D. Warhurst

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In silico comparative genomics analysis of Plasmodium falciparum for the identification of putative essential genes and therapeutic candidates.

M. Suar, R. Mahapatra, S. Rout, 2015, Journal of microbiological methods.

Increased pfmdr1 Copy Number and Sequence Polymorphisms in Plasmodium falciparum Isolates from Sudanese Malaria Patients Treated with Artemether-Lumefantrine

Badria B. El-Sayed, D. Warhurst, I. Adam, 2011, Antimicrobial Agents and Chemotherapy.

Accuracy of routine laboratory diagnosis of malaria in the United Kingdom.

P. Chiodini, D. Warhurst, L. M. Milne, 1994, Journal of clinical pathology.

ACP Broadsheet no 148. July 1996. Laboratory diagnosis of malaria.

D. Warhurst, J. Williams, D. C. Warhurst, 1996, Journal of clinical pathology.

In vitro antimalarial and cytotoxic activities of semisynthetic derivatives of brusatol

J. Phillipson, I. Toth, D. Warhurst, 1993 .

Plasmodium falciparum: detection of polymorphisms in the dihydrofolate reductase and dihydropteroate synthetase genes by PCR and restriction digestion.

M. Duraisingh, D. Warhurst, J. Curtis, 1998, Experimental parasitology.

Guanylyl Cyclase Activity Associated with Putative Bifunctional Integral Membrane Proteins in Plasmodium falciparum *

D. Carucci, A. Witney, D. Baker, 2000, The Journal of Biological Chemistry.

Alternatively spliced transcripts and novel pseudogenes of the Plasmodium falciparum resistance-associated locus pfcrt detected in East African malaria patients

Badria B. El-Sayed, B. Ngasala, A. Mårtensson, 2014, The Journal of antimicrobial chemotherapy.

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity

E. Chatelain, A. Torrecilhas, M. Miles, 2020, International journal for parasitology. Drugs and drug resistance.

Monitoring for multidrug‐resistant Plasmodium falciparum isolates and analysis of pyrimethamine resistance evolution in Uige province, Angola

C. Severini, G. Majori, Z. Bisoffi, 2009, Tropical medicine & international health : TM & IH.

High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine/pyrimethamine resistance

M. Lemnge, I. Bygbjerg, M. Duraisingh, 1997, Tropical medicine & international health : TM & IH.

Polymorphisms in the dihydrofolate reductase (DHFR) and dihydropteroate synthetase (DHPS) genes of Plasmodium falciparum and in vivo resistance to sulphadoxine/pyrimethamine in isolates from Tanzania

M. Lemnge, I. Bygbjerg, M. Duraisingh, 1998, Tropical medicine & international health : TM & IH.

Antimalarial activity from 'Mhekara' (Uapaca nitida Müll-Arg.), a Tanzanian tree.

J. Phillipson, D. Warhurst, G. Kirby, 1993, Journal of ethnopharmacology.

Chloroquine-Resistant Rodent Malaria and the Long-Acting Antimalarial 12,278 R.P.

D. Warhurst, 1966 .

The chemotherapy of rodent malaria, XXI. Action of quinine and WR 122 (a 9-phenanthrenemethanol) on the fine structure of Plasmodium berghei in mouse blood.

D. Warhurst, W. Peters, E. E. Davies, 1975, Annals of tropical medicine and parasitology.

The chemotherapy of rodent malaria, XXVII. Studies on mefloquine (WR 142,490).

R. Howells, D. Warhurst, W. Peters, 1977, Annals of tropical medicine and parasitology.

The chemotherapy of rodent malaria XXXIII. The activity of chloroquine and related blood schizontocides and of some analogues in drug-induced pigment clumping.

D. Warhurst, S. Gould, 1982, Annals of tropical medicine and parasitology.

Antimalarial interaction with ferriprotoporphyrin IX monomer and its relationship to activity of the blood schizontocides.

D. Warhurst, 1987, Annals of tropical medicine and parasitology.

ANTIHISTAMINIC DRUGS THAT REVERSE CHLOROQUINE RESISTANCE IN PLASMODIUM FALCIPARUM

R. Ekong, D. Warhurst, W. Peters, 1989, The Lancet.

Malaria prophylaxis: guidelines for travellers from Britain. Malaria Reference Laboratory of the Public Health Laboratory Service, London.

D. Bradley, D. Warhurst, 1995, BMJ.

Two cases of falciparum malaria acquired in Britain.

C. Curtis, D. Bradley, G. White, 1984, British medical journal.

Growth and survival, in vitro and in vivo, of Endolimax blattae, an entozoic amoeba of cockroaches.

D. Warhurst, 1964 .

The chemotherapy of rodent malaria. XLIV. Studies on the mode of action of CM 6606, an indolo (3,2-c) quinoline N-oxide.

D. Warhurst, W. Peters, B. Robinson, 1989, Annals of tropical medicine and parasitology.

The effect of combinations of qinghaosu (artemisinin) with standard antimalarial drugs in the suppressive treatment of malaria in mice.

D. Warhurst, W. Peters, B. Robinson, 1987, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Tropical Plants as Sources of Antiprotozoal Agents

J. Phillipson, D. Warhurst, C. Wright, 1993 .

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids

J. Craig, D. Warhurst, D. Meyer, 2003, Malaria Journal.

The effect of chemoprophylaxis on the timing of onset of falciparum malaria

H. Reyburn, D. Bradley, D. Warhurst, 1998, Tropical medicine & international health : TM & IH.

Oral Activated Charcoal Prevents Experimental Cerebral Malaria in Mice and in a Randomized Controlled Clinical Trial in Man Did Not Interfere with the Pharmacokinetics of Parenteral Artesunate

D. Conway, K. Tracey, P. Kaye, 2010, PloS one.

Antimalarial activity of parthenin and its derivatives

J. Phillipson, M. Hooper, D. Warhurst, 1990 .

The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.

