J. Whelan

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Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice.

M. Zemel, Hang Shi, M. Mcentee, 2002, Cancer research.

The saturated fat and dietary carbohydrate debate : are they ‘ ‘ one and the same ’ ’ relative to cardiovascular risk ?

W. Willett, A. Lichtenstein, P. Kris-Etherton, 2022 .

Prostaglandin E 2 Protects Intestinal Tumors from Nonsteroidal Anti-inflammatory Drug-induced Regression in ApcMin / Mice 1

M. Zemel, Hang Shi, M. Mcentee, 2002 .

Dietary stearidonic acid is a long chain (n-3) polyunsaturated fatty acid with potential health benefits.

J. Whelan, 2009, The Journal of nutrition.

Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway

Mohammed AlQuraishi, J. Whelan, D. Donohoe, 2020, Cell Communication and Signaling.

Antithetic relationship of dietary arachidonic acid and eicosapentaenoic acid on eicosanoid production in vivo.

J. Whelan, C. Birdwell, B. Li, 1994, Journal of lipid research.

Dietary arachidonic acid increases eicosanoid production in the presence of equal amounts of dietary eicosapentaenoic acid.

J. Whelan, C. Birdwell, B. Li, 1997, Advances in experimental medicine and biology.

Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice.

M. Mcentee, J. Whelan, Carol C. Ziegler, 2004, The Journal of nutrition.

Biochemical and Molecular Actions of Nutrients Dietary Resveratrol Does Not Affect Intestinal Tumorigenesis in ApcMin / Mice 1

M. Mcentee, J. Whelan, Carol C. Ziegler, 2003 .

Evidence for mechanisms of the hypotriglyceridemic effect of n-3 polyunsaturated fatty acids.

J. Kinsella, J. Whelan, M. Surette, 1992, Biochimica et biophysica acta.

Omega-3 Fatty Acid Consumption and Prostate Cancer: A Review of Exposure Measures and Results of Epidemiological Studies

J. Whelan, P. Terry, R. Patzer, 2016, Journal of the American College of Nutrition.

Increasing dietary linoleic acid does not increase tissue arachidonic acid content in adults consuming Western-type diets: a systematic review

J. Whelan, B. Rett, Brian S Rett, 2011, Nutrition & metabolism.

Fatty acids in cardiovascular health and disease: a comprehensive update.

W. Willett, A. Lichtenstein, P. Kris-Etherton, 2012, Journal of clinical lipidology.

Stearidonic and eicosapentaenoic acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via Toll-like receptor-2-mediated pathways.

N. Moustaid‐Moussa, Zhou Zhou, J. Whelan, 2011, The Journal of nutrition.

Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis.

M. Mcentee, J. Whelan, C. Chiu, 1997, Cancer research.

Sustainable Production of Omega-3 Fatty Acids

R. Hardy, H. Valentin, J. Whelan, 2014 .

Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention.

M. Freeman, M. Goldman, O. Grandas, 2019, Nutrition research.

Dietary Polyunsaturated Fatty Acids, Eicosanoids, and Intestinal Tumorigenesis

S. Baek, M. Mcentee, J. Whelan, 2005 .

Dietary (n-6) PUFA and intestinal tumorigenesis.

M. Mcentee, J. Whelan, 2004, The Journal of nutrition.

Discordant effect of aspirin and indomethacin on intestinal tumor burden in Apc(Min/+)mice.

M. Mcentee, J. Whelan, C. Chiu, 2000, Prostaglandins, leukotrienes, and essential fatty acids.

Assessment of the arachidonic acid content in foods commonly consumed in the American diet

J. Whelan, C. Chiu, Laura M Taber, 1998, Lipids.

Intestinal tumor load in the Min/+ mouse model is not correlated with eicosanoid biosynthesis.

M. Mcentee, J. Whelan, C. Chiu, 1999, Advances in experimental medicine and biology.

The effects of dietary n-3 polyunsaturated fatty acids and cyclic AMP-elevating agents on tumor necrosis factor production by murine-resident and thioglycollate-elicited peritoneal macrophages

J. Kinsella, J. Whelan, M. Surette, 1993 .

Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-κB and the lipolytic PKA activation in 3T3-L1 adipocytes.

