B. Pirotte

O. Diouf, P. Renard, B. Masereel, 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Chloro-substituted 3-alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel activators: impact of the position of the chlorine atom on the aromatic ring on activity and tissue selectivity.

P. Wahl, B. Pirotte, J. Hansen, 2010, Journal of medicinal chemistry.

Effect on K(ATP) channel activation properties and tissue selectivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine 1,1-dioxides.

B. Pirotte, M. Antoine, R. Ouedraogo, 2005, Journal of medicinal chemistry.

3-(Alkylamino)-4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as powerful inhibitors of insulin release from rat pancreatic B-cells: a new class of potassium channel openers?

B. Masereel, A. Herchuelz, B. Pirotte, 1993, Journal of medicinal chemistry.

Toward tissue-selective pancreatic B-cells KATP channel openers belonging to 3-alkylamino-7-halo-4H-1,2,4-benzothiadiazine 1,1-dioxides.

P. Wahl, B. Pirotte, M. Antoine, 2003, Journal of medicinal chemistry.

Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4- thiadiazine 1,1-dioxides: A new class of heterocyclic compounds with therapeutical promises

P. Tullio, J. Dogné, B. Pirotte, 1999 .

Study of the ring closure reaction of o-aminoarylsulfonamides with 1,1′-thiocarbonyldiimidazole.

P. Tullio, B. Pirotte, F. Lacan, 1998 .

Synthesis and Biological Evaluation of New 3‐Aralkylamino‐2‐aryl‐2H‐1,2,4‐pyridothiadiazine 1,1‐dioxides as Potential CCK‐Receptor Ligands

P. Tullio, O. Diouf, P. Renard, 1997, The Journal of pharmacy and pharmacology.

Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors.

L. Danober, T. Colson, P. Lestage, 2021, ACS chemical neuroscience.

AMPA receptor positive allosteric modulators: a patent review

B. Pirotte, P. Francotte, P. de Tullio, 2013, Expert opinion on therapeutic patents.

Novel dipyrazoles acting as glutamate modulators

B. Pirotte, P. Francotte, P. de Tullio, 2007 .

Synthesis and Structural Studies of a New Class of Heterocyclic Compounds: 1,2,4-Pyridothiadiazine 1,1-Dioxides, Pyridyl Analogues of 1,2,4-Benzothiadiazine 1,1-Dioxides.

P. Tullio, O. Diouf, B. Masereel, 2010 .

2-Alkyl-3-Alkylamino-2H-Benzo- and Pyridothiadiazine 1,1-Dioxides: From K+ATP Channel Openers to Ca++ Channel Blockers?

P. Tullio, B. Pirotte, M. Antoine, 2002, Biological chemistry.

3-and 4-substituted 4H-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as potassium channel openers: synthesis, pharmacological evaluation, and structure-activity relationships.

O. Diouf, B. Masereel, B. Pirotte, 1996, Journal of medicinal chemistry.

Fully Automated Synthesis and Evaluation of [18F]BPAM121: Potential of an AMPA Receptor Positive Allosteric Modulator as PET Radiotracer

A. Luxen, C. Lemaire, A. Plenevaux, 2019, ChemMedChem.

Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds.

J. Kastrup, S. Dilly, B. Pirotte, 2018, Journal of medicinal chemistry.

7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency.

P. Tullio, C. Ptak, R. Oswald, 2018, Journal of medicinal chemistry.

Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2.

L. Olsen, J. Kastrup, C. Krintel, 2016, Biophysical journal.

Identification and pharmacological characterization of succinate receptor agonists

F. Jouret, A. Inoue, S. Dilly, 2017, British journal of pharmacology.

Insight into SUCNR1 (GPR91) structure and function.

F. Jouret, B. Pirotte, J. Hanson, 2016, Pharmacology & therapeutics.

Forskolin-free cAMP assay for Gi-coupled receptors.

B. Pirotte, J. Hanson, Nadine Dupuis, 2015, Biochemical pharmacology.

Synthesis and vasodilator activity of new 1,4-dihyropyridines bearing sulfonylurea, urea and thiourea moieties

B. Pirotte, G. Faury, S. Khelili, 2019, Chemical Papers.

Esters and amides of 6-(chloromethyl)-2-oxo-2H-1-benzopyran-3-carboxylic acid as inhibitors of alpha-chymotrypsin: significance of the "aromatic" nature of the novel ester-type coumarin for strong inhibitory activity.

