K. V. van Meijgaarden

T. Ottenhoff, L. Kroft, C. Prins, 2018, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults

T. Ottenhoff, C. Prins, K. V. van Meijgaarden, 2015, Clinical and Vaccine Immunology.

A multistage-polyepitope vaccine protects against Mycobacterium tuberculosis infection in HLA-DR3 transgenic mice.

T. Ottenhoff, S. V. D. van den Eeden, K. Franken, 2012, Vaccine.

Functional analysis of DR17(DR3)-restricted mycobacterial T cell epitopes reveals DR17-binding motif and enables the design of allele-specific competitor peptides.

J. Drijfhout, T. Ottenhoff, A. Geluk, 1992, Journal of immunology.

Host biomarker-based quantitative rapid tests for detection and treatment monitoring of tuberculosis and COVID-19

Elisa M. Tjon Kon Fat, J. Goeman, R. Tsonaka, 2022, iScience.

Identification of Human T-Cell Responses to Mycobacterium tuberculosis Resuscitation-Promoting Factors in Long-Term Latently Infected Individuals

J. Drijfhout, T. Ottenhoff, A. Geluk, 2011, Clinical and Vaccine Immunology.

Immunological Crossreactivity of the Mycobacterium leprae CFP‐10 with its Homologue in Mycobacterium tuberculosis

T. Ottenhoff, K. Franken, A. Geluk, 2004, Scandinavian journal of immunology.

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment

T. Ottenhoff, H. Smits, K. V. van Meijgaarden, 2016, PLoS pathogens.

Clip binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs.

J. Drijfhout, A. Geluk, K. V. van Meijgaarden, 1995, Molecular immunology.

T cell receptor and peptide‐contacting residues in the HLA‐DR17(3) β1 chain

R. Karr, T. Ottenhoff, A. Geluk, 1994 .

Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent.

J. Drijfhout, T. Ottenhoff, K. Franken, 2000, Protein expression and purification.

Identification of a conserved universal Th epitope in HIV-1 reverse transcriptase that is processed and presented to HIV-specific CD4+ T cells by at least four unrelated HLA-DR molecules.

S. H. van der Burg, R. Offringa, J. Drijfhout, 1999, Journal of immunology.

Modulation of the Major Histocompatibility Complex Class II–Associated Peptide Repertoire by Human Histocompatibility Leukocyte Antigen (Hla)-Do

Jacques Neefjes, John Trowsdale, J. Trowsdale, 2000, The Journal of experimental medicine.

Clonal Analysis of the T-Cell Response to In Vivo Expressed Mycobacterium tuberculosis Protein Rv2034, Using a CD154 Expression Based T-Cell Cloning Method

T. Ottenhoff, S. V. D. van den Eeden, L. Wilson, 2014, PloS one.

Evolutionary conservation of major histocompatibility complex- DR/peptide/T cell interactions in primates

R. Bontrop, T. Ottenhoff, A. Geluk, 1993, The Journal of experimental medicine.

Cell-Mediated Immune Responses to in vivo-Expressed and Stage-Specific Mycobacterium tuberculosis Antigens in Latent and Active Tuberculosis Across Different Age Groups

T. Ottenhoff, K. Franken, A. Geluk, 2020, Frontiers in Immunology.

Mycobacterium tuberculosis Peptides Presented by HLA-E Molecules Are Targets for Human CD8+ T-Cells with Cytotoxic as well as Regulatory Activity

Darren R. Flower, Tom H. M. Ottenhoff, Annemieke Geluk, 2010, PLoS pathogens.

Differences in IgG responses against infection phase related Mycobacterium tuberculosis (Mtb) specific antigens in individuals exposed or not to Mtb correlate with control of TB infection and progression.

T. Ottenhoff, A. Geluk, K. V. van Meijgaarden, 2017, Tuberculosis.

Postgenomic Approach To Identify Novel Mycobacterium leprae Antigens with Potential To Improve Immunodiagnosis of Infection

T. Ottenhoff, E. Sampaio, P. Klatser, 2005, Infection and Immunity.

Longitudinal Immune Responses and Gene Expression Profiles in Type 1 Leprosy Reactions

T. Ottenhoff, T. Ottenhoff, S. V. D. van den Eeden, 2014, Journal of Clinical Immunology.

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.