M. Duraisingh, L. Seidlein, M. Pinder, 2000, Molecular and biochemical parasitology.

Gambian children successfully treated with chloroquine can harbor and transmit Plasmodium falciparum gametocytes carrying resistance genes.

C. Drakeley, B. Greenwood, M. Duraisingh, 2002, The American journal of tropical medicine and hygiene.

Co-trimoxazole compared with sulfadoxine-pyrimethamine in the treatment of uncomplicated malaria in Kenyan children.

I. Adagu, D. Warhurst, S. Omar, 2001, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Surrogate Models for Antimalarials

M. R. Levy, D. Warhurst, K. Conklin, 1984 .

Uptake of [3H] dihydroartemisinine by erythrocytes infected with Plasmodium falciparum in vitro.

D. Warhurst, W. Peters, H. Gu, 1984, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Mechanism of chloroquine resistance in malaria.

D. Warhurst, 1988, Parasitology today.

Dynamics of pfcrt alleles CVMNK and CVIET in chloroquine-treated Sudanese patients infected with Plasmodium falciparum

Badria B. El-Sayed, D. Warhurst, C. Sutherland, 2010, Malaria Journal.

Drug‐resistant Malaria: Laboratory and Field Investigations *

D. Warhurst, D. C. WARHURST, 1997 .

Antimalarial schizontocides: why a permease is necessary.

D. Warhurst, 1986, Parasitology today.

Qinghaosu resistance in rodent malaria.

D. Warhurst, W. Peters, A. Chawira, 1986, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Correlation of in vivo‐resistance to chloroquine and allelic polymorphisms in Plasmodium falciparum isolates from Uganda

I. Adagu, T. Jelínek, D. Warhurst, 2000, Tropical medicine & international health : TM & IH.

Pfmdr1Asn1042AspandAsp1246TyrPolymorphisms, Thought to Be Associated with Chloroquine Resistance, Are Present in Chloroquine-Resistant and -Sensitive Brazilian Field Isolates ofPlasmodium falciparum

I. Adagu, M. Póvoa, M. Miles, 1998 .

A multiplex allele specific polymerase chain reaction (MAS-PCR) on the dihydrofolate reductase gene for the detection of Cryptosporidium parvum genotypes 1 and 2

D. Warhurst, J. Marshall, K. Webster, 2002, Parasitology.

In Vitro Cytotoxicity of a Series of Quassinoids from Brucea javanica Fruits Against KB Cells

J. Phillipson, M. Anderson, D. Warhurst, 1991, Planta medica.

Malaria imported into the United Kingdom in 1996.

D. Bradley, D. Warhurst, V. Smith, 1998, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin.

Antiplasmodial activity of Artemisia annua plant cell cultures

J. Phillipson, M. Roberts, D. Warhurst, 1989, Plant Cell Reports.

Antimalarial Drugs

D. Warhurst, 2012, Drugs.

New developments: chloroquine-resistance in Plasmodium falciparum.

D. Warhurst, D. Warhurst, 2001, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.

In vitro activity of nitazoxanide and related compounds against isolates of Giardia intestinalis, Entamoeba histolytica and Trichomonas vaginalis.

D. Warhurst, J. Rossignol, I. S. Adagu, 2002, The Journal of antimicrobial chemotherapy.

Drug resistance inPlasmodium falciparum malaria

D. Warhurst, 1999 .

Drug resistance in Plasmodium falciparum malaria.

D. Warhurst, 1999, Infection.

Haemozoin and the mode of action of blood schizontocides: more controversy.

D. Warhurst, 1995, Parasitology today.

A physico-chemical explanation for the clumping of malaria pigment by chloroquine.

D. Warhurst, C. Homewood, V. Baggaley, 1971, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Concensus on the use of artemisinin derivative containing combinations (ADCC) for the treatment of falciparum malaria

D. Warhurst, S. Supavej, 2001 .

Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area

T. Clark, S. Campino, F. Huang, 2019, PloS one.

Effects of Piperaquine, Chloroquine, and Amodiaquine on Drug Uptake and of These in Combination with Dihydroartemisinin against Drug-Sensitive and -Resistant Plasmodium falciparum Strains

D. Warhurst, Q. L. Fivelman, I. S. Adagu, 2007, Antimicrobial Agents and Chemotherapy.

Activity of pyronaridine and mepacrine against twelve strains of Plasmodium falciparum in vitro.

S. Croft, D. Warhurst, E. Elueze, 1996, The Journal of antimicrobial chemotherapy.

Measurement of the growth rate of the erythrocytic stages of Plasmodium berghei and comparisons of the potency of inocula after various treatments.

D. Warhurst, R. Folwell, 1968, Annals of tropical medicine and parasitology.

Plasmodium falciparum: effects of phaeanthine, a naturally-occurring bisbenzylisoquinoline alkaloid, on chloroquine-resistant and -sensitive parasites in vitro, and its influence on chloroquine activity.

P. F. Russell, R. Ekong, S. J. Partridge, 1991, Annals of tropical medicine and parasitology.

Acanthamoeba genotype T4 from the UK and Iran and isolation of the T2 genotype from clinical isolates.

A. Maghsood, N. Khan, D. Warhurst, 2005, Journal of medical microbiology.

Acanthamoeba keratitis—Resistance to medical therapy

D. Seal, P. Wright, L. Ficker, 1990, Eye.

Toward the chemical ecology of medicinal plant use in chimpanzees: The case ofVernonia amygdalina, a plant used by wild chimpanzees possibly for parasite-related diseases

H. Ohigashi, D. Warhurst, D. Allen, 1994, Journal of Chemical Ecology.

In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum.

