Y. Dargaud

发表

C. Négrier, Y. Dargaud, 2007, Expert opinion on biological therapy.

Dose tailoring of human cell line‐derived recombinant factor VIII simoctocog alfa: Using a limited sampling strategy in patients with severe haemophilia A

E. Ollier, C. Négrier, Y. Dargaud, 2019, British journal of clinical pharmacology.

Haemophilia and thrombophilia: an unexpected association!

S. Meunier, C. Négrier, Y. Dargaud, 2004, Haemophilia : the official journal of the World Federation of Hemophilia.

Recommendations for the measurement of thrombin generation: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies

H. ten Cate, Y. Dargaud, V. Ignjatovic, 2021, Journal of thrombosis and haemostasis : JTH.

Case scenario: management of trauma-induced coagulopathy in a severe blunt trauma patient.

K. Inaba, J. David, Y. Dargaud, 2013, Anesthesiology.

Expression and characterization of a novel human recombinant factor IX molecule with enhanced in vitro and in vivo clotting activity.

C. Négrier, Y. Dargaud, E. Perot, 2015, Thrombosis research.

The modification of the thrombin generation assay for the clinical assessment of hypercoagulability in patients receiving heparin therapy

M. Simon, Y. Dargaud, H. Desmurs-Clavel, 2021, International journal of laboratory hematology.

A new paradigm for personalized prophylaxis for patients with severe haemophilia A

E. Ollier, A. Lienhart, Y. Dargaud, 2020, Haemophilia : the official journal of the World Federation of Hemophilia.

The challenge of myeloma-related thromboembolic disease: can thrombin generation assay help physicians to better predict the thromboembolic risk and personalize anti-thrombotic prophylaxis?

C. Dumontet, P. Moreau, Y. Dargaud, 2019, Leukemia & lymphoma.

Impact of Deficiency of Intrinsic Coagulation Factors XI and XII on Ex Vivo Thrombus Formation and Clot Lysis

H. ten Cate, J. Heemskerk, Y. Dargaud, 2019, TH Open.

Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq® (human‐cl rhFVIII) in previously treated patients with severe haemophilia A

C. Négrier, C. Solomon, R. Klamroth, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

Fusion of Factor IX to Factor XIII-B Sub-Unit Improves the Pharmacokinetic Profile of Factor IX

C. Négrier, Y. Dargaud, E. Perot, 2018, Thrombosis and Haemostasis.

Pre-analytical effects of pneumatic tube system transport on routine haematology and coagulation tests, global coagulation assays and platelet function assays.

C. Négrier, Y. Dargaud, J. Bordet, 2017, Thrombosis research.

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia

S. Milstein, K. G. Rajeev, M. Manoharan, 2015, Nature Medicine.

Diagnosis and management challenges in patients with mild haemophilia A and discrepant FVIII measurements

A. Lienhart, S. Meunier, C. Négrier, 2014, Haemophilia : the official journal of the World Federation of Hemophilia.

Bleeding risk in warfarinized patients with a therapeutic international normalized ratio: the effect of low factor IX levels

C. Négrier, Y. Dargaud, D. Monroe, 2013, Journal of thrombosis and haemostasis : JTH.

Evaluation of a standardized protocol for thrombin generation measurement using the calibrated automated thrombogram: an international multicentre study.

T. Baglin, C. Négrier, H. ten Cate, 2012, Thrombosis research.

Evaluation of the overall haemostatic effect of recombinant factor VIIa by measuring thrombin generation and stability of fibrin clots

A. Lienhart, C. Négrier, Y. Dargaud, 2011, Haemophilia : the official journal of the World Federation of Hemophilia.

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A

H. Hemker, R. van Oerle, Y. Dargaud, 2011, Journal of thrombosis and haemostasis : JTH.

Standardisation of thrombin generation test--which reference plasma for TGT? An international multicentre study.

T. Baglin, C. Négrier, T. Lecompte, 2010, Thrombosis research.

Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery.

