X. Xi

发表

In vitro and In vivo Model Systems for Hemophilia A Gene Therapy

P. Kapranov, Jenni Firrman, W. Xiao, 2013, Journal of genetic syndromes & gene therapy.

RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness.

Saijuan Chen, Zhu Chen, Xiao-Dan Ma, 2014, Molecular cell.

A Stimulatory Role for cGMP-Dependent Protein Kinase in Platelet Activation

F. Hofmann, R. Feil, Xiaoping Du, 2003, Cell.

Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition model

Ping Liu, Xiaofeng Shi, Quansheng Zhou, 2016, Frontiers of Medicine.

PALLD Regulates Phagocytosis by Enabling Timely Actin Polymerization and Depolymerization

Saijuan Chen, Zhu Chen, X. Xi, 2017, The Journal of Immunology.

Six novel missense mutations causing factor X deficiency and application of thrombin generation test.

X. Xi, Q. Ding, Xue-feng Wang, 2013, Thrombosis research.

Regulation of Glycoprotein Ib-IX-von Willebrand Factor Interaction by cAMP-dependent Protein Kinase-mediated Phosphorylation at Ser 166 of Glycoprotein Ibβ*

R. Bodnar, Xiaoping Du, X. Xi, 2002, The Journal of Biological Chemistry.

Multimodal imaging and clinical characteristics of bone lesions in POEMS syndrome.

Junmin Li, X. Xi, Shudong Hu, 2015, International journal of clinical and experimental medicine.

In vivo generated hematopoietic stem cells from genome edited induced pluripotent stem cells are functional in platelet-targeted gene therapy of murine hemophilia A

Jinyan Huang, Saijuan Chen, Zhu Chen, 2020, Haematologica.

Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway

Z. Chen, X. Xi, Y. Wang, 2016, Leukemia.

Integrin β3 Deficiency Results in Hypertriglyceridemia via Disrupting LPL (Lipoprotein Lipase) Secretion

Huiyuan Li, J. Mao, X. Xi, 2020, Arteriosclerosis, thrombosis, and vascular biology.

Trans-repressive effect of NUP98-PMX1 on PMX1-regulated c-FOS gene through recruitment of histone deacetylase 1 by FG repeats.

C. Niu, Saijuan Chen, Zhu Chen, 2006, Cancer research.

Effects of different shear rates on the attachment and detachment of platelet thrombi

Xiaofeng Shi, X. Xi, Jian-song Huang, 2016, Molecular medicine reports.

Evaluation of targeting c-Src by the RGT-containing peptide as a novel antithrombotic strategy

Ping Liu, Xiaofeng Shi, X. Xi, 2015, Journal of Hematology & Oncology.

Recent advances in the understanding of the molecular mechanisms regulating platelet integrin αIIbβ3 activation

N. Kieffer, X. Xi, Yue-Hui Zhang, 2010, Protein & Cell.

Fibrinogen interaction of CHO cells expressing chimeric αIIb/αvβ3 integrin

Jian Ding, X. Xi, Juan Chen, 2008, Acta Pharmacologica Sinica.

Haemophilia A in two unrelated females due to F8 gene inversions combined with skewed inactivation of X chromosome

X. Xi, Q. Ding, J. Dai, 2009, Thrombosis and Haemostasis.

Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets

Ping Liu, Xiaofeng Shi, J. Mao, 2016, PloS one.

Characterisation of large F9 deletions in seven unrelated patients with severe haemophilia B

X. Wu, X. Xi, Q. Ding, 2014, Thrombosis and Haemostasis.

RGT, a synthetic peptide corresponding to the integrin beta 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin alpha IIb beta 3 with Src kinase.

N. Kieffer, Saijuan Chen, P. Flevaris, 2008, Blood.

RGT, a synthetic peptide corresponding to the integrin (cid:1) 3 cytoplasmic C-terminal sequence, selectively inhibits outside-in signaling in human platelets by disrupting the interaction of integrin (cid:2) IIb (cid:1) 3 with Src kinase

N. Kieffer, P. Flevaris, Xiaoping Du, 2008 .

Tyrosine Phosphorylation of the Integrin β3 Subunit Regulates β3 Cleavage by Calpain*

P. Flevaris, Aleksandra Stojanovic, A. Chishti, 2006, Journal of Biological Chemistry.

Synchronous diagnosis of anaplastic large cell lymphoma and multiple myeloma in a patient

X. Xi, Jian-nong Wu, Jie Peng, 2020, Medicine.

Activated factor X targeted stored in platelets as an effective gene therapy strategy for both hemophilia A and B

Saijuan Chen, Zhu Chen, Zhugang Wang, 2021, Clinical and translational medicine.