J. Phillipson, D. Warhurst, M. J. O'neill, 1989, Biochemical pharmacology.

Identification of isoflavone derivatives as effective anticryptosporidial agents in vitro and in vivo.

N. Berry, D. Warhurst, A. Stachulski, 2006, Journal of medicinal chemistry.

Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids

J. Phillipson, D. Warhurst, C. Wright, 1988, Antimicrobial Agents and Chemotherapy.

In Vitro Amoebicidal Testing of Natural Products; Part I. Methodology

J. Phillipson, D. Warhurst, A. T. Keene, 1986, Planta medica.

Antiplasmodial activity of Cryptolepis sanguinolenta alkaloids from leaves and roots.

D. Warhurst, A. Paulo, P. Houghton, 2000, Planta medica.

Synthesis, Structure, and Antimalarial Activity of Tricyclic 1,2,4-Trioxanes Related to Artemisinin

Gérald Bernardinelli, Charles W. Jefford, Wilbur K. Milhous, 1993 .

In vitro antiplasmodial, antiamoebic, and cytotoxic activities of a series of bisbenzylisoquinoline alkaloids

P. F. Russell, J. Phillipson, M. Anderson, 1994, Antimicrobial Agents and Chemotherapy.

In vitro and in vivo Antimalarial Activity of Cryptolepine, a Plant-derived Indoloquinoline

J. Phillipson, D. Warhurst, A. Paine, 2022 .

Modified Fixed-Ratio Isobologram Method for Studying In Vitro Interactions between Atovaquone and Proguanil or Dihydroartemisinin against Drug-Resistant Strains of Plasmodium falciparum

D. Warhurst, Q. L. Fivelman, I. S. Adagu, 2004, Antimicrobial Agents and Chemotherapy.

Antimalarial Activity of Cryptolepine and Some Other Anhydronium Bases

L. Angenot, J. Phillipson, J. Quetin-Leclercq, 1996 .

In vitro antiamoebic and antiplasmodial activities of alkaloids isolated from Alstonia angustifolia roots

J. Phillipson, D. Warhurst, D. Allen, 1992 .

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.

R. Guy, J. Craig, D. Warhurst, 2007, Biochemical pharmacology.

Chemotherapy and drug resistance in malaria (2nd edn): by W Peters, Academic Press, 1987. £63.00 (Vol. 1) £75.00 (Vol. 2) (1100 pages) ISBN 0 12 552721 7

D. Warhurst, 1989 .

In vitro antimalarial activity of crude extracts and compounds from Artemisia abrotanum L

D. Warhurst, N. Özhatay, N. Ozhatay, 1990 .

Plants as sources of antimalarial drugs: in vitro antimalarial activities of some quassinoids

J. Phillipson, D. Warhurst, M. Suffness, 1986, Antimicrobial Agents and Chemotherapy.

Antiplasmodial and antiamoebic activities of medicinal plants from Sierra Leone

P. F. Russell, J. Phillipson, D. Warhurst, 2000, Phytotherapy research : PTR.

In vitro and In vivo evaluation of betulinic acid as an antimalarial

M. Simmonds, D. Warhurst, G. C. Kirby, 1999, Phytotherapy research : PTR.

Antiprotozoal activities of Centipeda minima

J. Phillipson, D. Warhurst, C. Wright, 1994 .

In vitro assessment of susceptibility of Acanthamoeba polyphaga to drugs using combined methods of dye-binding assay and uptake of radiolabelled adenosine.

D. Warhurst, P. O. Ogbunude, S. Asiri, 1994, International journal for parasitology.

Selective antiprotozoal activity of some Strychnos alkaloids

L. Angenot, J. Phillipson, M. Tits, 1994 .

Quassinoids Exhibit Greater Selectivity Against Plasmodium Falciparum Than Against Entamoeba Histolytica, Giardia Intestinalis Or Toxoplasma Gondii In Vitro

J. Phillipson, H. R. Chang, M. Anderson, 1993, The Journal of eukaryotic microbiology.

Parasitological and microbiological evaluation of Mixe Indian medicinal plants (Mexico).

J. Phillipson, M. Heinrich, D. Warhurst, 1992, Journal of ethnopharmacology.

ANTIAMOEBIC ACTIVITY OF INDOLE ANALOGUES OF EMETINE WITH IN‐VITRO POTENCY GREATER THAN THAT OF EMETINE

L. Angenot, J. Phillipson, J. Quetin-Leclercq, 1990 .

In vitro amoebicidal testing of natural products; Part 2. Alkaloids related to emetine.

J. Phillipson, E. Seguin, D. Warhurst, 1987, Planta medica.

Plants as sources of antimalarial drugs, Part 4: Activity of Brucea javanica fruits against chloroquine-resistant Plasmodium falciparum in vitro and against Plasmodium berghei in vivo.

J. Phillipson, K. Chan, D. Warhurst, 1987, Journal of natural products.

Antimalarial activity of bruceantin in vitro.

J. Phillipson, D. Warhurst, P. Y. Guru, 1983, Annals of tropical medicine and parasitology.

Activity of extracts and naphthylisoquinoline alkaloids from Triphyophyllum peltatum, Ancistrocladus abbreviatus and A. Barteri against Plasmodium falciparum in vitro

G. Bringmann, J. Phillipson, D. Warhurst, 1994 .

Plants as sources of antimalarial drugs. Part 1. In vitro test method for the evaluation of crude extracts from plants.

J. Phillipson, D. Warhurst, M. J. O'neill, 1985, Planta medica.

The chemotherapy of rodent malaria, XXXIX. Ultrastructural changes following treatment with artemisinine of Plasmodium berghei infection in mice, with observations of the localization of [3H]-dihydroartemisinine in P. falciparum in vitro.