J Delarge, B. Masereel, B. Pirotte, 1996, Journal of medicinal chemistry.

Toward the first class of suicide inhibitors of kallikreins involved in skin diseases.

A. Hovnanian, B. Pirotte, Xiao Tan, 2015, Journal of medicinal chemistry.

3-Bromophenyl 6-acetoxymethyl-2-oxo-2H-1-benzopyran-3-carboxylate inhibits cancer cell invasion in vitro and tumour growth in vivo

J. Foidart, A. Noël, B. Masereel, 2003, British Journal of Cancer.

Synthesis and vasodilator activity of 3,4-dihydropyrimidin-2(1H)-ones bearing urea, thiourea, and sulfonylurea moieties

P. Tullio, B. Pirotte, G. Faury, 2019, Canadian Journal of Chemistry.

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis.

J. Foidart, A. Noël, S. Blacher, 2008, European journal of medicinal chemistry.

Recent advances in the chemistry of potassium channel openers

B. Pirotte, J. Fontaine, P. Lebrun, 1995 .

Specific inhibitors of human leukocyte elastase

B. Masereel, B. Pirotte, L. Pochet, 2000 .

Coumarinic derivatives as mechanism-based inhibitors of alpha-chymotrypsin and human leukocyte elastase.

G. Dive, J. Wouters, B. Masereel, 2000, Bioorganic & medicinal chemistry.

6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid as a core structure for specific inhibitors of human leukocyte elastase.

B. Pirotte, L. Pochet, M. Reboud-Ravaux, 1999, Journal of medicinal chemistry.

Esters and Amides of 6‐(Chloromethyl)‐2‐oxo‐2H‐1‐benzopyran‐3‐ carboxylic Acid as Inhibitors of α‐Chymotrypsin: Significance of the “Aromatic” Nature of the Novel Ester‐Type Coumarin for Strong Inhibitory Activity.

P. Tullio, B. Masereel, B. Pirotte, 1996 .

Original 2-alkylamino-6-halogenoquinazolin-4(3H)-ones and K(ATP) channel activity.

B. Pirotte, L. Dupont, M. Antoine, 2001, Journal of medicinal chemistry.

3-Alkylamino-4H-1,2,4-benzothiadiazine 1,1-dioxides as ATP-sensitive potassium channel openers: effect of 6,7-disubstitution on potency and tissue selectivity.

B. Pirotte, M. Antoine, P. Francotte, 2005, Journal of medicinal chemistry.

Synthesis and pharmacological activity of N-(2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-4-yl)-4H-1,2,4-benzothiadiazine-3-carboxamides 1,1-dioxides on rat uterus, rat aorta and rat pancreatic β-cells.

B. Pirotte, S. Khelili, P. Lebrun, 2012, European journal of medicinal chemistry.

A new potential cyclooxygenase-2 inhibitor, pyridinic analogue of nimesulide.

J. Dogné, C. Charlier, C. Michaux, 2005, European journal of medicinal chemistry.

Antibacterial activity of 5-acylaminothiazole derivatives, synthetic drugs related to beta-lactam antibiotics.

J. Frère, B. Pirotte, J. Coyette, 1991, The Journal of antibiotics.

Thermodynamic Characterization of New Positive Allosteric Modulators Binding to the Glutamate Receptor A2 Ligand-Binding Domain: Combining Experimental and Computational Methods Unravels Differences in Driving Forces

Chris Oostenbrink, Lars Olsen, Ann-Beth Nørholm, 2014, J. Chem. Inf. Model..

Synthesis and pharmacological evaluation of 2-aryloxy/arylamino-5-cyanobenzenesulfonylureas as novel thromboxane A₂ receptor antagonists.

