J. Degen

H. Schwartz, J. Cates, T. Yoshii, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Plasminogen deficiency results in poor clearance of non-fibrin matrix and persistent activation of hepatic stellate cells after an acute injury.

V. Ng, N. Kelley-Loughnane, J. Degen, 2001, Journal of hepatology.

Leukocyte engagement of fibrin(ogen) via the integrin receptor alphaMbeta2/Mac-1 is critical for host inflammatory response in vivo.

D. Witte, J. Degen, E. Plow, 2004, The Journal of clinical investigation.

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice

B. Nielsen, D. Witte, L. Lund, 1998, Oncogene.

The murine urokinase-type plasminogen activator receptor gene.

K. Danø, C. Nerlov, J. Degen, 1994, The Journal of biological chemistry.

Fibrinogen, acting as a mitogen for tubulointerstitial fibroblasts, promotes renal fibrosis.

A. Melk, J. Degen, R. Schmitt, 2011, Kidney international.

Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia.

C. Kuan, K. Burns, G. Liao, 2008, The American journal of pathology.

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

T. Bugge, J. Degen, M. Flick, 1995, Genes & development.

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

A. Chauhan, D. Wagner, E. Di Cera, 2011, Blood.

Fibrin Accumulation Secondary to Loss of Plasmin‐Mediated Fibrinolysis Drives Inflammatory Osteoporosis in Mice

J. Nyman, Tetsuro Ohba, J. Cates, 2014, Arthritis & rheumatology.

Exacerbation of antigen-induced arthritis in urokinase-deficient mice.

T. Bugge, J. Degen, N. Busso, 1998, The Journal of clinical investigation.

Fibrin(ogen)-αMβ2 Interactions Regulate Leukocyte Function and Innate Immunity In Vivo

J. Degen, M. Flick, Xinli Du, 2004 .

Hemostatic Factors Contribute to Tumor Cell Metastatic Potential by a Mechanism Linked to Natural Killer Cell Function.

J. Degen, M. Flick, M. Jiroušková, 2004 .

Differential modulation of plasminogen activator gene expression by oncogene-encoded protein tyrosine kinases

N. Maihle, J. Degen, D. Connolly, 1993, Molecular and cellular biology.

Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII

Y. Takeishi, Shiori Koseki-Kuno, M. Yamakawa, 2008, Thrombosis and Haemostasis.

Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice

Shiori Koseki-Kuno, N. Takeda, J. Degen, 2008, International journal of hematology.

Genetic elimination of prothrombin in adult mice is not compatible with survival and results in spontaneous hemorrhagic events in both heart and brain.

D. Witte, S. J. Degen, E. Mullins, 2009, Blood.

Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion.

E. Mullins, J. Degen, M. Flick, 2015, Blood.

Hemostatic Factors and Inflammatory Disease

J. Degen, 1999, Thrombosis and Haemostasis.

Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin.

S. Tsirka, S. Strickland, T. Bugge, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells.

D. Morris, G. McKnight, C. Clegg, 1992, Biochemistry.

Role of fibrinogen‐ and platelet‐mediated hemostasis in mouse embryogenesis and reproduction

B. Isermann, H. Weiler, J. Degen, 2004, Journal of thrombosis and haemostasis : JTH.

Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection

David S. Paul, W. Bergmeier, B. Conlon, 2022, PLoS pathogens.

cell-surface P-selectin expression Fibrinogen is required for maintenance of platelet intracellular and

J. Freedman, J. Degen, W. Kahr, 2013 .

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

T. Bugge, J. Benach, J. Degen, 1999, The Journal of clinical investigation.

Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense.

S. Coughlin, T. David, E. Mullins, 2015, Blood.

THROMBOSIS AND HEMOSTASIS Mice expressing a mutant form of fi brinogen that cannot support fi brin formation exhibit compromised antimicrobial host defense

S. Coughlin, T. David, E. Mullins, 2015 .

Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia.

J. Degen, M. Höök, M. Flick, 2013, Blood.

Leukocyte engagement of fibrin(ogen) via the integrin receptor αMβ2/Mac-1 is critical for host inflammatory response in vivo

D. Witte, J. Degen, E. Plow, 2004 .

Antibody blockade or mutation of the fibrinogen gamma-chain C-terminus is more effective in inhibiting murine arterial thrombus formation than complete absence of fibrinogen.

B. Coller, J. Degen, H. Väänänen, 2004, Blood.

Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor

J. Degen, J. Bezerra, G. Sabla, 2006, BMC gastroenterology.

Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.

J. Degen, J. Bezerra, G. Sabla, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Plasminogen activators direct reorganization of the liver lobule after acute injury.

T. Bugge, J. Degen, G. Sabla, 2001, The American journal of pathology.

Isolation of a cDNA clone encoding S-adenosylmethionine decarboxylase. Expression of the gene in mitogen-activated lymphocytes.

D. Morris, M. Mach, M. White, 1986, The Journal of biological chemistry.

Control of thrombus embolization and fibronectin internalization by integrin alpha IIb beta 3 engagement of the fibrinogen gamma chain.

