D. Brophy

发表

Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients

D. Brophy, E. Martin, M. Nolte, 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

Resolution of Sterile Inflammation: Role for Vitamin C

C. Chalfant, A. Fowler, B. Fisher, 2014, Mediators of inflammation.

Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation.

K. Ward, D. Brophy, E. Martin, 2010, Resuscitation.

Systemic central venous oxygen saturation is associated with clot strength during traumatic hemorrhagic shock: A preclinical observational model

K. Ward, R. Diegelmann, Yongyun Shin, 2010, Scandinavian journal of trauma, resuscitation and emergency medicine.

Antifactor Xa activity correlates to thrombin generation time, platelet contractile force and clot elastic modulus following ex vivo enoxaparin exposure in patients with and without renal dysfunction

D. Brophy, E. Martin, A. Best, 2004, Journal of thrombosis and haemostasis : JTH.

Informing efficient pilot development of animal trauma models through quality improvement strategies

B. Fisher, P. Reynolds, D. Brophy, 2018, Laboratory animals.

Allosterism‐based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα‐binding and heparin‐binding site of thrombin

Akul Y Mehta, U. Desai, D. Brophy, 2016, Journal of thrombosis and haemostasis : JTH.

Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients

M. Carr, D. Brophy, E. Martin, 2011, Journal of thrombosis and haemostasis : JTH.

Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury.

K. Ward, C. Wade, D. Brophy, 2016, Free radical biology & medicine.

Utilization Patterns of IV Iron and Erythropoiesis Stimulating Agents in Anemic Chronic Kidney Disease Patients: A Multihospital Study

Spencer E. Harpe, S. Harpe, D. Brophy, 2012, Anemia.

An in vitro pharmacodynamic spiking study of befovacimab, a tissue factor pathway inhibitor monoclonal antibody, in blood samples from patients with severe FVIII deficiency

D. Brophy, E. Martin, M. Nolte, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas

John E. Murphy, D. Brophy, E. Martin, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

Evaluating the thrombin generation profiles of four different rFVIII products in FVIII‐deficient plasma using FIXa and FXIa activation

D. Brophy, E. Martin, M. Nolte, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Failure of corn trypsin inhibitor to affect the thrombin generation assay in plasma from severe hemophiliacs

G. Young, D. Brophy, E. Martin, 2014, Journal of thrombosis and haemostasis : JTH.

Modulation of the activated protein C pathway in severe haemophilia A patients: The effects of thrombomodulin and a factor V‐stabilizing fab

R. Salbo, D. Brophy, E. Martin, 2017, Haemophilia : the official journal of the World Federation of Hemophilia.

Is some better than none: are TEG and TGA profiles different in severe FVIII‐deficient patients with inhibitors?

G. Young, D. Brophy, E. Martin, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Laboratory assessment of warfarin reversal with global coagulation tests versus international normalized ratio in patients with intracranial bleeding

Stacy A. Voils, D. Brophy, E. Martin, 2015, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Monitoring rFVIII prophylaxis dosing using global haemostasis assays

J. Venitz, D. Brophy, E. Martin, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Monitoring rFVIIa 90 μg kg−1 dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h

M. Carr, D. Brophy, E. Martin, 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

Pharmacokinetic Interaction between Amprenavir and Rifabutin or Rifampin in Healthy Males

B. Sadler, D. Brophy, R. Polk, 2001, Antimicrobial Agents and Chemotherapy.

Characterizing Hospitalizations of End-Stage Renal Disease Patients on Dialysis and Inpatient Utilization of Erythropoiesis-Stimulating Agent Therapy

T. Mayne, D. Brophy, M. Gitlin, 2010, The Annals of pharmacotherapy.

Use and prescribing patterns for erythropoiesis-stimulating agents in inpatient and outpatient hospital settings.

Philip E. Johnson, J. Siegel, D. Brophy, 2008, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

Thrombin generation time is a novel parameter for monitoring enoxaparin therapy in patients with end‐stage renal disease

M. Carr, D. Brophy, E. Martin, 2006, Journal of thrombosis and haemostasis : JTH.

Pharmacotherapy of dyslipidemia in postmenopausal women: weighing the evidence.

