E. Martin

发表

Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients

D. Brophy, E. Martin, M. Nolte, 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation.

K. Ward, D. Brophy, E. Martin, 2010, Resuscitation.

Systemic central venous oxygen saturation is associated with clot strength during traumatic hemorrhagic shock: A preclinical observational model

K. Ward, R. Diegelmann, Yongyun Shin, 2010, Scandinavian journal of trauma, resuscitation and emergency medicine.

Antifactor Xa activity correlates to thrombin generation time, platelet contractile force and clot elastic modulus following ex vivo enoxaparin exposure in patients with and without renal dysfunction

D. Brophy, E. Martin, A. Best, 2004, Journal of thrombosis and haemostasis : JTH.

Informing efficient pilot development of animal trauma models through quality improvement strategies

B. Fisher, P. Reynolds, D. Brophy, 2018, Laboratory animals.

Batroxobin‐induced clots exhibit delayed and reduced platelet contractile force in some patients with clotting factor deficiencies

M. Carr, E. Martin, S. L. Carr, 2003, Journal of thrombosis and haemostasis : JTH.

Allosterism‐based simultaneous, dual anticoagulant and antiplatelet action: allosteric inhibitor targeting the glycoprotein Ibα‐binding and heparin‐binding site of thrombin

Akul Y Mehta, U. Desai, D. Brophy, 2016, Journal of thrombosis and haemostasis : JTH.

Recombinant human factor VIIa (rFVIIa) cleared principally by antithrombin following intravenous administration in hemophilia patients

M. Carr, D. Brophy, E. Martin, 2011, Journal of thrombosis and haemostasis : JTH.

Effects of recombinant factor VIIa on platelet function and clot structure in blood with deficient prothrombin conversion

M. Carr, S. Seremetis, E. Martin, 2003, Thrombosis and Haemostasis.

Post-translational oxidative modification of fibrinogen is associated with coagulopathy after traumatic injury.

K. Ward, C. Wade, D. Brophy, 2016, Free radical biology & medicine.

An in vitro pharmacodynamic spiking study of befovacimab, a tissue factor pathway inhibitor monoclonal antibody, in blood samples from patients with severe FVIII deficiency

D. Brophy, E. Martin, M. Nolte, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

Marstacimab, a tissue factor pathway inhibitor neutralizing antibody, improves coagulation parameters of ex vivo dosed haemophilic blood and plasmas

John E. Murphy, D. Brophy, E. Martin, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

Evaluating the thrombin generation profiles of four different rFVIII products in FVIII‐deficient plasma using FIXa and FXIa activation

D. Brophy, E. Martin, M. Nolte, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Failure of corn trypsin inhibitor to affect the thrombin generation assay in plasma from severe hemophiliacs

G. Young, D. Brophy, E. Martin, 2014, Journal of thrombosis and haemostasis : JTH.

Modulation of the activated protein C pathway in severe haemophilia A patients: The effects of thrombomodulin and a factor V‐stabilizing fab

R. Salbo, D. Brophy, E. Martin, 2017, Haemophilia : the official journal of the World Federation of Hemophilia.

Is some better than none: are TEG and TGA profiles different in severe FVIII‐deficient patients with inhibitors?

G. Young, D. Brophy, E. Martin, 2015, Haemophilia : the official journal of the World Federation of Hemophilia.

Laboratory assessment of warfarin reversal with global coagulation tests versus international normalized ratio in patients with intracranial bleeding

Stacy A. Voils, D. Brophy, E. Martin, 2015, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Monitoring rFVIII prophylaxis dosing using global haemostasis assays

J. Venitz, D. Brophy, E. Martin, 2013, Haemophilia : the official journal of the World Federation of Hemophilia.

Monitoring rFVIIa 90 μg kg−1 dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h

M. Carr, D. Brophy, E. Martin, 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

Rapid Clot Formation and Abnormal Fibrin Structure in a Symptomatic Patient Taking Fenfluramine

M. Carr, B. A. Johnson, E. Martin, 2001, Angiology.

Onset of force development as a marker of thrombin generation in whole blood: the thrombin generation time (TGT)