D. Warhurst, W. Peters, B. Robinson, 1985, Annals of tropical medicine and parasitology.

Indole and beta-carboline alkaloids from Geissospermum sericeum.

M. Simmonds, D. Warhurst, G. Kite, 2002, Journal of natural products.

In vitro antiplasmodial effects of diospyrin, a plant‐derived naphthoquinoid, and a novel series of derivatives

J. Phillipson, D. Warhurst, B. Hazra, 1995 .

Plants as sources of antimalarial drugs, Part 6: Activities of Simarouba amara fruits.

J. Phillipson, D. Warhurst, M. Gupta, 1988, Journal of ethnopharmacology.

Plants as sources of antimalarial drugs. Part 7. Activity of some species of meliaceae plants and their constituent limonoids

J. Phillipson, D. Warhurst, M. J. O'neill, 1990 .

Plants as sources of antimalarial drugs. Part 3. Eurycoma longifolia.

J. Phillipson, K. Chan, D. Warhurst, 1986, Planta Medica.

The chemotherapy of rodent malaria, XL. The action of artemisinin and related sesquiterpenes.

D. Warhurst, W. Peters, B. Robinson, 1986, Annals of tropical medicine and parasitology.

Plants as Sources of Antimalarial Drugs Part. 1. In vitro Test Method for the Evaluation of Crude Extracts from Plants.

J. Phillipson, D. Warhurst, M. J. O'neill, 1985, Planta medica.

ANTIMALARIAL ACTIVITY OF BRUCEA JAVANICA FRUITS

J. Phillipson, D. Warhurst, M. J. O'neill, 1985 .

Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area.

I. Adagu, D. Warhurst, S. Omar, 2001, Annals of tropical medicine and parasitology.

Alstonia species: are they effective in malaria treatment?

J. Phillipson, D. Warhurst, D. Allen, 1993, Journal of ethnopharmacology.

In vivo selection for a specific genotype of dihydropteroate synthetase of Plasmodium falciparum by pyrimethamine-sulfadoxine but not chlorproguanil-dapsone treatment.

M. Duraisingh, D. Warhurst, J. Curtis, 1998, The Journal of infectious diseases.

Plants as sources of antimalarial drugs. III. Eurycoma longifolia

J. Phillipson, K. Chan, D. Warhurst, 1986 .

Bioactive Compounds from Celaenodendron mexicanum

S. Croft, J. Phillipson, D. Warhurst, 2000, Planta medica.

Rapid action of Qinghaosu and related drugs on incorporation of [3H]isoleucine by Plasmodium falciparum in vitro.

D. Warhurst, W. Peters, H. Gu, 1983, Biochemical pharmacology.

Effects of qinghaosu and related compounds on incorporation of [G-3H] hypoxanthine by Plasmodium falciparum in vitro.

D. Warhurst, W. Peters, H. Gu, 1983, Transactions of the Royal Society of Tropical Medicine and Hygiene.

In vitro cytotoxicity testing of natural products using guinea‐pig ear keratinocytes

J. Phillipson, D. Warhurst, A. Harris, 1988 .

Plants as a source of antimalarial drugs 5. Activities of Ailanthus altissima stem constituents and of some related quassinoids

J. Phillipson, K. Chan, D. Warhurst, 1987 .

IN‐VITRO CYTOTOXIC, ANTIMALARIAL AND ANTIAMOEBIC ACTIVITIES OF PROTOBERBERINE ALKALOIDS

P. F. Russell, J. Phillipson, D. Warhurst, 1990 .

Localisation of mepacrine in Plasmodium berghei and Plasmodium falciparum by fluorescence microscopy

D. Warhurst, S. Thomas, 1975 .

Comparison of the in vitro activities of quassinoids with activity against Plasmodium falciparum, anisomycin and some other inhibitors of eukaryotic protein synthesis.

R. Ekong, J. Phillipson, D. Warhurst, 1990, Biochemical pharmacology.

Two novel assays for the detection of haemin-binding properties of antimalarials evaluated with compounds isolated from medicinal plants.

M. Simmonds, D. Warhurst, D. Meyer, 2002, The Journal of antimicrobial chemotherapy.

The chemotherapy of rodent malaria, XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei.

D. Warhurst, W. Peters, B. Robinson, 1976, Annals of tropical medicine and parasitology.

Pharmacology of the malaria parasite--a study of dose-response relationships in chloroquine-induced autophagic vacuole formation in Plasmodium berghei.

D. Warhurst, S. Thomas, 1975, Biochemical pharmacology.

Lysosomes, pH and the Anti-malarial Action of Chloroquine

D. Warhurst, W. Peters, C. Homewood, 1972, Nature.

Autophagic vacuole formation in P. berghei in vitro.

D. Warhurst, V. Baggaley, 1972, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Isolation of amoebae from the air.

D. Warhurst, D. Kingston, 1969, Journal of medical microbiology.

Acanthamoeba keratitis successfully treated medically.

P. Wright, D. Warhurst, B. Jones, 1985, The British journal of ophthalmology.

The action of minocycline, a tetracycline derivative on drug-resistant P. berghei.

J. Kaddu, D. Warhurst, 1973, Transactions of the Royal Society of Tropical Medicine and Hygiene.

D. Warhurst, S. C. Thomas, 1973, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Observations on the binding site for antimalarial schizontocides.

D. Warhurst, P. Mallory, 1973, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Preparation and characterization of DNA from rodent malarias.

D. Warhurst, M. Chance, W. Peters, 1972, Transactions of the Royal Society of Tropical Medicine and Hygiene.

The effect of cytotoxic agents on autophagic vacuole formation in chloroquine-treated malaria parasites (Plasmodium berghei).

R. Howells, D. Warhurst, W. Peters, 1971, Life sciences. Pt. 2: Biochemistry, general and molecular biology.

Cytotoxic agents and haemozoin pigment in malaria parasites (Plasmodium berghei).