J. Mckenney, M. Crouch, D. Brophy, 1999, Journal of women's health & gender-based medicine.

Off-Label Prescribing of Erythropoiesis-Stimulating Proteins in US Hospitals

D. Brophy, D. Holdford, A. Patkar, 2007 .

A pilot study of genetic polymorphisms and hemodialysis vascular access thrombosis

Bonny L. Bukaveckas, K. Archer, D. Brophy, 2009, Hemodialysis international. International Symposium on Home Hemodialysis.

Pharmacoeconomic considerations in the health system management of anaemia in patients with chronic kidney disease and end stage renal disease

D. Brophy, D. Holdford, E. Ripley, 2003, Expert opinion on pharmacotherapy.

Factor VIIa analog has marked effects on platelet function and clot kinetics in blood from patients with hemophilia A

D. Brophy, E. Martin, M. Nolte, 2010, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Thromboelastographic analysis of novel polyethylene glycol based low volume resuscitation solutions

S. Jayaraman, M. Mangino, M. Aboutanos, 2018, PloS one.

Vitamin C: A Novel Regulator of Neutrophil Extracellular Trap Formation

A. Fowler, B. Fisher, D. Brophy, 2013, Nutrients.

Metabolomics and Precision Medicine in Trauma: The State of the Field

S. Jayaraman, A. Valadka, R. Hayes, 2017, Shock.

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

U. Desai, M. Sakagami, D. Brophy, 2019, Journal of thrombosis and haemostasis : JTH.

Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acids

U. Desai, D. Brophy, E. Martin, 2009, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial.

G. Martin, J. Sevransky, R. Nanchal, 2019, JAMA.

Impact of high dose vitamin C on platelet function

C. Chalfant, B. Fisher, D. Brophy, 2017, World journal of critical care medicine.

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.

K. Ward, N. Voelkel, A. Fowler, 2012, American journal of physiology. Lung cellular and molecular physiology.

induced acute lung injury by ascorbic acid Mechanisms of attenuation of abdominal sepsis

K. Ward, N. Voelkel, A. Fowler, 2012 .

Efficacy and safety of fondaparinux and enoxaparin for acute coronary syndromes in CKD.

D. Brophy, 2008, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Continuous-Flow Left Ventricular Assist Device-Related Gastrointestinal Bleeding.

K. Shah, D. Brophy, Ju H Kim, 2018, Cardiology clinics.

The Pharmacokinetics of Subcutaneous Enoxaparin in End‐Stage Renal Disease

J. Venitz, D. Brophy, T. Gehr, 2001, Pharmacotherapy.

Differences in coagulation in clotting of vascular access in hemodialysis patients

D. Brophy, E. Martin, T. Gehr, 2015, Hemodialysis international. International Symposium on Home Hemodialysis.

The Pharmacokinetics of Enoxaparin Do Not Correlate With Its Pharmacodynamic Effect in Patients Receiving Dialysis Therapies

M. Carr, J. Venitz, D. Brophy, 2006, Journal of clinical pharmacology.

Prospective, Randomized Comparison of Lansoprazole Suspension, and Intermittent Intravenous Famotidine on Gastric pH and Acid Production in Critically ill Neurosurgical Patients

G. Brophy, D. Brophy, M. Brackbill, 2010, Neurocritical care.

Factor VIIa treatment increases circulating extracellular vesicles in hemophilia patients: Implications for the therapeutic hemostatic effect of FVIIa

U. Pendurthi, Kalpataru Das, D. Brophy, 2022, Journal of thrombosis and haemostasis : JTH.

Clot Formation Is Associated With Fibrinogen and Platelet Forces in a Cohort of Severely Injured Emergency Department Trauma Patients

K. Ward, G. Brophy, A. Pusateri, 2015, Shock.

Use of Enoxaparin in Patients with Chronic Kidney Disease

D. Sica, D. Brophy, 2007, Drug safety.

Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays

D. Brophy, E. Martin, M. Nolte, 2011, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets

D. Brophy, E. Martin, M. Kjelgaard‐Hansen, 2020, Journal of thrombosis and haemostasis : JTH.

Scholars A hypothesis-generating study to evaluate platelet activity in diabetics with chronic kidney disease

M. Carr, D. Brophy, T. Gehr, 2015 .

A hypothesis-generating study to evaluate platelet activity in diabetics with chronic kidney disease

M. Carr, D. Brophy, T. Gehr, 2005, Thrombosis journal.

Enhanced anticoagulant activity of enoxaparin in patients with ESRD as measured by thrombin generation time.