D. Wagner, H. Ni, J. Degen, 2003, Blood.

Fibrin(ogen)-alpha M beta 2 interactions regulate leukocyte function and innate immunity in vivo.

J. Degen, M. Flick, Xinli Du, 2004, Experimental biology and medicine.

Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen.

Thomas N. Sato, R. Hynes, D. Wagner, 2000, The Journal of clinical investigation.

Wound-healing defects in mice lacking fibrinogen.

J. Davidson, J. Degen, A. Drew, 2001, Blood.

Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

W. Kao, R. Converse, C. Kao, 1997, Investigative ophthalmology & visual science.

The fibrin-derived γ377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease

H. Lassmann, R. Adams, Shoana L. Sikorski, 2007, The Journal of experimental medicine.

Erratum: Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification (Journal of Clinical Investigation (2015) 125: 9 (3723) DOI: 10.1172/JCI84059)

J. Nyman, C. Duvall, W. Obremskey, 2015 .

Ligneous conjunctivitis in plasminogen-deficient mice.

T. Bugge, M. J. Danton, J. Degen, 1998, Blood.

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

T. Deerinck, Mark Ellisman, H. Lassmann, 2012, Nature Communications.

Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice

D. Witte, M. J. Danton, J. Degen, 2007, American journal of hematology.

Resolution of spontaneous bleeding events but failure of pregnancy in fibrinogen-deficient mice.

J. Degen, N. Jensen, K. Small, 1995, Genes & development.

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin αMβ2 binding motif

D. Witte, J. Degen, C. Lajeunesse, 2007 .

Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif.

D. Witte, J. Degen, C. Lajeunesse, 2007, The Journal of clinical investigation.

Activation of single‐chain urokinase‐type plasminogen activator by platelet‐associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

K. M. Baeten, S. Kanse, J. Degen, 2010, Journal of thrombosis and haemostasis : JTH.

The thrombomodulin–protein C system is essential for the maintenance of pregnancy

B. Isermann, N. Mackman, R. Pawlinski, 2003, Nature Medicine.

Physiological consequences of loss of plasminogen activator gene function in mice

P. Carmeliet, R. Bronson, R. Mulligan, 1994, Nature.

Neuronal Death and Blood–Brain Barrier Breakdown after Excitotoxic Injury Are Independent Processes

S. Strickland, T. Bugge, J. Degen, 1999, The Journal of Neuroscience.

Impaired wound healing in mice with a disrupted plasminogen gene

L. Lund, K. Danø, J. Rømer, 1996, Nature Medicine.

Plasminogen Is a Joint‐Specific Positive or Negative Determinant of Arthritis Pathogenesis in Mice

J. Degen, M. Flick, S. Thornton, 2014, Arthritis & rheumatology.

Spontaneous hematogenous and lymphatic metastasis, but not primary tumor growth or angiogenesis, is diminished in fibrinogen-deficient mice.

D. Jackson, J. Degen, Joseph S Palumbo, 2002, Cancer research.

Host fibrinogen drives antimicrobial function in Staphylococcus aureus peritonitis through bacterial-mediated prothrombin activation

N. Mackman, R. Pawlinski, S. Grover, 2020, Proceedings of the National Academy of Sciences.

Blood coagulation protein fibrinogen promotes autoimmunity and demyelination via chemokine release and antigen presentation

Sara G. Murray, H. Lassmann, J. Ryu, 2015, Nature Communications.

Replacement of diseased mouse liver by hepatic cell transplantation.

R. Palmiter, R. Palmiter, R. Brinster, 1994, Science.

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

J. Nyman, C. Duvall, W. Obremskey, 2015, The Journal of clinical investigation.

Antithrombotic thrombocytes: ectopic expression of urokinase-type plasminogen activator in platelets.

D. Eslin, M. Poncz, D. Cines, 2003, Blood.

Tissue Plasminogen Activator–Mediated Fibrinolysis Protects against Axonal Degeneration and Demyelination after Sciatic Nerve Injury

K. Akassoglou, S. Strickland, J. Degen, 2000, The Journal of cell biology.

Purification, properties and regulation of the level of bovine S-adenosylmethionine decarboxylase during lymphocyte mitogenesis.

K. Resing, D. Morris, J. Degen, 1982, Biochimica et biophysica acta.

Factor XIII activity mediates red blood cell retention in venous thrombi.

W. Lam, N. Mackman, J. Di Paola, 2014, Journal of Clinical Investigation.

Hepatic to pancreatic switch defines a role for hemostatic factors in cellular plasticity in mice.

J. Degen, J. Bezerra, G. Sabla, 2005, Proceedings of the National Academy of Sciences of the United States of America.

The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.

D. Witte, R. Muraoka, S. Waltz, 1999, The Journal of clinical investigation.

Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes.

E. Sandgren, J. Degen, T. C. Weglarz, 2000, The American journal of pathology.

Loss of Fibrinogen Rescues Mice from the Pleiotropic Effects of Plasminogen Deficiency

T. Bugge, M. J. Danton, J. Degen, 1996, Cell.

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells.

