S. V. Van Lanen

发表

The bifunctional glyceryl transferase/phosphatase OzmB belonging to the HAD superfamily that diverts 1,3-bisphosphoglycerate into polyketide biosynthesis.

B. Shen, P. Dorrestein, Z. Deng, 2006, Journal of the American Chemical Society.

Mechanistic studies of Bacillus subtilis QueF, the nitrile oxidoreductase involved in queuosine biosynthesis.

S. V. Van Lanen, D. Iwata‐Reuyl, Bobby W. K. Lee, 2007, Biochemistry.

The Biosynthesis of Liposidomycin‐like A‐90289 Antibiotics Featuring a New Type of Sulfotransferase

S. V. Van Lanen, K. Nonaka, M. Hosobuchi, 2010, Chembiochem : a European journal of chemical biology.

The muraminomicin biosynthetic gene cluster and enzymatic formation of the 2-deoxyaminoribosyl appendage.

S. V. Van Lanen, K. Nonaka, Masanori Funabashi, 2013, MedChemComm.

Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

J. Hower, J. Thorson, A. Morris, 2015, Organic letters.

Hypermodification of tRNA in Thermophilic Archaea

D. T. Fox, S. V. Van Lanen, D. Iwata‐Reuyl, 2000, The Journal of Biological Chemistry.

Macrolide derivatives reduce proinflammatory macrophage activation and macrophage‐mediated neurotoxicity

J. Gensel, Xiaodong Liu, S. V. Van Lanen, 2019, CNS neuroscience & therapeutics.

A Branch Point of Streptomyces Sulfur Amino Acid Metabolism Controls the Production of Albomycin

Weiwen Zhang, W. Zhou, S. V. Van Lanen, 2015, Applied and Environmental Microbiology.

Biosynthetic and Synthetic Strategies for Assembling Capuramycin-Type Antituberculosis Antibiotics

J. Thorson, Xiaodong Liu, Zhao-yong Yang, 2019, Molecules.

Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2008, Proceedings of the National Academy of Sciences.

Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme.

V. de Crécy-Lagard, P. Schimmel, M. Swairjo, 2005, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structure-based gene targeting discovery of sphaerimicin, a bacterial translocase I inhibitor.

S. V. Van Lanen, K. Nonaka, T. Takatsu, 2013, Angewandte Chemie.

Enzymatic Synthesis of the Ribosylated Glycyl-Uridine Disaccharide Core of Peptidyl Nucleoside Antibiotics.

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2018, The Journal of organic chemistry.

The crystal structure of AbsH3: A putative flavin adenine dinucleotide‐dependent reductase in the abyssomicin biosynthesis pathway

Mitchell D. Miller, G. Phillips, C. Zhan, 2020, Proteins.

Roles of the synergistic reductive O-methyltransferase GilM and of O-methyltransferase GilMT in the gilvocarcin biosynthetic pathway.

J. Rohr, G. O'Doherty, S. V. Van Lanen, 2012, Journal of the American Chemical Society.

The structure of L-tyrosine 2,3-aminomutase from the C-1027 enediyne antitumor antibiotic biosynthetic pathway.

B. Shen, S. V. Van Lanen, S. Bruner, 2007, Biochemistry.

Pyridoxal-5′-Phosphate-Dependent Alkyl Transfer in Nucleoside Antibiotic Biosynthesis

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2020, Nature Chemical Biology.

Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.

J. Rohr, Pallab Pahari, S. V. Van Lanen, 2012, Angewandte Chemie.

Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.

J. Rohr, Pallab Pahari, Guojun Wang, 2012, Angewandte Chemie.

Regiospecific chlorination of (S)-beta-tyrosyl-S-carrier protein catalyzed by SgcC3 in the biosynthesis of the enediyne antitumor antibiotic C-1027.

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2007, Journal of the American Chemical Society.

