C. Spahr

发表

Towards defining the urinary proteome using liquid chromatography‐tandem mass spectrometry I.Profiling an unfractionated tryptic digest

R. Wahl, P. Courchesne, S. Patterson, 2001, Proteomics.

Discovery of undefined protein cross-linking chemistry: a comprehensive methodology utilizing 18O-labeling and mass spectrometry.

Zhongqi Zhang, Da Ren, Zhongqi Zhang, 2013, Analytical chemistry.

Heparin is essential for a single keratinocyte growth factor molecule to bind and form a complex with two molecules of the extracellular domain of its receptor.

J. Philo, J. Sullivan, R. Pacifici, 1999, Biochemistry.

Effects of buffer composition on site specific glycation of lysine residues in monoclonal antibodies.

C. Spahr, Neeraj J. Agrawal, Andrew B Dykstra, 2019, Journal of pharmaceutical sciences.

High Mass Analysis with a Fourier Transform Ion Cyclotron Resonance Mass Spectrometer: From Inorganic Salt Clusters to Antibody Conjugates and Beyond.

I. Campuzano, Huilin Li, J. Loo, 2020, Journal of the American Society for Mass Spectrometry.

Ligand-Binding Mass Spectrometry to Study Biotransformation of Fusion Protein Drugs and Guide Immunoassay Development: Strategic Approach and Application to Peptibodies Targeting the Thrombopoietin Receptor

C. Gegg, Jean W. Lee, B. Desilva, 2010, The AAPS Journal.

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes

T. Boone, J. Xu, N. Chinookoswong, 2012, PloS one.

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor

G. Kroemer, A. Hammann, C. Garrido, 2003, Oncogene.

Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells.

C. Begley, S. Elliott, I. McCaffery, 2010, Journal of immunological methods.

A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward &bgr;-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys

Lei Zhou, Y. Li, Yang Li, 2017, Endocrinology.

Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.

L. Poppe, J. McCarter, Marc Payton, 2022, Journal of medicinal chemistry.

Gram's Stain Does Not Cross the Bacterial Cytoplasmic Membrane.

H. Dai, C. Spahr, M. Wilhelm, 2015, ACS chemical biology.

Automated LC-LC-MS-MS platform using binary ion-exchange and gradient reversed-phase chromatography for improved proteomic analyses.

S. Patterson, Michael T. Davis, M. T. Davis, 2001, Journal of chromatography. B, Biomedical sciences and applications.

Real-time molecular uptake and membrane-specific transport in living cells by optical microscopy and nonlinear light scattering

H. Dai, C. Spahr, Jia Zeng, 2014 .

Anti-Epo receptor antibodies do not predict Epo receptor expression.

C. Begley, I. Sarosi, M. Bass, 2006, Blood.

Purification and biochemical characterization of interchromatin granule clusters

A. F. Neuwald, D. Spector, S. Patterson, 1999, The EMBO journal.

Proteomic analysis of interchromatin granule clusters.

A. F. Neuwald, D. Spector, S. Patterson, 2004, Molecular biology of the cell.

General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies.

Hossein Salimi-Moosavi, Jean W. Lee, C. Spahr, 2012, Analytical chemistry.

Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells

C. Spahr, S. Shi, B. Soriano, 2018, mAbs.

A simplified device for protein identification by microcapillary gradient liquid chromatography‐tandem mass spectrometry

S. Patterson, Michael T. Davis, C. Spahr, 2000, Electrophoresis.

AIF and cyclophilin A cooperate in apoptosis-associated chromatinolysis

G. Kroemer, J. Luban, J. Penninger, 2004, Oncogene.

Rational selection of building blocks for the assembly of bispecific antibodies

D. Gong, Zhulun Wang, C. Spahr, 2021, mAbs.

Cancer biomarker discovery via low molecular weight serum proteome profiling – Where is the tumor?

S. Patterson, Michael T. Davis, C. Spahr, 2007, Proteomics. Clinical applications.

In vitro methionine oxidation of escherichia coli‐derived human stem cell factor: Effects on the molecular structure, biological activity, and dimerization

L. Narhi, C. Spahr, L O Narhi, 1996, Protein science : a publication of the Protein Society.

High-resolution mass spectrometry confirms the presence of a hydroxyproline (Hyp) post-translational modification in the GGGGP linker of an Fc-fusion protein

K. Gunasekaran, C. Spahr, K. Walker, 2017, mAbs.

Simplification of complex peptide mixtures for proteomic analysis: Reversible biotinylation of cysteinyl peptides

G. Kroemer, S. Patterson, Michael T. Davis, 2000, Electrophoresis.

Recombinant human lecithin‐cholesterol acyltransferase Fc fusion: Analysis of N‐ and O‐linked glycans and identification and elimination of a xylose‐based O‐linked tetrasaccharide core in the linker region

C. Spahr, Bram Estes, Hsieng S. Lu, 2013, Protein science : a publication of the Protein Society.

Optimization of capillary chromatography ion trap‐mass spectrometry for identification of gel‐separated proteins

S. Patterson, C. Spahr, R. Luethy, 1998, Electrophoresis.

Towards defining the urinary proteome using liquid chromatography‐tandem mass spectrometry II.Limitations of complex mixture analyses

Roland Luethy, Wen Yu, S. Patterson, 2001, Proteomics.

Mass spectrometric identification of proteins released from mitochondria undergoing permeability transition

G. Kroemer, S. Patterson, E. Daugas, 2000, Cell Death and Differentiation.

Rapid LC-MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins.

I. Campuzano, J. Loo, C. Spahr, 2018, Analytical chemistry.

Identification of incompletely processed potential Carboxypeptidase E substrates from CpEfat/CpEfat mice

Jilin Sun, R. Wahl, Michael D. Jones, 2001, Proteomics.

Fourier Transform-Ion Cyclotron Resonance Mass Spectrometry as a Platform for Characterizing Multimeric Membrane Protein Complexes

I. Campuzano, J. Loo, C. Spahr, 2017, Journal of The American Society for Mass Spectrometry.

Human Dickkopf‐1 (huDKK1) protein: Characterization of glycosylation and determination of disulfide linkages in the two cysteine‐rich domains

T. Horan, C. Spahr, M. Haniu, 2011, Protein science : a publication of the Protein Society.

Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities.

Todd Hager, Hossein Salimi-Moosavi, Jing Xu, 2013, Analytical chemistry.

O-Glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins

C. Spahr, S. Shi, Hsieng S. Lu, 2014, mAbs.

Protected hinge in the immunoglobulin G2‐A2 disulfide isoform

L. Poppe, T. Dillon, G. C. Flynn, 2014, Protein science : a publication of the Protein Society.

The effects of in vitro methionine oxidation on the bioactivity and structure of human keratinocyte growth factor

L. Narhi, C. Spahr, Hsieng S. Lu, 1997 .

Towards defining the urinary proteome using liquid chromatography‐tandem mass spectrometry I.Profiling an unfractionated tryptic digest

R. Wahl, S. Patterson, Michael T. Davis, 2001, Proteomics.

Identification of a sensitive anti-erythropoietin receptor monoclonal antibody allows detection of low levels of EpoR in cells.

S. Elliott, I. McCaffery, J. Rossi, 2010, Journal of immunological methods.

A simplified device for protein identification by microcapillary gradient liquid chromatography‐tandem mass spectrometry

S. Patterson, Michael T. Davis, C. Spahr, 2000, Electrophoresis.