D. Warhurst, B. Robinson, 1971, Life sciences. Pt. 2: Biochemistry, general and molecular biology.

Theory for the Mechanism of Chloroquine Resistance in Rodent Malaria

R. Howells, D. Warhurst, W. Peters, 1970, Nature.

Ribonucleic acid from Plasmodium knowlesi before and after chloroquine treatment.

D. Warhurst, J. Williamson, 1970, Chemico-biological interactions.

PYRIMETHAMINE/DAPSONE RESISTANT FALCIPARUM MALARIA IMPORTED FROM KENYA

D. Warhurst, H. Rogers, H. Lambert, 1982, The Lancet.

Assessment of the antiprotozoal activity of Galphimia glauca and the isolation of new nor-secofriedelanes and nor-friedelanes.

S. Croft, J. Phillipson, D. Warhurst, 2002, Journal of natural products.

Malarone treatment failure and in vitro confirmation of resistance of Plasmodium falciparum isolate from Lagos, Nigeria

G. Butcher, D. Warhurst, G. Pasvol, 2002, Malaria Journal.

Pathogenic free-living amoebae.

D. Warhurst, 1985, Parasitology today.

A COMMUTER MOSQUITO'S SECOND BITE?

C. Curtis, G. White, D. Warhurst, 1984, The Lancet.

A study of amoebae isolated from the Bristol cases of primary amoebic encephalitis.

D. Warhurst, A. Roome, G. Saygi, 1973, Proceedings of the Royal Society of Medicine.

Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests

J. Utzinger, S. Knopp, E. N'Goran, 2013, BMC Infectious Diseases.

Association of Vibrio cholerae with fresh water amoebae.

B. Drasar, D. Warhurst, S. Thom, 1992, Journal of medical microbiology.

Post-mortem culture of Balamuthia mandrillaris from the brain and cerebrospinal fluid of a case of granulomatous amoebic meningoencephalitis, using human brain microvascular endothelial cells.

N. Khan, D. Warhurst, D. Nolder, 2004, Journal of medical microbiology.

116 – Amebic Infections

D. Warhurst, 2017 .

Improved selective isolation of Naegleria fowleri from the environment.

D. Warhurst, S. Kilvington, P. Mann, 1986, Transactions of the Royal Society of Tropical Medicine and Hygiene.

New method for detachment and quantitation of Acanthamoeba trophozoites in culture.

D. Warhurst, P. O. Ogbunude, H. Baer, 1991, Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit.

Human infection with cyanobacterium-like bodies

R. Ashford, D. Warhurst, G. F. Reid, 1993, The Lancet.

Cryptosporidium Prevalence and Risk Factors among Mothers and Infants 0 to 6 Months in Rural and Semi-Rural Northwest Tanzania: A Prospective Cohort Study

J. Changalucha, D. Warhurst, M. Urassa, 2014, PLoS neglected tropical diseases.

Experimental Transmission of Human Genotype 1 Cryptosporidium Parvum Into Lambs

D. Warhurst, J. Marshall, J. Catchpole, 2003 .

Detection and species identification of Cryptosporidium oocysts using a system based on PCR and endonuclease restriction

D. Warhurst, V. Mcdonald, F. M. Awad-El-Kariem, 1994, Parasitology.

In vitro cultivation of Cryptosporidium parvum and screening for anticryptosporidial drugs

P. Chiodini, M. Barer, K. McAdam, 1990, Antimicrobial Agents and Chemotherapy.

Antimalarial activity of optical isomers of quinacrine dihydrochloride against chloroquine-sensitive and -resistant Plasmodium falciparum in vitro.

V. Shyamala, J. Craig, D. Warhurst, 1991, Biochemical pharmacology.

The quinine-haemin interaction and its relationship to antimalarial activity.

D. Warhurst, 1981, Biochemical pharmacology.

Exchange transfusion in falciparum malaria

D. Warhurst, T. Shwe, P. Myint, 1990, The Lancet.

Corticosteroid stimulation of the growth of Plasmodium falciparum gametocytes in vitro.

D. Warhurst, S. M. Maswoswe, W. Peters, 1985, Annals of tropical medicine and parasitology.

Study of a small amoeba from mammalian cell cultures infected with 'Ryan virus'.

J. Armstrong, D. Warhurst, 1968, Journal of general microbiology.

Ryan virus and the lipovirus: Examples of Acanthamoeba (Hartmannella) contamination of cell cultures.

D. Warhurst, 1989, Parasitology today.

In vitro antiplasmodial, antiamoebic, and cytotoxic activities of some monomeric isoquinoline alkaloids.

P. F. Russell, J. Phillipson, M. Anderson, 2000, Journal of natural products.

Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum

M. Duraisingh, D. Warhurst, C. Roper, 2000, Molecular microbiology.

Can pretreatment screening for dhps and dhfr point mutations in Plasmodium falciparum infections be used to predict sulfadoxine-pyrimethamine treatment failure?

I. Adagu, S. Omar, D. Warhurst, 2001, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance.

M. Miles, D. Warhurst, F. M. Awad-El-Kariem, 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Plasmodium falciparum: selection of serine 108 of dihydrofolate reductase during treatment of uncomplicated malaria with co-trimoxazole in Ugandan children.

M. Duraisingh, F. von Sonnenburg, D. Warhurst, 1999, The American journal of tropical medicine and hygiene.

A molecular marker for chloroquine-resistant falciparum malaria.

D. Warhurst, 2001, The New England journal of medicine.

Efficacy of artesunate plus pyrimethamine-sulphadoxine for uncomplicated malaria in Gambian children: a double-blind, randomised, controlled trial

K. Bojang, B. Greenwood, P. Olliaro, 2000, The Lancet.

Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania.

