I. Kimber

发表

Cytokines in non-genotoxic hepatocarcinogenesis.

R. Roberts, I. Kimber, 1999, Carcinogenesis.

Challenges and approaches for the development of safer immunomodulatory biologics

M. Pirmohamed, S. Holgate, R. Weaver, 2013, Nature Reviews Drug Discovery.

Examination of a vehicle for use with water soluble materials in the murine local lymph node assay.

I. Kimber, C. Ryan, L. Cruse, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Chemical Reactivity Measurement and the Predictive Identification of Skin Sensitisers

Silvia Casati, David Basketter, Petra Kern, 2008 .

Immunogenicity of therapeutic proteins: Influence of aggregation

Ian Kimber, Jeremy P. Derrick, J. Derrick, 2013, Journal of immunotoxicology.

The Cutaneous Biochemical Redox Barrier: A Component of the Innate Immune Defenses against Sensitization by Highly Reactive Environmental Xenobiotics1

E. Healy, Pawan Kumar, I. Kimber, 2009, The Journal of Immunology.

Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome*

G. López-Castejón, D. Brough, I. Kimber, 2014, The Journal of Biological Chemistry.

Gene ontology mapping as an unbiased method for identifying molecular pathways and processes affected by toxicant exposure: application to acute effects caused by the rodent non-genotoxic carcinogen diethylhexylphthalate.

Vincent Bombail, Ian Kimber, Kevin Chipman, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010

Valérie Zuang, George Loizou, Andrew Worth, 2011, Archives of Toxicology.

Anti-proliferative effect of estrogen in breast cancer cells that re-express ERalpha is mediated by aberrant regulation of cell cycle genes.

I Kimber, G. Orphanides, J. Moggs, 2005, Journal of molecular endocrinology.

Phenotypic Anchoring of Gene Expression Changes during Estrogen-Induced Uterine Growth

Ian Pate, Ian Kimber, Jonathan G. Moggs, 2004, Environmental health perspectives.

Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response.

R. Callard, J. Hourihane, S. Strobel, 2004, European journal of immunology.

Disruption of the stratum corneum allows potent epicutaneous immunization with protein antigens resulting in a dominant systemic Th2 response

R. Callard, J. Hourihane, S. Strobel, 2004 .

Compilation of Historical Local Lymph Node Data for Evaluation of Skin Sensitization Alternative Methods

Ian Kimber, David A. Basketter, Petra S. Kern, 2005, Dermatitis : contact, atopic, occupational, drug.

Food processing and allergenicity.

K. Verhoeckx, J. Baumert, H. Wichers, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies

M. Wadhwa, R. Thorpe, J. Derrick, 2019, The Journal of Biological Chemistry.

REVIEWCytokines and chemokines in the initiation and regulation of epidermal Langerhans cell mobilization

I. Kimber, R. Dearman, M. Cumberbatch, 2000, The British journal of dermatology.

Skin sensitization induced Langerhans’ cell mobilization: variable requirements for tumour necrosis factor‐α

R. Roberts, I. Kimber, R. Dearman, 2015, Immunology.

Epicutaneous exposure to proteins and skin immune function

D. Basketter, C. Griffiths, I. Kimber, 2014, European Journal of Dermatology.

The XS106 cell: a Langerhans’ cell surrogate with a selective type 2 phenotype

I. Kimber, R. Dearman, L. H. Eaton, 2014, Cutaneous and ocular toxicology.

Dendritic cells and the assessment in vitro of skin sensitizing potential

D. Basketter, I. Kimber, R. Dearman, 2013, Cutaneous and ocular toxicology.

Chemical allergy: translating biology into hazard characterization.

G Frank Gerberick, Ian Kimber, David A Basketter, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.

I. Kimber, R. Dearman, M. Cumberbatch, 2009, The Journal of investigative dermatology.

Dose metrics in the acquisition of skin sensitization: thresholds and importance of dose per unit area.

D. Basketter, I. Kimber, C. Ryan, 2008, Regulatory toxicology and pharmacology : RTP.

The Development of Novel Approaches to the Identification of Chemical and Protein Respiratory Allergens

Silvia Casati, David B. Warheit, Sue Gibbs, 2008, Alternatives to laboratory animals : ATLA.

Chemical Respiratory Allergy: Opportunities for Hazard Identification and Characterisation

Emanuela Corsini, Paul Cullinan, Raymond Agius, 2007, Alternatives to laboratory animals : ATLA.

Langerhans Cells and Skin Irritation

I. Kimber, R. Dearman, M. Cumberbatch, 2006 .

Recent Developments in Allergic Contact Dermatitis

I. Kimber, R. Dearman, 2005 .

Dendritic cells and skin sensitisation hazard assessment.

I. Kimber, R. Dearman, M. Cumberbatch, 2004, Toxicology in vitro : an international journal published in association with BIBRA.

Exogenous interleukin‐1β restores impaired Langerhans cell migration in aged skin

C. Griffiths, I. Kimber, R. Dearman, 2004, The British journal of dermatology.

Measurement of cytokine expression and Langerhans cell migration in human skin following suction blister formation

C. Griffiths, I. Kimber, R. Dearman, 2004, Experimental dermatology.

Cutaneous Cytokine Expression: Induction by Chemical Allergen and Paracrine Regulation

I. Kimber, R. Dearman, M. Cumberbatch, 2003 .

IL‐1β‐induced Langerhans’ cell migration and TNF‐α production in human skin: regulation by lactoferrin

I. Kimber, R. Dearman, M. Cumberbatch, 2003 .

Assessment of glycosylation-dependent cell adhesion molecule 1 as a correlate of allergen-stimulated lymph node activation.

G. Orphanides, J. Moggs, I. Kimber, 2003, Toxicology.

Epidermal Langerhans cell migration and sensitisation to chemical allergens

C. Griffiths, I. Kimber, R. Dearman, 2003, APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.

Danger signals and skin sensitization

C. Griffiths, I. Kimber, M. Cumberbatch, 2002, The British journal of dermatology.

Reduction, Refinement and Replacement: Putting the Immune System to Work

I. Kimber, 2002, Alternatives to laboratory animals : ATLA.

Influence of ageing on Langerhans cell migration in mice: identification of a putative deficiency of epidermal interleukin‐1β

I. Kimber, R. Dearman, M. Cumberbatch, 2002, Immunology.

Differential regulation of epidermal langerhans cell migration by interleukins (IL)-1alpha and IL-1beta during irritant- and allergen-induced cutaneous immune responses.

I. Kimber, R. Dearman, M. Cumberbatch, 2002, Toxicology and applied pharmacology.

Toxicogenomics; transcript profiling and potential application to chemical allergy.

W. Pennie, I. Kimber, 2002, Toxicology in vitro : an international journal published in association with BIBRA.

Lactoferrin: influences on Langerhans cells, epidermal cytokines, and cutaneous inflammation.

C. Griffiths, D. Headon, I. Kimber, 2002, Biochemistry and cell biology = Biochimie et biologie cellulaire.

The local lymph node assay and potential application to the identification of drug allergens.

I. Kimber, 2001, Toxicology.

Dendritic cell accumulation in draining lymph nodes during the induction phase of contact allergy in mice.

I. Kimber, J. Foster, A. Kinnaird, 1989, International archives of allergy and applied immunology.

Phenotypic characteristics of antigen-bearing cells in the draining lymph nodes of contact sensitized mice.

I. Kimber, M. Cumberbatch, 1990, Immunology.

Correlation between lymphocyte proliferative responses and dendritic cell migration in regional lymph nodes following skin painting with contact-sensitizing agents.

I. Kimber, J. Mitchell, A. Kinnaird, 1990, International archives of allergy and applied immunology.

MHC class II expression by Langerhans' cells and lymph node dendritic cells: possible evidence for maturation of Langerhans' cells following contact sensitization.

S. Gould, I. Kimber, M. Cumberbatch, 1991, Immunology.

The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration.

M. Norval, I. Kimber, A. Moodycliffe, 1992, Immunology.

Intercellular adhesion molecule-1 (ICAM-1) expression by lymph node dendritic cells: comparison with epidermal Langerhans cells.

