J. Saint-Remy

J. Saint-Remy, J. Machiels, J. Saint-Remy, 1994, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Suppression de la rponse immunitaire IgE l'aide d'anticorps spcifiques

J. Saint-Remy, 1994 .

Novel approaches in immunotherapy

J. Saint-Remy, 1994, Clinical reviews in allergy.

Healthy subjects produce both anti-factor VIII and specific anti-idiotypic antibodies.

J. Saint-Remy, J. Gilles, 1994, The Journal of clinical investigation.

Efficiency of onco-retroviral and lentiviral gene transfer into primary mouse and human B-lymphocytes is pseudotype dependent.

W. Janssens, L. Naldini, T. VandenDriessche, 2003, Human gene therapy.

Regulatory CD4 + Tc ells in allergic asthma

J. Saint-Remy, M. Jacquemin, V. Carlier, 2006 .

Variable region heavy chain glycosylation determines the anticoagulant activity of a factor VIII antibody

R. Dwek, M. Wormald, M. Dewerchin, 2006, Journal of thrombosis and haemostasis : JTH.

Establishing an allergic eczema model employing recombinant house dust mite allergens Der p 1 and Der p 2 in BALB/c mice

C. Stremnitzer, L. Vander Elst, I. Pali-Schöll, 2012, Experimental dermatology.

A role for exposed mannosylations in presentation of human therapeutic self-proteins to CD4+ T lymphocytes

S. Kaveri, S. Lacroix-Desmazes, M. Kazatchkine, 2007, Proceedings of the National Academy of Sciences.

Antithrombotic effects of controlled inhibition of factor VIII with a partially inhibitory human monoclonal antibody in a murine vena cava thrombosis model.

Alberto Smith, K. Burnand, J. Saint-Remy, 2002, Blood.

Increased Synapse Formation Obtained by T Cell Epitopes Containing a CxxC Motif in Flanking Residues Convert CD4+ T Cells into Cytolytic Effectors

W. Janssens, J. Saint-Remy, M. Jacquemin, 2012, PloS one.

Identification of a specific epitope on the extracellular domain of the LDL-receptor of Trypanosoma brucei brucei.

I. Coppens, F. Opperdoes, P. Courtoy, 1994, Molecular and biochemical parasitology.

A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF‐binding site distant from its epitope

B. Atanasov, S. Kaveri, S. Lacroix-Desmazes, 2010, Journal of thrombosis and haemostasis : JTH.

Latex allergosorbent test (LAST): a new immunoassay for specific IgE with latex particles.

J. Saint-Remy, J. Gilles, J. Mareschal, 1988, The Journal of allergy and clinical immunology.

FVIII production by human lung microvascular endothelial cells.

C. Kirkpatrick, M. Hermanns, F. Rega, 2006, Blood.

Humanized severe combined immunodeficient mice as a potential model for the study of tolerance to factor VIII.

J. Vermylen, J. Saint-Remy, J. Gilles, 2000, Thrombosis and haemostasis.

Inhibition of factor VIII with a partially inhibitory human recombinant monoclonal antibody prevents thrombotic events in a transgenic model of type II HBS antithrombin deficiency in mice

M. Dewerchin, J. Saint-Remy, M. Jacquemin, 2004, Journal of thrombosis and haemostasis : JTH.

An M(r) 145,000 low-density lipoprotein (LDL)-binding protein is conserved throughout the Kinetoplastida order.

F. Opperdoes, P. Courtoy, J. Raper, 1996, Molecular and biochemical parasitology.

Seasonal variation in specific IgE antibodies of grass-pollen hypersensitive patients depends on the steady state IgE concentration and is not related to clinical symptoms.

