M. Beullens

发表

Functions and therapeutic potential of protein phosphatase 1: Insights from mouse genetics

M. Bollen, Monica Ferreira, M. Beullens, 2018, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research.

Overexpression of PP1–NIPP1 limits the capacity of cells to repair DNA double-strand breaks

M. Bollen, R. Rouget, M. Beullens, 2018, Journal of Cell Science.

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint.

M. Bollen, J. Qian, L. Gelens, 2017, Molecular cell.

Nucleocytoplasmic Shuttling of the Splicing Factor SIPP1*

M. Llorian, M. Bollen, Bart Lesage, 2005, Journal of Biological Chemistry.

The KH-Tudor domain of a-kinase anchoring protein 149 mediates RNA-dependent self-association.

M. Bollen, P. Collas, M. Beullens, 2006, Biochemistry.

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

Tatiana Ammosova, S. Nekhai, M. Bollen, 2011, PloS one.

Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription*

Tatiana Ammosova, S. Nekhai, M. Bollen, 2010, The Journal of Biological Chemistry.

A SERCA2 pump with an increased Ca2+ affinity can lead to severe cardiac hypertrophy, stress intolerance and reduced life span.

P. Carmeliet, K. Sipido, E. Kranias, 2006, Journal of molecular and cellular cardiology.

Inhibitor‐3 ensures bipolar mitotic spindle attachment by limiting association of SDS22 with kinetochore‐bound protein phosphatase‐1

M. Bollen, Bart Lesage, A. Musacchio, 2014, The EMBO journal.

Determinants of the nucleolar targeting of protein phosphatase‐1

M. Bollen, Bart Lesage, H. Ceulemans, 2005, FEBS letters.

Interactor-mediated Nuclear Translocation and Retention of Protein Phosphatase-1*

M. Bollen, Bart Lesage, M. Beullens, 2004, Journal of Biological Chemistry.

Methylation of PITX2, HOXD3, RASSF1 and TDRD1 predicts biochemical recurrence in high-risk prostate cancer

O. Gevaert, K. Haustermans, M. Bollen, 2014, Journal of Cancer Research and Clinical Oncology.

Maternal embryonic leucine zipper kinase (MELK) reduces replication stress in glioblastoma cells.

M. Bollen, D. Brehmer, M. Beullens, 2013, The Journal of Biological Chemistry.

Identification of MYPT1 and NIPP1 as subunits of protein phosphatase 1 in rat liver cytosol

M. Bollen, E. Waelkens, M. Beullens, 1999, FEBS letters.

The translation initiation factor eIF2β is an interactor of protein phosphatase-1

M. Bollen, H. Ceulemans, M. Beullens, 2006 .

Nuclear and subnuclear targeting sequences of the protein phosphatase-1 regulator NIPP1.

M. Bollen, M. Beullens, A. Van Eynde, 2000, Journal of cell science.

Split‐BioID: a proximity biotinylation assay for dimerization‐dependent protein interactions

M. Bollen, Bart Lesage, J. Qian, 2017, FEBS letters.

The PP1‐R6 protein phosphatase holoenzyme is involved in the glucose‐induced dephosphorylation and inactivation of AMP‐activated protein kinase, a key regulator of insulin secretion, in MIN6 β cells

M. Bollen, D. Neumann, M. Beullens, 2010, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The PP 1R 6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase , a key regulator of insulin secretion , in MIN 6 cells

M. Bollen, D. Neumann, M. Beullens, 2010 .

Glucose-induced Trehalase Activation and Trehalose Mobilization Early Germination of Phycomyces blizkesleeanus Spores

J. Thevelein, M. Beullens, A. Laere, 2008 .

Glucose-induced Trehalase Activation and Trehalose Mobilization during Early Germination of Phycomyces blakesleeanus Spores

J. Thevelein, M. Beullens, J. V. Assche, 1983 .

Testing for recombinant erythropoietin

M. Bollen, J. Delanghe, M. Beullens, 2008, American journal of hematology.

Microsoft Word-01062013 manuscript2

M. Bollen, D. Brehmer, M. Beullens, 2013 .

Inhibition of Spliceosome Assembly by the Cell Cycle-regulated Protein Kinase MELK and Involvement of Splicing Factor NIPP1*

M. Bollen, M. Rider, M. Beullens, 2004, Journal of Biological Chemistry.

Functional interaction between nuclear inhibitor of protein phosphatase type 1 (NIPP1) and protein phosphatase type 1 (PP1) in Drosophila: consequences of over-expression of NIPP1 in flies and suppression by co-expression of PP1.