S. Gould, I. Kimber, M. Cumberbatch, 1992, Immunology letters.

Dermal tumour necrosis factor-alpha induces dendritic cell migration to draining lymph nodes, and possibly provides one stimulus for Langerhans' cell migration.

I. Kimber, M. Cumberbatch, Ian Kimber, 1992, Immunology.

Stimulation of Langerhans Cell Migration by Tumor Necrosis Factor α (TNF-α)

I. Kimber, M. Cumberbatch, 1992 .

Influence of sodium lauryl sulphate on 2,4-dinitrochlorobenzene-induced lymph node activation.

D. Basketter, I. Kimber, R. Scott, 1993, Toxicology.

Role of tumour necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity.

M. Norval, I. Kimber, A. Moodycliffe, 1994, Immunology.

Modulation of epidermal Langerhans' cell frequency by tumour necrosis factor-alpha.

I. Kimber, M. Cumberbatch, I. Fielding, 1994, Immunology.

Tumour necrosis factor-alpha is required for accumulation of dendritic cells in draining lymph nodes and for optimal contact sensitization.

I. Kimber, M. Cumberbatch, 1995, Immunology.

Cytokine regulation of chemical sensitization.

I. Kimber, R. Dearman, M. R. Holliday, 1995, Toxicology letters.

Selective Stimulation of Cutaneous Interleukin 6 Expression by Skin Allergens

D. Basketter, E. Corsini, I. Kimber, 1996, Journal of applied toxicology : JAT.

Stimulation by oxazolone of increased IL-6, but not IL-10, in the skin of mice.

D. Basketter, I. Kimber, R. Dearman, 1996, Toxicology.

Constitutive and inducible expression of interleukin‐6 by Langerhans cells and lymph node dendritic cells

I. Kimber, R. Dearman, M. Cumberbatch, 1996, Immunology.

Interleukin 1β and the stimulation of Langerhans cell migration: comparisons with tumour necrosis factor α

I. Kimber, R. Dearman, M. Cumberbatch, 1997, Archives of Dermatological Research.

Differential induction of cutaneous TNF-alpha and IL-6 by topically applied chemicals.

D. Basketter, E. Corsini, S. Smith, 1997, American Journal of Contact Dermatitis.

α6 Integrins Are Required for Langerhans Cell Migration from the Epidermis

I. Kimber, M. Cumberbatch, A. Ager, 1997, The Journal of experimental medicine.

Langerhans cells require signals from both tumour necrosis factor‐α and interleukin‐1β for migration

I. Kimber, R. Dearman, M. Cumberbatch, 1997, Immunology.

Langerhans cells and chemical allergy.

I. Kimber, R. Dearman, M. Cumberbatch, 1998, Current opinion in immunology.

Production and in situ localization of cutaneous tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) following skin sensitization.

M. Flint, S. Hotchkiss, I. Kimber, 1998, Cytokine.

Characteristics and regulation of the expression of interleukin 1 receptors by murine Langerhans cells and keratinocytes

I. Kimber, R. Dearman, M. Cumberbatch, 1998, Archives of Dermatological Research.

Induction by tumour necrosis factor α of dose-related changes in Langerhans cell frequency in mice

I. Kimber, R. Dearman, M. Cumberbatch, 1999, Archives of Dermatological Research.

Inhibition by dexamethasone of Langerhans cell migration: influence of epidermal cytokine signals.

I. Kimber, R. Dearman, M. Cumberbatch, 1999, Immunopharmacology.

Langerhans cell migration in mice requires intact type I interleukin 1 receptor (IL-1RI) function

I. Kimber, R. Dearman, M. Cumberbatch, 1999, Archives of Dermatological Research.

Factors governing susceptibility to chemical allergy.

E. Corsini, I. Kimber, 2007, Toxicology letters.

Proteomic analysis of suction blister fluid isolated from human skin

G. Orphanides, C. Griffiths, I. Kimber, 2006, Clinical and experimental dermatology.

Classification of chemicals as respiratory allergens based on human data: requirements and practical considerations.

M. Pemberton, I. Kimber, 2021, Regulatory toxicology and pharmacology : RTP.

Household chemicals, immune function, and allergy: A commentary

R. Pieters, I. Kimber, 2013, Journal of Immunotoxicology.

Chemical pollution, respiratory allergy and asthma: a perspective

D. Cadogan, C. Hennes, I. Kimber, 2008, Journal of applied toxicology : JAT.

Evaluation of the Sensitizing Potential of Eugenol and Isoeugenol in Mice and Guinea Pigs

D. Basketter, I. Kimber, R. Dearman, 1996, Journal of applied toxicology : JAT.

Predictive Tests for Irritants and Allergens and Their Use in Quantitative Risk Assessment

David Basketter, Ian Kimber, D. Basketter, 2011 .

Dimethylfumarate: potency prediction and clinical experience

D. Basketter, I. Kimber, I. White, 2013, Contact Dermatitis.

The Hapten‐Atopy hypothesis II: the ‘cutaneous hapten paradox’

D. Basketter, J. Mcfadden, I. Kimber, 2011, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing.

C. Rovida, D. Basketter, L. Tosti, 2007, Alternatives to laboratory animals : ATLA.

Toxicology of Contact Dermatitis: Allergy, Irritancy and Urticaria

D. Basketter, I. Kimber, Carolyn Willis, 1999 .

Immune responses to contact allergens: novel approaches to hazard evaluation.

D. Basketter, I. Kimber, R. Dearman, 1999, Toxicology letters.

Adaptation of an ELISA assay for detection of IgG2a responses against therapeutic monoclonal antibodies in a mouse immunization model

J. Derrick, I. Kimber, R. Dearman, 2022, Journal of Immunotoxicology.

Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies

S. Uddin, J. Derrick, A. Pluen, 2019, Pharmaceutical Research.

Characterisation of immune responses to food allergens in mice

I. Kimber, R. Dearman, 2005, Proceedings of the Nutrition Society.

Assessment of allergenic potential of genetically modified foods: an agenda for future research.

L. Goldman, D. Germolec, I. Kimber, 2002, Environmental health perspectives.

Protein digestibility and relevance to allergenicity.

G. Bannon, I. Kimber, D. Hinton, 2003, Environmental health perspectives.

Assessment of protein allergenicity on the basis of immune reactivity: animal models.

R. Helm, B. Hammerberg, I. Kimber, 2002, Environmental health perspectives.

Immunotoxicological Aspects of Food Allergy

I. Kimber, R. Dearman, C. Betts, 2002 .

Food Allergy Safety Assessment: An Introduction

I. Kimber, R. Dearman, 2002 .

Respiratory allergenic potential of plant-derived proteins: Understanding the relationship between exposure and potency for risk assessments

I. Kimber, R. Dearman, G. Gerberick, 2015, Critical reviews in toxicology.

Predictive Tests for Irritants and Allergens: Human, Animal, and In Vitro Tests

D. Basketter, I. Kimber, J. Ezendam, 2020, Contact Dermatitis.

Predictive Tests for Irritants and Allergens: Human, Animal, and In Vitro Tests

D. Basketter, I. Kimber, J. Ezendam, 2020, Contact Dermatitis.

The murine local lymph node assay for identification of contact allergens: a preliminary evaluation of in situ measurement of lymphocyte proliferation

I. Kimber, J. Hilton, Claudia Weisenberger, 1989, Contact dermatitis.

Dichloronitrobenzene: a reappraisal of its skin sensitization potential

D. Basketter, I. Kimber, R. Dearman, 1996, Contact dermatitis.

Dinitrohalobenzenes: evaluation of relative skin sensitization potential using the local lymph node assay

D. Basketter, I. Kimber, R. Dearman, 1997, Contact dermatitis.

The use of ethanol:diethylphthalate as a vehicle for the local lymph node assay

I. Kimber, R. Dearman, C. Betts, 2007, Contact dermatitis.

The impact of vehicle on assessment of relative skin sensitization potency of 1,4-dihydroquinone in the local lymph node assay.

D. Basketter, I. Kimber, R. Dearman, 1999, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Oral exposure to mineral oils: Is there an association with immune perturbation and autoimmunity?

I. Kimber, J. Carrillo, 2016, Toxicology.

Editor’s Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response

M. Wadhwa, R. Thorpe, J. Derrick, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

The European Long-range Research Initiative (LRI): A decade of contributions to human health protection, exposure modelling and environmental integrity.

