J. Lenhard

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Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs.

J. Lehmann, S. Kliewer, G. Ringold, 1997, The Journal of biological chemistry.

Diabetes Education for Adults Diabetes Education for Adults with Diabetes (Part 2) with Diabetes (Part 2)

B. Zinman, P. Raskin, H. Chase, 2013 .

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Peter J. Brown, Timothy M. Willson, J. Lehmann, 1997 .

Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs*

J. Lehmann, S. Kliewer, G. Ringold, 1997, The Journal of Biological Chemistry.

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.

J. Lehmann, T. Willson, S. Kliewer, 1998, Journal of medicinal chemistry.

A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.

J. Lehmann, T. Willson, S. Kliewer, 1999, Diabetes.

Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.

T. Willson, J. L. Shenk, L. Leesnitzer, 2002, Biochemistry.

The Use of the Continuous The Use of the Continuous Glucose Monitors in Glucose Monitors in Pr Pr egnancy egnancy

B. Zinman, P. Raskin, H. Chase, 2007 .

Altered tricarboxylic acid cycle flux in primary myotubes from severely obese humans

D. Zheng, G. Dohm, W. Pories, 2018, International Journal of Obesity.

Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial

W. E. Sanabria, John A. Hamling, Ju Han Kim, 2019, The Lancet.

Dulaglutide and renal outcomes in type 2 diabetes: an exploratory analysis of the REWIND randomised, placebo-controlled trial.

W. E. Sanabria, John A. Hamling, Ju Han Kim, 2019, Lancet.

MBX-102/JNJ39659100, a novel peroxisome proliferator-activated receptor-ligand with weak transactivation activity retains antidiabetic properties in the absence of weight gain and edema.

Dorothy D. Sears, D. Sears, T. Gustafson, 2009, Molecular endocrinology.

Impaired Glucose Partitioning in Primary Myotubes from Severely Obese Women with Type 2 Diabetes.

D. Zheng, G. Dohm, W. Pories, 2020, American journal of physiology. Cell physiology.

Spousal Influence on Diabetes Self-care: Moderating Effects of Distress and Relationship Quality on Glycemic Control.

J. Laurenceau, Sy-Miin Chow, H. Tennen, 2020, Annals of behavioral medicine : a publication of the Society of Behavioral Medicine.

Identification of Proteins Involved in Endosome Fusion: Implications for Toxin Activity

M. Colombo, P. Stahl, Michael Koval, 1993 .

Muscle Rad Expression and Human Metabolism: Potential Role of the Novel Ras-Related GTPase in Energy Expenditure and Body Composition

D. Yarnall, W. Garvey, P. Wallace, 1997, Diabetes.

Identification of Rad's effector‐binding domain, intracellular localization, and analysis of expression in Pima Indians

D. Yarnall, R. Pratley, W. Garvey, 1997, Journal of cellular biochemistry.

Targeting Enteropeptidase with Reversible Covalent Inhibitors To Achieve Metabolic Benefits

Jiejun Wu, M. Cummings, Xuqing Zhang, 2020, The Journal of Pharmacology and Experimental Therapeutics.

IBC's 6th International Symposium on Obesity and 3rd International Symposium on Insulin Resistance: March 22-25, 1999, Washington, DC.

J. Lenhard, J. Cobb, 1999, Expert opinion on investigational drugs.

Chapter 13. In vitro and in vivo approaches to studying antiretroviral therapy (ART)-induced metabolic complications

J. Weiel, J. Lenhard, 2001 .

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

J. Lehmann, T. Willson, S. Kliewer, 1995, Cell.

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.

J. Lehmann, L. Moore, T. Willson, 1999, Proceedings of the National Academy of Sciences of the United States of America.

In vitro studies of endocytic vesicle fusion.

M. Colombo, P. Stahl, J. Lenhard, 1993, Methods in enzymology.

Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists.

Songfeng Lu, J. Lenhard, G. Kuo, 2007, Journal of medicinal chemistry.