P. Kolh, J. Dogné, B. Pirotte, 2013, European journal of medicinal chemistry.

Synthesis and biological evaluation of sulfonylcyanoguanidines and sulfonamidonitroethylenes as bioisosteres of hypoglycemic sulfonylureas

P. Tullio, B. Masereel, J. Dogné, 1997 .

Effective resolution of racemic pirlindole at the preparative scale

P. Tullio, P. Hubert, J. Liégeois, 1998 .

Ligand effects in the hydrogenation of methacycline to doxycycline and epi-doxycycline catalysed by rhodium complexes molecular structure of the key catalyst [closo-3,3-(η2,3-C7H7CH2)-3,1,2-RhC2B9H11]

J. Liégeois, B. Pirotte, V. Bregadze, 1997 .

Three-dimensional quantitative structure-activity relationships of ATP-sensitive potassium (KATP) channel openers belonging to the 3-alkylamino-4H-1,2,4-benzo- and 3-alkylamino-4H-1,2,4-pyridothiadiazine 1,1-dioxide families.

Pierre Francotte, Bernard Pirotte, Philippe Lebrun, 2006, Journal of medicinal chemistry.

Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes.

L Delattre, J Delarge, L. Delattre, 1997, Journal of pharmaceutical sciences.

Stereoselective hydrogenation of methacycline to Doxycycline catalysed by rhodium-carborane complexes

B. Pirotte, V. Bregadze, I. V. Pisareva, 1993 .

Synthesis of ticagrelor analogues belonging to 1,2,3-triazolo[4,5-d]pyrimidines and study of their antiplatelet and antibacterial activity.

C. Oury, P. Lancellotti, B. Pirotte, 2020, European journal of medicinal chemistry.

3-Alkylamino-4H-pyrido[2,3-e]-1,2,4-thiadiazine 1,1-dioxides structurally related to diazoxide and pinacidil as potassium channel openers acting on vascular smooth muscle cells: design, synthesis, and pharmacological evaluation.

B. Pirotte, L. Dupont, J. Fontaine, 2000, Journal of medicinal chemistry.

3-Alkylamino-pyrido[4,3-e]-1,2,4-thiadiazine 1,1-dioxides as Potent KATP-Channel Activators: Structural Study and Influence of Stereochemistry

P. Tullio, B. Pirotte, L. Dupont, 1999 .

A pyridothiadiazine (BPDZ 44) as a new and potent activator of ATP-sensitive K+ channels.

A. Herchuelz, B. Pirotte, M. Antoine, 1994, Biochemical pharmacology.

Absolute Configuration of (R)-1-Phenylethylammonium (S)-2-(6-Methoxy-2-naphthyl)propionate

B. Pirotte, L. Dupont, J. Delarge, 1996 .

Design, synthesis, and pharmacological evaluation of pyridinic analogues of nimesulide as cyclooxygenase-2 selective inhibitors.

J. Winum, J. Montero, J. Dogné, 2004, Journal of medicinal chemistry.

Spectral and crystallographic study of pyridinic analogues of nimesulide: determination of the active form of methanesulfonamides as COX-2 selective inhibitors.

J. Dogné, C. Charlier, C. Michaux, 2002, Journal of medicinal chemistry.

Recent advances in the chemistry of cholecystokinin receptor ligands (agonists and antagonists).

B. Pirotte, J. Delarge, P. de Tullio, 1999, Current medicinal chemistry.

4,6-Disubstituted 2,2-dimethylchromans structurally related to the K(ATP) channel opener cromakalim: design, synthesis, and effect on insulin release and vascular tone.

B. Pirotte, M. Antoine, P. Lebrun, 2005, Journal of medicinal chemistry.

Synthesis, crystal structure, Hirshfeld surface and interaction energies analysis of 5-methyl-1,3-bis(3-nitrobenzyl)pyrimidine-2,4(1H,3H)-dione

G. Zaragoza, B. Pirotte, Koffi Sénam Etsè, 2020 .

Inhibition of LTβR signalling activates WNT-induced regeneration in lung

F. Tacke, M. Boutros, S. Verleden, 2020, Nature.

Crystal structure and Hirshfeld surface analysis of N-(2-(N-methylsulfamoyl)phenyl)formamide: Degradation product of 2-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

G. Zaragoza, B. Pirotte, Koffi Sénam Etsè, 2019, European Journal of Chemistry.

Recent developments in 5lipoxygenase inhibitors

J. Dogné, B. Pirotte, F. Julémont, 2003 .

Recent developments in 5-lipoxygenase inhibitors

J. Dogné, B. Pirotte, F. Julémont, 2003 .

Influence of the alkylsulfonylamino substituent located at the 6-position of 2,2-dimethylchromans structurally related to cromakalim: from potassium channel openers to calcium entry blockers?