Molecular basis of type I antithrombin deficiency in two women with recurrent venous thromboembolism in the first trimester of pregnancy.

X. Xi, Q. Ding, J. Dai, 2012, Blood cells, molecules & diseases.

Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling

R. Bodnar, Xiaoping Du, S. Lam, 2003, The Journal of cell biology.

CT characteristics in 24 patients with POEMS syndrome

X. Xi, Shudong Hu, Xianfu Luo, 2016, Acta radiologica.

PML/RARα fusion protein transactivates the tissue factor promoter through a GAGC-containing element without direct DNA association

N. Kieffer, Saijuan Chen, Zhu Chen, 2010, Proceedings of the National Academy of Sciences.

Characteristics of the Thrombus Formation in Transgenic Mice with Platelet-Targeted Factor VIII Expression.

J. Mao, X. Xi, Z. Ruan, 2021, Thrombosis and haemostasis.

Long-term correction of hemorrhagic diathesis in hemophilia A mice by an AAV-delivered hybrid FVIII composed of the human heavy chain and the rat light chain

J. Mao, X. Xi, Yan Shen, 2022, Frontiers of Medicine.

Evaluation of the activity levels of rat FVIII and human FVIII delivered by adeno-associated viral vectors both in vitro and in vivo.

Saijuan Chen, Wenman Wu, Weidong Xiao, 2018, Blood cells, molecules & diseases.

Inherent hepatocytic heterogeneity determines expression and retention of edited F9 alleles post-AAV/CRISPR infusion

Saijuan Chen, Zhu Chen, J. Mao, 2021, Proceedings of the National Academy of Sciences.

Recombination in a Chinese haemophilia A family.

X. Xi, Q. Ding, J. Dai, 2008, Pathology.

Characterization of large deletions in the F8 gene using multiple competitive amplification and the genome walking technique

X. Xi, X. Wang, Q. Ding, 2013, Journal of thrombosis and haemostasis : JTH.

X. Xi, X. Wang, Q. Ding, 2014, Blood cells, molecules & diseases.

Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer

Saijuan Chen, Zhu Chen, K. Zhu, 2018, Cell Death & Disease.

Clinicopathologic analysis of POEMS syndrome and related diseases.

X. Xi, Shudong Hu, X. Fei, 2015, Clinical lymphoma, myeloma & leukemia.

Molecular basis and thrombotic manifestations of antithrombin deficiency in 15 unrelated Chinese patients.

Tingting Yu, X. Xi, Q. Ding, 2013, Thrombosis research.

Analysis of the Roles of 14-3-3 in the Platelet Glycoprotein Ib-IX–Mediated Activation of Integrin αIIbβ3 Using a Reconstituted Mammalian Cell Expression Model

Xiaoping Du, X. Xi, M. Berndt, 1999, The Journal of cell biology.

Characterisation and validation of a novel panel of the six short tandem repeats for genetic counselling in Chinese haemophilia A pedigrees

X. Xi, X. Wang, Q. Ding, 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

Prevalence of the factor 8 gene intron 1 inversion in Chinese haemophiliacs and its application to carrier detection and prenatal diagnosis in haemophilia A families

X. Xi, X. Wang, Q. Ding, 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

Opposite regulation by PI3K/Akt and MAPK/ERK pathways of tissue factor expression, cell-associated procoagulant activity and invasiveness in MDA-MB-231 cells

Hong Li, C. Soria, He Lu, 2012, Journal of Hematology & Oncology.

Identification and characterisation of a novel aberrant pattern of intron 1 inversion with concomitant large insertion and deletion within the F8 gene

X. Xi, Q. Ding, J. Dai, 2014, Thrombosis and Haemostasis.

Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells

Xia Li, Z. Chen, X. Xi, 2013, Proceedings of the National Academy of Sciences.

A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3 *

Xiaoping Du, X. Xi, Zhenyu Li, 2001, The Journal of Biological Chemistry.

A mitogen-activated protein kinase-dependent signaling pathway in the activation of platelet integrin alpha IIbbeta3.

