A. Kohen

发表

Mechanisms and inhibition of uracil methylating enzymes.

T. V. Mishanina, E. Koehn, A. Kohen, 2012, Bioorganic chemistry.

Preserved hydride transfer mechanism in evolutionarily divergent thymidylate synthases.

Zhen Wang, A. Kohen, T. Abeysinghe, 2016, Current topics in biochemical research.

Targeting the de novo biosynthesis of thymidylate for the development of a PET probe for pancreatic cancer imaging.

A. Kohen, M. Saeed, T. D. Nilaweera, 2015, Biochemistry.

Improved Sugar Puckering Profiles for Nicotinamide Ribonucleoside for Hybrid QM/MM Simulations.

D. Major, A. Kohen, R. Eitan, 2016, Journal of chemical theory and computation.

Structural and Kinetic Studies of Formate Dehydrogenase from Candida boidinii.

D. Major, L. Gakhar, A. Kohen, 2016, Biochemistry.

A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase.

V. Moliner, S. Martí, A. Kohen, 2007, Biochemistry.

Benchmarking Quantum Mechanics/Molecular Mechanics (QM/MM) Methods on the Thymidylate Synthase-Catalyzed Hydride Transfer.

V. Moliner, A. Kohen, K. Świderek, 2017, Journal of chemical theory and computation.

Escherichia coli dihydrofolate reductase catalyzed proton and hydride transfers: Temporal order and the roles of Asp27 and Tyr100

S. Benkovic, S. Hammes-Schiffer, A. Kohen, 2014, Proceedings of the National Academy of Sciences.

Mechanistic studies of a flavin-dependent thymidylate synthase.

Peter Kuhn, Scott A Lesley, Amnon Kohen, 2004, Biochemistry.

Flavin-dependent thymidylate synthase: N5 of flavin as a Methylene carrier.

A. Kohen, D. Quinn, N. Luedtke, 2017, Archives of biochemistry and biophysics.

Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target

A. Kohen, K. Karunaratne, Michael Choi, 2016, Molecules.

Folate binding site of flavin-dependent thymidylate synthase

S. Lesley, I. Mathews, Arjun Prabhakar, 2012, Proceedings of the National Academy of Sciences.

Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase.

S. Lesley, B. Palfey, T. V. Mishanina, 2012, Journal of the American Chemical Society.

The relationships between oxidase and synthase activities of flavin dependent thymidylate synthase (FDTS).

S. Lesley, E. Koehn, A. Kohen, 2007, Chemical communications.

Enzyme Catalysis: Beyond Classical Paradigms

J. Klinman, A. Kohen, 1998 .

Microscale synthesis of 2-tritiated isopropanol and 4R-tritiated reduced nicotinamide adenine dinucleotide phosphate.

A. Kohen, Nitish Agrawal, 2003, Analytical biochemistry.

Microscale synthesis of isotopically labeled R-[6-xH]N5,N10-methylene-5,6,7,8-tetrahydrofolate as a cofactor for thymidylate synthase.

A. Kohen, Nitish Agrawal, C. Mihai, 2004, Analytical biochemistry.

Synthesis of R and S tritiated reduced beta-nicotinamide adenine dinucleotide 2' phosphate.

A. Kohen, Lin Wang, J. A. McCracken, 2004, Analytical biochemistry.

Chemo-enzymatic synthesis of the exocyclic olefin isomer of thymidine monophosphate.

E. Koehn, A. Kohen, D. Mondal, 2018, Bioorganic & medicinal chemistry.

Synthesis and utility of 14C-labeled nicotinamide cofactors.

A. Kohen, K. A. Markham, R. Sikorski, 2004, Analytical biochemistry.

The Kinetic Isotope Effect in the Photo-Dissociation Reaction of Excited-State Acids in Aqueous Solutions

A. Kohen, H. Limbach, 2005 .

Noncovalent Intermediate of Thymidylate Synthase: Fact or Fiction?

