S. Unger

发表

Direct plasma sample injection in multiple-component LC-MS-MS assays for high-throughput pharmacokinetic screening.

J. T. Wu, H. Zeng, M. Qian, 2000, Analytical chemistry.

Combined HPLC, NMR spectroscopy, and ion-trap mass spectrometry with application to the detection and characterization of xenobiotic and endogenous metabolites in human urine.

J P Shockcor, J C Lindon, I. Wilson, 1996, Analytical chemistry.

Making methods rugged for regulated bioanalysis.

Kevin McManus, S. Unger, T. Horvath, 2015, Bioanalysis.

N-in-1 dosing pharmacokinetics in drug discovery: experience, theoretical and practical considerations.

P. Lam, K. He, T. Olah, 2008, Journal of pharmaceutical sciences.

Differentiation of cationic from neutral transition-metal complexes using wires as field desorption emitters

S. Unger, 1985 .

Possitive and negative secondary ion mass spectra and mass-analyzed ion kinetic energy spectra of some amides, amines and related compounds: Mechanisms in molecular sims

R. Cooks, S. Unger, R. Day, 1981 .

Chapter 30. Using Mass Spectrometry to Determine ADME Properties in Drug Discovery

S. Unger, 1999 .

Bioanalytical Methods: Challenges and Opportunities in Drug Development

S. Unger, M. Powell, 2004 .

Structure of the quinone antibiotic EM5519 and the behavior of quinones in fast atom bombardment mass spectrometry.

S. Unger, R. Cooper, 1985, The Journal of antibiotics.

The science of laboratory and project management in regulated bioanalysis.

S. Unger, Melvin Tan, Thomas Lloyd, 2014, Bioanalysis.

Best Practice in Liquid Chromatography for LC‐MS Bioanalysis

S. Unger, Naidong Weng, 2013 .

Packed capillary liquid chromatography/electrospray ionization/mass spectrometry in the pharmaceutical sciences: Characterization of protein mixtures

M. A. Moseley, S. Unger, 1992 .

Pharmacokinetic Interaction Between Efavirenz and Carbamazepine After Multiple‐Dose Administration in Healthy Subjects

Jingdong Xie, D. Grasela, S. Unger, 2008, Journal of clinical pharmacology.

Metabolism of methylenedioxymethamphetamine: formation of dihydroxymethamphetamine and a quinone identified as its glutathione adduct.

A. Cho, S. Unger, M. Hiramatsu, 1990, The Journal of pharmacology and experimental therapeutics.

Transformation of dopamine and alpha-methyldopamine by NG108-15 cells: formation of thiol adducts.

A. Cho, J. Fukuto, S. Unger, 1991, Chemical research in toxicology.

Application of Mass Spectrometry/Mass Spectrometry (MS/MS) to the Identification of Natural Products in Psilocybe Cyanescens

R. Cooks, S. Unger, 1979 .

NMR and HPLC-NMR spectroscopic studies of futile deacetylation in paracetamol metabolites in rat and man.

I. Wilson, J. Lindon, J. Nicholson, 1997, Journal of pharmaceutical and biomedical analysis.

Simultaneous determination of a selective adenosine 2A agonist, BMS-068645, and its acid metabolite in human plasma by liquid chromatography-tandem mass spectrometry--evaluation of the esterase inhibitor, diisopropyl fluorophosphate, in the stabilization of a labile ester-containing drug.

S. Unger, P. Crane, Naiyu Zheng, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Xylocandin: a new complex of antifungal peptides. II. Structural studies and chemical modifications.

S. Unger, G. Bisacchi, W. Parker, 1987, The Journal of antibiotics.

Quantitative determination of pioglitazone in human serum by direct-injection high-performance liquid chromatography mass spectrometry and its application to a bioequivalence study.

S. Unger, J. Pursley, M. Arnold, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Negative and positive secondary ion mass spectra of organic acids

R. Cooks, S. Unger, L. K. Liu, 1981 .

A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes.

S. Unger, H. Karnes, S. Bhoopathy, 2005, Journal of pharmaceutical and biomedical analysis.

Novel direct detection method for quantitative determination of intracellular nucleoside triphosphates using weak anion exchange liquid chromatography/tandem mass spectrometry.