B. Spiess, M. Carr, E. Martin, 2003, Journal of thrombosis and haemostasis : JTH.

Patients with Coronary Artery Disease who Present with Chest Pain Have Significantly Elevated Platelet Contractile Force and Clot Elastic Modulus

J. Ornato, G. Vetrovec, M. Carr, 2002, Thrombosis and Haemostasis.

Thrombin generation time is a novel parameter for monitoring enoxaparin therapy in patients with end‐stage renal disease

M. Carr, D. Brophy, E. Martin, 2006, Journal of thrombosis and haemostasis : JTH.

Recombinant Factor VIIa: clinical applications for an intravenous hemostatic agent with broad-spectrum potential

E. Martin, M. E. CARR JR, 2004, Expert review of cardiovascular therapy.

A pilot study of genetic polymorphisms and hemodialysis vascular access thrombosis

Bonny L. Bukaveckas, K. Archer, D. Brophy, 2009, Hemodialysis international. International Symposium on Home Hemodialysis.

Factor VIIa analog has marked effects on platelet function and clot kinetics in blood from patients with hemophilia A

D. Brophy, E. Martin, M. Nolte, 2010, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Thromboelastographic analysis of novel polyethylene glycol based low volume resuscitation solutions

S. Jayaraman, M. Mangino, M. Aboutanos, 2018, PloS one.

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding

U. Desai, M. Sakagami, D. Brophy, 2019, Journal of thrombosis and haemostasis : JTH.

Characterization of the plasma and blood anticoagulant potential of structurally and mechanistically novel oligomers of 4-hydroxycinnamic acids

U. Desai, D. Brophy, E. Martin, 2009, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Impact of high dose vitamin C on platelet function

C. Chalfant, B. Fisher, D. Brophy, 2017, World journal of critical care medicine.

Mechanisms of attenuation of abdominal sepsis induced acute lung injury by ascorbic acid.

K. Ward, N. Voelkel, A. Fowler, 2012, American journal of physiology. Lung cellular and molecular physiology.

induced acute lung injury by ascorbic acid Mechanisms of attenuation of abdominal sepsis

K. Ward, N. Voelkel, A. Fowler, 2012 .

Differences in coagulation in clotting of vascular access in hemodialysis patients

D. Brophy, E. Martin, T. Gehr, 2015, Hemodialysis international. International Symposium on Home Hemodialysis.

The Pharmacokinetics of Enoxaparin Do Not Correlate With Its Pharmacodynamic Effect in Patients Receiving Dialysis Therapies

M. Carr, J. Venitz, D. Brophy, 2006, Journal of clinical pharmacology.

Factor VIIa treatment increases circulating extracellular vesicles in hemophilia patients: Implications for the therapeutic hemostatic effect of FVIIa

U. Pendurthi, Kalpataru Das, D. Brophy, 2022, Journal of thrombosis and haemostasis : JTH.

Clot Formation Is Associated With Fibrinogen and Platelet Forces in a Cohort of Severely Injured Emergency Department Trauma Patients

K. Ward, G. Brophy, A. Pusateri, 2015, Shock.

Overcoming delayed in-vitro response to rFVIIa: effects of rFVIIa and rFVIIa analogue (vatreptacog alfa) concentration escalation in whole blood assays

D. Brophy, E. Martin, M. Nolte, 2011, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Enhanced potency of recombinant factor VIIa with increased affinity to activated platelets

D. Brophy, E. Martin, M. Kjelgaard‐Hansen, 2020, Journal of thrombosis and haemostasis : JTH.

Enhanced anticoagulant activity of enoxaparin in patients with ESRD as measured by thrombin generation time.