Jacob de Boer, Ellen Fritsche, Ian Kimber, 2015, Toxicology.

Cytokine fingerprinting and hazard assessment of chemical respiratory allergy

I. Kimber, R. Dearman, R. Dearman, 2001, Journal of applied toxicology : JAT.

Diisocyanates, occupational asthma and IgE antibody: implications for hazard characterization

D. Basketter, I. Kimber, R. Dearman, 2014, Journal of applied toxicology : JAT.

Differential stimulation of immune function by respiratory and contact chemical allergens.

I. Kimber, R. Dearman, 1991, Immunology.

Cytokine fingerprinting: characterization of chemical allergens.

I. Kimber, R. Dearman, 1999, Methods.

Allergen‐induced cytokine phenotypes in mice: role of CD4+ and CD8+ T cell populations

N. Humphreys, I. Kimber, R. Skinner, 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Development of non-radio isotopic endpoint of murine local lymph node assay based on 5-bromo-2'-deoxyuridine (BrdU) incorporation.

I Kimber, Y Yakabe, M. Takatsuki, 2001, Toxicology letters.

Advantage of using CBA/N strain mice in a non‐radioisotopic modification of the local lymph node assay

M. Takeyoshi, I. Kimber, K. Yamasaki, 2006, Journal of applied toxicology : JAT.

Local lymph node assay: use in hazard and risk assessment

D. Basketter, I. Kimber, R. Dearman, 1999, Journal of applied toxicology : JAT.

The performance of the local lymph node assay with chemicals identified as contact allergens in the human maximization test.

D. Basketter, I. Kimber, E. Scholes, 1994, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Current challenges facing the assessment of the allergenic capacity of food allergens in animal models

R. Pieters, K. Verhoeckx, J. V. van Bilsen, 2016, Clinical and Translational Allergy.

Relationship between protein digestibility and allergenicity: comparisons of pepsin and cathepsin.

I. Kimber, R. Dearman, Emily S Foster, 2013, Toxicology.

Influence of protein expression system on elicitation of IgE antibody responses: experience with lactoferrin.

I. Kimber, R. Dearman, B. Flanagan, 2012, Toxicology.

Does hapten exposure predispose to atopic disease? The hapten-atopy hypothesis.

D. Basketter, I. Kimber, J. McFadden, 2009, Trends in immunology.

Animal models of protein allergenicity: potential benefits, pitfalls and challenges

I. Kimber, R. Dearman, 2009, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

A mouse model for food allergy using intraperitoneal sensitization.

I. Kimber, R. Dearman, 2007, Methods.

Influence of plant lipids on immune responses in mice to the major Brazil nut allergen Ber e 1

M. Alcocer, I. Kimber, R. Dearman, 2007, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Immunogenic properties of rapidly digested food proteins following gavage exposure of mice: a comparison of ovalbumin with a potato acid phosphatase preparation.

D. Basketter, I. Kimber, J. G. Kenna, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Protein Allergenicity in Mice

I. Kimber, R. Dearman, K. Atherton, 2002, Annals of the New York Academy of Sciences.

Approaches to assessment of the allergenic potential of novel proteins in food from genetically modified crops.

I. Kimber, R. Dearman, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Can animal models predict food allergenicity

I. Kimber, R. Dearman, 2001 .

Characterization of antibody responses induced in rodents by exposure to food proteins: influence of route of exposure.

D. Basketter, I. Kimber, R. Dearman, 2001, Toxicology.

Food allergy: what are the issues?

I. Kimber, R. Dearman, 2001, Toxicology letters.

FORUM Why Are Some Proteins Allergens

I. Kimber, R. Dearman, R. Huby, 2000 .

Divergent antibody isotype responses induced in mice by systemic exposure to proteins: a comparison of ovalbumin with bovine serum albumin.

D. Basketter, I. Kimber, R. Dearman, 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Toxicology of protein allergenicity: prediction and characterization.

N. Kerkvliet, S. Taylor, I. Kimber, 1999, Toxicological sciences : an official journal of the Society of Toxicology.

Allergenicity of proteins

D. Metcalfe, I. Kimber, C. Lumley, 1997, Human & experimental toxicology.

Selection of Chemicals for the Development and Evaluation of In Vitro Methods for Skin Sensitisation Testing

C. Rovida, D. Basketter, L. Tosti, 2009 .

Results with OECD recommended positive control sensitizers in the maximization, Buehler and local lymph node assays.

D. Basketter, P. Botham, I. Kimber, 1993, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin

I. Kimber, R. Dearman, G. Gerberick, 2015, The Journal of Biological Chemistry.

The expanding interleukin-1 family and its receptors

N. Rothwell, H. Boutin, I. Kimber, 2003, Molecular Neurobiology.

Fragrance sensitisers: Is inhalation an allergy risk?

D. Basketter, I. Kimber, 2015, Regulatory toxicology and pharmacology : RTP.

The multiple factors affecting the association between atopic dermatitis and contact sensitization

J. Thyssen, J. Mcfadden, I. Kimber, 2014, Allergy.

Food allergy--science and policy needs--The UK Food Standards Agency Research Programme.

I. Kimber, S. Hattersley, J. Buck, 2010, Toxicology.

The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomised controlled study

J. Wason, C. Mills, S. Durham, 2020 .

The impact of LLNA group size on the identification and potency classification of skin sensitizers: a review of published data

D. Basketter, I. Kimber, C. Ryan, 2009, Cutaneous and ocular toxicology.

Identification of B cell epitopes enhanced by protein unfolding and aggregation

L. Johannissen, J. Derrick, I. Kimber, 2019, Molecular immunology.

Influence of dibutyl phthalate on dermal sensitization to fluorescein isothiocyanate.

J. Heylings, I. Kimber, R. Dearman, 1996, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Function of dendritic cells and changes in T cell proliferation in antigen-induced nonresponsiveness.

I. Kimber, S. Knight, A. Stackpoole, 1992, Cellular immunology.

Reviewing the Utility of Two Species in General Toxicology Related to Drug Development

I. Kimber, L. de Haan, Elisabeth Mortimer‐Cassen, 2018, International Journal of Toxicology.

Factors affecting the development of food allergy

I. Kimber, R. Dearman, 2002, Proceedings of the Nutrition Society.

Using problem formulation to clarify the meaning of weight of evidence and biological relevance in environmental risk assessments for genetically modified crops.

A. Raybould, K. Holt, I. Kimber, 2019, GM crops & food.

Local lymph node assay: validation assessment for regulatory purposes.

D. Basketter, I. Kimber, C. Ryan, 2000, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Are skin sensitisation test methods relevant for proteins?

D. Basketter, I. Kimber, 2018, Regulatory toxicology and pharmacology : RTP.

Phthalic anhydride: Illustrating a conundrum in chemical allergy

D. Basketter, I. Kimber, 2016, Journal of immunotoxicology.

The local lymph node assay in 2014.

D. Basketter, I. Kimber, G. Gerberick, 2014, Dermatitis : contact, atopic, occupational, drug.

Inter‐relationships between different classes of chemical allergens

D. Basketter, I. Kimber, R. Dearman, 2013, Journal of applied toxicology : JAT.

Assessing the potency of respiratory allergens: uncertainties and challenges.

D. Basketter, I. Kimber, 2011, Regulatory toxicology and pharmacology : RTP.

What makes a chemical a respiratory sensitizer?

I. Kimber, R. Dearman, 2005, Current opinion in allergy and clinical immunology.

Designation of substances as skin sensitizing chemicals: a commentary

D. Basketter, I. Kimber, R. Dearman, 2003, Human & experimental toxicology.

Utility of historical vehicle‐control data in the interpretation of the local lymph node assay

D. Basketter, I. Kimber, G. Gerberick, 2003, Contact dermatitis.

Development of the local lymph node assay for risk assessment of chemicals and formulations

I. Kimber, R. Dearman, 2001 .

Predictive testing in contact all_ergy: facts and future

D. Basketter, I. Kimber, 2001, Allergy.

Toxicology of Contact Hypersensitivity

I. Kimber, T. Maurer, 1996 .

A Modified Murine Local Lymph Node Assay for Identification of Contact Allergens

I. Kimber, C. Weisenberger, 1989 .

Aspects of the immune response to contact allergens: opportunities for the development and modification of predictive test methods.