X. Xi, X. Du, Z. Li, 2001, The Journal of biological chemistry.

Structure, signal transduction, activation, and inhibition of integrin αIIbβ3

J. Mao, X. Xi, Jian-song Huang, 2023, Thrombosis Journal.

Targeting of multiple senescence‐promoting genes and signaling pathways by triptonide induces complete senescence of acute myeloid leukemia cells

Ping Yang, Quansheng Zhou, X. Xi, 2017, Biochemical pharmacology.

Preferential eradication of acute myelogenous leukemia stem cells by fenretinide

M. Minden, Junmin Li, Saijuan Chen, 2013, Proceedings of the National Academy of Sciences.

Structural framework of c-Src activation by integrin β3.

Saijuan Chen, Zhu Chen, G. Meng, 2013, Blood.

Characterisation and quantification of F8 transcripts of ten putative splice site mutations

X. Xi, Q. Ding, Xue-feng Wang, 2014, Thrombosis and Haemostasis.

Arsenic trioxide at conventional dosage does not aggravate hemorrhage in the first‐line treatment of adult acute promyelocytic leukemia

Jiong Hu, Zhi-xiang Shen, Junmin Li, 2018, European journal of haematology.

Clinical significance of day 5 peripheral blast clearance rate in the evaluation of early treatment response and prognosis of patients with acute myeloid leukemia

Jing Wu, Yong-mei Zhu, Junmin Li, 2015, Journal of Hematology & Oncology.

Homoharringtonine deregulates MYC transcriptional expression by directly binding NF-κB repressing factor

Junmin Li, Saijuan Chen, Zhu Chen, 2019, Proceedings of the National Academy of Sciences.

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Jian Huang, J. Mao, X. Xi, 2018, Frontiers of Medicine.

Targeting the RT loop of Src SH3 in Platelets Prevents Thrombosis without Compromising Hemostasis

Yvonne Ying-Ya Wen, Hu Zhou, J. Mao, 2022, Advanced science.

Establishment and characterization of a novel ‘double‐hit’ follicular lymphoma cell line, FL‐SJC

J. Mao, X. Xi, Jinlan Pan, 2020, Journal of cellular and molecular medicine.

Rare synchronous co-existence of acute myeloid leukemia and hairy cell leukemia in a same patient

X. Xi, Jingan Liu, Jie Peng, 2020, Annals of Hematology.

Mutation profile and associated clinical features in Chinese patients with cytogenetically normal acute myeloid leukemia

J. Lu, Jinyan Huang, X. Xi, 2018, International journal of laboratory hematology.

Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer

Saijuan Chen, Zhu Chen, K. Zhu, 2018, Cell Death & Disease.

HDAC6 controls the kinetics of platelet activation.

Karin Sadoul, P. Matthias, B. Polack, 2012, Blood.

Clinical manifestations and mutation spectrum of 57 subjects with congenital factor XI deficiency in China.

X. Xi, Q. Ding, J. Dai, 2016, Blood cells, molecules & diseases.

Molecular defects in the factor X gene caused by novel heterozygous mutations IVS5+1G>A and Asp409del

X. Xi, X. Wang, Q. Ding, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Arsenic Inhibits Proliferation and Induces Autophagy of Tumor Cells in Pleural Effusion of Patients with Non-Small Cell Lung Cancer Expressing EGFR with or without Mutations via PI3K/AKT/mTOR Pathway

J. Mao, X. Xi, Yan Shen, 2023, Biomedicines.

Identification of a novel splicing mutation in the fibrinogen Aα chain gene leading to hypofibrinogenaemia in a Chinese pedigree

X. Wang, X. Xi, Q. Ding, 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

Maternal chromosome 4 heterodisomy/isodisomy and Bβ chain Trp323X mutation resulting in severe hypodysfibrinogenaemia

Yiping Shen, X. Xi, Q. Ding, 2012, Thrombosis and Haemostasis.

Tyrosine phosphorylation of the integrin beta 3 subunit regulates beta 3 cleavage by calpain.

P. Flevaris, Aleksandra Stojanovic, A. Chishti, 2006, The Journal of biological chemistry.

Using a minigene approach to characterize a novel splice site mutation in human F7 gene causing inherited factor VII deficiency in a Chinese pedigree

X. Wang, X. Xi, Q. Ding, 2009, Haemophilia : the official journal of the World Federation of Hemophilia.

Lymphadenopathy in POEMS syndrome: a correlation between clinical features and imaging findings.

X. Xi, Shudong Hu, Jian-nong Wu, 2020, International journal of clinical and experimental pathology.