A. Kohen, S. A. Kholodar, 2016, Journal of the American Chemical Society.

Protein Mass Effects on Formate Dehydrogenase.

Andrew L. Lee, P. Sapienza, A. Kohen, 2017, Journal of the American Chemical Society.

Role of Dynamics in Enzyme Catalysis: Substantial versus Semantic Controversies

A. Kohen, 2014, Accounts of chemical research.

Evolutionary Aspects of Enzyme Dynamics*

J. Klinman, A. Kohen, 2014, The Journal of Biological Chemistry.

Effects of enzyme glycosylation on the chemical step of catalysis, as probed by hydrogen tunneling and enthalpy of activation

J. Klinman, T. Jonsson, A. Kohen, 1997 .

Catalytic mechanism of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase. The use of synthetic analogues to probe the structure of the putative reaction intermediate.

V. Belakhov, T. Baasov, A. Kohen, 1993, European journal of biochemistry.

Mechanistic studies of 3-deoxy-D-manno-2-octulosonate-8-phosphate synthase from Escherichia coli.

T. Baasov, A. Kohen, A. Jakob, 1992, European journal of biochemistry.

Oscillatory Enzyme Dynamics Revealed by Two-Dimensional Infrared Spectroscopy.

A. Kohen, C. Cheatum, Q. Guo, 2016, The journal of physical chemistry letters.

3-picolyl azide adenine dinucleotide as a probe of femtosecond to picosecond enzyme dynamics.

J. Houtman, A. Kohen, Yun-Liang Li, 2012, The journal of physical chemistry. B.

Exploring the molecular origins of protein dynamics in the active site of human carbonic anhydrase II.

Jigar N. Bandaria, A. Kohen, C. Cheatum, 2009, The journal of physical chemistry. B.

Fast enzyme dynamics at the active site of formate dehydrogenase.

Jigar N. Bandaria, A. Kohen, S. Dutta, 2008, Journal of the American Chemical Society.

Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog.

R. Stroud, J. Finer-Moore, V. Moliner, 2021, Biochemistry.

Parallel reaction pathways and noncovalent intermediates in thymidylate synthase revealed by experimental and computational tools

V. Moliner, A. Kohen, K. Świderek, 2018, Proceedings of the National Academy of Sciences.

Activation of Two Sequential H-transfers in the Thymidylate Synthase Catalyzed Reaction.

Z. Islam, A. Kohen, T. Strutzenberg, 2015, ACS catalysis.

Tunneling and coupled motion in the Escherichia coli dihydrofolate reductase catalysis.

S. Benkovic, P. Rajagopalan, A. Kohen, 2004, Journal of the American Chemical Society.

Protein motions and the activation of the CH bond catalyzed by dihydrofolate reductase.

A. Kohen, K. Francis, 2014, Current opinion in chemical biology.

The influence of active site conformations on the hydride transfer step of the thymidylate synthase reaction mechanism.

V. Moliner, A. Kohen, K. Świderek, 2015, Physical chemistry chemical physics : PCCP.

Nonperfect synchronization of reaction center rehybridization in the transition state of the hydride transfer catalyzed by dihydrofolate reductase.

D. Truhlar, Jiali Gao, Shuhua Ma, 2005, Journal of the American Chemical Society.

Isotope Effects In Chemistry and Biology

A. Kohen, H. Limbach, 2005 .

Hybrid Quantum and Classical Simulations of the Dihydrofolate Reductase Catalyzed Hydride Transfer Reaction on an Accurate Semi-Empirical Potential Energy Surface.

W. Thiel, D. Major, Xin Wu, 2011, Journal of chemical theory and computation.

Catalytic mechanism of KDO8P synthase. Pre-steady-state kinetic analysis using rapid chemical quench flow methods

K. Anderson, P. Liang, T. Baasov, 1997 .

Towards the synthesis of the putative reaction intermediate in the Kdo8P synthase-catalyzed reaction. Synthesis and evaluation of 3-deoxy--manno-2-octulosonate-2-phosphate

V. Belakhov, T. Baasov, A. Kohen, 1994 .

Arrhenius curves of hydrogen transfers: tunnel effects, isotope effects and effects of pre-equilibria

Amnon Kohen, Hans-Heinrich Limbach, A. Kohen, 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

Thymidylate synthase catalyzed H-transfers: two chapters in one tale.