I. Kimber, 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Differential effect of thalidomide and dexamethasone on the transcription factor NF-κB

J. Deighton, I. Kimber, R. Dearman, 2001 .

Selective down-regulation of T cell- and non-T cell-derived tumour necrosis factor alpha by thalidomide: comparisons with dexamethasone.

J. Deighton, I. Kimber, R. Dearman, 1999, Immunology letters.

Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells.

J. Deighton, I. Kimber, R. Dearman, 1998, Immunopharmacology.

Cell and molecular biology of chemical allergy

I. Kimber, R. Dearman, 1997, Clinical reviews in allergy & immunology.

Skin Sensitization Tests: The LLNA and the RhE IL-18 Potency Assay.

D. Basketter, E. Corsini, I. Kimber, 2021, Methods in molecular biology.

Setting Occupational Exposure Limits for Chemical Allergens—Understanding the Challenges

A. Maier, S. Anderson, P. Siegel, 2015, Journal of occupational and environmental hygiene.

Why does allergic contact dermatitis exist?

D. Basketter, J. Mcfadden, I. Kimber, 2013, The British journal of dermatology.

Sodium metabisulfite as a contact allergen – an example of a rare chemical mechanism for protein modification

D. Roberts, D. Basketter, I. Kimber, 2012, Contact dermatitis.

Detection of Allergen-Specific IgE Antibody Responses

I. Kimber, R. Dearman, P. Wachholz, 2005, Journal of immunotoxicology.

Distinguishing between adverse and non-adverse effects. Session summary.

P. Foster, G. Williams, I. Kimber, 2002, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

Distinguishing between Adverse and Non-Adverse Effects

Gary M Williams, P. Foster, I. Kimber, 2001 .

Cytokine Responses Induced by Skin Exposure of Mice to Chemical Allergens: Role of Interleukin 12

I. Kimber, R. Dearman, 2004 .

Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.

J. Moggs, I. Kimber, R. Terranova, 2016, Toxicology.

Enzymes and sensitization via skin exposure: A critical analysis.

D. Basketter, I. Kimber, 2021, Regulatory toxicology and pharmacology : RTP.

The activity of methacrylate esters in skin sensitisation test methods II. A review of complementary and additional analyses.

I. Kimber, 2020, Regulatory toxicology and pharmacology : RTP.

The activity of methacrylate esters in skin sensitisation test methods: A review

I. Kimber, 2019, Regulatory toxicology and pharmacology : RTP.

Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway.

D. Basketter, A. Poole, I. Kimber, 2018, Toxicology research.

The hapten–atopy hypothesis III: the potential role of airborne chemicals

D. Basketter, J. Mcfadden, I. Kimber, 2014, The British journal of dermatology.

Acne, quorum sensing and danger

J. Mcfadden, I. Kimber, J. McFadden, 2014, Clinical and experimental dermatology.

alpha 6 integrins are required for Langerhans cell migration.

I. Kimber, M. Cumberbatch, A. Ager, 1997, Advances in experimental medicine and biology.

Characterization of murine immune responses to allergenic diisocyanates.

I. Kimber, R. Dearman, L. Spence, 1992, Toxicology and applied pharmacology.

Differential immunogenicity and allergenicity of native and recombinant human lactoferrins: Role of glycosylation

A. Dell, A. Antonopoulos, S. Haslam, 2013, European journal of immunology.

Allergy, asthma and the environment: an introduction.

I. Kimber, 1998, Toxicology letters.

Modulation of T-helper cell populations: potential mechanisms of respiratory hypersensitivity and immune suppression.

D. Lawrence, S. Ullrich, I. Kimber, 1997, Toxicology and applied pharmacology.

Tumour necrosis factor-alpha-induced migration of human Langerhans cells: the influence of ageing.

C. Griffiths, I. Kimber, R. Dearman, 2002, The British journal of dermatology.

The effect of sleep deprivation and exercise on reaction threshold in peanut-allergic adults: a randomised controlled study.

J. Wason, C. Mills, S. Durham, 2019, The Journal of allergy and clinical immunology.

Intracellular Phosphotyrosine Induction by Major Histocompatibility Complex Class II Requires Co-aggregation with Membrane Rafts*

I. Kimber, R. Dearman, R. Huby, 1999, The Journal of Biological Chemistry.

The local lymph node assay: An interlaboratory evaluation of Interleukin 6 (IL‐6) production by draining lymph node cells

D. Basketter, I. Kimber, R. Dearman, 1994, Journal of applied toxicology : JAT.

Interleukin 6 production in vitro: An alternative read-out for the local lymph node assay.

I. Kimber, R. Dearman, J. Hilton, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Langerhans Cell Migration: Initiation and Regulation

I. Kimber, M. Cumberbatch, 1995 .

COMMENTARY Cytokines in non-genotoxic hepatocarcinogenesis

R. Roberts, I. Kimber, 1999 .

Anti‐hapten antibodies in response to skin sensitization

I. Kimber, R. Dearman, N. Gellatly, 2016, Contact dermatitis.

Assessment of the allergenic potential of proteins.

I. Kimber, R. Dearman, C. Betts, 2003, Toxicology letters.

Characteristics of antibody responses induced in mice by protein allergens.

D. Basketter, I. Kimber, R. Dearman, 1997, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Divergent immune responses to respiratory and contact chemical allergens: antibody elicited by phthalic anhydride and oxazolone

I. Kimber, R. Dearman, R. Dearman, 1992, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Natural killer cells.

I. Kimber, 1985, Medical laboratory sciences.

Classification of Chemical Allergens According to Cytokine Secretion Profiles of Murine Lymph Node Cells

D. Basketter, S. Smith, I. Kimber, 1997, Journal of applied toxicology : JAT.

Induced changes in total serum IgE concentration in the Brown Norway rat: potential for identification of chemical respiratory allergens

I. Kimber, R. Dearman, R. Dearman, 2002, Journal of applied toxicology : JAT.

Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium

P. Howarth, T. Sandström, S. Holgate, 2005, European Respiratory Journal.

The role of the epidermal growth factor receptor in sustaining neutrophil inflammation in severe asthma

R. Djukanović, S. Holgate, D. Davies, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Immunotoxicology: suppressive and stimulatory effects of drugs and environmental chemicals on the immune system

I. Kimber, E. Gleichmann, I. Purchase, 2004, Archives of Toxicology.

Exogenous topical lactoferrin inhibits allergen‐induced Langerhans cell migration and cutaneous inflammation in humans

D. Headon, I. Kimber, R. Dearman, 2001, The British journal of dermatology.

Regulation of epidermal Langerhans cell migration by lactoferrin

O. Conneely, D. Headon, I. Kimber, 2000, Immunology.

Characterization of circulating immune complexes in bronchiectasis by gel filtration

I. Kimber, J. Howat, A. Hilton, 1979, Clinical allergy.

Inter‐laboratory comparisons of assessment of the allergenic potential of proteins in mice

D. Rouquié, B. Stahl, I. Kimber, 2009, Journal of applied toxicology : JAT.

Immunotoxicology and allergy: Opportunities for in vitro analysis.

I. Kimber, R. Dearman, Ian Kimber, 1991, Toxicology in vitro : an international journal published in association with BIBRA.

Functional Caspase-1 Is Required for Langerhans Cell Migration and Optimal Contact Sensitization in Mice1

I. Kimber, R. Dearman, M. Cumberbatch, 2001, The Journal of Immunology.

Contact Sensitization in Mice Langerhans Cell Migration and Optimal Functional Caspase-1 Is Required for

I. Kimber, R. Dearman, M. Cumberbatch, 2001 .

1-Chloromethylpyrene: a reference skin sensitizer and genotoxin.