J. Saint-Remy, J. Gilles, J. Machiels, 1989, The Journal of allergy and clinical immunology.

The human immune response against major allergens from house dust mite, Dermatophagoides pteronyssinus: II. Idiotypic cross‐reactions of allergen‐specific antibodies

S. Lebecque, J. Saint-Remy, P. Lebrun, 1986, European journal of immunology.

The use of factor VIII/von Willebrand factor concentrate for immune tolerance induction in haemophilia A patients with high‐titre inhibitors: association of clinical outcome with inhibitor epitope profile

J. Saint-Remy, M. Jacquemin, D. A. Greninger, 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors.

S. Kaveri, S. Lacroix-Desmazes, P. Lenting, 2007, Blood.

Von Willebrand Factor Modulates Factor VIII Immunogenicity: Comparative Study of Different Factor VIII Concentrates in a Haemophilia A Mouse Model

J. Saint-Remy, R. Kotitschke, J. Pasi, 2002, Thrombosis and Haemostasis.

In Vivo Induction of Type 1-Like Regulatory T Cells Using Genetically Modified B Cells Confers Long-Term IL-10-Dependent Antigen-Specific Unresponsiveness1

B. Weynand, W. Janssens, J. Vanoirbeek, 2009, The Journal of Immunology.

Antigen-Specific Unresponsiveness Confers Long-Term IL-10-Dependent T Cells Using Genetically Modified B Cells In Vivo Induction of Type 1-Like Regulatory and

B. Weynand, W. Janssens, J. Vanoirbeek, 2009 .

Significant reduction of nonspecific bronchial reactivity in patients with Dermatophagoides pteronyssinus-sensitive allergic asthma under therapy with allergen-antibody complexes.

J. Saint-Remy, M. Jacquemin, P. Lebrun, 1993, The American review of respiratory disease.

Allergic bronchial asthma due to Dermatophagoides pteronyssinus hypersensitivity can be efficiently treated by inoculation of allergen-antibody complexes.

S. Lebecque, J. Saint-Remy, M. Jacquemin, 1990, The Journal of clinical investigation.

Plasmacytoid dendritic cells in Kimura disease.

P. Vannuffel, F. Facchetti, J. Saint-Remy, 2009, The American Journal of dermatopathology.

Models for assessing immunogenicity and efficacy of new therapeutics for the treatment of haemophilia

B. Reipert, J. Saint-Remy, D. Monroe, 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

Factor VIII bypasses CD91/LRP for endocytosis by dendritic cells leading to T-cell activation

S. Kaveri, S. Lacroix-Desmazes, S. Dasgupta, 2008, Haematologica.

Mimotopes identify conformational B-cell epitopes on the two major house dust mite allergens Der p 1 and Der p 2.

J. Fuhrmann, M. Scheidl, I. Pali-Schöll, 2008, Molecular immunology.

Suppression of Immune Response to Adenovirus Serotype 5 Vector by Immunization with Peptides Containing an MHC Class II Epitope and a Thio-Oxidoreductase Motif.

L. Vander Elst, J. Saint-Remy, V. Carlier, 2016, Human gene therapy.

Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinius

S. Lebecque, J. Saint-Remy, P. Lebrun, 1988 .

Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinus. Isotypic analysis of antibodies in atopic and non-atopic subjects.

S. Lebecque, J. Saint-Remy, P. Lebrun, 1988, Allergy.

Anti-heavy-chain monoclonal antibodies directed to the acidic regions of the factor VIII molecule inhibit the binding of factor VIII to phospholipids and von Willebrand factor

C. Granier, J. Saint-Remy, J. Gilles, 2003, Thrombosis and Haemostasis.

Anti-factor VIII antibodies of hemophiliac patients are frequently directed towards nonfunctional determinants and do not exhibit isotypic restriction.

J. Arnout, J. Vermylen, J. Saint-Remy, 1993, Blood.

Effect of Age-Dependent Enzymatic Degradation of Zymosan into Oligosaccharides during Incubation with Serum on Its Opsonization by Complement

J. Saint-Remy, G. Berghe, L. Corbeel, 1985, Pediatric Research.

Comparative enzymology of native and recombinant house dust mite allergen Der p 1

C. Robinson, J. Saint-Remy, D. Garrod, 2009, Allergy.

Autoantibodies to coagulation factors

J. Saint-Remy, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Low Molecular Weight Peptides Restore the Procoagulant Activity of Factor VIII in the Presence of the Potent Inhibitor Antibody ESH8*

C. Granier, J. Leonetti, J. Saint-Remy, 2002, The Journal of Biological Chemistry.

Modulation of anti-allergen immune responses by allergen-antibody complexes.