M. Bollen, L. Alphey, D. Bennett, 2002, The Biochemical journal.

Properties and Phosphorylation Sites of Baculovirus-expressed Nuclear Inhibitor of Protein Phosphatase-1 (NIPP-1)*

M. Bollen, E. Waelkens, M. Beullens, 1997, The Journal of Biological Chemistry.

Full activation of a nuclear species of protein phosphatase-1 by phosphorylation with protein kinase A and casein kinase-2.

M. Bollen, M. Beullens, A. Van Eynde, 1994, The Biochemical journal.

The isolation of novel inhibitory polypeptides of protein phosphatase 1 from bovine thymus nuclei.

M. Bollen, M. Beullens, A. Van Eynde, 1992, The Journal of biological chemistry.

The molecular basis for substrate specificity of the nuclear NIPP1:PP1 holoenzyme.

M. Bollen, W. Peti, R. Page, 2012, Structure.

Characterization of the Condensin Component Cnap1 and Protein Kinase Melk as Novel E2F Target Genes Down-regulated by 1,25-Dihydroxyvitamin D3*

B. De Moor, K. Marchal, M. Bollen, 2005, Journal of Biological Chemistry.

Regulation of protein phosphatase 1γ activity in hypoxia through increased interaction with NIPP1: Implications for cellular metabolism

M. Bollen, M. Leonard, E. Cummins, 2006, Journal of cellular physiology.

Characterization of Novel Nuclear Inhibitors of Protein Phosphatase — 1

M. Bollen, M. Beullens, A. V. Eynde, 1993 .

Nature of the nuclear inclusions formed by PQBP1, a protein linked to neurodegenerative polyglutamine diseases.

M. Bollen, Bart Lesage, M. Beullens, 2008, European journal of cell biology.

The Nuclear Scaffold Protein NIPP1 Is Essential for Early Embryonic Development and Cell Proliferation

P. Carmeliet, M. Bollen, L. Moons, 2004, Molecular and Cellular Biology.

Investigation of transport-associated phosphorylation of sugar in yeast mutants (snf3) lacking high-affinity glucose transport and in a mutant (fdp1) showing deficient regulation of initial sugar metabolism

J. Thevelein, M. Beullens, 2005, Current Microbiology.

A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3.

M. Bollen, Bart Lesage, E. Waelkens, 2007, Biochemistry.

NIPP1-mediated Interaction of Protein Phosphatase-1 with CDC5L, a Regulator of Pre-mRNA Splicing and Mitotic Entry*

A. Krainer, M. Bollen, P. Groenen, 2000, The Journal of Biological Chemistry.

AKAP149 is a novel PP1 specifier required to maintain nuclear envelope integrity in G1 phase

M. Bollen, P. Collas, M. Beullens, 2003, Journal of Cell Science.

Subunit Structure and Regulation of Protein Phosphatase-1 in Rat Liver Nuclei (*)

M. Bollen, M. Beullens, W. Stalmans, 1995, The Journal of Biological Chemistry.

Characterization of a ribosomal inhibitory polypeptide of protein phosphatase-1 from rat liver.

M. Bollen, M. Beullens, W. Stalmans, 1996, European journal of biochemistry.

SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.