J. Ashby, D. Paton, I. Kimber, 1990, Mutation research.

Mannosylation Allows for Synergic (CD44/C‐Type Lectin) Uptake of Hyaluronic Acid Nanoparticles in Dendritic Cells, but Only upon Correct Ligand Presentation

M. Pelliccia, N. Tirelli, I. Kimber, 2016, Advanced healthcare materials.

Regulation of expression of the novel IL‐1 receptor family members in the mouse brain

N. Rothwell, I. Kimber, E. Pinteaux, 2005, Journal of neurochemistry.

Immunoregulation of skin sensitization and regulatory T cells

I. Kimber, M. Travis, Stefan F Martin, 2012, Contact dermatitis.

Epicutaneous exposure to peanut protein prevents oral tolerance and enhances allergic sensitization

R. Callard, J. Hourihane, S. Strobel, 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Psoriasis and basement‐membrane laminin

J. Mcfadden, I. Kimber, L. Fry, 2013, The British journal of dermatology.

The cosmetic allergy conundrum: inference of an immunoregulatory response to cosmetic allergens

D. Basketter, I. Kimber, I. White, 2013, Contact dermatitis.

Langerhans cells require signals from both tumour necrosis factor alpha and interleukin 1 beta for migration.

I. Kimber, R. Dearman, M. Cumberbatch, 1997, Advances in experimental medicine and biology.

Immunologic Defects in Laboratory Animals

I. Kimber, 1982, British Journal of Cancer.

The Local Lymph Node Assay (LLNA)

C. Rovida, D. Basketter, I. Kimber, 2012, Current protocols in toxicology.

Anamnestic responses to contact allergens: Application in the murine local lymph node assay

I. Kimber, C. Weisenberger, 1991, Journal of applied toxicology : JAT.

A fresh look at T cells in psoriasis

C. Griffiths, I. Kimber, L. H. Eaton, 2015, The British journal of dermatology.

Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones

N. Rothwell, I. Kimber, E. Pinteaux, 2008, Molecular and Cellular Neuroscience.

Contribution of CD4+ and CD8+ T lymphocyte subsets to the cytokine secretion patterns induced in mice during sensitization to contact and respiratory chemical allergens

D. Kemeny, I. Kimber, R. Dearman, 1996, Immunology.

Characterization of chemical allergens as a function of divergent cytokine secretion profiles induced in mice.

D. Basketter, I. Kimber, R. Dearman, 1996, Toxicology and applied pharmacology.

Perforin, COVID‐19 and a possible pathogenic auto‐inflammatory feedback loop

P. Simmonds, D. Basketter, I. Kimber, 2021, Scandinavian journal of immunology.

Why judiciously timed anti-IL 6 therapy may be of benefit in severe COVID-19 infection

D. Basketter, I. Kimber, J. McFadden, 2020, Autoimmunity Reviews.

Bisphenol A and immunotoxic potential: A commentary.

I. Kimber, 2017, Regulatory toxicology and pharmacology : RTP.

Long-term tolerance after allergen immunotherapy is accompanied by selective persistence of blocking antibodies.

S. Durham, L. James, S. Walker, 2011, The Journal of allergy and clinical immunology.

Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy

S. Durham, M. Calderón, A. Frew, 2012, Allergy.

Review Food processing and allergenicity

K. Verhoeckx, J. Baumert, H. Wichers, 2015 .

Interleukin‐1‐induced interleukin‐6 synthesis is mediated by the neutral sphingomyelinase/Src kinase pathway in neurones

I. Kimber, E. Pinteaux, N. Rothwell, 2008, British journal of pharmacology.

A novel model of sensitization and oral tolerance to peanut protein

J. Hourihane, S. Strobel, J. Strid, 2004, Immunology.

Characterization in mice of the immunological properties of five allergenic acid anhydrides

I. Humphreys, I. Kimber, R. Dearman, 2000, Journal of applied toxicology : JAT.

Chemical respiratory allergy, IgE and the relevance of predictive test methods: a commentary

I. Kimber, R. Dearman, E. V. Warbrick, 1998, Human & experimental toxicology.

Respiratory Allergy : Hazard Identification and Risk Assessment 1

I. Kimber, T. Hofmann, G. Briatico-Vangosa, 2022 .

Role of CD4+ T helper 2‐type cells in cutaneous inflammatory responses induced by fluorescein isothiocyanate

I. Kimber, R. Dearman, R. Dearman, 2000, Immunology.

Perforin and resistance to SARS coronavirus 2

P. Simmonds, D. Basketter, I. Kimber, 2020, Journal of Allergy and Clinical Immunology.

Methyl methacrylate and respiratory sensitisation: a comprehensive review

M. Pemberton, I. Kimber, 2022, Critical reviews in toxicology.

Interleukins 5 and 13 characterize immune responses to respiratory sensitizing acid anhydrides

I. Humphreys, I. Kimber, R. Dearman, 2002, Journal of applied toxicology : JAT.

Cytokines and regulation of allergic sensitization to chemicals.

I. Kimber, Ian Kimber, 1994, Toxicology.

Behaviour of chemical respiratory allergens in novel predictive methods for skin sensitisation.

D. Basketter, A. Poole, I. Kimber, 2017, Regulatory toxicology and pharmacology : RTP.

Cytokine profiling of chemical allergens in mice: impact of mitogen on selectivity of response

I. Kimber, R. Dearman, C. Betts, 2009, Journal of applied toxicology : JAT.

Cytokine profiling of chemical allergens in mice: measurement of message versus protein.

I. Kimber, R. Dearman, C. Betts, 2008, Toxicology.

The Use of Cytokines in the Identification and Characterization of Chemical Allergens

I. Kimber, R. Dearman, 2007 .

Methods for the identiﬁcation of chemical respiratory allergens in rodents: comparisons of cytokine proﬁling with induced changes in serum IgE

N. Humphreys, I. Kimber, R. Skinner, 2003, Journal of applied toxicology : JAT.

Cytokine fingerprinting of chemical allergens: species comparisons and statistical analyses.

I. Kimber, R. Skinner, R. Dearman, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Impaired Langerhans cell migration in psoriasis is due to an altered keratinocyte phenotype induced by interleukin‐17

C. Griffiths, I. Kimber, R. Dearman, 2018, The British journal of dermatology.

Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser.

I. Kimber, J. Arts, 2017, Regulatory toxicology and pharmacology : RTP.

Chemical allergy in humans: Fresh perspectives

D. Basketter, J. Thyssen, I. Kimber, 2014, Journal of immunotoxicology.

Chemical allergen induced perturbations of the mouse lymph node DNA methylome.

J. Moggs, I. Kimber, R. Terranova, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Chemical respiratory allergy: role of IgE antibody and relevance of route of exposure.

I. Kimber, R. Dearman, 2002, Toxicology.

Selective induction of type 2 cytokines following topical exposure of mice to platinum salts.

D. Basketter, I. Kimber, R. Dearman, 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Skin sensitization: Uncertainties, challenges, and opportunities for improved risk assessment

I. Kimber, G. Maxwell, Jason D. L. Williams, 2018, Contact dermatitis.

The interleukin-1-related cytokine IL-1F8 is expressed in glial cells, but fails to induce IL-1beta signalling responses.

N. Rothwell, I. Kimber, E. Pinteaux, 2005, Cytokine.

No impairment of monocyte-derived Langerhans cell phenotype or function in early-onset psoriasis

C. Griffiths, I. Kimber, R. Dearman, 2012, Clinical and experimental dermatology.

Impaired Langerhans cell migration in psoriasis

H. Young, C. Griffiths, I. Kimber, 2006, The Journal of experimental medicine.

Reduced allergy rates in atopic eczema to contact allergens used in both skin products and foods: atopy and the ‘hapten‐atopy hypothesis’

D. Basketter, I. Kimber, Jonathan M L White, 2008, Contact dermatitis.

T helper cell 2 immune skewing in pregnancy/early life: chemical exposure and the development of atopic disease and allergy

D. Basketter, J. Thyssen, J. Mcfadden, 2015, The British journal of dermatology.

Cytokines and Langerhans cell mobilisation in mouse and man.

C. Griffiths, I. Kimber, R. Dearman, 2005, Cytokine.

C. Griffiths, I. Kimber, R. Dearman, 2013, The Journal of investigative dermatology.

Adhesion molecule expression by epidermal Langerhans cells and lymph node dendritic cells: a comparison

I. Kimber, R. Dearman, M. Cumberbatch, 1996, Archives of Dermatological Research.

Temporal changes in cytokine gene expression profiles induced in mice by trimellitic anhydride.