T. Theander, J. Lusingu, M. Lemnge, 2006, The Journal of infectious diseases.

Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine

D. Warhurst, D. C. Warhurst, 2003, Malaria Journal.

Molecular determinants of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum in Nigeria and the regional emergence of dhps 431V

D. Chandramohan, J. Webster, D. Warhurst, 2016, International journal for parasitology. Drugs and drug resistance.

Restricted genetic and antigenic diversity of Plasmodium falciparum under mesoendemic transmission in the Venezuelan Amazon

H. Grundmann, D. Cavanagh, G. Snounou, 2002, Parasitology.

Terpenoids from Guarea rhophalocarpa.

S. Croft, J. Phillipson, D. Warhurst, 2001, Phytochemistry.

HTV-2-ASSOCIATED AIDS IN THE 1970s

J. Parry, Dennis Ridley, A. Goldstone, 1988, The Lancet.

RI QUININE-FANSIDAR RESISTANT FALCIPARUM MALARIA FROM MALAWI

D. Warhurst, A. Hall, S. Tjokrosonto, 1985, The Lancet.

Allele-specific, nested, one tube PCR: application to Pfmdr1 polymorphisms in Plasmodium falciparum

I. Adagu, D. Warhurst, 1999, Parasitology.

Specific anti-amoebic immunoglobulins and the cellulose acetate precipitin test in Entamoeba histolytica infection.

D. Warhurst, J. Osisanya, 1980, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Synergism between arteether and mefloquine or quinine in a multidrug-resistant strain of Plasmodium falciparum in vitro.

R. Ekong, D. Warhurst, 1990, Transactions of the Royal Society of Tropical Medicine and Hygiene.

An enzyme-linked immunosorbent assay for the detection of Entamoeba histolytica antigens in faecal material.

D. Warhurst, A. Voller, M. S. Grundy, 1987, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Polymerase chain reaction-solution hybridization enzyme-linked immunoassay (PCR-SHELA) for the differential diagnosis of pathogenic and non-pathogenic Entamoeba histolytica.

F. Guhl, D. Warhurst, I. Frame, 1995, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Cultivation in vitro of Endolimax blattae Lucas, 1927 from the cockroach hind gut

D. Warhurst, 1967, Parasitology.

The effect of artemisinin combined with standard antimalarials against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro.

D. Warhurst, A. Chawira, 1987, The Journal of tropical medicine and hygiene.

The chemotherapy of rodent malaria, XIX. The action of a tetracycline derivative, minocycline, on drug-resistant Plasmodium berghei.

J. Kaddu, D. Warhurst, W. Peters, 1974, Annals of tropical medicine and parasitology.

Simplified diagnosis of malaria infection: GFM/PCR/ELISA a simplified nucleic acid amplification technique by PCR/ELISA.

I. Adagu, M. Póvoa, D. Warhurst, 1998, Revista do Instituto de Medicina Tropical de Sao Paulo.

Electrophoretic studies of the hexokinase of Entamoeba histolytica groups I to IV.

D. Warhurst, J. Williams, P. Sargeaunt, 1980, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Detection of Giardia in human jejunum by the immunoperoxidase method. Specific and non-specific results.

S. Fleck, D. Warhurst, S. Hames, 1985, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Letter: Psychiatric manifestations of giardiasis.

D. Warhurst, P. Isaacs, 1975, British medical journal.

Mutation in the Plasmodium falciparum CRT Protein Determines the Stereospecific Activity of Antimalarial Cinchona Alkaloids

Jianbing Mu, J. Duan, M. Ferdig, 2012, Antimicrobial Agents and Chemotherapy.

The use of infectivity titrations for measurement of the viability of Entamoeba histolytica after cryopreservation.

T. Marshall, D. Warhurst, T. A. Farri, 1983, Transactions of the Royal Society of Tropical Medicine and Hygiene.

QUINOLONES AND MULTIRESISTANT PLASMODIUM FALCIPARUM

J. Phillipson, D. Warhurst, D. Keter, 1988, The Lancet.

Determination of anti-giardial activity in vitro by means of soluble formazan production.

J. Phillipson, D. Warhurst, C. Wright, 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Association of cg2 and pfmdr1 genotype with chloroquine resistance in field samples of Plasmodium falciparum from Nigeria

I. Adagu, D. Warhurst, 1999, Parasitology.

Plasmodium falciparum: in vitro chloroquine susceptibility and allele-specific PCR detection of Pfmdr1Asn86Tyr polymorphism in Lambarene, Gabon

I. Adagu, P. Kremsner, M. Grobusch, 1998, Parasitology.

Evidence for selection for the tyrosine-86 allele of the pfmdr 1 gene of Plasmodium falciparum by chloroquine and amodiaquine

C. Drakeley, B. Greenwood, G. Snounou, 1997, Parasitology.

Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum

R. Ekong, D. Baker, K. Robson, 1993, Parasitology.

Field study of cyproheptadine/chloroquine synergism in falciparum malaria

D. Warhurst, A. Björkman, C. Kihamia, 1990, The Lancet.

Antimalarial drugs: mode of action and resistance.

D. Warhurst, 1986, Journal of Antimicrobial Chemotherapy.

Polyamine content of Acanthamoeba polyphaga at different stages of development and the effect of pentamidine.

D. Warhurst, P. O. Ogbunude, S. Asiri, 1994, Advances in experimental medicine and biology.

Linkage disequilibrium between two chromosomally distinct loci associated with increased resistance to chloroquine in Plasmodium falciparum

M. Duraisingh, M. Pinder, L. von Seidlein, 2000, Parasitology.

Understanding resistance to antimalarial 4-aminoquinolines, cinchona alkaloids and the highly hydrophobic arylaminoalcohols

D. Warhurst, 2007 .

PfCRT and the trans‐vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX

Ruth H. Hughes, D. Fidock, P. Stocks, 2006, Molecular microbiology.

Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties.

J. Craig, D. Warhurst, C. Cullander, 2003, The Journal of antimicrobial chemotherapy.

Lysosomes and drug resistance in malaria

J. Craig, D. Warhurst, I. S. Adagu, 2002, The Lancet.

Guinea Bissau: association of chloroquine resistance of Plasmodium falciparum with the Tyr86 allele of the multiple drug-resistance gene Pfmdr1.

I. Adagu, V. do Rosário, F. Dias, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Rapid detection of pfmdr1 mutations in chloroquine-resistant Plasmodium falciparum malaria by polymerase chain reaction analysis of blood spots.

M. Miles, J. Frean, D. Warhurst, 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area

I. Adagu, D. Warhurst, S. Omar, 2001 .

Pfmdr1 Asn1042Asp and Asp1246Tyr polymorphisms, thought to be associated with chloroquine resistance, are present in chloroquine-resistant and -sensitive Brazilian field isolates of Plasmodium falciparum.

I. Adagu, M. Póvoa, M. Miles, 1998, Experimental parasitology.

Plasmodium falciparum: linkage disequilibrium between loci in chromosomes 7 and 5 and chloroquine selective pressure in Northern Nigeria

I. Adagu, D. Warhurst, 2001, Parasitology.

Field chloroquine-resistance determinants

D. Carucci, I. Adagu, M. Duraisingh, 1997 .

Antimalarial drug response of Plasmodium falciparum from Zaria, Nigeria.

I. Adagu, D. Warhurst, W. Ogala, 1995, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Rational use of drugs against Plasmodium falciparum.

M. Duraisingh, D. Warhurst, 2001, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Direct evidence that asparagine at position 108 of the Plasmodium falciparum dihydrofolate reductase is involved in resistance to antifolate drugs in Tanzania.

C. Curtis, M. Duraisingh, D. Warhurst, 1996, Transactions of the Royal Society of Tropical Medicine and Hygiene.

The mode of action of chloroquine and related malarial schizontocides.

D. Warhurst, C. D. Fitch, 1986, Parasitology today.

An improved technique for the cultivation of Plasmodium falciparum in vitro without daily medium change.

D. Warhurst, W. Peters, A. Fairlamb, 1985, Annals of tropical medicine and parasitology.

The chemotherapy of rodent malaria. XLV. Reversal of chloroquine resistance in rodent and human Plasmodium by antihistaminic agents.

B L Robinson, R. Ekong, D. Warhurst, 1990, Annals of tropical medicine and parasitology.

Oxoaporphine Alkaloids and Quinones from Stephania dinklagei and Evaluation of Their Antiprotozoal Activities

S. Croft, J. Phillipson, D. Warhurst, 2000, Planta medica.

SEPARATION OF MALARIA-INFECTED ERYTHROCYTES FROM WHOLE BLOOD: USE OF A SELECTIVE HIGH-GRADIENT MAGNETIC SEPARATION TECHNIQUE

D. Warhurst, S. Roath, F. Paul, 1981, The Lancet.

Antimalarial activity of erythromycin.

D. Warhurst, B. Robinson, 1972, Transactions of the Royal Society of Tropical Medicine and Hygiene.

FAILURE OF CHLOROQUINE-ERYTHROMYCIN AND CHLOROQUINE-TETRACYCLINE COMBINATIONS IN TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA IN EASTERN THAILAND

D. Warrell, S. Looareesuwan, D. Warhurst, 1984, The Lancet.

Guidelines for the prevention of malaria in travellers from the United Kingdom. PHLS Malaria Reference Laboratory, London School of Hygiene and Tropical Medicine.

D. Warhurst, D. Bradley, 1997, Communicable disease report. CDR review.

Antimalarial drug discovery: development of inhibitors of dihydrofolate reductase active in drug resistance

D. Warhurst, David C. Warhurst, 1998 .

A simplified culture technique for Plasmodium falciparum.

D. Warhurst, S. Gould, J. O. Osisany, 1981, Annals of tropical medicine and parasitology.

The Mu Subunit of Plasmodium falciparum Clathrin-Associated Adaptor Protein 2 Modulates In Vitro Parasite Response to Artemisinin and Quinine

R. Hallett, D. V. van Schalkwyk, D. Fidock, 2015, Antimicrobial Agents and Chemotherapy.

Resistance to Antifolates in Plasmodium Falciparum, the Causative Agent of Tropical Malaria

D. Warhurst, David C Warhurst, 2002, Science progress.

Mutations in dhfr in Plasmodium falciparum infections selected by chlorproguanil-dapsone treatment.

C. Maxwell, A. Alloueche, D. Warhurst, 2002, The Journal of infectious diseases.

TV or not TV?

D. Warhurst, A. Smith, P. Kell, 2002, Sexually transmitted infections.

In vitro antiplasmodial activity of extracts of Argentinian plants.

P. Houghton, D. Warhurst, A. Broussalis, 2002, Journal of ethnopharmacology.

Pathogenic Naegleria amoebae in the waters of Bath: a fatality and its consequences

D. Warhurst, S. Kilvington, P. Mann, 1991 .

Survival of Naegleria fowleri cysts at 4 °C for eight months with retention of virulence

D. Warhurst, J. A. Carman, P. Mann, 1980 .

Novel alleles of the Plasmodium falciparum dhfr highly resistant to pyrimethamine and chlorcycloguanil, but not WR99210.

D. Warhurst, C. Sibley, E. Hankins, 2001, Molecular and biochemical parasitology.

Inoculum effect leads to overestimation of in vitro resistance for artemisinin derivatives and standard antimalarials: a Gambian field study

M. Duraisingh, L. Seidlein, M. Pinder, 1999, Parasitology.

Malaria imported into the United Kingdom in 1992 and 1993.