R. Geleziunas, T. Olah, S. Unger, 2002, Rapid communications in mass spectrometry : RCM.

Structure determination of lysobactin, a macrocyclic peptide lactone antibiotic

S. Unger, A. Tymiak, T. J. McCormick, 1989 .

Simultaneous quantification of seven active metabolites of roxifiban in human plasma by LC/MS/MS in the presence of an interfering displacer at millimolar concentrations.

H. Pieniaszek, A. Mutlib, S. Unger, 2003, Journal of pharmaceutical and biomedical analysis.

A validated LC-MS/MS assay for the simultaneous determination of the anti-leukemic agent dasatinib and two pharmacologically active metabolites in human plasma: application to a clinical pharmacokinetic study.

S. Agrawal, S. Unger, M. Furlong, 2012, Journal of pharmaceutical and biomedical analysis.

Pharmaceutical development and specification of stereoisomers.

R. C. Williams, S. Unger, C. Riley, 1998, Journal of pharmaceutical and biomedical analysis.

DESORPTION IONIZATION MASS SPECTROMETRY: SAMPLE PREPARATION FOR SECONDARY ION MASS SPECTROMETRY, LASER DESORPTION, AND FIELD DESORPTION

R. Cooks, T. Keough, S. Unger, 1982 .

Molecular secondary ion mass spectrometry.

R. Cooks, S. Unger, R. Day, 1980, Analytical chemistry.

Identification of quaternary alkaloids in mushroom by chromatography/secondary ion mass spectrometry

R. Cooks, S. Unger, R. Chrisman, 1981 .

Detection limits for organic salts in secondary ion mass spectrometry

R. Cooks, S. Unger, T. M. Ryan, 1980 .

Comparison of SPE and fast LC to eliminate mass spectrometric matrix effects from microsomal incubation products.

S. Unger, Joanna J Zheng, E. Lynch, 2002, Journal of pharmaceutical and biomedical analysis.

Comparison of desorption ionization methods for the analysis of neutral seven-coordinate technetium radiopharmaceuticals.

A. Nunn, S. Unger, E. Treher, 1987, Analytical chemistry.

Pharmaceutical analysis using fast atom bombardment mass spectrometry-mass spectrometry

S. Unger, Terry J. McCormick, 1985 .

Fast atom bombardment mass spectrometry/mass spectrometry of cationic technetium and iron complexes

S. Unger, 1984 .

The metabolism and excretion of carbovir, a carbocyclic nucleoside, in the rat.

J. Walsh, S. Unger, G. Miwa, 1990, Drug metabolism and disposition: the biological fate of chemicals.

The impact of hemolysis on stability of N-desethyloxybutynin in human plasma.

S. Unger, Melvin Tan, Edward Wells, 2019, Bioanalysis.

Development and validation of a liquid chromatography-mass spectrometric method for the determination of DPC 423, an antithrombotic agent, in rat and dog plasma.

Cecilia L Chi, S. Unger, L. Liang, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

The impact of decreased bead count to determine concentrations of amyloid beta1-42, total-tau, and phosphorylated-tau181 in human cerebrospinal fluid using xMAP technology.

W. Nowatzke, S. Unger, W. Zhang, 2011, Journal of pharmaceutical sciences.

Formation of metal chelates in secondary ion mass spectrometry. Comparisons with solution chemistry

R. J. Day, R. Cooks, S. Unger, 1979 .

Ionization of quaternary nitrogen compounds by secondary ion mass spectrometry

R. J. Day, R. Cooks, S. Unger, 1979 .

Phenanthroline cationization by various metals in secondary ion mass spectrometry

R. Cooks, S. Unger, R. Day, 1980 .

Dihydropyrimidine calcium channel blockers. 3. 3-Carbamoyl-4-aryl-1,2,3,4-tetrahydro-6-methyl-5-pyrimidinecarboxylic acid esters as orally effective antihypertensive agents.

A Hedberg, S. Moreland, D. Floyd, 1991, Journal of medicinal chemistry.