I. Kimber, R. Dearman, C. Betts, 2002, Toxicology letters.

Inducible interleukin 4 (IL-4) production and mRNA expression following exposure of mice to chemical allergens.

I. Kimber, F. Gerberick, C. Ryan, 1998, Toxicology letters.

The bronchial epithelium in asthma--much more than a passive barrier.

S. Holgate, D. Davies, I. Kimber, 2001, Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace.

Differential regulation of mast cell cytokines by both dexamethasone and the p38 mitogen‐activated protein kinase (MAPK) inhibitor SB203580

I. Kimber, J. Coleman, E. Swindle, 2004, Clinical and experimental immunology.

The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses.

S. Durham, M. Larché, M. Shamji, 2006, Journal of immunological methods.

Chemical respiratory allergy: classification and labelling.

D. Basketter, I. Kimber, R. Roggeband, 2001, Toxicology.

Diet and the aetiology of temporal advances in human and rodent sexual development

J. Ashby, J. Odum, I. Kimber, 2000, Journal of applied toxicology : JAT.

Interleukin‐17 and interleukin‐23 regulate Langerhans cell migration

C. Griffiths, I. Kimber, R. Dearman, 2016, The British journal of dermatology.

Allergic contact dermatitis: the cellular effectors

I. Kimber, R. Dearman, 2002, Contact dermatitis.

The role of dendritic cells in cutaneous immunity

M. Norval, I. Kimber, M. B. Lappin, 1996, Archives of Dermatological Research.

Selective Enhancement of Human Mononuclear Leucocyte Cytotoxic Function by Interferon

I. Kimber, M. Moore, 1981, Scandinavian journal of immunology.

AUGMENTATION OF HUMAN NK AND ADCC BY INTERFERON

I. Kimber, M. Moore, 1980 .

Di-(2-ethylhexyl) phthalate is without adjuvant effect in mice on ovalbumin.

I. Kimber, R. Dearman, C. Betts, 2008, Toxicology.

Differential ability of occupational chemical contact and respiratory allergens to cause immediate and delayed dermal hypersensitivity reactions in mice.

D. Basketter, I. Kimber, R. Dearman, 1992, International archives of allergy and immunology.

A Review on the Potential Role of Basement Membrane Laminin in the Pathogenesis of Psoriasis

I. Kimber, J. McFadden, 2016, Scandinavian journal of immunology.

Inhibition of CD23‐dependent facilitated allergen binding to B cells following vaccination with genetically modified hypoallergenic Bet v 1 molecules

S. Durham, R. Valenta, I. Kimber, 2010, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Influence of corticotrophin releasing factor on neuronal cell death in vitro and in vivo

N. Rothwell, S. Allan, M. Craighead, 2000, Brain Research.

Cytokine Production by CD4+ and CD8+ T Cells in Mice following Primary Exposure to Chemical Allergens: Evidence for Functional Differentiation of T Lymphocytes in vivo

D. Kemeny, I. Kimber, R. Dearman, 1998, International Archives of Allergy and Immunology.

T lymphocyte dynamics in methylisothiazolinone‐allergic patients

I. Kimber, R. Dearman, N. Gellatly, 2016, Contact dermatitis.

Contact and respiratory sensitization by chemical allergens: Uneasy relationships☆

I. Kimber, 1995 .

FORUM Toxicology of Protein Allergenicity: Prediction and Characterization

Steve L. Taylor, N. Kerkvliet, I. Kimber, 1999 .

Predictive testing for respiratory sensitization in the mouse.

D. Basketter, I. Kimber, R. Dearman, 1996, Toxicology letters.

Experimental assessment of the sensitizing properties of formaldehyde.

D. Basketter, I. Kimber, R. Dearman, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification of Chemical Respiratory Allergens: Dose-Response Relationships in the Mouse IgE Test

D. Basketter, I. Kimber, R. Dearman, 1995 .

Chemical allergy: Cellular and molecular mechanisms and novel approaches to predictive testing.

I. Kimber, Ian Kimber, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Serological responses induced in mice by immunogenic proteins and by protein respiratory allergens.

D. Basketter, I. Kimber, R. Dearman, 1994, Toxicology letters.

Newer approaches to the evaluation of sensitization phenomena.

I. Kimber, Ian Kimber, 1994, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Induction of mast cell sensitization by chemical allergens: A comparative study

I. Kimber, J. Coleman, R. Dearman, 1993, Journal of applied toxicology : JAT.

The mechanisms and evaluation of chemically induced allergy.

I. Kimber, R. Dearman, 1992, Toxicology letters.

Langerhans cells, antigen presentation, and the diversity of responses to chemical allergens.

S. Gould, D. Basketter, I. Kimber, 1992, The Journal of investigative dermatology.

Chemical allergy: molecular mechanisms and practical applications.

H. van Loveren, I. Kimber, G. Gerberick, 1992, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Variable effects of chemical allergens on serum ige concentration in mice. Preliminary evaluation of a novel approach to the identification of respiratory sensitizers

D. Basketter, I. Kimber, R. Dearman, 1992, Journal of applied toxicology : JAT.

The cellular and molecular basis for divergent allergic responses to chemicals.

D. Basketter, I. Kimber, R. Dearman, 1992, Chemico-biological interactions.

Accessory cell requirements for T lymphocyte activation and interferon-gamma production in peripheral lymph nodes.

I. Kimber, R. Dearman, A. Morris, 1996, Immunology letters.

Cytokine-mast cell interactions: relevance to IgE-mediated chemical allergy.

I. Kimber, R. Dearman, J. Coleman, 1994, Toxicology.

A murine local lymph node assay for the identification of contact allergens

I. Kimber, C. Weisenberger, Dr. I. Kimber, 2004, Archives of Toxicology.

Attempts to identify the causative allergen in cases of allergic contact dermatitis using an in vitro lymphocyte transformation test.

I. Kimber, M. Beck, S. Quirke, 1990, Toxicology in vitro : an international journal published in association with BIBRA.

Influence of chronic low-level exposure to lead on plasma immunoglobulin concentration and cellular immune function in man

I. Kimber, M. Stonard, D. Gidlow, 1986, International archives of occupational and environmental health.

K cell mediated haemolysis: influence of large numbers of unsensitized cells on the antibody‐dependent lysis of anti‐D‐sensitized erythrocytes by human lymphocytes

T. Bakács, I. Kimber, M. Moore, 1984, British journal of haematology.

Induction of respiratory hypersensitivity to diphenylmethane-4,4'-diisocyanate (MDI) in guinea pigs. Influence of route of exposure.

P. Botham, P. Hext, I. Kimber, 1994, Toxicology.

Contact allergy across the human lifespan.

I. Kimber, I. White, C. Tziotzios, 2020, The Journal of allergy and clinical immunology.

Mechanisms of interleukin-6 synthesis and release induced by interleukin-1 and cell depolarisation in neurones

N. Rothwell, I. Kimber, E. Pinteaux, 2008, Molecular and Cellular Neuroscience.

REVIEW Assessing the Potential to Induce Respiratory Hypersensitivity

I. Kimber, David R. Jones, M. Selgrade, 2006 .

Phenotypic variation in mast cell responsiveness to the inhibitory action of nitric oxide

I. Kimber, R. Dearman, J. Coleman, 2000, Inflammation Research.

The Local Lymph Node Assay

D. Basketter, I. Kimber, G. Gerberick, 2019, Dermatotoxicology Methods: The Laboratory Worker’s Vade Mecum.

Quantitative risk assessment for skin sensitization: Success or failure?

D. Basketter, I. Kimber, G. Gerberick, 2017, Regulatory toxicology and pharmacology : RTP.

Hexyl cinnamal: consideration of skin-sensitizing properties and suitability as a positive control

D. Basketter, I. Kimber, I. White, 2015, Cutaneous and ocular toxicology.

Consideration of criteria required for assignment of a (skin) sensitiser a substance of very high concern (SVHC) under the REACH regulation.

D. Basketter, I. Kimber, 2014, Regulatory toxicology and pharmacology : RTP.

Skin irritation, false positives and the local lymph node assay: a guideline issue?

D. Basketter, I. Kimber, 2011, Regulatory toxicology and pharmacology : RTP.

The reduced local lymph node assay: the impact of group size

G. Patlewicz, D. Basketter, I. Kimber, 2008, Journal of applied toxicology : JAT.

Chemical respiratory allergy and occupational asthma: what are the key areas of uncertainty?