Evidence that oxidative dephosphorylation by the nonheme Fe(II), α‐ketoglutarate:UMP oxygenase occurs by stereospecific hydroxylation

J. Rohr, Xiaodong Liu, M. Meurillon, 2017, FEBS letters.

The Biosynthesis of Capuramycin-type Antibiotics

J. Thorson, S. Garneau‐Tsodikova, A. Morris, 2015, The Journal of Biological Chemistry.

Antibacterial and Cytotoxic Actinomycins Y6-Y9 and Zp from Streptomyces sp. Strain Gö-GS12.

J. Thorson, Xiaodong Liu, S. V. Van Lanen, 2016, Journal of natural products.

Baraphenazines A-G, Divergent Fused Phenazine-Based Metabolites from a Himalayan Streptomyces.

S. Voss, J. Thorson, S. V. Van Lanen, 2019, Journal of natural products.

A Theranostic Gallium Siderophore Ciprofloxacin Conjugate with Broad Spectrum Antibiotic Potency.

Apurva Pandey, E. Boros, Zhao-yong Yang, 2019, Journal of medicinal chemistry.

Structure Determination, Functional Characterization, and Biosynthetic Implications of Nybomycin Metabolites from a Mining Reclamation Site-Associated Streptomyces.

S. Voss, Q. She, J. Hower, 2019, Journal of natural products.

Sugar-pirating as an enabling platform for the synthesis of 4,6-dideoxyhexoses.

J. Thorson, S. V. Van Lanen, L. Ponomareva, 2020, Journal of the American Chemical Society.

Kinetic mechanism of the tRNA-modifying enzyme S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA).

S. V. Van Lanen, D. Iwata‐Reuyl, D. Iwata-Reuyl, 2003, Biochemistry.

Biosynthesis of enediyne antitumor antibiotics.

B. Shen, S. V. Van Lanen, 2008, Current topics in medicinal chemistry.

Biosynthesis of albomycin δ(2) provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates.

Wei Zhou, Zhao-yong Yang, S. V. Van Lanen, 2012, ACS chemical biology.

Nature’s combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces

S. V. Van Lanen, W. Kinney, Shawn Chen, 2017, World journal of microbiology & biotechnology.

Total synthesis of griseusins and elucidation of the griseusin mechanism of action† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc02289a

S. Voss, Q. She, J. Thorson, 2019, Chemical science.

Self-Resistance during Muraymycin Biosynthesis: a Complementary Nucleotidyltransferase and Phosphotransferase with Identical Modification Sites and Distinct Temporal Order

J. Thorson, J. Rohr, Xiaodong Liu, 2018, Antimicrobial Agents and Chemotherapy.

Terfestatins B and C, New p-Terphenyl Glycosides Produced by Streptomyces sp. RM-5-8.

J. Hower, J. Thorson, A. Morris, 2015, Organic letters.

Insights into the Target Interaction of Naturally Occurring Muraymycin Nucleoside Antibiotics

J. Thorson, S. V. Van Lanen, C. Ducho, 2018, ChemMedChem.

Biosynthetic origin and mechanism of formation of the aminoribosyl moiety of peptidyl nucleoside antibiotics.

Pallab Pahari, S. V. Van Lanen, K. Nonaka, 2011, Journal of the American Chemical Society.

Enzymatic strategies and biocatalysts for amide bond formation: tricks of the trade outside of the ribosome.

S. V. Van Lanen, Steven G Van Lanen, Anwesha Goswami, 2015, Molecular bioSystems.

Facile chemoenzymatic strategies for the synthesis and utilization of S-adenosyl-(L)-methionine analogues.

J. Thorson, J. Rohr, A. Morris, 2014, Angewandte Chemie.

An ATP-independent strategy for amide bond formation in antibiotic biosynthesis.

Zhao-yong Yang, S. V. Van Lanen, K. Nonaka, 2010, Nature chemical biology.

Identification and characterization of enzymes involved in the biosynthesis of pyrimidine nucleoside antibiotics.