Zhen Wang, A. Kohen, 2010, Journal of the American Chemical Society.

The effect of active-site isoleucine to alanine mutation on the DHFR catalyzed hydride-transfer.

S. Benkovic, Jeeyeon Lee, A. Kohen, 2010, Chemical communications.

Hydrogen tunneling in biology.

J. Klinman, A. Kohen, Amnon Kohen, 1999, Chemistry & biology.

Chemoenzymatic Synthesis of Ubiquitous Biological Redox Cofactors

A. Kohen, Q. Guo, Priyanka Singh, 2017, Synlett.

Analytical Procedures for the Preparation, Isolation, Analysis and Preservation of Reduced Nicotinamides

A. Kohen, K. A. Markham, 2006 .

An unprecedented mechanism of nucleotide methylation in organisms containing thyX

Liping Yu, A. Kohen, D. Mondal, 2016, Science.

Microscale synthesis of isotopically labeled 6R-N5, N10 methylene-5, 6, 7, 8-tetrahydrofolate

A. Kohen, B. Hong, 2005 .

Measurement of Enzyme Isotope Effects.

A. Kohen, S. A. Kholodar, Ananda K Ghosh, 2017, Methods in enzymology.

Protein Mass-Modulated Effects in the Catalytic Mechanism of Dihydrofolate Reductase: Beyond Promoting Vibrations

V. Schramm, Zhen Wang, A. Kohen, 2014, Journal of the American Chemical Society.

Characterizing the dynamics of functionally relevant complexes of formate dehydrogenase

William Rock, Amnon Kohen, Jigar N. Bandaria, 2010, Proceedings of the National Academy of Sciences.

QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase.

Zhen Wang, V. Moliner, A. Kohen, 2013, Biochemistry.

Two-dimensional infrared spectroscopy of azido-nicotinamide adenine dinucleotide in water.

R. J. Cook, A. Kohen, S. Dutta, 2011, The Journal of chemical physics.

A model reaction assesses contribution of H-tunneling and coupled motions to enzyme catalysis.

Yu Zhao, A. Kohen, J. Eilers, 2012, The Journal of organic chemistry.

Hybrid Quantum and Classical Simulations of the Formate Dehydrogenase Catalyzed Hydride Transfer Reaction on an Accurate Semiempirical Potential Energy Surface.

D. Major, A. Kohen, Alexandra Vardi-Kilshtain, 2012, Journal of chemical theory and computation.

Stereochemistry of the KDO8P synthase. An efficient synthesis of the 3-fluoro analogues of KDO8P

V. Belakhov, T. Baasov, A. Kohen, 1993 .

Free energy simulations of active-site mutants of dihydrofolate reductase.

D. Major, L. Gakhar, A. Kohen, 2015, The journal of physical chemistry. B.

An unusual mechanism of thymidylate biosynthesis in organisms containing the thyX Gene

Scott A. Lesley, Irimpan I. Mathews, Amnon Kohen, 2009, Nature.

Kinetic Isotope Effects in Enzymes

Zhen Wang, A. Kohen, D. Roston, 2010 .

Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Andrew L. Lee, R. Stroud, J. Finer-Moore, 2013, Journal of the American Chemical Society.

The Effect of Protein Mass Modulation on Human Dihydrofolate Reductase.

Andrew L. Lee, P. Sapienza, A. Kohen, 2016, Biochemistry.

Examinations of the Chemical Step in Enzyme Catalysis.