I. Sipes, D. Isola, I. Kimber, 2008, Journal of applied toxicology : JAT.

Chemical respiratory sensitizers: Activity in a non-standard local lymph node assay (LLNA)

D. Basketter, I. Kimber, R. Dearman, 2007 .

Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3 or IL-4.

S. Galli, K. Zsebo, I. Kimber, 1993, Journal of immunology.

The lymphocyte transformation test in allergic contact dermatitis: New opportunities

I. Kimber, R. Dearman, N. Gellatly, 2016, Journal of immunotoxicology.

Guinea Pig, Mouse, and Rat Models for Safety Assessment of Protein Allergenicity

I. Kimber, R. Dearman, K. Sarlo, 2005 .

Systemic migration of dendritic cells during contact sensitization.

I. Kimber, S. Knight, A. Edwards, 1990, Immunology.

Analysis of interleukin 12 protein production and mRNA expression in mice exposed topically to chemical allergens.

D. Basketter, I. Kimber, R. Dearman, 1999, Toxicology.

Antigen-specific and nonspecific determinants of cytokine production during topical sensitization of mice to chemical allergens.

D. Kemeny, I. Kimber, R. Dearman, 2000, The Journal of allergy and clinical immunology.

Epidermal cytokines and the induction of allergic and non-allergic contact dermatitis.

I. Kimber, R. Dearman, M. Cumberbatch, 1997, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Cytokine profiling and chemical allergy.

I. Kimber, R. Dearman, 2002, Toxicology and applied pharmacology.

IgG and IgE antibody responses following exposure of Brown Norway rats to trimellitic anhydride: comparison of inhalation and topical exposure.

I. Kimber, R. Dearman, E. V. Warbrick, 2002, Toxicology.

THE MOUSE IgE TEST: INTERLABORATORY EVALUATION AND COMPARISON OF BALB/c AND C57BL/6 STRAIN MICE

D. Basketter, G. Ladics, I. Kimber, 1998 .

Examination of Phenotypic Changes in Peripheral Blood‐Derived Dendritic Cells Following Exposure to a Contact Allergen: Cell Surface Marker and Gene Expression

I. Kimber, C. Ryan, R. Dearman, 2005 .

Reference Chemical Potency List (RCPL): A new tool for evaluating the accuracy of skin sensitisation potency measurements by New Approach Methodologies (NAMs).

A. Irizar, A. Natsch, I. Kimber, 2022, Regulatory toxicology and pharmacology : RTP.

Identifying key priorities for research to protect the consumer with food hypersensitivity: A UK Food Standards Agency Priority Setting Exercise

G. Roberts, J. Barnett, K. Cowan, 2021, Clinical and Experimental Allergy.

Exposure of UVB‐sensitive mice to immunosuppressive doses of UVB in vivo fails to affect the accessory function or the phenotype of draining lymph node dendritic cells

M. Norval, I. Kimber, R. Dearman, 1996, Experimental dermatology.

Workshop on Status of Test Methods for Assessing Potential of Chemicals to Induce Respiratory Allergic Reactions

M. Henry, C. Zeiss, I. Kimber, 1994 .

Bisphenol A, TH17 cells, and allergy: A commentary

I. Kimber, K. Sondenheimer, Nicole Woeffen, 2022, Journal of immunotoxicology.

Mechanistic relationship among mutagenicity, skin sensitization, and skin carcinogenicity.

J. Ashby, I. Kimber, R. Dearman, 1993, Environmental health perspectives.

Differential actions of IL-1 alpha and IL-1 beta in glial cells share common IL-1 signalling pathways

N. Rothwell, I. Kimber, E. Pinteaux, 2005, Neuroreport.

Native and inducible levels of natural cytotoxicity in lymph nodes draining mammary carcinoma

I. Kimber, A. Howell, M. Moore, 2004, Cancer Immunology, Immunotherapy.

Naturally Cytotoxic Tonsillar Lymphocytes: A Manifestation of Heterogeneity among Human NK Cells

I. Kimber, M. Moore, 1983, Scandinavian journal of immunology.

Allergic Contact Dermatitis

G Frank Gerberick, Ian Kimber, David A Basketter, 1998, Springer Berlin Heidelberg.

Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals.

G Frank Gerberick, Ian Kimber, I. Kimber, 2007, Methods.

Contact allergenic potency: correlation of human and local lymph node assay data.

I Kimber, G F Gerberick, R J Dearman, 2001, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Opportunities for use of one species for longer-term toxicology testing during drug development: A cross-industry evaluation.

R. Weaver, W. Casey, O. Doehr, 2020, Regulatory toxicology and pharmacology : RTP.

Determination of the relative allergenic potency of proteins: hurdles and opportunities

Nora L. Krutz, S. Maurer-Stroh, I. Kimber, 2020, Critical reviews in toxicology.

A critique of the World Resources Institute's report "Pesticides and the immune system: the public health risks".

I Kimber, G. Ladics, C. Burns, 1998, Environmental health perspectives.

Alternative Methods for Skin Sensitisation Testing

Emanuela Corsini, Jean-Pierre Lepoittevin, Maria Ponec, 1996 .

Skin sensitization testing in potency and risk assessment.

I Kimber, D A Basketter, W Steiling, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea‐pig data and human experience

Ian Kimber, David A Basketter, D. Basketter, 2006, Contact dermatitis.

This information is current as Environmental Xenobiotics against Sensitization by Highly Reactive DefensesA Component of the Innate Immune The Cutaneous Biochemical Redox Barrier : and

E. Healy, Pawan Kumar, I. Kimber, 2009 .

Use of a B cell marker (B220) to discriminate between allergens and irritants in the local lymph node assay.

G Frank Gerberick, Ian Kimber, I. Kimber, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Alternative approaches to the identification and characterization of chemical allergens.

I Kimber, R J Dearman, D A Basketter, 2001, Toxicology in vitro : an international journal published in association with BIBRA.

Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.

Petra S Kern, Grace Patlewicz, David W Roberts, 2007, Chemical research in toxicology.

Skin sensitization risk assessment: a comparative evaluation of 3 isothiazolinone biocides

I Kimber, D A Basketter, D. Basketter, 1999, Contact dermatitis.

Contact sensitization: A new approach to risk assessment

Ian Kimber, David A. Basketter, D. Basketter, 1997 .

Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects

A. M. Api, T. L. Diepgen, D. A. Basketter, 2011, Cellular and Molecular Life Sciences.

Skin sensitisation testing--new perspectives and recommendations.

I Kimber, W Steiling, D. Basketter, 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

IL‐18 is a key proximal mediator of contact hypersensitivity and allergen‐induced Langerhans cell migration in murine epidermis

Ian Kimber, I. Kimber, R. Dearman, 2008, Journal of leukocyte biology.

Interleukin (IL)‐18 induces Langerhans cell migration by a tumour necrosis factor‐α‐ and IL‐1β‐dependent mechanism

I. Kimber, I. Kimber, R. Dearman, 2001, Immunology.

Thresholds in contact sensitization: theoretical and practical considerations.

I Kimber, G F Gerberick, D A Basketter, 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sensitization to 2,4-dinitrochlorobenzene: influence of vehicle on absorption and lymph node activation.

J. Heylings, I. Kimber, R. Dearman, 1996, Toxicology.

Potency values from the local lymph node assay: application to classification, labelling and risk assessment.

I Kimber, W Steiling, R W R Crevel, 2010, Regulatory toxicology and pharmacology : RTP.

The local lymph node assay and the assessment of relative potency: status of validation

Frank Gerberick, Ian Kimber, David A Basketter, 2007, Contact dermatitis.

Predictive identification of human skin sensitization thresholds

Frank Gerberick, Ian Kimber, Bob Safford, 2005, Contact dermatitis.

Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum.

M. Pemberton, I. Kimber, 2023, Regulatory toxicology and pharmacology : RTP.

Potency and risk assessment of a skin‐sensitizing disperse dye using the local lymph node assay

I. Kimber, R. Dearman, C. Betts, 2005, Contact dermatitis.

Dendritic Cells as a Tool for the Predictive Identification of Skin Sensitisation Hazard

Valérie Zuang, Silvia Casati, Thomas Hartung, 2005, Alternatives to laboratory animals : ATLA.