M. Carr, D. Brophy, E. Martin, 2004, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Platelet contractile force (PCF) and clot elastic modulus (CEM) are elevated in diabetic patients with chest pain

M. Carr, E. Martin, A. Krishnaswami, 2002, Diabetic medicine : a journal of the British Diabetic Association.

Delayed, reduced or inhibited thrombin production reduces platelet contractile force and results in weaker clot formation

M. Carr, E. Martin, S. L. Carr, 2002, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Unsupervised analysis of combined lipid and coagulation data reveals coagulopathy subtypes among dialysis patients[S]

B. V. Van Tassell, C. Chalfant, D. Brophy, 2017, Journal of Lipid Research.

Enhanced Platelet Force Development Despite Drug-Induced Inhibition of Platelet Aggregation in Patients with Thromboanglitis Obliterans

M. Carr, E. Martin, S. L. Carr, 2002, Vascular and endovascular surgery.

Reductions in platelet contractile force correlate with duration of cardiopulmonary bypass and blood loss in patients undergoing cardiac surgery.

M. Carr, E. Martin, M. Jessen, 2002, Thrombosis research.

Use of global assays to monitor emicizumab prophylactic therapy in patients with haemophilia A with inhibitors

D. Brophy, E. Martin, J. Kuhn, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

Examining platelet–fibrin interactions during traumatic shock in a swine model using platelet contractile force and clot elastic modulus

K. Ward, D. Brophy, E. Martin, 2011, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Coated platelet assay: a feasible approach to a complicated science

D. Brophy, E. Martin, B. Mohammed, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

A. Fowler, B. Fisher, D. Brophy, 2014, Journal of Translational Medicine.

Phase I safety trial of intravenous ascorbic acid in patients with severe sepsis

A. Fowler, B. Fisher, D. Brophy, 2014, Journal of Translational Medicine.

Interventional vitamin C: A strategy for attenuation of coagulopathy and inflammation in a swine multiple injuries model

B. Spiess, A. Fowler, B. Fisher, 2018, The journal of trauma and acute care surgery.

Early hemostatic responses to trauma identified with hierarchical clustering analysis

G. Brophy, A. Pusateri, D. Brophy, 2015, Journal of thrombosis and haemostasis : JTH.

Pseudoprolongation of the Prothrombin Time During Treatment with Recombinant Factor VIIa for Bleeding in a Patient with a Spontaneous Factor VIII Inhibitor

M. Carr, E. Martin, J. Kuhn, 2003, International journal of hematology.

Intact stable isotope labeled plasma proteins from the SILAC‐labeled HepG2 secretome

Adam M. Hawkridge, D. Brophy, E. Martin, 2015, Proteomics.

Attenuation of sepsis-induced organ injury in mice by vitamin C.

N. Voelkel, P. Puri, A. Fowler, 2014, JPEN. Journal of parenteral and enteral nutrition.

Platelets retain inducible alpha granule secretion by P‐selectin expression but exhibit mechanical dysfunction during trauma‐induced coagulopathy

K. Ward, G. Brophy, B. Spiess, 2019, Journal of thrombosis and haemostasis : JTH.

Coagulopathy during cardiac arrest and resuscitation in a swine model of electrically induced ventricular fibrillation.

J. Ornato, K. Ward, M. Peberdy, 2011, Resuscitation.

Effects of a novel low volume resuscitation solutions on coagulation and platelet function

S. Jayaraman, M. Mangino, M. Aboutanos, 2019, PloS one.

The effect of uremia on platelet contractile force, clot elastic modulus and bleeding time in hemodialysis patients.

M. Carr, D. Brophy, E. Martin, 2007, Thrombosis research.

Differences in Coagulation Between Hemodialysis and Peritoneal Dialysis

D. Brophy, E. Martin, T. Gehr, 2014, Peritoneal Dialysis International.

Targeting the GPIbα Binding Site of Thrombin To Simultaneously Induce Dual Anticoagulant and Antiplatelet Effects

U. Desai, D. Brophy, E. Martin, 2014, Journal of medicinal chemistry.

Temporal map of the pig polytrauma plasma proteome with fluid resuscitation and intravenous vitamin C treatment

L. Kang, B. Spiess, Adam M. Hawkridge, 2019, Journal of thrombosis and haemostasis : JTH.

Monitoring of hemostatic status in four patients being treated with recombinant factor VIIa.

M. Carr, E. Martin, J. Kuhn, 2004, Clinical laboratory.

Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation.

K. Ward, D. Brophy, E. Martin, 2010, Resuscitation.