N. Moustaid‐Moussa, Guoxun Chen, J. Whelan, 2013, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Presence and Biotransformation of three Heteroaromatic Compounds Compared to an Aromatic Hydrocarbon

J. Hellou, J. Banoub, S. Papiernik, 1999 .

Biochemical and Molecular Actions of Nutrients Angiotensin II Increases Leptin Secretion by 3 T 3L 1 and Human Adipocytes via a Prostaglandin-Independent Mechanism 1 , 2

N. Moustaid‐Moussa, J. Whelan, K. Claycombe, 2002 .

Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism.

N. Moustaid‐Moussa, J. Whelan, K. Claycombe, 2002, The Journal of nutrition.

The comparative effects of dietary α-linolenic acid and fish oil on 4- and 5-series leukotriene formationin vivo

J. Kinsella, J. Whelan, K. Broughton, 1991, Lipids.

Effects of eicosapentaenoic and gamma-linolenic acid on lung permeability and alveolar macrophage eicosanoid synthesis in endotoxic rats.

J. Whelan, T. Gregory, M. Karlstad, 1997, Critical care medicine.

Dietary n − 3 polyunsaturated fatty acids modify Syrian hamster platelet and macrophage phospholipid fatty acyl composition and eicosanoid synthesis: a controlled study

J. Kinsella, J. Whelan, M. Surette, 1995 .

The Unique Characteristics of the Purified 5-Lipoxygenase from Potato Tubers and the Proposed Mechanism of Formation of Leukotrienes and Lipoxins

P. Reddanna, J. Whelan, C. C. Reddy, 1990 .

Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis.

J. Kinsella, J. Whelan, K. Broughton, 1990, The Journal of nutritional biochemistry.

Zyflamend, a unique herbal blend, induces cell death and inhibits adipogenesis through the coordinated regulation of PKA and JNK

Mohammed AlQuraishi, J. Whelan, D. Donohoe, 2020, Adipocyte.

Cellular Metabolism and Dose Reveal Carnitine‐Dependent and ‐Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells

J. Whelan, D. Donohoe, Megan E Johnstone, 2016, Journal of cellular physiology.

Adipose tissue stearoyl-CoA desaturase mRNA is increased by obesity and decreased by polyunsaturated fatty acids.

M. Zemel, P. Smith, W. Banz, 1996, The American journal of physiology.

Selective inhibition of Δ-6 desaturase impedes intestinal tumorigenesis

J. Masferrer, M. Mcentee, B. Zweifel, 2002 .

Dietary polyunsaturated fatty acids and eicosanoids: potential effects on the modulation of inflammatory and immune cells: an overview.

J. Kinsella, J. Whelan, B. Lokesh, 1990, Nutrition.

(n-6) and (n-3) Polyunsaturated fatty acids and the aging brain: food for thought.

J. Whelan, 2008, The Journal of nutrition.

Characterization of the Pro‐Inflammatory Cytokine IL‐1β on Butyrate Oxidation in Colorectal Cancer Cells

J. Whelan, D. Donohoe, Megan E Johnstone, 2017, Journal of cellular biochemistry.

Biochemical and Molecular Actions of Nutrients Dietary Resveratrol Does Not Affect Intestinal Tumorigenesis in Apc Min/ (cid:1) Mice 1

M. Mcentee, J. Whelan, Carol C. Ziegler, 2003 .

Dietary (n-6) PUFA and intestinal tumorigenesis.

M. Mcentee, J. Whelan, 2004, The Journal of nutrition.

Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis.

J. Masferrer, M. Mcentee, B. Zweifel, 2002, Cancer letters.

Synthesis of arachidonic acid metabolites by syrian hamster platelets and peritoneal cells

J. Kinsella, J. Whelan, M. Surette, 1993, Lipids.

In vivo formation of leukotriene E5 by murine peritoneal cells.