Z. Islam, A. Kohen, P. Singh, 2016, Methods in enzymology.

Evolution of Optimized Hydride Transfer Reaction and Overall Enzyme Turnover in Human Dihydrofolate Reductase

A. Kohen, K. Francis, Jiayue Li, 2021, Biochemistry.

Evolution of the Chemical Step in Enzyme Catalysis

D. Hilvert, A. Kohen, Cindy Schulenburg, 2021 .

Isotopic Labeling of Formate Dehydrogenase Perturbs the Protein Dynamics.

Andrew L. Lee, P. Sapienza, A. Kohen, 2019, The journal of physical chemistry. B.

Evolution Conserves the Network of Coupled Residues in Dihydrofolate Reductase.

P. Agarwal, A. Kohen, Jiayue Li, 2019, Biochemistry.

Evolutionary Effects on Bound Substrate p Ka in Dihydrofolate Reductase.

D. Major, A. Kohen, A. Mhashal, 2018, Journal of the American Chemical Society.

Bacterial versus human thymidylate synthase: Kinetics and functionality

Z. Islam, A. Kohen, T. Strutzenberg, 2018, PloS one.

Network of remote and local protein dynamics in dihydrofolate reductase catalysis.

A. Kohen, K. Francis, Priyanka Singh, 2015, ACS catalysis.

Linking Protein Motion to Enzyme Catalysis

A. Kohen, T. Abeysinghe, Priyanka Singh, 2015, Molecules.

Extension and Limits of the Network of Coupled Motions Correlated to Hydride Transfer in Dihydrofolate Reductase

Arundhuti Sen, A. Kohen, K. Francis, 2014, Journal of the American Chemical Society.

Preservation of Protein Dynamics in Dihydrofolate Reductase Evolution*

A. Kohen, K. Francis, Vanja Stojković, 2013, The Journal of Biological Chemistry.

Relationship of femtosecond-picosecond dynamics to enzyme-catalyzed H-transfer.

A. Kohen, C. Cheatum, 2013, Topics in current chemistry.

Synthesis of radiolabeled nicotinamide cofactors from labeled pyridines: versatile probes for enzyme kinetics.

Arundhuti Sen, A. Kohen, Vanja Stojković, 2012, Analytical biochemistry.

Hydrogen donor-acceptor fluctuations from kinetic isotope effects: a phenomenological model.

A. Kohen, D. Roston, C. Cheatum, 2012, Biochemistry.

Effects of the donor-acceptor distance and dynamics on hydride tunneling in the dihydrofolate reductase catalyzed reaction.

S. Benkovic, A. Kohen, Laura L. Perissinotti, 2012, Journal of the American Chemical Society.

Triple isotopic labeling and kinetic isotope effects: exposing H-transfer steps in enzymatic systems.

Arundhuti Sen, A. Kohen, Atsushi Yahashiri, 2011, Biochemistry.

Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase

N. Goodey, S. Benkovic, A. Kohen, 2006, Proceedings of the National Academy of Sciences.

Purification, analysis, and preservation of reduced nicotinamide adenine dinucleotide 2'-phosphate.

A. Kohen, K. A. Markham, R. Sikorski, 2003, Analytical biochemistry.

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase

Amnon Kohen, J. Klinman, A. Kohen, 1999, Nature.

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis

A. Kohen, 2015, F1000Research.

Hydrogen tunneling links protein dynamics to enzyme catalysis.

Judith P Klinman, Amnon Kohen, J. Klinman, 2013, Annual review of biochemistry.

Line shape analysis of two-dimensional infrared spectra.

A. Kohen, Yun-Liang Li, C. Cheatum, 2015, The Journal of chemical physics.

A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase.

R. Stroud, J. Finer-Moore, Zhen Wang, 2012, Journal of the American Chemical Society.

Enzymatic tunneling and kinetic isotope effects: chemistry at the crossroads

Arundhuti Sen, A. Kohen, 2010 .

Examination of enzymatic H-tunneling through kinetics and dynamics.

Jigar N. Bandaria, A. Kohen, C. Cheatum, 2009, Journal of the American Chemical Society.