M. Llorian, M. Bollen, M. Beullens, 2004, The Biochemical journal.

SIPP 1 , a novel pre-mRNA splicing factor and interactor of protein phosphatase-1

M. Llorian, M. Bollen, M. Beullens, 2004 .

NIPP-1, a Nuclear Inhibitory Subunit of Protein Phosphatase-1, Has RNA-binding Properties*

M. Bollen, M. Beullens, W. Stalmans, 1997, The Journal of Biological Chemistry.

Identification of sds22 as an inhibitory subunit of protein phosphatase‐1 in rat liver nuclei

M. Bollen, A. Dinischiotu, M. Beullens, 1997, FEBS letters.

Synthesis and Characterization of Pseudocantharidins, Novel Phosphatase Modulators That Promote the Inclusion of Exon 7 into the SMN (Survival of Motoneuron) pre-mRNA*

S. Stamm, M. Bollen, H. Urlaub, 2011, The Journal of Biological Chemistry.

Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: the glucose-induced cAMP signal is not mediated by a transient drop in the intracellular pH.

J. Thevelein, M. Beullens, A. Jans, 1987, Journal of general microbiology.

Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: intracellular pH and the effect of membrane depolarizing compounds.

J. Thevelein, M. Beullens, A. Jans, 1987, Journal of general microbiology.

CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

Tatiana Ammosova, S. Nekhai, F. Kashanchi, 2012, Retrovirology.

Cyclic AMP and the stimulation of trehalase activity in the yeast Saccharomyces cerevisiae by carbon sources, nitrogen sources and inhibitors of protein synthesis.

J. Thevelein, M. Beullens, 1985, Journal of general microbiology.

Nuclear Inhibitor of Protein Phosphatase-1 (NIPP1) Directs Protein Phosphatase-1 (PP1) to Dephosphorylate the U2 Small Nuclear Ribonucleoprotein Particle (snRNP) Component, Spliceosome-associated Protein 155 (Sap155)*

M. Bollen, N. Tanuma, H. Shima, 2008, Journal of Biological Chemistry.

MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

Kaushal Joshi, I. Nakano, Sung-Hak Kim, 2013, Stem cells.

CANCER STEM CELLS MELK-Dependent FOXM1 Phosphorylation is Essential for Proliferation of Glioma Stem Cells

Kaushal Joshi, I. Nakano, Sung-Hak Kim, 2013 .

Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1.

M. Bollen, H. Ceulemans, M. Beullens, 1999, European journal of biochemistry.

The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing

M. Bollen, H. Ceulemans, P. Hummelen, 2008, Oncogene.

The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.

M. Bollen, H. Ceulemans, D. Oxley, 2012, The Biochemical journal.

The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2

M. Bollen, M. Beullens, A. V. Eynde, 2007, Oncogene.

MELK—a conserved kinase: functions, signaling, cancer, and controversy

I. Nakano, H. Kornblum, Ahmed Mohyeldin, 2015, Clinical and Translational Medicine.

Irradiation of necrotic cancer cells, employed for pulsing dendritic cells (DCs), potentiates DC vaccine-induced antitumor immunity against high-grade glioma

P. Agostinis, S. V. Van Gool, Abhishek D Garg, 2015, Oncoimmunology.

Molecular Cloning of NIPP-1, a Nuclear Inhibitor of Protein Phosphatase-1, Reveals Homology with Polypeptides Involved in RNA Processing (*)

M. Bollen, M. Beullens, W. Stalmans, 1995, The Journal of Biological Chemistry.

Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae

J. Thevelein, M. Beullens, L. Geerts, 1988, Molecular and cellular biology.

Chemical activators of protein phosphatase-1 induce calcium release inside intact cells.

M. Bollen, M. Köhn, J. Chatterjee, 2013, Chemistry & biology.

Phosphorylation, Subcellular Localization, and Membrane Orientation of the Alzheimer's Disease-associated Presenilins*

P. S. St George-Hyslop, B. de Strooper, M. Bollen, 1997, The Journal of Biological Chemistry.

The transcription factor ERG recruits CCR4–NOT to control mRNA decay and mitotic progression

M. Vidal, N. Simonis, F. Dequiedt, 2016, Nature Structural &Molecular Biology.

Nuclear Protein Phosphatase-1 Regulates HIV-1 Transcription*

Sergei Nekhai, Ajit Kumar, S. Nekhai, 2003, Journal of Biological Chemistry.