J. Kinsella, J. Whelan, B. Lokesh, 1991, Prostaglandins.

Butyrate decreases its own oxidation in colorectal cancer cells through inhibition of histone deacetylases

J. Whelan, D. Donohoe, Anna Han, 2018, Oncotarget.

Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice.

P. Calder, W. Harris, C. Akoh, 2012, The Journal of nutrition.

Effects of dietary stearidonic acid on biomarkers of lipid metabolism.

Julia S. Gouffon, J. Whelan, Yi Zhao, 2012, The Journal of nutrition.

Docosahexaenoic acid: measurements in food and dietary exposure.

Katherine F. Kavanagh, J. Whelan, L. Jahns, 2009, Prostaglandins, leukotrienes, and essential fatty acids.

The health implications of changing linoleic acid intakes.

J. Whelan, 2008, Prostaglandins, leukotrienes, and essential fatty acids.

Conversion of dietary polyunsaturated fats between humans and rodents: A review of allometric scaling models.

J. Whelan, 2020, Prostaglandins, leukotrienes, and essential fatty acids.

Lost in Translation: Allometric scaling of bioactive dietary n-3 and n-6 fatty acids

J. Whelan, 2017 .

Nutrition 1-21-2009 n 3 and n 6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes

N. Kalupahana, N. Moustaid‐Moussa, A. Saxton, 2016 .

n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes

N. Kalupahana, N. Moustaid‐Moussa, A. Saxton, 2009, Nutrition & metabolism.

Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend.

Edward D. Kim, Allen K. Bourdon, S. Campagna, 2017, Journal of medicinal food.

Evidence that dietary arachidonic acid increases circulating triglycerides

J. Whelan, M. Surette, J. Bailey, 1995, Lipids.

Purification of arachidonate 5-lipoxygenase from potato tubers.

P. Reddanna, K. Maddipati, J. Whelan, 1990, Methods in enzymology.

Carboxypeptidase A-catalyzed direct conversion of leukotriene C4 to leukotriene F4.

P. Reddanna, K. S. Prabhu, J. Whelan, 2003, Archives of biochemistry and biophysics.

Allometric scaling of dietary linoleic acid on changes in tissue arachidonic acid using human equivalent diets in mice

J. Whelan, Kylie A Weldon, 2011, Nutrition & metabolism.

Dietary fish oil and fish and borage oil suppress intrapulmonary proinflammatory eicosanoid biosynthesis and attenuate pulmonary neutrophil accumulation in endotoxic rats.

J. Whelan, M. Karlstad, S. Demichele, 1997, Critical care medicine.

Zyflamend induces apoptosis in pancreatic cancer cells via modulation of the JNK pathway

Mohammed AlQuraishi, J. Whelan, Dexter L. Puckett, 2020, Cell Communication and Signaling.

Dietary arachidonic and linoleic acids: Comparative effects on tissue lipids

J. Kinsella, J. Whelan, M. Surette, 2006, Lipids.

Zyflamend Reduces the Expression of Androgen Receptor in a Model of Castrate-Resistant Prostate Cancer

S. Baek, M. Mcentee, Guoxun Chen, 2011, Nutrition and cancer.

Towards establishing dietary reference intakes for eicosapentaenoic and docosahexaenoic acids.

D. Mozaffarian, W. Harris, M. Morris, 2009, The Journal of nutrition.

Stereochemical nature of the products of linoleic acid oxidation catalyzed by lipoxygenases from potato and soybean.