A. Lienhart, C. Négrier, Y. Dargaud, 2010, Blood.

Thrombin generation in patients with factor XI deficiency and clinical bleeding risk

P. de Mazancourt, C. Négrier, Y. Dargaud, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Thrombin generation testing in haemophilia comprehensive care centres

C. Négrier, Y. Dargaud, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Tests of global haemostasis and their applications in bleeding disorders

S. Nair, A. Srivastava, Y. Dargaud, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Monitoring platelet dependent thrombin generation in mice.

H. Hemker, H. ten Cate, Y. Dargaud, 2010, Thrombosis research.

Reversal of the inhibitory effect of fondaparinux on thrombin generation by rFVIIa, aPCC and PCC.

C. Négrier, Y. Dargaud, H. Desmurs-Clavel, 2009, Thrombosis research.

Intraindividual thrombin generation measurement variability in healthy adults over a one year period.

C. Négrier, Y. Dargaud, Stéphanie Francillon, 2009, Thrombosis research.

Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study

C. Négrier, Y. Dargaud, J. Bordet, 2008, Journal of thrombosis and haemostasis : JTH.

New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors

T. Lambert, Y. Dargaud, M. Trossaert, 2008, Haemophilia : the official journal of the World Federation of Hemophilia.

Effect of standardization and normalization on imprecision of calibrated automated thrombography: an international multicentre study

T. Baglin, C. Négrier, T. Lecompte, 2007, British journal of haematology.

Thrombin-generating capacity in patients with von Willebrand’s disease

S. Béguin, C. Négrier, Y. Dargaud, 2007, Haematologica.

Elimination of contact factor activation improves measurement of platelet‐dependent thrombin generation by calibrated automated thrombography at low‐concentration tissue factor

T. Baglin, Y. Dargaud, R. Luddington, 2006, Journal of thrombosis and haemostasis : JTH.

Platelet‐dependent thrombography: a method for diagnostic laboratories

T. Baglin, Y. Dargaud, R. Luddington, 2006, British journal of haematology.

Major surgery in a severe haemophilia A patient with high titre inhibitor: use of the thrombin generation test in the therapeutic decision

A. Lienhart, S. Meunier, C. Négrier, 2005, Haemophilia : the official journal of the World Federation of Hemophilia.

Use of calibrated automated thrombinography ± thrombomodulin to recognise the prothrombotic phenotype

C. Négrier, Y. Dargaud, J. Ninet, 2006, Thrombosis and Haemostasis.

Activated factor X cleaves factor VIII at arginine 562, limiting its cofactor efficiency

C. Négrier, Y. Dargaud, H. Boukerche, 2010, Journal of thrombosis and haemostasis : JTH.

Towards a recommendation for the standardization of the measurement of platelet‐dependent thrombin generation 1

T. Baglin, N. Key, T. Lecompte, 2011, Journal of thrombosis and haemostasis : JTH.

Response to “Studies on hemostasis in COVID‐19 deserve careful reporting of the laboratory methods, their significance and their limitation”: Don’t throw the baby out with the bathwater

Y. Dargaud, R. Benoit, C. Nougier, 2020, Journal of Thrombosis and Haemostasis.

A case of Glanzmann's thrombasthenia successfully treated with recombinant factor viia during a surgical procedure: observations on the monitoring and the mechanism of action of this drug.

C. Négrier, Y. Dargaud, C. Vinciguerra, 2006, Haematologica.

Inherited bleeding disorder due to familial type 2 platelet cyclo-oxygenase deficiency.

C. Négrier, M. Dechavanne, Y. Dargaud, 2005, Thrombosis research.

Reversal of rivaroxaban anticoagulant effect by prothrombin complex concentrates: which dose is sufficient to restore normal thrombin generation?

Y. Dargaud, H. Desmurs-Clavel, Y. Jourdy, 2020, Thrombosis Journal.

Global haemostasis and point of care testing

C. Négrier, M. Shima, A. Srivastava, 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐COV2 associated thrombosis

L. Argaud, C. Négrier, M. Simon, 2020, Journal of Thrombosis and Haemostasis.

The potential value of thrombin generation assay in the diagnosis of FV inhibitors

A. Lienhart, Y. Dargaud, Y. Jourdy, 2019, International journal of laboratory hematology.

Why patients with THBD c.1611C>A (p.Cys537X) nonsense mutation have high levels of soluble thrombomodulin?