Dihydropyrimidine Calcium Channel Blockers. Part 3. 3‐Carbamoyl‐4‐aryl‐1,2,3,4‐tetrahydro‐6‐methyl‐5‐pyrimidinecarboxylic Acid Esters as Orally Effective Antihypertensive Agents.

S. Moreland, D. Floyd, S. Unger, 1991 .

Novel potentiators of β-lactam antibiotics: structures of SW 28504 and SQ 28546

S. Unger, R. Cooper, 1986 .

A Novel Reaction between Acetone and the Benzo[c]phenanthrene K-Region o-Quinone Containing a Peri-Fluoro Substituent

D. Thakker, S. Unger, S. Mirsadeghi, 1991 .

Analysis and validation of the phosphorylated metabolites of two anti‐human immunodeficiency virus nucleotides (stavudine and didanosine) by pressure‐assisted CE‐ESI‐MS/MS in cell extracts: Sensitivity enhancement by the use of perfluorinated acids and alcohols as coaxial sheath‐liquid make‐up const

P. Morin, P. Chaimbault, S. Unger, 2006, Electrophoresis.

Cellular Pharmacology of D-d4FC, a Nucleoside Analogue Active against Drug-Resistant HIV

M. Otto, R. Schinazi, R. Geleziunas, 2003, Antiviral chemistry & chemotherapy.

Chemistry of Tc(oxime)3 (μ -OH)SnCl3 and TcCl(oxime)3: Neutral intermediates in the synthesis of boron-caped 99-TcOXIME complexes

A. Nunn, K. Linder, S. Unger, 1989 .

A re‐assessment of the oxidation state of Tc(DMG)3(μ‐OH)SnCl3: Evidence for Tc(III)

A. Nunn, K. Linder, S. Unger, 1989 .

High-speed gradient parallel liquid chromatography/tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma.

T. L. Lloyd, Yuzhong Deng, T. Olah, 2002, Rapid communications in mass spectrometry : RCM.

The investigation and the use of high flow column-switching LC/MS/MS as a high-throughput approach for direct plasma sample analysis of single and multiple components in pharmacokinetic studies.

H. Zeng, S. Unger, Jing-tao Wu, 2002, Journal of pharmaceutical and biomedical analysis.

Isomer differentiation in fast atom bombardment mass spectrometry/mass spectrometry

S. Unger, 1985 .

Interchangeable insert thermospray probe

S. Unger, M. Bolgar, J. Hunt, 1987 .

Chemical modification of polynucleotides. Quantitative studies of polycytidylic acid by nuclear magnetic resonance spectroscopy and secondary-ion mass spectrometry

R. Cooks, S. Unger, Ching‐jer Chang, 1981 .

Identification of modified nucleosides by secondary-ion and laser-desorption mass spectrometry

R. Cooks, S. Unger, A. Schoen, 1981 .

Separation of a BMS drug candidate and acyl glucuronide from seven glucuronide positional isomers in rat plasma via high-performance liquid chromatography with tandem mass spectrometric detection.

S. Unger, Jane Liu, Danielle F Anderson, 2006, Rapid communications in mass spectrometry : RCM.

Quantitative determination of BMS-378806 in human plasma and urine by high-performance liquid chromatography/tandem mass spectrometry.

D. Grasela, S. Unger, Y. Xue, 2007, Journal of separation science.

Destruction of American Indian families

S. Unger, Evelyn Lance Blanchard, 1977 .

The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection.

S. Unger, A. Rose, N. Contel, 2001, Journal of pharmaceutical and biomedical analysis.

Analytical Method Development and Validation in Accordance to the Regulatory Guidelines

S. Unger, 2012 .

A 96-well single-pot liquid-liquid extraction, hydrophilic interaction liquid chromatography-mass spectrometry method for the determination of muraglitazar in human plasma.

S. Unger, Jane Liu, Y. Xue, 2006, Journal of pharmaceutical and biomedical analysis.

High-speed liquid chromatography/tandem mass spectrometry using a monolithic column for high-throughput bioanalysis.