J. Saint-Remy, 1996, Advances in experimental medicine and biology.

Molecular mechanisms of mild and moderate hemophilia A

M. de Maeyer, K. Peerlinck, J. Saint-Remy, 2003, Journal of thrombosis and haemostasis : JTH.

Development of a small molecule peptidomimetic affinity ligand for efficient purification of the large protein factor VIII.

H. Kessler, V. Magdolen, C. Hauser, 2009, Advances in experimental medicine and biology.

Factor VIII alloantibodies in hemophilia

J. Saint-Remy, M. Jacquemin, J. Saint‐Remy, 2004, Current opinion in hematology.

A human antibody directed to the factor VIII C1 domain inhibits factor VIII cofactor activity and binding to von Willebrand factor.

J. Vermylen, L. Vander Elst, K. Thielemans, 2000, Blood.

Some Factor VIII (FVIII) Inhibitors Recognise a FVIII Epitope(s) that Is Present only on FVIII-vWF Complexes

J. Vermylen, M. Hoylaerts, J. Vermylen, 1999, Thrombosis and Haemostasis.

Point mutations scattered in the FVIII C1 and C2 domains reduce FVIII binding to vWF and are associated to mild/moderate hemophilia A

R. Schwaab, J. Vermylen, K. Peerlinck, 1999 .

Human auto‐anti‐idiotypic antibodies to mite‐specific IgE can degranulate human basophils in vitro

J. Saint-Remy, M. Guinnepain, M. Etievant, 1995, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

A novel therapy for atopic dermatitis with allergen-antibody complexes: a double-blind, placebo-controlled study.

J. Saint-Remy, M. Jacquemin, J. Lachapelle, 1993, Journal of the American Academy of Dermatology.

Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2.

W. Janssens, T. VandenDriessche, M. Chuah, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Natural Autoantibodies and Anti-Idiotypes

J. Saint-Remy, J. Gilles, B. Vanzieleghem, 2000 .

Hemophilia factor VIII therapy. B- and T-cell tolerance: from basic concepts to clinical practice.

J. Saint-Remy, 2000, Haematologica.

Evaluating the differences between fibrin sealants: recommendations from an international advisory panel of hospital pharmacists

I. Debrix, J. Saint-Remy, W. Beierlein, 2006 .

Epitope specificity of anti-FVIII antibodies during immune tolerance therapy with factor VIII preparation containing von Willebrand factor.

A. Kallas, M. Pooga, J. Saint-Remy, 2002, Thrombosis research.

Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.

B. Stoddard, J. Saint-Remy, K. Pratt, 2001, Blood.

Mechanism and kinetics of factor VIII inactivation: study with an IgG4 monoclonal antibody derived from a hemophilia A patient with inhibitor.

M F Hoylaerts, J. Vermylen, L. Vander Elst, 1998, Blood.

Factor VIII immunogenicity

C. Kessler, J. Saint-Remy, U. Martinowitz, 1998, Haemophilia : the official journal of the World Federation of Hemophilia.

identification of an inhibitory antibody epitope on the surface of factor VIII Fab complex: κ immunoglobulin G4 - Structure of a factor VIII C2 domain

B. Stoddard, J. Saint-Remy, K. Pratt, 2013 .

Pathogenesis and Management of Acquired Haemophilia.

A. J. Stewart, J. Saint-Remy, C. Ludlam, 1998, Hematology.

Coagulation Factor VIII Autoantibodies

J. Saint-Remy, J. Gilles, J. Saint‐Remy, 1996 .

In vivo neutralization of a C2 domain-specific human anti-Factor VIII inhibitor by an anti-idiotypic antibody.