C. Négrier, Y. Dargaud, C. Vinciguerra, 2017, PloS one.

Effect of five therapeutic strategies on the coagulation defect induced by the thrombomodulin c.1611C>A mutation

C. Négrier, Y. Dargaud, C. Hemker, 2015, British journal of haematology.

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.

H. Hemker, J. Scoazec, C. Négrier, 2015, Blood.

Successive bleeding and thrombotic complications in a patient with afibrinogenemia: a case report.

L. Argaud, C. Négrier, Y. Dargaud, 2011, Thrombosis research.

Multiple arterial thromboses in a patient with primary antiphospholipid syndrome receiving a bromocriptine therapy

C. Négrier, Y. Dargaud, J. Ninet, 2004, Lupus.

Haemophilia patients exhibit prolonged coagulation time but normal lag time of thrombin generation test: Are these results really discordant?

C. Négrier, Y. Dargaud, J. Bordet, 2007, Thrombosis and Haemostasis.

Acquired Glanzmann's thrombasthenia associated with acute lymphoblastic leukemia.

Y. Bertrand, Y. Dargaud, V. Jallu, 2005, Journal of pediatric hematology/oncology.

A risk score for the management of pregnant women with increased risk of venous thromboembolism: a multicentre prospective study

C. Négrier, P. Gaucherand, Y. Dargaud, 2009, British journal of haematology.

Management of pregnant women with increased risk of venous thrombosis

C. Négrier, Y. Dargaud, J. Ninet, 2005, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

The potential role of synovial thrombomodulin in the pathophysiology of joint bleeds in haemophilia

O. Guyen, J. Scoazec, T. Baglin, 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

Personalized thromboprophylaxis using a risk score for the management of pregnancies with high risk of thrombosis: a prospective clinical study

P. Gaucherand, Y. Dargaud, J. Ninet, 2017, Journal of thrombosis and haemostasis : JTH.

An unusual clinical presentation of factor XIII deficiency and issues relating to the monitoring of factor XIII replacement therapy

P. de Mazancourt, C. Négrier, P. Gaucherand, 2008, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Human hepatoma cell line HuH-7 is an effective cellular system to produce recombinant factor IX with improved post-translational modifications.

C. Négrier, Y. Dargaud, M. Becchi, 2012, Thrombosis research.

On‐demand treatment of bleeds in haemophilia patients with inhibitors: strategies for securing and maintaining predictable efficacy with recombinant activated factor VII

A. Mumford, S. Pipe, G. Kenet, 2012, Haemophilia : the official journal of the World Federation of Hemophilia.

Mechanisms and monitoring of bypassing agent therapy

Y. Dargaud, M. Hoffman, M. Hoffman, 2012, Journal of thrombosis and haemostasis : JTH.

Use of the thrombin generation test to evaluate response to treatment with recombinant activated factor VII.

A. Lienhart, C. Négrier, Y. Dargaud, 2008, Seminars in hematology.

Combined life-threatening thromboses and hemorrhages in a patient with afibrinogenemia and antithrombin deficiency

Y. Dargaud, L. Mechtouff, F. Farhat, 2018, Thrombosis Journal.

Hemostatic effect of tranexamic acid combined with factor VIII concentrate in prophylactic setting in severe hemophilia A: A preclinical study

C. Leissinger, M. Brevet, Y. Dargaud, 2019, Journal of thrombosis and haemostasis : JTH.

[Acquired factor V deficiency: a rare bleeding disorder with variable clinical presentations].

Y. Dargaud, S. Ducastelle, L. Rugeri, 2011, La Revue de medecine interne.

Direct Oral Anticoagulants for the Treatment of Cerebral Venous Thrombosis

L. Bertoletti, A. Lurkin, P. Mismetti, 2019, Cerebrovascular Diseases.

Eltrombopag for the Treatment of Severe Inherited Thrombocytopenia

R. Favier, Y. Dargaud, P. Ballerini, 2020, Acta Haematologica.

Recombinant porcine factor VIII corrects thrombin generation in vitro in plasma from patients with congenital hemophilia A and inhibitors

C. Négrier, S. Meeks, G. Kenet, 2022, Research and practice in thrombosis and haemostasis.

Pharmacokinetics for haemophilia treaters: Meaning of PK parameters, interpretation pitfalls, and use in the clinic.