J. T. Wu, H. Zeng, S. Unger, 2001, Rapid communications in mass spectrometry : RCM.

Chemotaxonomy of columnar Mexican cacti by mass spectrometry/mass spectrometry.

R. Cooks, S. Unger, J. McLaughlin, 1980 .

Molecular SIMS at surfaces: Thiophene on silver

R. Cooks, W. Delgass, S. Unger, 1982 .

The identification of choline and its esters by secondary ion mass spectrometry

R. Cooks, S. Unger, T. M. Ryan, 1981 .

Detection of malignancy-associated metabolites in the sera of cancer patients by electron capture gas chromatography.

P. Almenoff, B. Schwartz, S. Unger, 1994, British Journal of Cancer.

Characterization of p-hydroxyphenobarbital glucuronide generated from immobilized rat hepatic UDP-glucuronosyltransferase.

S. Unger, J. Shockcor, K. Brouwer, 1995, Journal of pharmaceutical sciences.

Safety assessment of drug metabolites: Characterization of chemically stable metabolites.

W Griffith Humphreys, W. Humphreys, S. Unger, 2006, Chemical research in toxicology.

Identification of a glucuronide conjugate of the carbocyclic nucleoside, carbovir, isolated from marmoset urine.

J. Walsh, S. Unger, G. Miwa, 1990, Drug Metabolism And Disposition.

A simplified protein precipitation/mixed-mode cation-exchange solid-phase extraction, followed by high-speed liquid chromatography/mass spectrometry, for the determination of a basic drug in human plasma.

S. Unger, Jane Liu, Y-J Xue, 2006, Rapid communications in mass spectrometry : RCM.

Roles of LC‐MS Bioanalysis in Drug Discovery, Development, and Therapeutic Drug Monitoring

F. Tse, S. Unger, J. Flarakos, 2013 .

1 ROLES OF LC-MS BIOANALYSIS IN DRUG DISCOVERY , DEVELOPMENT , AND THERAPEUTIC DRUG MONITORING

F. Tse, S. Unger, J. Flarakos, 2013 .

LC-MS/MS-based approach for obtaining exposure estimates of metabolites in early clinical trials using radioactive metabolites as reference standards.

Nirmala Raghavan, Yunlin Fu, Donglu Zhang, 2007, Drug metabolism letters.

Degradation of peptide drugs by immobilized digestive proteases.

R. V. van Breemen, S. Unger, M. Bartlett, 1991, Drug metabolism and disposition: the biological fate of chemicals.

Application of directly coupled LC-NMR-MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83.

J. Lindon, J. Nicholson, S. Unger, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Disposition of 8-methoxypsoralen in the rat. Induction of metabolism in vivo and in vitro and identification of urinary metabolites by thermospray mass spectrometry.

S. Unger, D. Mays, N. Gerber, 1987, Drug metabolism and disposition: the biological fate of chemicals.

Neutral, seven-coordinate dioxime complexes of technetium(III): synthesis and characterization

A. Nunn, K. Linder, S. Unger, 1990 .

Species-specific, P450- and sulfotransferase-mediated novel ring contraction of a naphthyridine-N-oxide compound in cynomolgus monkey.

A. Mutlib, S. Unger, Barry C. Johnson, 2007, Chemical research in toxicology.

Unique challenges of providing bioanalytical support for biological therapeutic pharmacokinetic programs.

Edward Wells, Kathryn Rogers, Chad Ray, 2011, Bioanalysis.

A 96-well single-pot protein precipitation, liquid chromatography/tandem mass spectrometry (LC/MS/MS) method for the determination of muraglitazar, a novel diabetes drug, in human plasma.

S. Unger, Jane Liu, Steve Unger, 2006, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Multiple-sprayer tandem mass spectrometry with parallel high flow extraction and parallel separation for high-throughput quantitation in biological fluids.

J. T. Wu, H. Zeng, S. Unger, 2001, Rapid communications in mass spectrometry : RCM.

Fast atom bombardment and plasma desorption mass spectrometry of degraded insulins in intermediate and long-acting preparations.

P. Demirev, R. Cotter, S. Unger, 1988, Rapid communications in mass spectrometry : RCM.