J. Degen, M. Flick, Joseph S Palumbo, 2005, Blood.

Cerebral ischemia-hypoxia induces intravascular coagulation and autophagy.

V. Schmithorst, S. Holland, P. Rakic, 2006, The American journal of pathology.

A conserved TATA-less proximal promoter drives basal transcription from the urokinase-type plasminogen activator receptor gene.

K. Helin, F. Blasi, P. De Luca, 1995, Blood.

Crescentic glomerulonephritis is diminished in fibrinogen-deficient mice.

D. Witte, P. Tipping, J. Degen, 2001, American journal of physiology. Renal physiology.

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.

T. Bugge, J. Degen, A. Drew, 2000, Blood.

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

M. Daemen, C. Esmon, O. Soehnlein, 2013, PloS one.

The murine urokinase-type plasminogen activator gene.

J. Degen, J. L. Heckel, E. Reich, 1987, Biochemistry.

Fibrinogen Triggers Astrocyte Scar Formation by Promoting the Availability of Active TGF-β after Vascular Damage

C. Schachtrup, J. Ryu, K. Akassoglou, 2010, The Journal of Neuroscience.

Genetic Interactions between the Coagulation and Fibrinolytic Systems

J. Degen, 2001, Thrombosis and Haemostasis.

Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice.

T. Bugge, J. Goguen, J. Degen, 2000, Methods.

An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

S. Tsirka, S. Strickland, T. Bugge, 1997, The Journal of Neuroscience.

Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3.

M. J. Danton, J. Degen, C. Daugherty, 1996, The EMBO journal.

Mechanisms coupling the hemostatic system to colitis-associated cancer.

J. Degen, J. Palumbo, 2010, Thrombosis research.

Plasminogen activator gene expression is induced by the src oncogene product and tumor promoters.

N. Leslie, J. Degen, S. Bell, 1990, The Journal of biological chemistry.

Fibrinogen is required for maintenance of platelet intracellular and cell-surface P-selectin expression.

J. Freedman, H. Ni, J. Degen, 2009, Blood.

Genetic Analysis of Hemostatic Factors and Cancer

E. Mullins, J. Degen, J. Palumbo, 2007 .

Role of fibrinogen in acute ischemic kidney injury.

S. Rong, F. Gueler, A. Melk, 2013, American journal of physiology. Renal physiology.

Mechanisms Linking Hemostatic Factors to Tumor Growth in Mice

J. Degen, J. Palumbo, 2003, Pathophysiology of Haemostasis and Thrombosis.

Early detection of thrombin activity in neuroinflammatory disease

R. Tsien, J. Ryu, K. M. Baeten, 2014, Annals of neurology.

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

J. Nyman, C. Duvall, W. Obremskey, 2015, The Journal of clinical investigation.

Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway.

P. Carmeliet, M. Dierssen, P. Muñoz-Cánoves, 2008, Genes & development.

Plasminogen and wound healing

L. Lund, K. Danø, J. Rømer, 1996, Nature Medicine.

The Tissue Plasminogen Activator (Tpa/Plasmin) Extracellular Proteolytic System Regulates Seizure-Induced Hippocampal Mossy Fiber Outgrowth through a Proteoglycan Substrate

Weiquan Lu, Stella E. Tsirka, Joel M. Levine, 2000, The Journal of cell biology.

DNA rearrangement causes hepatocarcinogenesis in albumin-plasminogen activator transgenic mice.

R. Palmiter, R. Palmiter, R. Brinster, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The chicken urokinase-type plasminogen activator gene.

N. Leslie, C. Kessler, J. Degen, 1990, The Journal of biological chemistry.

Factor XIII activity mediates red blood cell retention in venous thrombi.

W. Lam, N. Mackman, J. Di Paola, 2014, The Journal of clinical investigation.

Thrombomodulin is a determinant of metastasis through a mechanism linked to the thrombin binding domain but not the lectin-like domain.

H. Weiler, E. Mullins, J. Degen, 2011, Blood.

Genetic diminution of circulating prothrombin ameliorates multiorgan pathologies in sickle cell disease mice.

J. Wansapura, B. Monia, T. Rizvi, 2015, Blood.

The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A.

A. Chauhan, D. Wagner, E. Di Cera, 2011, Blood.

Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells.

T. Bugge, J. Degen, A. Drew, 2000, Blood.

Wound-healing defects in mice lacking fibrinogen.

J. Degen, Jeffrey M Davidson, Angela F. Drew, 2001, Blood.

Genetic and Pharmacological Modifications of Thrombin Formation in Apolipoprotein E-deficient Mice Determine Atherosclerosis Severity and Atherothrombosis Onset in a Neutrophil-Dependent Manner

M. Daemen, C. Esmon, O. Soehnlein, 2013, PloS one.

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

J. Nyman, C. Duvall, W. Obremskey, 2015, The Journal of clinical investigation.

Hemostatic factors support metastasis by impeding NK cell-mediated elimination of embolic tumor cells

J. Degen, M. Flick, K. Talmage, 2009 .

Plasmin Prevents Dystrophic Calcification After Muscle Injury

H. Schwartz, J. Cates, T. Yoshii, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.