B. Pirotte, P. Lebrun, P. de Tullio, 2014, European journal of medicinal chemistry.

Modulation of the 6-position of benzopyran derivatives and inhibitory effects on the insulin releasing process.

S. Dilly, B. Pirotte, P. Lebrun, 2011, Bioorganic & medicinal chemistry.

Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro.

J. Scuvée-Moreau, A. Dresse, B. Vrijens, 1997, Archives of physiology and biochemistry.

BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.

P. Clayton, K. Hussain, J. Saudubray, 2002, The Journal of clinical endocrinology and metabolism.

First and second generations of COX-2 selective inhibitors.

V. Benoît, J. Dogné, M. Frédérich, 2004, Mini reviews in medicinal chemistry.

Is thrombin generation the new rapid, reliable and relevant pharmacological tool for the development of anticoagulant drugs?

Bernard Pirotte, Bernard Masereel, B. Masereel, 2009, Pharmacological research.

Discovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines.

W. Berger, R. Kiss, A. Mazumder, 2017, Journal of medicinal chemistry.

Development and validation of a nonaqueous capillary electrophoretic method for the enantiomeric purity determination of a synthetic intermediate of new 3,4-dihydro-2,2-dimethyl-2H-1-benzopyrans using a single-isomer anionic cyclodextrin derivative and an ionic liquid.

D. Villemin, A. Varenne, A. Servais, 2010, Journal of chromatography. A.

Design, Synthesis, and Evaluation of Novel Pyruvate Dehydrogenase Kinase Inhibitors.

V. Lambert, A. Noël, B. Elmoualij, 2022, Medicinal chemistry (Shariqah (United Arab Emirates)).

N-Aryl-N'-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: screening, synthesis of simplified derivatives, and structure-activity relationship analysis.

R. Kiss, F. Lefranc, B. Pirotte, 2012, European journal of medicinal chemistry.

Ring-fused thiadiazines as core structures for the development of potent AMPA receptor potentiators.

L. Danober, P. Lestage, B. Pirotte, 2010, Current medicinal chemistry.

Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

L. Danober, P. Lestage, J. Kastrup, 2016, ACS Chemical Neuroscience.

New insights in the development of positive allosteric modulators of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors belonging to 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides: Introduction of (mono/difluoro)methyl groups at the 2-position of the thiadiazine ring.

L. Danober, B. Pirotte, J. Hanson, 2023, European journal of medicinal chemistry.

Simple di- and trivanillates exhibit cytostatic properties toward cancer cells resistant to pro-apoptotic stimuli.

R. Kiss, J. Kraus, A. Kornienko, 2010, Bioorganic & medicinal chemistry.

From the design to the clinical application of thromboxane modulators.

Bernard Pirotte, Pierre Drion, D. Praticò, 2006, Current pharmaceutical design.

New biological investigations on 3‐bromophenyl 6‐acetoxymethyl‐2‐oxo‐2H‐1‐benzopyran‐3‐carboxylate as anti‐angiogenic agent

V. Lambert, J. Foidart, A. Noël, 2010 .

Verapamil, a phenylalkylamine Ca2 + channel blocker, inhibits ATP-sensitive K + channels in insulin-secreting cells from rats

A. Herchuelz, B. Pirotte, R. Ouédraogo, 1997, Diabetologia.

Unusual Amino Acids and Monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a Toxic Plant from Rwanda

L. Angenot, A. Servais, M. Tits, 2013, Planta Medica.

Design, synthesis, and pharmacological evaluation of R/S-3,4-dihydro-2,2-dimethyl- 6-halo-4-(phenylaminocarbonylamino)-2H-1-benzopyrans: toward tissue-selective pancreatic beta-cell KATP channel openers structurally related to (+/-)-cromakalim.

B. Pirotte, D. Gall, P. Lebrun, 2006, Journal of medicinal chemistry.

Metabolomics as a Challenging Approach for Medicinal Chemistry and Personalized Medicine.