Why sporadic glucose monitoring Why sporadic glucose monitoring when there is Continuous (CGM)

B. Zinman, P. Raskin, H. Chase, 2014 .

Select HIV Protease Inhibitors Alter Bone and Fat Metabolismex Vivo *

J. Lenhard, R. Jain, 2002, The Journal of Biological Chemistry.

Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion.

R. Kahn, P. Stahl, J. Lenhard, 1992, The Journal of biological chemistry.

Inhibition of endocytic transport by aluminum fluoride implicates GTPases as regulators of endocytosis.

M. Colombo, P. Stahl, J. Lenhard, 1994, Molecular membrane biology.

Personal Considerations on Personal Considerations on Clinical Development of Clinical Development of Continuous Glucose Continuous Glucose Monitoring Systems Monitoring Systems

B. Zinman, P. Raskin, H. Chase, 2007 .

Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.

J. Lenhard, M. W. Verghese, R. McConnell, 1995, Molecular pharmacology.

Characterization of endosome-endosome fusion in a cell-free system using Dictyostelium discoideum.

P. Stahl, J. Lenhard, L. Mayorga, 1992, The Journal of biological chemistry.

β-Adrenoceptor assays.

T. Kenakin, J. Lenhard, M. Paulik, 2001, Current protocols in pharmacology.

Dietary fat alters HIV protease inhibitor-induced metabolic changes in mice.

E. Furfine, J. Weiel, D. Reynolds, 2000, The Journal of nutrition.

Is brittle diabetes an Is brittle diabetes an indication for alternative indication for alternative methods of insulin delivery? methods of insulin delivery?

B. Zinman, P. Raskin, H. Chase, 2007 .

Developing Dictyostelium discoideum cells contain two distinct acid hydrolase-containing vesicles.

S. Free, J. Lenhard, E. Kasperek, 1989, Experimental cell research.

Lipogenic enzymes as therapeutic targets for obesity and diabetes.

J. Lenhard, 2011, Current pharmaceutical design.

Reconstitution of endosome fusion: identification of factors necessary for fusion competency.

M. Colombo, P. Stahl, J. Lenhard, 1992, Methods in enzymology.

Developing Dictyostelium cells contain the lysosomal enzyme alpha- mannosidase in a secretory granule

S. Free, J. Lenhard, A. Siegel, 1989, The Journal of cell biology.

Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.

J. Lenhard, D. T. Minnick, D. Croom, 2004, Biochemical and biophysical research communications.

Metabolic complications associated with antiretroviral therapy.

E. Furfine, J. Lenhard, L. Pedneault, 2001, Antiviral research.

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma.

J. Lehmann, T. Willson, S. Kliewer, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Stimulation of vitamin A(1) acid signaling by the HIV protease inhibitor indinavir.

E. Furfine, J. Weiel, J. Lenhard, 2000, Biochemical pharmacology.

Thiazolidinediones inhibit alkaline phosphatase activity while increasing expression of uncoupling protein, deiodinase, and increasing mitochondrial mass in C3H10T1/2 cells

J. Lenhard, M. Paulik, 1997, Cell and Tissue Research.

HIV protease inhibitors block adipogenesis and increase lipolysis in vitro.

E. Furfine, J. Weiel, S. Blanchard, 2000, Antiviral research.

Therapeutic approaches to Type 2 diabetes mellitus

J. Lenhard, M. Paulik, M. L. Rose, 1999 .

Effects of troglitazone and metformin on glucose and lipid metabolism: alterations of two distinct molecular pathways.

J. Lehmann, S. Kliewer, J. Weiel, 1997, Biochemical pharmacology.

Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.

J. Lenhard, P. Hornby, Bhanu Singh, 2019, American journal of physiology. Gastrointestinal and liver physiology.

Discovery of a novel series of guanidinebenzoates as gut-restricted enteropeptidase and trypsin dual inhibitors for the treatment of metabolic syndrome.