J. M. van der Hulst, S. H. van der Burg, G. Kenter, 2002, Cancer research.

Human CD8+ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, Multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset

T. Ottenhoff, F. Dieli, K. V. van Meijgaarden, 2015, PLoS pathogens.

HLA-DR3 molecules can bind peptides carrying two alternative specific submotifs.

C Oseroff, A Sette, A. Sette, 1994, Journal of immunology.

Genome-Based In Silico Identification of New Mycobacterium tuberculosis Antigens Activating Polyfunctional CD8+ T Cells in Human Tuberculosis

Ole Lund, Ugur Sahin, Søren Buus, 2011, The Journal of Immunology.

T cell receptor repertoires associated with control and disease progression following Mycobacterium tuberculosis infection

G. Schoolnik, F. Miedema, D. Tabb, 2023, Nature Medicine.

Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis.

Gerrit Borchard, Annemieke Geluk, Tom H M Ottenhoff, 2004, Vaccine.

Intracellular Cytokine Staining and Flow Cytometry: Considerations for Application in Clinical Trials of Novel Tuberculosis Vaccines

Tom H. M. Ottenhoff, Hazel M. Dockrell, F. Mascart, 2015, PloS one.

Identification of HLA-E Binding Mycobacterium tuberculosis–Derived Epitopes through Improved Prediction Models

T. Abeel, T. Ottenhoff, K. Franken, 2022, The Journal of Immunology.

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

O. Lund, G. Schoolnik, T. Ottenhoff, 2016, Scientific Reports.

Innovative Strategies to Identify M. tuberculosis Antigens and Epitopes Using Genome-Wide Analyses

T. Ottenhoff, A. Geluk, K. V. van Meijgaarden, 2014, Front. Immunol..

Peptide Binding to HLA-E Molecules in Humans, Nonhuman Primates, and Mice Reveals Unique Binding Peptides but Remarkably Conserved Anchor Residues

T. Ottenhoff, K. V. van Meijgaarden, K. Franken, 2020, The Journal of Immunology.

Extensive flow cytometric immunophenotyping of human PBMC incorporating detection of chemokine receptors, cytokines and tetramers

T. Ottenhoff, K. V. van Meijgaarden, S. Joosten, 2023, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Natural T‐helper immunity against human papillomavirus type 16 (hpv16) e7–derived peptide epitopes in patients with hpv16‐positive cervical lesions: Identification of 3 human leukocyte antigen class ii–restricted epitopes

S. H. van der Burg, G. Fleuren, G. Kenter, 2001, International journal of cancer.

A DR17‐restricted T cell epitope from a secreted Mycobacterium tuberculosis antigen only binds to DR17 molecules at neutral pH

A. Sette, T. Ottenhoff, A. Geluk, 1997, European journal of immunology.

Antigenic Equivalence of Human T-Cell Responses toMycobacterium tuberculosis-Specific RD1-Encoded Protein Antigens ESAT-6 and Culture Filtrate Protein 10 and to Mixtures of Synthetic Peptides

T. Ottenhoff, P. Andersen, A. Geluk, 2000, Infection and Immunity.

Double‐ and monofunctional CD4+ and CD8+ T‐cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long‐term latently infected individuals

J. Drijfhout, T. Ottenhoff, K. Franken, 2011, European journal of immunology.

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.

T. Ottenhoff, S. V. D. van den Eeden, L. Wilson, 2014, Vaccine.

Definition of natural T cell antigens with mimicry epitopes obtained from dedicated synthetic peptide libraries.

J. Leunissen, T. Ottenhoff, A. Geluk, 1998, Journal of immunology.

Detection of active tuberculosis infection by T cell responses to early-secreted antigenic target 6-kDa protein and culture filtrate protein 10.

T. Ottenhoff, P. Andersen, K. V. van Meijgaarden, 2000, The Journal of infectious diseases.

KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults.