P. Reddanna, J. Whelan, C. C. Reddy, 1990, Biochemical and biophysical research communications.

Turmeric and Chinese goldthread synergistically inhibit prostate cancer cell proliferation and NF-kB signaling

J. Whelan, J. Collier, Yi Zhao, 2014 .

The Role of Vitamin E and Selenium on Arachidonic Acid Oxidation by way of the 5‐Lipoxygenase Pathway

P. Reddanna, J. Burgess, J. Whelan, 1989, Annals of the New York Academy of Sciences.

Highly Unsaturated (n-3) Fatty Acids, but Not α-Linolenic, Conjugated Linoleic or γ-Linolenic Acids, Reduce Tumorigenesis in ApcMin/+ Mice

M. Mcentee, J. Whelan, M. Obukowicz, 2000 .

Avian Inflammatory Macrophage Function: Shifts in Arachidonic Acid Metabolism, Respiratory Burst, and Cell‐Surface Phenotype During the Response to Sephadex

J. Kinsella, J. Whelan, R. Dietert, 1990, Journal of leukocyte biology.

Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc -Driven Intestinal Tumorigenesis

M. Mcentee, J. Whelan, 2003 .

Dietary polyunsaturated fatty acids and colorectal neoplasia.

M. Mcentee, J. Whelan, 2002, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Dietary fats and APC-driven intestinal tumorigenesis.

C. Berdanier, N. Moustaid‐Moussa, M. Mcentee, 2001 .

Zyflamend, a polyherbal mixture, inhibits lipogenesis and mTORC1 signalling via activation of AMPK

J. Whelan, Yi Zhao, Dallas R. Donohoe, 2015 .

M. Zemel, M. Mcentee, J. Whelan, 2007, Nutrition and cancer.

Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer.

K. Tomer, M. Mcentee, F. Lih, 2008, The American journal of pathology.

Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice.

M. Mcentee, J. Whelan, C. Chiu, 1999, Carcinogenesis.

Prostaglandin E2 Protects Intestinal Tumors from Nonsteroidal Anti-inflammatory Drug-induced Regression in ApcMin/+ Mice

M. Zemel, Hang Shi, M. Mcentee, 2002 .

Antagonism of arachidonic acid is linked to the antitumorigenic effect of dietary eicosapentaenoic acid in Apc(Min/+) mice.

M. Mcentee, J. Whelan, C. Chiu, 2000, The Journal of nutrition.

Innovative dietary sources of n-3 fatty acids.

J. Whelan, Jay Whelan, Cheryl Rust, 2006, Annual review of nutrition.

Effect of increasing the dietary (n-3) to (n-6) polyunsaturated fatty acid ratio on murine liver and peritoneal cell fatty acids and eicosanoid formation.

J. Kinsella, J. Whelan, I. Hardardottir, 1991, The Journal of nutrition.

Antagonistic effects of dietary arachidonic acid and n-3 polyunsaturated fatty acids.

J. Whelan, 1996, The Journal of nutrition.

Dietary arachidonate enhances tissue arachidonate levels and eicosanoid production in Syrian hamsters.

J. Kinsella, J. Whelan, M. Surette, 1993, The Journal of nutrition.

Pyruvate kinase M2: A simple molecule with complex functions.

Amal S. Humidat, Mohammed AlQuraishi, J. Whelan, 2019, Free radical biology & medicine.

Dietary polyherbal supplementation decreases CD3+ cell infiltration into pancreatic islets and prevents hyperglycemia in nonobese diabetic mice.

J. Whelan, Susan J. Burke, J. Collier, 2015, Nutrition research.

Linoleic acid.

J. Whelan, K. Fritsche, 2013, Advances in nutrition.

Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia

R. Paulson, K. S. Prabhu, J. Whelan, 2015, Cancer Prevention Research.

The comparative effects of dietary alpha-linolenic acid and fish oil on 4- and 5-series leukotriene formation in vivo.

J. Kinsella, J. Whelan, K. Broughton, 1991, Lipids.

Biological effects of dietary arachidonic acid. Introduction.

J. German, C. Dillard, J. Whelan, 1996, The Journal of nutrition.

Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect.