M. Cummings, Xuqing Zhang, Weimei Sun, 2021, Bioorganic & Medicinal Chemistry Letters.

1104 - Intestinal Serine Protease Inhibition Increases Liver FGF21 Secretion in Diabetic Obese Mice

J. Lenhard, P. Hornby, J. Lanter, 2018 .

Clathrin-coated vesicles from human placenta contain GTP-binding proteins.

P. Stahl, J. Lenhard, M. Levy, 1991, Biochemical and biophysical research communications.

Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome

G. Dohm, W. Pories, G. Leo, 2018, PloS one.

Microbiota‐derived tryptophan indoles increase after gastric bypass surgery and reduce intestinal permeability in vitro and in vivo

G. Leo, J. Lenhard, P. Hornby, 2018, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

HIV Protease Inhibitors Stimulate Hepatic Triglyceride Synthesis

J. Weiel, J. Lenhard, D. Winegar, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents.

H. Askari, J. Geisler, R. Patch, 2011, Journal of medicinal chemistry.

Thioredoxin-mimetic peptide CB3 lowers MAPKinase activity in the Zucker rat brain

D. Atlas, M. Trus, J. Lenhard, 2014, Redox biology.

A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus

K. Konvička, M. Athanasiou, Qingqin S. Li, 2016, Pharmacogenetics and genomics.

Bone mineral loss in HIV-positive patients receiving antiretroviral therapy.

J. Weiel, J. Lenhard, 2000, AIDS.

The RXR agonist LG100268 causes hepatomegaly, improves glycaemic control and decreases cardiovascular risk and cachexia in diabetic mice suffering from pancreatic beta-cell dysfunction

R. M. Lightfoot, J. Weiel, J. Lenhard, 1999, Diabetologia.

Metabolic and Hormonal Alterations Induced by Roux-en-Y Gastric Bypass

G. Dohm, W. Pories, G. Leo, 2017, bioRxiv.

Cardiovascular Autonomic Neuropathy: The Clinical Significance of Its Determination

R. Maser, J. Lenhard, James M. Lenhard, 2000 .

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.

J. Lehmann, P. Charifson, L. Leesnitzer, 1998, Journal of medicinal chemistry.

Preclinical developments in type 2 diabetes.

J. Lenhard, W. Gottschalk, James M Lenhard, 2002, Advanced drug delivery reviews.

2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV.

T. Tomaszek, K. Wells-Knecht, J. Lenhard, 2005, Bioorganic & medicinal chemistry letters.

N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.

P. Charifson, K. Brown, S. Blanchard, 1998, Journal of medicinal chemistry.

Potent Sodium/Glucose Cotransporter SGLT1/2 Dual Inhibition Improves Glycemic Control Without Marked Gastrointestinal Adaptation or Colonic Microbiota Changes in Rodents

N. Ajami, T. Kirchner, F. Du, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.

Ling Lin, M. McDonnell, J. Lenhard, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Development of Infrared Imaging to Measure Thermogenesis in Cell Culture: Thermogenic Effects of Uncoupling Protein-2, Troglitazone, and β-Adrenoceptor Agonists

J. Weiel, R. Buckholz, J. Lenhard, 1998, Pharmaceutical Research.

Structure-based design of potent retinoid X receptor alpha agonists.

H. Xu, S. Blanchard, V. Montana, 2004, Journal of medicinal chemistry.

PPAR gamma/RXR as a molecular target for diabetes.

J. Lenhard, 2001, Receptors and Channels.

Pathological Significance of Pathological Significance of Glycemic Variability Glycemic Variability

B. Zinman, P. Raskin, H. Chase, 2011 .

A peroxisome proliferator-activated receptor g ligand inhibits adipocyte differentiation

J. Lehmann, L. Moore, T. Willson, 1999 .

Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase.

D. Kassel, W. Rocque, W. Holmes, 1996, The Biochemical journal.

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.

J. Lenhard, G. Kuo, T. Rano, 2013, Bioorganic & medicinal chemistry letters.

Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial.

W. E. Sanabria, John A. Hamling, Ju Han Kim, 2019, Lancet.

Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion.

R. Kahn, P. Stahl, J. Lenhard, 1992, The Journal of biological chemistry.