M. Frédérich, M. Fillet, B. Pirotte, 2016, Journal of medicinal chemistry.

N-tert-butyl-N'-[5-cyano-2-(4-methylphenoxy)phenylsulfonyl]urea, a new TXA₂ receptor antagonist.

B. Pirotte, L. Van Meervelt, Sylvie-Mireille Bambi-Nyanguile, 2013, Acta crystallographica. Section C, Crystal structure communications.

New developments on thromboxane and prostacyclin modulators part II: prostacyclin modulators.

B. Masereel, J. Dogné, J. David, 2004, Current medicinal chemistry.

New developments on thromboxane and prostacyclin modulators part I: thromboxane modulators.

P. Kolh, A. Casini, B. Lambermont, 2004, Current medicinal chemistry.

Pharmacological evaluation of the novel thromboxane modulator BM-567 (I/II). Effects of BM-567 on platelet function.

P. Kolh, B. Masereel, S. Rolin, 2003, Prostaglandins, leukotrienes, and essential fatty acids.

A Sulphonylthiourea (BM 20) Related to Torasemide: a new Loop Diuretic with Relative Potassium‐sparing Properties

B. Masereel, B. Pirotte, G. Rorive, 1993, The Journal of pharmacy and pharmacology.

A short series of antidiabetic sulfonylureas exhibit multiple ligand PPARgamma-binding patterns.

S. Rocchi, B. Pirotte, A. Arrault, 2009, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Activation of the Orphan G Protein–Coupled Receptor GPR27 by Surrogate Ligands Promotes β-Arrestin 2 Recruitment

J. Twizere, A. Soni, D. Franssen, 2017, Molecular Pharmacology.

Effect on insulin release of compounds structurally related to the potassium‐channel opener 7‐chloro‐3‐isopropylamino‐4H‐1,2,4‐benzothiadiazine 1,1‐dioxide (BPDZ 73): introduction of heteroatoms on the 3‐alkylamino side chain of the benzothiadiazine 1,1‐dioxide ring

P. Tullio, B. Pirotte, M. Antoine, 2001, The Journal of pharmacy and pharmacology.

Advances in the field of COX-2 inhibition

J. Dogné, B. Pirotte, F. Julémont, 2002 .

Investigation of the inhibition mechanism of coumarins on chymotrypsin by mass spectrometry

B. Masereel, B. Pirotte, R. Frédérick, 2003 .

Deciphering Structure–Activity Relationships in a Series of 2,2‐Dimethylchromans Acting as Inhibitors of Insulin Release and Smooth Muscle Relaxants

B. Pirotte, P. Lebrun, Xavier Florence, 2017, ChemMedChem.

N-(3-Arylaminopyridin-4-yl)alkanesulfonamides as pyridine analogs of nimesulide: cyclooxygenases inhibition, anti-inflammatory studies and insight on metabolism.

P. Hubert, F. Lecomte, X. de Leval, 2014, European journal of medicinal chemistry.

Activity and inhibition mechanism of coumarin-based derivatives as protease inhibitor

B. Masereel, B. Pirotte, L. Pochet, 2000 .

Protective Effect of Ticagrelor Against Infective Endocarditis Induced by Virulent Staphylococcus aureus in Mice

P. Delvenne, C. Hubert, P. Verhamme, 2023, JACC. Basic to translational science.

New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.

L. Danober, P. Chiap, P. Lestage, 2010, Journal of Medicinal Chemistry.

3‐Isopropylamino‐4‐methyl‐4H‐pyrido[4,3‐e][1,2,4]thiadiazine 1,1‐Dioxide

P. Tullio, B. Pirotte, L. Dupont, 1996 .

Structural Study of Pinacidil, a Potassium‐Channel Opener Belonging to the chemical class of N‐alkyl‐N″‐cyano‐N′‐pyridylguanidines

P. Tullio, B. Masereel, B. Pirotte, 1993 .

New developments on thromboxane modulators.

P. Kolh, B. Masereel, J. Dogné, 2004, Mini reviews in medicinal chemistry.

Publisher Correction: Inhibition of LTβR signalling activates WNT-induced regeneration in lung

Fabian J Theis, F. Tacke, M. Boutros, 2020, Nature.

First preparative enantiomer resolution of pirlindole, a potent antidepressant drug

P. Tullio, P. Hubert, J. Liégeois, 1998 .

The riddle of formycin A insulinotropic action.