B. Gust, S. V. Van Lanen, Z. Cui, 2021, Natural product reports.

Structure and Function of a Dual Reductase-Dehydratase Enzyme System Involved in p-Terphenyl Biosynthesis.

Mitchell D. Miller, G. Phillips, J. Thorson, 2021, ACS chemical biology.

Enzymatic total synthesis of defucogilvocarcin M and its implications for gilvocarcin biosynthesis.

J. Rohr, Pallab Pahari, S. V. Van Lanen, 2012, Angewandte Chemie.

Characterization of SgcE6, the flavin reductase component supporting FAD-dependent halogenation and hydroxylation in the biosynthesis of the enediyne antitumor antibiotic C-1027.

B. Shen, Geoff P. Horsman, Shuangjun Lin, 2009, FEMS microbiology letters.

A High-Throughput Screen for Directed Evolution of the Natural Product Sulfotransferase LipB

Gavin J. Williams, S. V. Van Lanen, K. Nonaka, 2011, Journal of biomolecular screening.

Bi- and Tetracyclic Spirotetronates from the Coal Mine Fire Isolate Streptomyces sp. LC-6-2.

J. Hower, C. Zhan, J. Thorson, 2017, Journal of natural products.

Characterization of the two-component, FAD-dependent monooxygenase SgcC that requires carrier protein-tethered substrates for the biosynthesis of the enediyne antitumor antibiotic C-1027.

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2008, Journal of the American Chemical Society.

Antitumor antibiotics: bleomycin, enediynes, and mitomycin.

B. Shen, M. Hager, J. Thorson, 2005, Chemical reviews.

Characterization of the maduropeptin biosynthetic gene cluster from Actinomadura madurae ATCC 39144 supporting a unifying paradigm for enediyne biosynthesis.

B. Shen, Wen Liu, S. V. Van Lanen, 2007, Journal of the American Chemical Society.

Iterative type I polyketide synthases for enediyne core biosynthesis.

B. Shen, Geoff P. Horsman, S. V. Van Lanen, 2009, Methods in enzymology.

A phosphopantetheinylating polyketide synthase producing a linear polyene to initiate enediyne antitumor antibiotic biosynthesis

B. Shen, P. Dorrestein, N. Kelleher, 2008, Proceedings of the National Academy of Sciences.

From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold.

J. Reader, V. de Crécy-Lagard, M. Swairjo, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Functional and Kinetic Analysis of the Phosphotransferase CapP Conferring Selective Self-resistance to Capuramycin Antibiotics*

Pallab Pahari, Zhao-yong Yang, S. V. Van Lanen, 2010, The Journal of Biological Chemistry.

tRNA Modification by S-Adenosylmethionine:tRNA Ribosyltransferase-Isomerase

J. Culp, S. V. Van Lanen, S. D. Kinzie, 2003, The Journal of Biological Chemistry.

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

B. Shen, C. Farnet, Wen Liu, 2005, Chemistry & biology.

The role of tandem acyl carrier protein domains in polyunsaturated fatty acid biosynthesis.

B. Shen, Hui Jiang, S. V. Van Lanen, 2008, Journal of the American Chemical Society.

Delineating the earliest steps of gilvocarcin biosynthesis: role of GilP and GilQ in starter unit specificity.

J. Rohr, S. V. Van Lanen, Lili Zhu, 2010, Organic & biomolecular chemistry.

Nature’s combinatorial biosynthesis and recently engineered production of nucleoside antibiotics in Streptomyces

S. V. Van Lanen, W. Kinney, Shawn Chen, 2017, World Journal of Microbiology and Biotechnology.

Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.

J. Rohr, Pallab Pahari, S. V. Van Lanen, 2012, Journal of the American Chemical Society.

Progress in combinatorial biosynthesis for drug discovery.

Ben Shen, B. Shen, S. V. Van Lanen, 2006, Drug discovery today. Technologies.