D. Bradley, D. Warhurst, V. Smith, 1994, Communicable disease report. CDR review.

Malaria imported into the United Kingdom 1989 and 1990.

D. Bradley, D. Warhurst, V. Smith, 1991, CDR.

A simple magnetic method for the purification of malarial pigment.

D. Warhurst, F. Paul, A. Fairlamb, 1984, Molecular and biochemical parasitology.

Spontaneous Resistance to Chloroquine in a Strain of Rodent Malaria (Plasmodium berghei yoelii)

R. Killick-Kendrick, D. Warhurst, 1967, Nature.

The chemotherapy of rodent malaria, XXX. The enigmas of the 'NS lines' of P. berghei.

H. Momen, D. Warhurst, M. Chance, 1978, Annals of tropical medicine and parasitology.

The design, synthesis and biological evaluation of stable ozonides with antimalarial activity

D. Warhurst, M. Crabbe, J. Mann, 1996 .

Synthesis of some stable ozonides with anti-malarial activity

D. Warhurst, J. Mann, D. Cutler, 1992 .

Synthesis of Some Stable Ozonides with Antimalarial Activity.

D. Warhurst, J. Mann, D. Cutler, 1993 .

The Design, Synthesis and Biological Evaluation of Stable Ozonides with Antimalarial Activity.

D. Warhurst, M. Crabbe, J. Mann, 1996 .

The composition of haemozoin from Plasmodium falciparum.

D. Warhurst, I. Blench, J. Ashong, 1989, Transactions of the Royal Society of Tropical Medicine and Hygiene.

ACP Broadsheet No 148 Laboratory diagnosis of malaria

D. Warhurst, J. Williams, 2022 .

A bench top magnetic separator for malarial parasite concentration

D. Warhurst, S. Roath, F. Paul, 1981 .

Drug treatment and the control of malaria in Africa: a time of hope?

D. Warhurst, 1997, Africa health.

Influence of LAR and VAR on Para-Aminopyridine Antimalarials Targetting Haematin in Chloroquine-Resistance

J. Craig, D. Warhurst, K. Raheem, 2016, PloS one.

In vitro amoebicical testing of natural products. I: Methodology

J. Phillipson, D. Warhurst, A. T. Keene, 1986 .

A study of the uptake of chloroquine in malaria-infected erythrocytes. High and low affinity uptake and the influence of glucose and its analogues.

D. Warhurst, C. Diribe, D. Warhurst, 1985, Biochemical pharmacology.

The chemotherapy of rodent malaria, XXIX DNA relationships within the subgenus Plasmodium (Vinckeia).

H. Momen, D. Warhurst, M. Chance, 1978, Annals of tropical medicine and parasitology.

The chemotherapy of rodent malaria, XXXVIII. Studies on the activity of three new antimalarials (WR 194,965, WR 228,258 and WR 225,448) against rodent and human malaria parasites (Plasmodium berghei and P. falciparum).

D. Warhurst, W. Peters, B. Robinson, 1984, Annals of tropical medicine and parasitology.

Effect of Antimicrobial Compounds on Balamuthia mandrillaris Encystment and Human Brain Microvascular Endothelial Cell Cytopathogenicity

M. Stins, R. Siddiqui, N. Khan, 2007, Antimicrobial Agents and Chemotherapy.

Antimalarial drugs. An update.

D. Warhurst, 1987, Drugs.

Diagnosis of amebic dysentery by detection of Entamoeba histolytica fecal antigen by an invasive strain-specific, monoclonal antibody-based enzyme-linked immunosorbent assay

R. Haque, A. Hall, M. Miles, 1994, Journal of clinical microbiology.

Treatment of Plasmodium vivax malaria--time for a change?

P. Chiodini, J. Day, D. Warhurst, 1997, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Value of microscopy in the diagnosis of dysentery associated with invasive Entamoeba histolytica.

R. Haque, A. Hall, M. Miles, 1994, Journal of clinical pathology.

Mode of Action of Chloroquine on Plasmodium berghei and P. cynomolgi

D. Hockley, D. Warhurst, D. C. WARHURST, 1967, Nature.

The chemotherapy of rodent malaria. XX. Autophagic vacuole formation in Plasmodium berghei in vitro.

D. Warhurst, C. Homewood, V. Baggaley, 1974, Annals of tropical medicine and parasitology.

Getting to the guts of the problem

D. Warhurst, H. Smith, 1992 .

Evaluation of the anti-plasmodial activity of bisbenzylisoquinoline alkaloids from Abuta grandifolia.

M. Simmonds, D. Warhurst, N. C. Veitch, 1999, Planta medica.

Artemisinin resistance-associated markers in Plasmodium falciparum parasites from the China-Myanmar border: predicted structural stability of K13 propeller variants detected in a low-prevalence area

T. Clark, S. Campino, F. Huang, 2019, PloS one.

Explorer Restricted genetic and antigenic diversity of Plasmodium falciparum under mesoendemic transmission in the Venezuelan Amazon

D. Warhurst, G. Snounou, C. Sutherland, 2017 .

CINCHONA ALKALOIDS AND MALARIA

D. Warhurst, 1981, The Lancet.

Malaria Journal the Relationship of Physico-chemical Properties and Structure to the Differential Antiplasmodial Activity of the Cinchona Alkaloids

J. Craig, D. Warhurst, D. Meyer, 2022 .

IgA AND PRIMARY AMŒBIC MENINGOENCEPHALITIS

D. Warhurst, P. Mann, A. Cain, 1979, The Lancet.

Antimalarial drugs II: Current antimalarials and new drug development: edited by W. Peters and W. H. G. Richards, Springer-Verlag, 1984. DM390/$145.50 (xviii + 520 pages) ISBN 3 540 12617 1

D. Warhurst, 1985 .