M. Carr, D. Brophy, E. Martin, 2004, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Clopidogrel Responsiveness in Patients With Decompensated Cirrhosis of the Liver Undergoing Pre-Transplant PCI.

L. Puckett, C. Trankle, D. Brophy, 2019, JACC. Cardiovascular interventions.

Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients[S]

B. V. Van Tassell, C. Chalfant, D. Brophy, 2017, Journal of Lipid Research.

Vancomycin Removal by Plasmapheresis

D. Brophy, B. A. Mueller, 1996, The Annals of pharmacotherapy.

Pharmacokinetic Interaction between Amprenavir and Clarithromycin in Healthy Male Volunteers

A. Pastor, B. Sadler, D. Brophy, 2000, Antimicrobial Agents and Chemotherapy.

Venous Thromboembolism Prevention in Acutely Ill Nonsurgical Patients

D. Brophy, J. Garrelts, R. Parish, 2005, The Annals of pharmacotherapy.

Small and Middle Molecular Weight Solute Clearance in Nocturnal Intermittent Peritoneal Dialysis

S. Moe, J. Klaunig, M. Kraus, 1999, Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.

The Pharmacokinetics and Pharmacodynamics of Losartan in Continuous Ambulatory Peritoneal Dialysis

D. Sica, D. Brophy, T. Gehr, 2000, Journal of clinical pharmacology.

An In Vivo‐In Vitro Study of Cefepime and Cefazolin Dialytic Clearance During High‐Flux Hemodialysis

G. Matzke, D. Brophy, T. Gehr, 2008, Pharmacotherapy.

Use of global assays to monitor emicizumab prophylactic therapy in patients with haemophilia A with inhibitors

D. Brophy, E. Martin, J. Kuhn, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

Amiloride for the Prevention of Amphotericin B–Induced Hypokalemia and Hypomagnesemia

D. Brophy, L. Wazny, 2000, The Annals of pharmacotherapy.

High-Performance Liquid Chromatographic Determination of Cefepime and Cefazolin in Human Plasma and Dialysate

D. Brophy, T. Gehr, D. Farthing, 2008 .

Examining platelet–fibrin interactions during traumatic shock in a swine model using platelet contractile force and clot elastic modulus

K. Ward, D. Brophy, E. Martin, 2011, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Coated platelet assay: a feasible approach to a complicated science

D. Brophy, E. Martin, B. Mohammed, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

A. Fowler, B. Fisher, D. Brophy, 2014, Journal of Translational Medicine.

A Unique Nonsaccharide Mimetic of Heparin Hexasaccharide Inhibits Colon Cancer Stem Cells via p38 MAP Kinase Activation

U. Desai, D. Brophy, Rio S Boothello, 2018, Molecular Cancer Therapeutics.

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

A. Fowler, B. Fisher, D. Brophy, 2014, Journal of Translational Medicine.

Interventional vitamin C: A strategy for attenuation of coagulopathy and inflammation in a swine multiple injuries model

B. Spiess, A. Fowler, B. Fisher, 2018, The journal of trauma and acute care surgery.

Immunological determinants of clinical outcomes in COVID-19: A quantitative perspective

M. Neale, G. Buck, R. Sabo, 2020, 2005.06541.

Vitamin C promotes wound healing through novel pleiotropic mechanisms

A. Fowler, B. Fisher, D. Brophy, 2016, International wound journal.

Early hemostatic responses to trauma identified with hierarchical clustering analysis

G. Brophy, A. Pusateri, D. Brophy, 2015, Journal of thrombosis and haemostasis : JTH.

Intact stable isotope labeled plasma proteins from the SILAC‐labeled HepG2 secretome

Adam M. Hawkridge, D. Brophy, E. Martin, 2015, Proteomics.