T. Ottenhoff, C. Prins, K. V. van Meijgaarden, 2016, Tuberculosis.

Inflammatory responses in SARS-CoV-2 associated Multisystem Inflammatory Syndrome and Kawasaki Disease in children: An observational study

T. Ottenhoff, G. Biesbroek, P. Hombrink, 2022, PloS one.

Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis

Greg Finak, T. Ottenhoff, S. D. De Rosa, 2017, Scientific Reports.

Cross-Reactive Immunity to Mycobacterium tuberculosis DosR Regulon-Encoded Antigens in Individuals Infected with Environmental, Nontuberculous Mycobacteria

G. Schoolnik, T. Ottenhoff, K. Franken, 2009, Infection and Immunity.

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

Daniel E. Zak, D. Zak, G. Schoolnik, 2020, Scientific Reports.

Cross-laboratory evaluation of multiplex bead assays including independent common reference standards for immunological monitoring of observational and interventional human studies

Krista E. van Meijgaarden, Bhagwati Khatri, Steven G. Smith, 2018, PloS one.

Identification and Characterization of the ESAT-6 Homologue of Mycobacterium leprae and T-Cell Cross-Reactivity with Mycobacterium tuberculosis

T. Ottenhoff, E. Sampaio, T. de Boer, 2002, Infection and Immunity.

HLA-DR binding analysis of peptides from islet antigens in IDDM.

J. Drijfhout, A. Geluk, B. Roep, 1998, Diabetes.

Tuberculin skin testing and in vitro T cell responses to ESAT-6 and culture filtrate protein 10 after infection with Mycobacterium marinum or M. kansasii.

T. Ottenhoff, D. van Soolingen, K. V. van Meijgaarden, 2002, The Journal of infectious diseases.

Identification of circulating monocytes as producers of tuberculosis disease biomarker C1q

L. Trouw, T. Ottenhoff, A. Pollard, 2023, Scientific reports.

Biomarkers to identify Mycobacterium tuberculosis infection among borderline QuantiFERON results

T. Ottenhoff, J. Bakker, J. Kerremans, 2022, European Respiratory Journal.

A single-cell view on host immune transcriptional response to in vivo BCG-induced trained immunity

L. Joosten, Jianbo Fu, K. V. van Meijgaarden, 2023, Cell reports.

Enhancing Sensitivity of Detection of Immune Responses to Mycobacterium leprae Peptides in Whole-Blood Assays

Tom H. M. Ottenhoff, Annemieke Geluk, J. Drijfhout, 2010, Clinical and Vaccine Immunology.

New Genome-Wide Algorithm Identifies Novel In-Vivo Expressed Mycobacterium Tuberculosis Antigens Inducing Human T-Cell Responses with Classical and Unconventional Cytokine Profiles

O. Lund, G. Schoolnik, T. Ottenhoff, 2016, Scientific Reports.

Analysis of Immune Responses against a Wide Range of Mycobacterium tuberculosis Antigens in Patients with Active Pulmonary Tuberculosis

T. Ottenhoff, D. van Baarle, K. Franken, 2012, Clinical and Vaccine Immunology.

BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways

T. Ottenhoff, K. V. van Meijgaarden, S. Joosten, 2023, iScience.

C-Terminal PEGylation Improves SAAP-148 Peptide’s Immunomodulatory Activities

J. Drijfhout, P. Nibbering, K. V. van Meijgaarden, 2023, Journal of Innate Immunity.

BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination

L. Joosten, T. Ottenhoff, K. V. van Meijgaarden, 2024, Nature communications.

Longitudinal soluble marker profiles reveal strong association between cytokine storms resulting from macrophage activation and disease severity in COVID-19 disease

J. Goeman, M. Feltkamp, L. Trouw, 2024, Scientific reports.

Cationic pH-sensitive liposome-based subunit tuberculosis vaccine induces protection in mice challenged with Mycobacterium tuberculosis.

S. V. D. van den Eeden, A. Geluk, K. V. van Meijgaarden, 2024, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Intrinsic immunogenicity of liposomes for tuberculosis vaccines: effect of cationic lipid and cholesterol.

A. Geluk, K. V. van Meijgaarden, T. Ottenhoff, 2024, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.