Y65C Missense Mutation in the WW Domain of the Golabi-Ito-Hall Syndrome Protein PQBP1 Affects Its Binding Activity and Deregulates Pre-mRNA Splicing*

Annalisa Pastore, Rudolf Volkmer, Marius Sudol, 2010, The Journal of Biological Chemistry.

Phosphorylation-dependent Interaction between the Splicing Factors SAP155 and NIPP1*

M. Bollen, E. Waelkens, M. Beullens, 2002, Journal of Biological Chemistry.

The Protein Phosphatase-1 Regulator NIPP1 Is Also a Splicing Factor Involved in a Late Step of Spliceosome Assembly*

M. Bollen, M. Beullens, 2002, The Journal of Biological Chemistry.

C 6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1

Manjula., Sunkara, S. Stamm, 2019 .

The Protein Phosphatase-1 (PP1) Regulator, Nuclear Inhibitor of PP1 (NIPP1), Interacts with the Polycomb Group Protein, Embryonic Ectoderm Development (EED), and Functions as a Transcriptional Repressor*

M. Bollen, M. Beullens, A. Van Eynde, 2003, Journal of Biological Chemistry.

Maternal Embryonic Leucine Zipper Kinase (MELK) Reduces Replication Stress in Glioblastoma Cells*

M. Bollen, D. Brehmer, M. Beullens, 2013, The Journal of Biological Chemistry.

PPP1R8 (protein phosphatase 1, regulatory (inhibitor) subunit 8)

M. Bollen, M. Beullens, Nikki Minnebo, 2012 .

The extended PP1 toolkit: designed to create specificity.

M. Bollen, W. Peti, M. Beullens, 2010, Trends in biochemical sciences.

The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets

M. Bollen, N. Tanuma, H. Shima, 2010, Nucleic acids research.

Docking motif-guided mapping of the interactome of protein phosphatase-1.

M. Bollen, Bart Lesage, H. Ceulemans, 2009, Chemistry & biology.

The C-terminus of NIPP1 (nuclear inhibitor of protein phosphatase-1) contains a novel binding site for protein phosphatase-1 that is controlled by tyrosine phosphorylation and RNA binding.

M. Bollen, M. Beullens, A. Van Eynde, 2000, The Biochemical journal.

Mapping of the RNA-binding and endoribonuclease domains of NIPP1, a nuclear targeting subunit of protein phosphatase 1.

M. Bollen, M. Beullens, A. Van Eynde, 1999, The Biochemical journal.

Molecular Determinants of Nuclear Protein Phosphatase-1 Regulation by NIPP-1*

S. Shenolikar, M. Bollen, M. Beullens, 1999, The Journal of Biological Chemistry.

Inactivation of nuclear inhibitory polypeptides of protein phosphatase-1 (NIPP-1) by protein kinase A.

M. Bollen, M. Beullens, A. Van Eynde, 1993, The Journal of biological chemistry.

NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes

M. Bollen, W. Peti, R. Page, 2012, Nucleic acids research.

Structure-Guided Exploration of SDS22 Interactions with Protein Phosphatase PP1 and the Splicing Factor BCLAF1.

Rebecca Page, Luc Van Meervelt, Rita Derua, 2019, Structure.

Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase‐1

J. Sikela, M. Bollen, M. Beullens, 1995, FEBS letters.

MELK-T1, a small-molecule inhibitor of protein kinase MELK, decreases DNA-damage tolerance in proliferating cancer cells

M. Bollen, D. Brehmer, M. Paradé, 2015, Bioscience reports.

Substrate Specificity and Activity Regulation of Protein Kinase MELK*

M. Bollen, H. Ceulemans, N. Morrice, 2005, Journal of Biological Chemistry.

Protein Phosphatase 1 Regulates the Histone Code for Long-Term Memory

M. Bollen, K. Koshibu, I. Mansuy, 2009, The Journal of Neuroscience.

Genome-wide promoter binding profiling of protein phosphatase-1 and its major nuclear targeting subunits

M. Bollen, M. Beullens, A. Van Eynde, 2015, Nucleic acids research.

Aurora B Defines Its Own Chromosomal Targeting by Opposing the Recruitment of the Phosphatase Scaffold Repo-Man