Microbial genomics for the improvement of natural product discovery.

Ben Shen, B. Shen, S. V. Van Lanen, 2006, Current opinion in microbiology.

Antibacterial Muraymycins from Mutant Strains of Streptomyces sp. NRRL 30471.

J. Thorson, S. V. Van Lanen, C. Ducho, 2018, Journal of natural products.

A free-standing condensation enzyme catalyzing ester bond formation in C-1027 biosynthesis

B. Shen, Shuangjun Lin, S. V. Van Lanen, 2009, Proceedings of the National Academy of Sciences.

Enzymatic Cβ-H Functionalization of l-Arg and l-Leu in Nonribosomally Derived Peptidyl Natural Products: A Tale of Two Oxidoreductases.

J. Thorson, S. V. Van Lanen, C. Ducho, 2021, Journal of the American Chemical Society.

Advances in polyketide synthase structure and function.

Ben Shen, B. Shen, S. V. Van Lanen, 2008, Current opinion in drug discovery & development.

Substrate Specificity of the Adenylation Enzyme SgcC1 Involved in the Biosynthesis of the Enediyne Antitumor Antibiotic C-1027*

B. Shen, P. Dorrestein, N. Kelleher, 2006, Journal of Biological Chemistry.

The Role of a Nonribosomal Peptide Synthetase in l‐Lysine Lactamization During Capuramycin Biosynthesis

Xiaodong Liu, Zhao-yong Yang, S. V. Van Lanen, 2016, Chembiochem : a European journal of chemical biology.

Computer-aided drug design of capuramycin analogues as anti-tuberculosis antibiotics by 3D-QSAR and molecular docking

S. Fan, Zhao-yong Yang, S. V. Van Lanen, 2017 .

Characterization of a dual specificity aryl acid adenylation enzyme with dual function in nikkomycin biosynthesis.

S. V. Van Lanen, M. Moon, 2010, Biopolymers.

Fe(II)-dependent, uridine-5'-monophosphate α-ketoglutarate dioxygenases in the synthesis of 5'-modified nucleosides.

J. Unrine, Zhao-yong Yang, S. V. Van Lanen, 2012, Methods in enzymology.

Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy.

J. Thorson, O. Tsodikov, J. Rohr, 2020, Journal of medicinal chemistry.

Characterization of LipL as a Non-heme, Fe(II)-dependent α-Ketoglutarate:UMP Dioxygenase That Generates Uridine-5′-aldehyde during A-90289 Biosynthesis*

Gregory I. Elliott, J. Rohr, Pallab Pahari, 2011, The Journal of Biological Chemistry.

Pyridoxal-5′-phosphate as an oxygenase cofactor: Discovery of a carboxamide-forming, α-amino acid monooxygenase-decarboxylase

Xiaodong Liu, Zhao-yong Yang, S. V. Van Lanen, 2018, Proceedings of the National Academy of Sciences.

Characterization of NcsB2 as a promiscuous naphthoic acid/coenzyme A ligase integral to the biosynthesis of the enediyne antitumor antibiotic neocarzinostatin.

B. Shen, H. Cooke, S. V. Van Lanen, 2007, Journal of the American Chemical Society.

Structure of the Oxygen, Pyridoxal Phosphate-Dependent Capuramycin Biosynthetic Protein Cap15.

S. V. Van Lanen, K. Ryan, P. Daniel-Ivad, 2023, Biochemistry.

A biocatalytic approach to capuramycin analogues by exploiting a substrate permissive N-transacylase CapW.

Sylvie Garneau-Tsodikova, S. Garneau‐Tsodikova, Xiaodong Liu, 2016, Organic & biomolecular chemistry.

Structural characterization of DynU16, a START/Bet v1-like protein involved in dynemicin biosynthesis

Mitchell D. Miller, G. Phillips, J. Thorson, 2021, Acta crystallographica. Section F, Structural biology communications.