Automated Peritoneal Dialysis: New Implications for Pharmacists

D. Brophy, B. A. Mueller, 1997, The Annals of pharmacotherapy.

AUTOMATEDPERITONEAL DIALYSIS: NEWIMPLICATIONS FOR PHARMACISTS

D. Brophy, B. A. Mueller, 1997 .

Attenuation of sepsis-induced organ injury in mice by vitamin C.

N. Voelkel, P. Puri, A. Fowler, 2014, JPEN. Journal of parenteral and enteral nutrition.

Development of an Efficient Sampling Strategy to Predict Enoxaparin Pharmacokinetics in Stage 5 Chronic Kidney Disease

K. Sowinski, D. Brophy, B. Overholser, 2006, Therapeutic drug monitoring.

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

K. Ward, G. Brophy, B. Spiess, 2019, Journal of thrombosis and haemostasis : JTH.

Dietary Bioactive Fatty Acids as Modulators of Immune Function: Implications on Human Health

S. Carbone, B. V. Van Tassell, P. Madurantakam, 2019, Nutrients.

Coagulopathy during cardiac arrest and resuscitation in a swine model of electrically induced ventricular fibrillation.

J. Ornato, K. Ward, M. Peberdy, 2011, Resuscitation.

Darbepoetin Alfa Therapeutic Interchange Protocol for Anemia in Dialysis

D. Brophy, E. Ripley, Seina P. Lee, 2005, The Annals of pharmacotherapy.

Effects of a novel low volume resuscitation solutions on coagulation and platelet function

S. Jayaraman, M. Mangino, M. Aboutanos, 2019, PloS one.

Multicenter Evaluation of Octreotide as Secondary Prophylaxis in Patients With Left Ventricular Assist Devices and Gastrointestinal Bleeding

N. Uriel, D. Farrar, K. Shah, 2017, Circulation. Heart failure.

Tolerability and Biological Effects of Long-Acting Octreotide in Patients With Continuous Flow Left Ventricular Assist Devices

R. Malhotra, K. Shah, D. Brophy, 2017, ASAIO journal.

An Epidemiological Study of Anemia and Renal Dysfunction in Patients Admitted to ICUs across the United States

Spencer E. Harpe, G. Brophy, D. Brophy, 2012, Anemia.

The effect of uremia on platelet contractile force, clot elastic modulus and bleeding time in hemodialysis patients.

M. Carr, D. Brophy, E. Martin, 2007, Thrombosis research.

Warfarin Resistance in a Patient with Short Bowel Syndrome

M. Crouch, D. Brophy, S. Ford, 1998, Pharmacotherapy.

Role of N-Acetylcysteine in the Prevention of Radiocontrast-Induced Nephropathy

D. Brophy, 2002, The Annals of pharmacotherapy.

Differences in Coagulation Between Hemodialysis and Peritoneal Dialysis

D. Brophy, E. Martin, T. Gehr, 2014, Peritoneal Dialysis International.

PILOT STUDY TO ASSESS EFFECT OF HIGH DOSE ASCORBIC ACID (VITAMIN C) ON INFLAMMATION REDUCTION IN CARDIAC SURGERY PATIENTS

D. Brophy, 2018 .

Risk of Infection with Intravenous Iron Therapy

D. Brophy, Lena M. Maynor, 2007, The Annals of pharmacotherapy.

Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects

U. Desai, D. Brophy, E. Martin, 2014, Journal of medicinal chemistry.

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment

L. Kang, B. Spiess, Adam M. Hawkridge, 2019, Journal of thrombosis and haemostasis : JTH.

Cost‐Effectiveness of Sevelamer versus Calcium Carbonate plus Atorvastatin to Reduce LDL in Patients with Chronic Renal Insufficiency with Dyslipidemia and Hyperphosphatemia

D. Brophy, D. Holdford, T. Gehr, 2000, Pharmacotherapy.

Recombinant Activated Factor VII Use in Critically III Patients: Clinical Outcomes and Thromboembolic Events

G. Brophy, D. Brophy, Jaime R. Robles, 2013, The Annals of pharmacotherapy.