.

Recombinant factor VIII Fc fusion protein for the prevention and treatment of bleeding in children with severe hemophilia A

J. Mahlangu, R. Liesner, B. Nolan, 2015, Journal of thrombosis and haemostasis : JTH.

Long-Term Efficacy and Quality of Life with Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) Prophylaxis in Pediatric, Adolescent, and Adult Subjects with Target Joints and Severe Hemophilia a

B. Kerlin, Michael Wang, S. Lethagen, 2016 .

Vaccinations are not associated with inhibitor development in boys with severe haemophilia A

M. Carcao, A. Rafowicz, K. Fischer, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

The incidence of factor VIII inhibitors in severe haemophilia A following a major switch from full‐length to B‐domain‐deleted factor VIII: a prospective cohort comparison

R. Liesner, D. Hart, B. Palmer, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Extended half‐life pegylated, full‐length recombinant factor VIII for prophylaxis in children with severe haemophilia A

O. Stasyshyn, R. Liesner, E. Mullins, 2017, Haemophilia : the official journal of the World Federation of Hemophilia.

Novel, human cell line‐derived recombinant factor VIII (Human‐cl rhFVIII, Nuwiq®) in children with severe haemophilia A: efficacy, safety and pharmacokinetics

R. Liesner, A. Klukowska, V. Vdovin, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

Stem cell transplantation for children with Glanzmann thrombasthenia

P. Veys, K. Khair, P. Amrolia, 2008, British journal of haematology.

Intranasal desmopressin (OctimTM): a safe and efficacious treatment option for children with bleeding disorders

K. Khair, R. Liesner, R. Liesner, 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

R. Liesner, R. Liesner, T. Yee, 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

Factor XIII – an under diagnosed deficiency – are we using the right assays?

R. Liesner, Ian J. Mackie, Anthony Lawrie, 2010, Journal of thrombosis and haemostasis : JTH.

SUBCUTANEOUS ADMINISTRATION OF PROTEIN C CONCENTRATE

K. Khair, R. Liesner, R. Liesner, 2004, Pediatric hematology and oncology.