M. de Maeyer, J. Saint-Remy, J. Gilles, 2004, Blood.

The prevalence of proteolytic antibodies against factor VIII in hemophilia A.

S. Kaveri, S. Lacroix-Desmazes, M. Kazatchkine, 2002, The New England journal of medicine.

New high‐technology products for the treatment of haemophilia

S. Pipe, J. Saint-Remy, C. Walsh, 2004, Haemophilia : the official journal of the World Federation of Hemophilia.

inhibitor by an anti-idiotypic antibody Factor VIII - specific human anti - In vivo neutralization of a C2 domain

J. Saint-Remy, M. Jacquemin, M. Maeyer, 2013 .

Factor VIII Inhibitors

J. Saint-Remy, J. Gilles, M. Jacquemin, 1997, Thrombosis and Haemostasis.

Neutralizing antiidiotypic antibodies to factor VIII inhibitors after desensitization in patients with hemophilia A.

J. Vermylen, J. Saint-Remy, H. Lenk, 1996, The Journal of clinical investigation.

Tolerability and pharmacokinetics of TB-402 in healthy male volunteers.

P. Verhamme, K. Peerlinck, J. Saint-Remy, 2010, Clinical therapeutics.

A human monoclonal antibody inhibiting partially factor VIII activity reduces thrombus growth in baboons

P. Verhamme, J. Saint-Remy, M. Jacquemin, 2009, Journal of thrombosis and haemostasis : JTH.

Natural Antibodies to Factor VIII

S. Kaveri, S. Lacroix-Desmazes, M. Kazatchkine, 2000, Seminars in thrombosis and hemostasis.

Inhibitors to Factor VIII—Immunology

J. Saint-Remy, M. Jacquemin, 2010 .

Activation of human endothelial cells from specific vascular beds induces the release of a FVIII storage pool.

A. Luttun, K. Peerlinck, J. Saint-Remy, 2010, Blood.

Antigenicity of putative phospholipid membrane-binding residues in factor VIII.

J. Healey, P. Lollar, J. Saint-Remy, 2001, Blood.

Inhibitors in haemophilia: pathophysiology

S. Lacroix-Desmazes, J. Oldenburg, J. Saint-Remy, 2004, Haemophilia : the official journal of the World Federation of Hemophilia.

Restricted Epitope Specificity of Anti-FVIII Antibodies that Appeared during a Recent Outbreak of Inhibitors

J. Vermylen, J. Arnout, J. Vermylen, 1997, Thrombosis and Haemostasis.

Coagulation Factor autoantibodies

J. Saint-Remy, J. Gilles, 2007 .

Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor.

Dominique Piquer, Sylvie Villard, Claude Granier, 2003, Blood.

Low Molecular Weight Peptides Restore the Procoagulant Activity of Factor VIII in the Presence of the Potent Inhibitor Antibody ESH 8 *

C. Granier, J. Leonetti, J. Saint-Remy, 2002 .

Factor VIII Inhibitors. Natural autoantibodies and anti-idiotypes.

J. Saint-Remy, J. Gilles, B. Vanzieleghem, 2000, Seminars in thrombosis and hemostasis.

Human interleukin 10 induces naive surface immunoglobulin D+ (sIgD+) B cells to secrete IgG1 and IgG3

J. Banchereau, J. Saint-Remy, F. Brière, 1994, The Journal of experimental medicine.

Treatment of atopic dermatitis by allergen-antibody complexes: long-term clinical results and evolution of IgE antibodies.

J. Saint-Remy, M. Jacquemin, J. Lachapelle, 1992, Dermatology.

Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding.

W. Minor, M. Chruszcz, A. Pomés, 2009, Journal of molecular biology.

Three-dimensional structure and IgE-binding properties of mature fully active Der p 1, a clinically relevant major allergen.