Y. Dargaud, X. Delavenne, 2020, Thrombosis research.

Endogenous thrombin potential, prothrombin fragment 1+2 and D-dimers during pregnancy

C. Négrier, P. Gaucherand, Y. Dargaud, 2009, Thrombosis and Haemostasis.

Achievements, challenges and unmet needs for haemophilia patients with inhibitors

D. Scott, David Steven Scott, S. Lacroix-Desmazes, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

Seventy‐two total knee arthroplasties performed in patients with haemophilia using continuous infusion

A. Lienhart, C. Négrier, Y. Dargaud, 2013, Vox sanguinis.

In vivo efficacy of human recombinant factor IX produced by the human hepatoma cell line HuH‐7

C. Négrier, Y. Dargaud, E. Perot, 2015, Haemophilia.

Thrombin generation and whole blood viscoelastic assays in the management of hemophilia: current state of art and future perspectives.

Guy Young, C. Négrier, N. Key, 2013, Blood.

Basic aspects of bypassing agents

C. Négrier, Y. Dargaud, J. Bordet, 2006, Haemophilia : the official journal of the World Federation of Hemophilia.

Spontaneous proximal deep vein thrombosis in a patient with severe haemophilia A.

A. Lienhart, C. Négrier, Y. Dargaud, 2003, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B

H. Hemker, R. al Dieri, S. Béguin, 2005, Thrombosis and Haemostasis.

Individualized PK‐based prophylaxis in severe haemophilia

S. Meunier, P. Mismetti, D. Hart, 2018, Haemophilia : the official journal of the World Federation of Hemophilia.

The second Team Haemophilia Education Meeting, 2016, Frankfurt, Germany

L. Mantovani, J. Blatny, D. Perry, 2017, European journal of haematology.

Clinical Utility of Subcutaneous Factor VIII Replacement Therapies in Hemophilia A: A Review of the Evidence

Y. Dargaud, M. Janbain, 2021, Journal of blood medicine.

New developments in laboratory diagnosis and monitoring

C. Négrier, S. Kitchen, Y. Dargaud, 2010, Haemophilia : the official journal of the World Federation of Hemophilia.

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH

H. Hemker, C. Négrier, A. Wolberg, 2017, Journal of thrombosis and haemostasis : JTH.

Haemostatic effect of adding tranexamic acid to emicizumab prophylaxis in severe haemophilia A: A preclinical study

M. Brevet, Y. Dargaud, R. Bolbos, 2021, Haemophilia : the official journal of the World Federation of Hemophilia.

Recombinant porcine factor VIII: Lessons from the past and place in the management of hemophilia A with inhibitors in 2021

C. Escuriola-Ettingshausen, Y. Dargaud, 2021, Research and practice in thrombosis and haemostasis.

Recombinant Adeno-Associated Viral Vectors Expressing Human Coagulation FIX-E456H Variant in Hemophilia B Mice

C. Négrier, Y. Dargaud, F. Mingozzi, 2019, Thrombosis and Haemostasis.

Effectiveness of individualized management using WILFACTIN® in patients with von Willebrand disease during surgical procedures: A single-center study.

Y. Dargaud, L. Rugeri, R. Benoit, 2022, Thrombosis research.

Report of surgeries, their outcome and the thrombin generation assay in patients with Factor XI deficiency: A retrospective single‐centre study

A. Lienhart, S. Meunier, C. Négrier, 2022, Haemophilia : the official journal of the World Federation of Hemophilia.

Use of thrombin generation assay to personalize treatment of breakthrough bleeds in a patient with hemophilia and inhibitors receiving prophylaxis with emicizumab

A. Lienhart, C. Négrier, Y. Dargaud, 2018, Haematologica.

Genotyping might help therapeutic decision‐making in patients with von Willebrand disease type 2 B

Y. Dargaud, C. Vinciguerra, L. Rugeri, 2016, Haemophilia : the official journal of the World Federation of Hemophilia.

A single‐centre study of management of pregnant women with von Willebrand disease

A. Lienhart, S. Meunier, Y. Dargaud, 2019, Haemophilia : the official journal of the World Federation of Hemophilia.

Development of simple and rapid method for Emicizumab quantification by LC-MS/MS in human plasma

Y. Dargaud, X. Delavenne, S. Hodin, 2022, Journal of Pharmaceutical and Biomedical Analysis.

Increased blood viscosity and red blood cell aggregation in patients with COVID‐19

Y. Bertrand, P. Joly, Y. Dargaud, 2021, American journal of hematology.

Feasibility of an easy-to-use risk score in the prevention of venous thromboembolism and placental vascular complications in pregnant women. A rebuttal.