Characterization of azido-NAD+ to assess its potential as a two-dimensional infrared probe of enzyme dynamics.

J. Houtman, R. J. Cook, A. Kohen, 2010, Analytical biochemistry.

Microscale synthesis and kinetic isotope effect analysis of (4R)-[Ad-14C, 4-2H] NADPH and (4R)-[Ad-3H,4-2H] NADPH.

Arundhuti Sen, A. Kohen, Atsushi Yahashiri, 2009, Journal of labelled compounds & radiopharmaceuticals.

Effects of a distal mutation on active site chemistry.

S. Benkovic, T. Selzer, A. Kohen, 2006, Biochemistry.

Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction.

J. Klinman, T. Jonsson, A. Kohen, 1997, Biochemistry.

The enigmatic conservation of enzyme dynamics in evolution

A. Kohen, 2016 .

Standards for the reporting of kinetic isotope effects in enzymology

Kevin Francis, Amnon Kohen, A. Kohen, 2014 .

Kinetic isotope effects as a probe of hydrogen transfers to and from common enzymatic cofactors.

Z. Islam, A. Kohen, D. Roston, 2014, Archives of biochemistry and biophysics.

Isotope Effects as Probes for Enzyme Catalyzed Hydrogen-Transfer Reactions

Z. Islam, A. Kohen, D. Roston, 2013, Molecules.

Experimental and theoretical studies of enzyme-catalyzed hydrogen-transfer reactions.

Zhen Wang, A. Kohen, D. Roston, 2012, Advances in protein chemistry and structural biology.

Elusive transition state of alcohol dehydrogenase unveiled

A. Kohen, D. Roston, Daniel Roston, 2010, Proceedings of the National Academy of Sciences.

Tuning of the H-transfer coordinate in primitive versus well-evolved enzymes.

A. Kohen, E. Howell, Atsushi Yahashiri, 2008, Chemphyschem : a European journal of chemical physics and physical chemistry.

Current Issues in Enzymatic Hydrogen Transfer from Carbon: Tunneling and Coupled Motion from Kinetic Isotope Effect Studies

A. Kohen, 2007 .

Kinetic Isotope Effects as Probes for Hydrogen Tunneling in Enzyme Catalysis

A. Kohen, H. Limbach, 2005 .

Vibrationally enhanced hydrogen tunneling in the Escherichia coli thymidylate synthase catalyzed reaction.

A. Kohen, B. Hong, Nitish Agrawal, 2004, Biochemistry.

Experimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer for E. coli Thymidylate Synthase.

Z. Islam, V. Moliner, A. Kohen, 2018, ACS catalysis.

Effect of Asp122 Mutation on the Hydride Transfer in E. coli DHFR Demonstrates the Goldilocks of Enzyme Flexibility.

D. Major, A. Kohen, R. Eitan, 2018, The journal of physical chemistry. B.

Simulations of remote mutants of dihydrofolate reductase reveal the nature of a network of residues coupled to hydride transfer

Dan Thomas Major, Dvir Doron, Amnon Kohen, 2014, J. Comput. Chem..

How Accurate Are Transition States from Simulations of Enzymatic Reactions?

K. Nam, D. Major, A. Kohen, 2014, Journal of chemical theory and computation.

Collective Reaction Coordinate for Hybrid Quantum and Molecular Mechanics Simulations: A Case Study of the Hydride Transfer in Dihydrofolate Reductase.

Dan Thomas Major, Dvir Doron, Amnon Kohen, 2012, Journal of chemical theory and computation.

Momentum Distribution as a Fingerprint of Quantum Delocalization in Enzymatic Reactions: Open-Chain Path-Integral Simulations of Model Systems and the Hydride Transfer in Dihydrofolate Reductase.

Dan Thomas Major, Dvir Doron, Amnon Kohen, 2012, Journal of chemical theory and computation.

Temperature dependence of the kinetic isotope effects in thymidylate synthase. A theoretical study.