M. Bollen, Bart Lesage, J. Qian, 2013, Current Biology.

The PP1 binding code: a molecular‐lego strategy that governs specificity

M. Bollen, Bart Lesage, M. Beullens, 2013, The FEBS journal.

Nuclear Targeting of Protein Phosphatase-1 by HIV-1 Tat Protein*

S. Nekhai, F. Kashanchi, M. Bollen, 2005, Journal of Biological Chemistry.

Protein Phosphatase-1 Dephosphorylates the C-terminal Domain of RNA Polymerase-II*

S. Nekhai, M. Bollen, Ajit Kumar, 2002, The Journal of Biological Chemistry.

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth

M. Bollen, Bart Lesage, M. Beullens, 2015, Journal of Cell Science.

Structure and Function of the Two Tandem WW Domains of the Pre-mRNA Splicing Factor FBP21 (Formin-binding Protein 21)*

Jiahai Zhang, Yi Zhou, M. Bollen, 2009, The Journal of Biological Chemistry.

Degeneracy and Function of the Ubiquitous RVXF Motif That Mediates Binding to Protein Phosphatase-1*

M. Bollen, H. Ceulemans, M. Beullens, 2003, Journal of Biological Chemistry.

Studies on the mechanism of the glucose-induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae.

J M Thevelein, J. Thevelein, M. Beullens, 1988, European journal of biochemistry.

Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch

M. Bollen, Bart Lesage, J. Qian, 2015, Nature Communications.

Metals in the active site of native protein phosphatase-1.

M. Bollen, S. De Gendt, M. Beullens, 2015, Journal of inorganic biochemistry.

Signaling by protein phosphatases in the nucleus.

M. Bollen, M. Beullens, 2002, Trends in cell biology.

AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase.

B. Viollet, D. Vertommen, M. Foretz, 2012, The Biochemical journal.

A Role for PP1/NIPP1 in Steering Migration of Human Cancer Cells

J. Forrester, M. Bollen, A. Prescott, 2012, PloS one.

Glucose‐dependent regulation of AMP‐activated protein kinase in MIN6 beta cells is not affected by the protein kinase A pathway

M. Bollen, D. Neumann, M. Beullens, 2012, FEBS letters.

Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic beta-cells.

M. Bollen, D. Scheuner, R. Kaufman, 2007, Endocrinology.

The translation initiation factor eIF2beta is an interactor of protein phosphatase-1.

M. Bollen, H. Ceulemans, M. Beullens, 2006, The Biochemical journal.

A substrate-trapping strategy for protein phosphatase PP1 holoenzymes using hypoactive subunit fusions

M. Bollen, R. Derua, M. Beullens, 2018, The Journal of Biological Chemistry.

Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.

M. Cookson, M. Bollen, V. Baekelandt, 2013, The Biochemical journal.

Protein phosphatase-1 is a novel regulator of the interaction between IRBIT and the inositol 1,4,5-trisphosphate receptor.

M. Bollen, E. Sammels, B. Devogelaere, 2007, The Biochemical journal.

Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells

M. Bollen, Bart Lesage, D. Hart, 2012, Angewandte Chemie.

False-positive detection of recombinant human erythropoietin in urine following strenuous physical exercise.

M. Bollen, J. Delanghe, M. Beullens, 2006, Blood.

C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1

S. Stamm, M. Bollen, J. Adams, 2011, Nucleic acids research.

PP1/Repo-Man Dephosphorylates Mitotic Histone H3 at T3 and Regulates Chromosomal Aurora B Targeting

M. Bollen, Bart Lesage, J. Qian, 2011, Current Biology.

Post-translational Control of the Temporal Dynamics of Transcription Factor Activity Regulates Neurogenesis

Bassem A. Hassan, H. Zoghbi, B. Hassan, 2016, Cell.

The biochemical identification and characterization of new species of protein phosphatase 1.

M. Bollen, M. Beullens, W. Stalmans, 1998, Methods in molecular biology.

On the detection of newer Epo forms in serum and urine using isoelectric focusing

M. Bollen, J. Delanghe, M. Beullens, 2008 .