M. Mcentee, J. Whelan, M. Obukowicz, 2002, Advances in experimental medicine and biology.

Ginsenoside Rc from Panax Ginseng Ameliorates Palmitate-Induced UB/OC-2 Cochlear Cell Injury

M. Hedrick, J. Whelan, B. Voy, 2023, International journal of molecular sciences.

Concurrent regulation of LKB1 and CaMKK2 in the activation of AMPK in castrate-resistant prostate cancer by a well-defined polyherbal mixture with anticancer properties

J. Whelan, Dina S. Alani, Anna Han, 2018, BMC Complementary and Alternative Medicine.

Chapter 11 Zyfl amend and Prostate Cancer Therapy

J. Whelan, A. MacDonald, Yi Zhao, 2016 .

Zyflamend, a polyherbal mixture, down regulates class I and class II histone deacetylases and increases p21 levels in castrate-resistant prostate cancer cells

S. Baek, M. Mcentee, Guoxun Chen, 2014, BMC Complementary and Alternative Medicine.

Zyflamend, a Combination of Herbal Extracts, Attenuates Tumor Growth in Murine Xenograft Models of Prostate Cancer

M. Mcentee, J. Whelan, E‐Chu Huang, 2012, Nutrition and cancer.

Dietary N-3 polyunsaturated fatty acids alter cardiac lipids in hamsters

J. Kinsella, J. Whelan, M. Surette, 1993 .

Characterization of leukotriene production in vivo and in vitro in resident and elicited peritoneal macrophages in chickens and mice.

J. Kinsella, J. Whelan, R. Dietert, 1997, Prostaglandins, leukotrienes, and essential fatty acids.

Isolation and characterization of 5-lipoxygenase from tulip bulbs.

P. Reddanna, J. Whelan, C. C. Reddy, 1988, Biochemical and biophysical research communications.

Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice.

M. Mcentee, J. Whelan, M. Obukowicz, 2000, The Journal of nutrition.

Dependence on dietary cholesterol for n-3 polyunsaturated fatty acid-induced changes in plasma cholesterol in the Syrian hamster.

J. Kinsella, J. Whelan, M. Surette, 1992, Journal of lipid research.

The effects of dietary a‐linolenic acid or eicosapentaenoic acid on hepatic gene expression patterns in C57BL/6J mice when provided at human equivalent doses

J. Whelan, Micah Brandon Flynt, 2007 .

Effect of enteral feeding with eicosapentaenoic acid, gamma-linolenic acid, and antioxidants in patients with acute respiratory distress syndrome. Enteral Nutrition in ARDS Study Group.

M. Murray, T. Albertson, P. Farmer, 1999, Critical care medicine.

Nonsteroidal Anti-Inflammatory Drugs, Prostaglandins, and Apc -Driven Intestinal Tumorigenesis

M. Mcentee, J. Whelan, 2003 .

Nonregiospecificity of the Purified Lipoxygenase from Potato Tubers

P. Reddanna, J. Whelan, G. Prasad, 1988 .

A New Pathway for the Biosynthesis of Leukotriene F4

P. Reddanna, J. Whelan, C. C. Reddy, 1988 .

Cellular Metabolism and Dose Reveal Carnitine‐Dependent and ‐Independent Mechanisms of Butyrate Oxidation in Colorectal Cancer Cells

J. Whelan, Megan E Johnstone, Anna Han, 2016, Journal of cellular physiology.

Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia

R. Paulson, K. S. Prabhu, J. Whelan, 2015, Cancer Prevention Research.

Conclusions and recommendations from the symposium, Heart Healthy Omega-3s for Food: Stearidonic Acid (SDA) as a Sustainable Choice.

P. Calder, W. Harris, C. Akoh, 2012, The Journal of nutrition.

Allometric Scaling: Determining human equivalent doses for n‐3 PUFA in rodent diets

J. Whelan, L. Jones, 2006 .

Effects of dietary stearidonic acid on biomarkers of lipid metabolism.

Julia S. Gouffon, J. Whelan, Yi Zhao, 2012, The Journal of nutrition.

Kinetics of tumour necrosis factor and prostaglandin production by murine resident peritoneal macrophages as affected by dietary n-3 polyunsaturated fatty acids.

J. Kinsella, J. Whelan, I. Hardard'ottir, 1992, Immunology.