E. Stura, J. Saint-Remy, M. Jacquemin, 2006, The Journal of allergy and clinical immunology.

The Dermatophagoides pteronyssinus Group 2 Allergen Contains a Universally Immunogenic T Cell Epitope

J. Saint-Remy, M. Jacquemin, L. V. Elst, 2002, The Journal of Immunology.

Right atrium rhabdomyosarcoma.

J. Chaudron, J. Saint-Remy, E. Lebacq, 1977, Acta cardiologica.

Occupational asthma caused by sarsaparilla root dust.

O. Vandenplas, J. Saint-Remy, S. Depelchin, 1996, The Journal of allergy and clinical immunology.

Interactions of chrysotile asbestos fibres with the complement system.

J. Saint-Remy, P. Cole, 1980, Immunology.

Idiotypes and anti-idiotypes in allergy

J. Saint-Remy, M. Jacquemin, 1997 .

Antielastin B-cell and T-cell immunity in patients with chronic obstructive pulmonary disease

M. Decramer, W. Janssens, G. Gayan‐Ramirez, 2012, Thorax.

Regulatory CD4+ T cells in allergic asthma

J. Saint-Remy, M. Jacquemin, V. Carlier, 2006, Expert review of clinical immunology.

CD4+CD25+ T Cells Lyse Antigen-Presenting B Cells by Fas-Fas Ligand Interaction in an Epitope-Specific Manner 1

W. Janssens, J. Saint-Remy, M. Jacquemin, 2003, The Journal of Immunology.

Therapeutic levels of human Factor VIII in mice implanted with encapsulated cells: potential for gene therapy of haemophilia A

T. VandenDriessche, M. Chuah, G. Hortelano, 2002, The journal of gene medicine.

Immunotherapy of allergic diseases: a forthcoming therapy.

J. Saint-Remy, 1989, Acta clinica Belgica.

Idiotopes carried by antiallergen antibodies.

J. Saint-Remy, M. Jacquemin, 1989, Methods in enzymology.

Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinus. IV. Occurrence of natural autologous anti‐idiotypic antibodies

S. Lebecque, J. Saint-Remy, P. Lebrun, 1988, European journal of immunology.

Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model

L. Vander Elst, J. Saint-Remy, V. Carlier, 2016, Front. Immunol..

Thioreductase-Containing Epitopes Inhibit the Development of Type 1 Diabetes in the NOD Mouse Model

J. Saint-Remy, V. Carlier, L. Elst, 2016, Front. Immunol..

Response to DDAVP in mild/moderate haemophilia A patients according to the underlying Factor VIII genotype

J. Oldenburg, T. Lambert, B. Guillet, 2003 .

Kinetics and thermodynamics of interaction of coagulation factor VIII with a pathogenic human antibody.

B. Atanasov, S. Kaveri, S. Lacroix-Desmazes, 2009, Molecular immunology.

Placental growth factor contributes to bronchial neutrophilic inflammation and edema in allergic asthma.

C. Dooms, P. Carmeliet, P. Hellings, 2012, American journal of respiratory cell and molecular biology.

Injection of allergen-antibody complexes is an effective treatment of atopic dermatitis.

J. Saint-Remy, M. Jacquemin, J. Lachapelle, 1991, Dermatologica.

Immunotherapy of atopic dermatitis by injections of antigen-antibody complexes.

J. Saint-Remy, M. Jacquemin, J. Lachapelle, 1993, Dermatology.

development destroys a major FVIII antigenic determinant involved in inhibitor hemophilia A by impairing FVIII binding to VWF and phospholipids and Deletion of alanine 2201 in the FVIII C2 domain results in mild

J. Vermylen, C. Négrier, K. Peerlinck, 2013 .

Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development.

J. Vermylen, C. Négrier, K. Peerlinck, 2004, Blood.

Deletion of residue Ala2201 in the Factor VIII C2 domain results in mild haemophilia A and destroys a major antigenic determinant recognized by Factor VIII inhibitor antibodies

B. Stoddard, J. Vermylen, K. Peerlinck, 2001 .

Abstract

J. Oldenburg, B. Guillet, A. Rafowicz, 2003 .

Human Interleukin 10 Induces Naive Surface Immunoglobulln D + (sIgD +) B Cells to Secrete IgG1 and IgG3 By Francine Bri~re,* Christine Servet-Delprat,* Jean-Michel Bridon,*

J. Banchereau, J. Saint-Remy, 1994 .

Mechanisms of B-cell tolerance.