P. Rorsman, P. D. van Poelje, W. Malaisse, 1996, Biochemical and Molecular Medicine.

Modulation of the arachidonic cascade with omega3 fatty acids or analogues: potential therapeutic benefits.

L. Delattre, J. Dogné, B. Evrard, 2004, Mini reviews in medicinal chemistry.

Structural studies on the inhibitory binding mode of aromatic coumarinic esters to human kallikrein-related peptidase 7.

N. Sträter, S. Hanke, B. Pirotte, 2020, Journal of medicinal chemistry.

Frontiers in Medicinal Chemistry

S. A. Hutchinson, H. Wolfson, R. Nussinov, 2016 .

Polyhydroxybenzoic acid derivatives as potential new antimalarial agents

M. Frédérich, B. Pirotte, P. Francotte, 2021, Archiv der Pharmazie.

4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.

B. Pirotte, P. Lebrun, P. de Tullio, 2016, European journal of medicinal chemistry.

2,2-Dimethyl-3,4-dihydro-2H-1,4-benzoxazines as isosteres of 2,2-dimethylchromans acting as inhibitors of insulin release and vascular smooth muscle relaxants.

B. Pirotte, P. Lebrun, Xavier Florence, 2019, MedChemComm.

Selective pancreatic ATP-sensitive potassium channel openers for the treatment of glucose homeostasis disorders

P. Tullio, B. Pirotte, M. Antoine, 2006 .

Synthesis and pharmacological evaluation of some N-arylsulfonyl-N-methyl-N'-(2,2-dimethyl-2H-1-benzopyran-4-yl)ureas structurally related to cromakalim.

B. Pirotte, S. Khelili, P. Lebrun, 2006, Bioorganic & medicinal chemistry.

Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor.

J. Kastrup, B. Pirotte, S. Laulumaa, 2018, ACS medicinal chemistry letters.

V. Lambert, A. Noël, B. Elmoualij, 2013 .

Recent advances in inducible cyclooxygenase (COX-2) inhibition.

J Delarge, J. Dogné, Y. Henrotin, 2000, Current medicinal chemistry.

Synthesis and structural studies of a new class of heterocyclic compounds: 1,2,4-Pyridothiadiazine 1,1-dioxides, pyridyl analogues of 1,2,4-benzothiadiazine 1,1-dioxides

P. Tullio, O. Diouf, B. Masereel, 1995 .

4-Phenylureido/thioureido-substituted 2,2-dimethylchroman analogs of cromakalim bearing a bulky 'carbamate' moiety at the 6-position as potent inhibitors of glucose-sensitive insulin secretion.

B. Pirotte, P. Lebrun, P. de Tullio, 2016, European journal of medicinal chemistry.

Synthesis and activity on rat aorta rings and rat pancreatic beta-cells of ring-opened analogues of benzopyran-type potassium channel activators.

B. Pirotte, S. Khelili, P. Lebrun, 2008, Bioorganic & medicinal chemistry.

Pyridine analogues of nimesulide: design, synthesis, and in vitro and in vivo pharmacological evaluation as promising cyclooxygenase 1 and 2 inhibitors.

N. Garbacki, X. de Leval, B. Pirotte, 2009, Journal of medicinal chemistry.

Cationic and secretory effects of BPDZ 44 and diazoxide in rat pancreatic islets

P. Tullio, A. Herchuelz, B. Pirotte, 1994, Experientia.

Pyridothiadiazines as potent inhibitors of glucose-induced insulin release.

A. Herchuelz, B. Pirotte, M. Antoine, 1997, Advances in experimental medicine and biology.

Synthesis and structural studies of 3-alkylamino-pyrido[4,3-e]-1,2,4- thiadiazine 1,1-dioxides: A new class of heterocyclic compounds with therapeutical promises

P. Tullio, J. Dogné, B. Pirotte, 1999 .

Evaluation of the Inhibitory Activity on Serine and Aspartic Proteases of 4‐Amino‐4H‐1,2,4‐triazole and 5‐Aminothiazole Derivatives Structurally Related to β‐Lactam Antibiotics

B. Masereel, B. Pirotte, M. Reboud-Ravaux, 1993, The Journal of pharmacy and pharmacology.