M. Garcia-Viloca, V. Moliner, S. Martí, 2011, Journal of the American Chemical Society.

Comparative Hydrogen–Deuterium Exchange for a Mesophilic vs Thermophilic Dihydrofolate Reductase at 25 °C: Identification of a Single Active Site Region with Enhanced Flexibility in the Mesophilic Protein

J. Klinman, K. Resing, N. Ahn, 2011, Biochemistry.

Enzyme Dynamics: Consensus and Controversy

A. Kohen, 2012 .

Characterization of azo-NAD + to assess its potential as a 2D IR probe of enzyme dynamics

J. Houtman, R. J. Cook, A. Kohen, 2011 .

Kinetic Isotope Effects as Probes for Hydrogen Tunneling, Coupled Motion and Dynamics Contributions to Enzyme Catalysis

A. Kohen, 2003 .

Enzyme Catalysis: Beyond Classical Paradigms†

Amnon Kohen, J. Klinman, A. Kohen, 1998 .

Rigid double-stranded DNA Linkers for Single Molecule Enzyme-Drug Interaction Measurements Using Molecular Recognition Force Spectroscopy.

A. Tivanski, A. Kohen, Thiranjeewa I. Lansakara, 2020, Langmuir : the ACS journal of surfaces and colloids.

The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase

N. Goodey, S. Benkovic, A. Kohen, 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase.

A. Aspuru‐Guzik, D. Major, F. Häse, 2019, ACS catalysis.

Kinetic Isotope Effects as Probesfor Hydrogen Tunneling in Enzyme Catalysis

A. Kohen, 2005 .

The role of the Met20 loop in the hydride transfer in Escherichia coli dihydrofolate reductase

D. Major, A. Kohen, A. Mhashal, 2017, The Journal of Biological Chemistry.

Enzymatic H Transfers: Quantum Tunneling and Coupled Motion from Kinetic Isotope Effect Studies

A. Kohen, Vanja Stojković, 2009 .

Determination of concentration and activity of immobilized enzymes.

A. Tivanski, A. Kohen, Priyanka Singh, 2015, Analytical biochemistry.

Self-assembled enzymatic monolayer directly bound to a gold surface: activity and molecular recognition force spectroscopy studies.

A. Tivanski, Arundhuti Sen, A. Kohen, 2011, Journal of the American Chemical Society.

Solution and computational studies of kinetic isotope effects in flavoprotein and quinoprotein catalyzed substrate oxidations as probes of enzymic hydrogen tunneling and mechanism

M. Sutcliffe, N. Scrutton, A. Kohen, 2005 .

Substrate Activation in Flavin-Dependent Thymidylate Synthase

A. Kohen, T. Mishanina, J. Corcoran, 2014, Journal of the American Chemical Society.

Synthesis and application of isotopically labeled flavin nucleotides.

A. Kohen, T. Mishanina, 2015, Journal of labelled compounds & radiopharmaceuticals.

Flavin-dependent thymidylate synthase: a novel pathway towards thymine.

A. Kohen, Eric M Koehn, 2010, Archives of biochemistry and biophysics.

Synthesis, Inhibition, and Acid-Catalyzed Hydrolysis Studies of Model Compounds of the Proposed Intermediate in the Kdo8P-Synthase-Catalyzed Reaction

T. Baasov, A. Kohen, 1995 .

Thymidyl biosynthesis enzymes as antibiotic targets

A. Kohen, A. Chernyshev, Todd Fleischmann, 2007, Applied Microbiology and Biotechnology.

The General Base for the Thymidylate Synthase Catalyzed Proton Abstraction

Z. Islam, A. Kohen, Ananda K Ghosh, 2015, Physical chemistry chemical physics : PCCP.

Role of Y94 in proton and hydride transfers catalyzed by thymidylate synthase.