J. Saint-Remy, M. Jacquemin, B. Vanzieleghem, 2001, Advances in experimental medicine and biology.

CHAPTER 45 – Clotting Disorders

J. Saint-Remy, J. Saint‐Remy, 2006 .

Major T cell epitope‐containing peptides can elicit strong antibody responses

L. Vander Elst, C. Granier, J. Saint-Remy, 2000, European journal of immunology.

Human immune response to allergens of house dust mite, Dermatophagoides pteronyssinus

S. Lebecque, J. Saint-Remy, M. Jacquemin, 1988, European journal of immunology.

Activation of the classical pathway of human complement by a human monoclonal IgE, IgE(DES).

J. Saint-Remy, P. Masson, C. Magnusson, 1983, Journal of immunology.

The use of antibodies to coagulation factors for anticoagulant therapy.

J. Saint-Remy, M. Jacquemin, 2004, Current medicinal chemistry.

cofactor activity and binding to von Willebrand factor A human antibody directed to the factor VIII C1 domain inhibits factor VIII

J. Vermylen, K. Thielemans, R. Schwaab, 2013 .

A patient with mild hemophilia A and a high titer antifactor VIII antibody against exogenous factor VIII only: clinical features, surgical management, and partial characterization of the inhibitor

J. Vermylen, K. Peerlinck, J. Saint-Remy, 1997 .

Epitope mapping: a new method for biological evaluation and immunotoxicology.

J. Saint-Remy, J M Saint-Remy, 1997, Toxicology.

MHC Class II-Restricted Epitopes Containing an Oxidoreductase Activity Prompt CD4+ T Cells with Apoptosis-Inducing Properties

L. Vander Elst, J. Saint-Remy, V. Carlier, 2015, Front. Immunol..

Successful treatment of atopic dermatitis with complexes of allergen and specific antibodies

J. Saint-Remy, M. Jacquemin, P. Lebrun, 1990, The Lancet.

Variations in Antigenicity of Factor VIII Concentrates: Preclinical Evaluation

J. Saint-Remy, J. Gilles, 1996, Vox sanguinis.

In vivo production of functional anti-factor VIII antibodies in severe combined immunodeficiency (SCID) mice reconstituted with PBL of healthy blood donors

J. Vermylen, J. Saint-Remy, J. Gilles, 1997 .

Heating Lyophilised Factor VIII Does Not Alter Its Recognition by Specific Antibodies

J. Saint-Remy, J. Gilles, R. Laub, 1997, Vox Sanguinis.

Efficient factor VIII affinity purification using a small synthetic ligand

J. Oldenburg, H. Kessler, R. Schwaab, 2008, Journal of thrombosis and haemostasis : JTH.

Allergen-antibody complexes in the treatment of atopic dermatitis: preliminary results of a double-blind placebo-controlled study.

J. Saint-Remy, M. Jacquemin, J. Lachapelle, 1992, Acta dermato-venereologica. Supplementum.

Tolerance induction: a job for B cells?

J. Saint-Remy, M. Jacquemin, 2005 .

Retroviral vectors induce epigenetic chromatin modifications and IL-10 production in transduced B cells via activation of toll-like receptor 2.

W. Janssens, T. VandenDriessche, M. Chuah, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Allergen‐antibody complexes can efficiently prevent seasonal rhinitis and asthma in grass pollen, hypersensitive patients

J. Saint-Remy, M. Jacquemin, J. Machiels, 1991, Allergy.

A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF‐binding site distant from its epitope

S. Kaveri, S. Lacroix-Desmazes, J. Dimitrov, 2010, Journal of thrombosis and haemostasis : JTH.