C. Négrier, Y. Dargaud, J. Ninet, 2008, Thrombosis research.

ix recombinant factor production in a human hepatocyte cell line

C. Négrier, Y. Dargaud, N. Enjolras, 2009 .

Pregnancy and thrombosis: Adrenal vein thrombosis. A retrospective descriptive study of 14 cases.

M. Doret, P. Gaucherand, Y. Dargaud, 2019, European journal of obstetrics, gynecology, and reproductive biology.

Arterial and venous thromboembolism in COVID-19: a study-level meta-analysis

L. Bertoletti, A. Friggeri, S. Provencher, 2021, Thorax.

Y. Dargaud, L. Rugeri, M. Doret‐Dion, 2019, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

H. Hemker, Y. Dargaud, M. Ninivaggi, 2012, Clinical chemistry.

Comparison of current platelet functional tests for the assessment of aspirin and clopidogrel response

C. Négrier, Y. Dargaud, J. Bordet, 2016, Thrombosis and Haemostasis.

Effects of a Maximal Exercise Followed by a Submaximal Exercise Performed in Normobaric Hypoxia (2500 m), on Blood Rheology, Red Blood Cell Senescence, and Coagulation in Well-Trained Cyclists

P. Joly, Y. Dargaud, P. Connes, 2023, Metabolites.

Characterisation of 96 mutations in 128 unrelated severe haemophilia A patients from France

C. Berger, C. Négrier, C. Zawadzki, 2006, Thrombosis and Haemostasis.

Thrombin generation and implications for hemophilia therapies: A narrative review

G. Kenet, R. Sidonio, Y. Dargaud, 2022, Research and practice in thrombosis and haemostasis.

Increased retention of functional mitochondria in mature sickle red blood cells is associated with increased sickling tendency, hemolysis and oxidative stress

D. Roussel, P. Joly, Y. Dargaud, 2023, Haematologica.

Whole F8 gene sequencing combined with splicing functional analyses led to a substantial increase of the molecular diagnosis yield for non‐severe haemophilia A

S. Castet, Y. Huguenin, C. Zawadzki, 2023, Haemophilia : the official journal of the World Federation of Hemophilia.

Evaluation of the Care Pathway in the Context of the Dispensing of Emicizumab (Hemlibra) in Community Pharmacies in France: Protocol for a Cross-sectional Study Based on the Kirkpatrick Model

Y. Dargaud, J. Freyssenge, V. Chamouard, 2022, JMIR research protocols.

Study of the relationship between the suprascapular artery and the brachial plexus

Y. Dargaud, T. Quesnel, J. Dargaud, 2002, Surgical and Radiologic Anatomy.

Comparison of the capacities of two prothrombin complex concentrates to restore thrombin generation in plasma from orally anticoagulated patients: an in vitro study

C. Négrier, Y. Dargaud, J. Bordet, 2008, Journal of thrombosis and haemostasis : JTH.

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.

C. Négrier, Y. Dargaud, T. Lindhout, 2015, Blood.

Characterization of a recombinant factor IX molecule fused to coagulation factor XIII‐B subunit

Sneha Singh, A. Wolberg, Y. Dargaud, 2023, Haemophilia : the official journal of the World Federation of Hemophilia.

A focus on dominant negative variants in a series of 170 heterozygous FXI‐deficient patients

P. de Mazancourt, C. Biron-Andréani, E. de Raucourt, 2023, Haemophilia : the official journal of the World Federation of Hemophilia.

Reinvestigation of unidentified causative variants in FXI‐deficient patients: Focus on gene segment deletions

P. de Mazancourt, A. Harroche, S. Castet, 2022, Haemophilia : the official journal of the World Federation of Hemophilia.