F. Maley, A. Kohen, B. Hong, 2007, Biochemistry.

Role of Long-Range Protein Dynamics in Different Thymidylate Synthase Catalyzed Reactions

A. Kohen, T. Abeysinghe, 2015, International journal of molecular sciences.

Concerted versus Stepwise Mechanism in Thymidylate Synthase

Z. Islam, A. Kohen, T. Strutzenberg, 2014, Journal of the American Chemical Society.

Stereospecific multiple isotopic labeling of benzyl alcohol.

A. Kohen, D. Roston, Daniel Roston, 2014, Journal of labelled compounds & radiopharmaceuticals.

A critical test of the "tunneling and coupled motion" concept in enzymatic alcohol oxidation.

A. Kohen, D. Roston, Daniel Roston, 2013, Journal of the American Chemical Society.

Boundary conditions for the Swain-Schaad relationship as a criterion for hydrogen tunneling.

J. Jensen, A. Kohen, 2002, Journal of the American Chemical Society.

A fast chemoenzymatic synthesis of [11C]-N5,N10-methylenetetrahydrofolate as a potential PET tracer for proliferating cells.

A. Kohen, M. Saeed, T. Tewson, 2012, Nuclear medicine and biology.

Novel Positron Emission Tomography Tracer Distinguishes Normal from Cancerous Cells*

D. Sheff, A. Kohen, M. Saeed, 2011, The Journal of Biological Chemistry.

Catalytic mechanism of Kdo8P synthase: transient kinetic studies and evaluation of a putative reaction intermediate.

Y. Benenson, F. D’Souza, K. Anderson, 1998, Biochemistry.

The Effect of Electrostatic Shielding on H Tunneling in R67 Dihydrofolate Reductase

Guy Nimrod, N. Ben-Tal, A. Kohen, 2009, Chembiochem : a European journal of chemical biology.

Hybrid Quantum and Classical Simulations of the Dihydrofolate Reductase Catalyzed Hydride Transfer Reaction on an Accurate Semi-Empirical Potential Energy Surface.

W. Thiel, D. Major, Xin Wu, 2011, Journal of chemical theory and computation.

Self-assembled enzymatic monolayer directly bound to a gold surface: activity and molecular recognition force spectroscopy studies.

A. Tivanski, Arundhuti Sen, A. Kohen, 2011, Journal of the American Chemical Society.

Mg2+ binds to the surface of thymidylate synthase and affects hydride transfer at the interior active site.

Andrew L. Lee, R. Stroud, J. Finer-Moore, 2013, Journal of the American Chemical Society.

QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase.

Zhen Wang, V. Moliner, A. Kohen, 2013, Biochemistry.

Hydrogen tunneling links protein dynamics to enzyme catalysis.

J. Klinman, A. Kohen, 2013, Annual review of biochemistry.

2 Kinetic Isotope Effects : Basic Terms and Concepts 7 . 2 . 1 Defining KIEs

Arundhuti Sen, A. Kohen, 2008 .

Extension and Limits of the Network of Coupled Motions Correlated to Hydride Transfer in Dihydrofolate Reductase

Arundhuti Sen, A. Kohen, Priyanka Singh, 2014, Journal of the American Chemical Society.

Convex Arrhenius plots and their interpretation.

D. Truhlar, A. Kohen, A. Kohen, 2001, Proceedings of the National Academy of Sciences of the United States of America.

A critical test of the "tunneling and coupled motion" concept in enzymatic alcohol oxidation.

A. Kohen, Daniel Roston, 2013, Journal of the American Chemical Society.

Oxidase activity of a flavin‐dependent thymidylate synthase

Zhen Wang, S. Lesley, A. Kohen, 2009, The FEBS journal.

QM/MM study of thymidylate synthase: enzymatic motions and the temperature dependence of the rate limiting step.

V. Moliner, S. Martí, A. Kohen, 2009, The journal of physical chemistry. A.

A quantum mechanics/molecular mechanics study of the catalytic mechanism of the thymidylate synthase.

V. Moliner, S. Martí, A. Kohen, 2007, Biochemistry.