The Report and Recommendations of ECVAM Workshop 51 1,2

T. Hartung, D. Basketter, A. Cavani, 2005 .

Activity of human contact allergens in the murine local lymph node assay

I Kimber, G F Gerberick, R J Dearman, 2000, Contact dermatitis.

The local lymph node assay: developments and applications.

I Kimber, R J Dearman, D A Basketter, 1994, Toxicology.

The murine local lymph node assay: results of an inter-laboratory trial.

T. Gray, D. Basketter, P. Botham, 1991, Toxicology letters.

Identification of contact allergens using the murine local lymph node assay: Comparisons with the buehler occluded patch test in guinea pigs

I. Kimber, P. Botham, I. Kimber, 1990, Journal of applied toxicology : JAT.

Models for contact sensitization‐novel approaches and future developments

I Kimber, P. Botham, I. Kimber, 1986, British Journal of Dermatology.

Oral tolerance to contact allergens: a common occurrence? A review

D. Basketter, I. Kimber, I. Jowsey, 2007, Contact dermatitis.

Skin sensitisation, vehicle effects and the local lymph node assay.

I Kimber, G F Gerberick, D A Basketter, 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification of metal allergens in the local lymph node assay.

I Kimber, G F Gerberick, R J Dearman, 1999, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Local Lymph Node Assays

Ian Kimber, I. Kimber, R. Dearman, 2004, Current protocols in toxicology.

Investigation of TNF-alpha release as a measure of skin irritancy.

J. C. McCall, P. Botham, I. Kimber, 1993, Toxicology in vitro : an international journal published in association with BIBRA.

Human potency predictions for aldehydes using the local lymph node assay

I Kimber, G F Gerberick, R J Dearman, 2001, Contact dermatitis.

Threshold for classification as a skin sensitizer in the local lymph node assay: a statistical evaluation.

I Kimber, R J Dearman, D A Basketter, 1999, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Strategies for identifying false positive responses in predictive skin sensitization tests.

I Kimber, G F Gerberick, D A Basketter, 1998, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

An international evaluation of the murine local lymph node assay and comparison of modified procedures.

J Hilton, I Kimber, G F Gerberick, 1995, Toxicology.

The direct peptide reactivity assay: selectivity of chemical respiratory allergens.

A. M. Api, I. Kimber, R. Dearman, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

The local lymph node assay: a viable alternative to currently accepted skin sensitization tests.

I Kimber, G F Gerberick, D A Basketter, 1996, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Assessment of the skin sensitising potency of the lower alkyl methacrylate esters.

M. Pemberton, I. Kimber, 2014, Regulatory toxicology and pharmacology : RTP.

Comparative analysis of skin sensitization potency of acrylates (methyl acrylate, ethyl acrylate, butyl acrylate, and ethylhexyl acrylate) using the local lymph node assay

Ian Kimber, Karin Wiench, K. Wiench, 2007, Contact dermatitis.

Induction of IgE antibody responses by protein allergens: inter-laboratory comparisons.

E. Debruyne, I. Kimber, R. Skinner, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Proteomic and Bioinformatic Analyses for the Identification of Proteins With Low Allergenic Potential for Hazard Assessment.

Nora L. Krutz, S. Maurer-Stroh, I. Kimber, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Evaluation of an in vitro method for the measurement of specific IgE antibody responses: the rat basophilic leukemia (RBL) cell assay.

I. Kimber, R. Skinner, R. Dearman, 2005, Toxicology.

Intradermal exposure of BALB/c strain mice to peanut protein elicits a type 2 cytokine response.

I. Kimber, R. Dearman, C. Betts, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Evaluation of protein allergenic potential in mice: dose–response analyses

I Kimber, R J Dearman, D A Basketter, 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

Assessment of the inherent allergenic potential of proteins in mice.

I. Kimber, R. Dearman, S. Stone, 2003, Environmental health perspectives.

The safety of genetically modified foods produced through biotechnology.

Ian Kimber, Steve L Taylor, Steve L. Taylor, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Protein Allergenicity: Mouse Models

D. Basketter, I. Kimber, R. Dearman, 2002 .

Peanut lectin elicits a Th2 cytokine gene expression and protein secretion profile in mice

I. Kimber, R. Dearman, C. Betts, 2002 .

Identification of a possible association between carbon tetrachloride–induced hepatotoxicity and interleukin‐8 expression

W. Pennie, R. Roberts, I. Kimber, 2000, Journal of biochemical and molecular toxicology.

Tumour necrosis factor‐α‐induced migration of human Langerhans cells: the influence of ageing

I. Kimber, R. Dearman, M. Cumberbatch, 2002 .

An assessment of the ability of phthalates to influence immune and allergic responses.

I. Kimber, R. Dearman, 2010, Toxicology.

Skin sensitization quantitative risk assessment for occupational exposure of hairdressers to hair dye ingredients

A. Schnuch, C. Goebel, I. Kimber, 2018, Regulatory toxicology and pharmacology : RTP.

Characterization of the allergenic potential of proteins: an assessment of the kiwifruit allergen actinidin

I. Kimber, R. Dearman, S. McClain, 2014, Journal of applied toxicology : JAT.

Enhanced K-cell activity in the peripheral blood of patients with malignant disease

T. Bakács, I. Kimber, M. Moore, 2004, Cancer Immunology, Immunotherapy.

Langerhans cell migration

I. Kimber, R. Dearman, M. Cumberbatch, 2000, Clinical and experimental dermatology.

Thresholds, dose–response relationships and dose metrics in allergic contact dermatitis

D. Basketter, I. Kimber, 2008, British Journal of Dermatology.

Regulation of allergic responses to chemicals and drugs: possible roles of epigenetic mechanisms.

J. Moggs, I. Kimber, R. Terranova, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Induction of iron homeostasis genes during estrogen-induced uterine growth and differentiation

G. Orphanides, J. Ashby, Andrew G Smith, 2006, Molecular and Cellular Endocrinology.

Chemical respiratory allergy: reverse engineering an adverse outcome pathway.

Darrell R Boverhof, Ian Kimber, David A Basketter, 2014, Toxicology.

Chemical reactivity measurements: potential for characterization of respiratory chemical allergens.

G Frank Gerberick, Anne Marie Api, Jon F Lalko, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

Dendritic cells and skin sensitization: biological roles and uses in hazard identification.

G Frank Gerberick, Ian Kimber, David A Basketter, 2007, Toxicology and applied pharmacology.

Identification of gene expression changes induced by chemical allergens in dendritic cells: opportunities for skin sensitization testing.

G Frank Gerberick, Ian Kimber, I. Kimber, 2006, The Journal of investigative dermatology.

Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment.

G Frank Gerberick, Ian Kimber, I. Kimber, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing.

T. Knudsen, J. Jaworska, G. Patlewicz, 2012, ALTEX.

Consensus report on the future of animal-free systemic toxicity testing.

Mardas Daneshian, Thomas B Knudsen, Francois Busquet, 2014, ALTEX.

Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen.

G Frank Gerberick, Ian Kimber, I. Kimber, 2004, Toxicology letters.

Assessment of the safety of foods derived from genetically modified (GM) crops.

I Kimber, R W R Crevel, U Hammerling, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

An in vitro human skin test for assessing sensitization potential

X. N. Wang, I Kimber, M Fielding, 2016, Journal of applied toxicology : JAT.

Determination of protein allergenicity: studies in mice.

I Kimber, R J Dearman, I. Kimber, 2001, Toxicology letters.

Immune Responses: Adverse Versus Non-Adverse Effects

I. Kimber, R. Dearman, 2002, Toxicologic pathology.

Immunotoxicology of Lead

I. Kimber, 1990 .

A preliminary evaluation of immune stimulation following exposure to metal particles and ions using the mouse popliteal lymph node assay.

Brooke E. Tvermoes, D. Paustenbach, M. Kovochich, 2016, Toxicology and applied pharmacology.

Retrospective appraisal of the relationship between skin irritancy and contact sensitization potential.

T. Auton, P. Botham, I. Kimber, 1995, Journal of toxicology and environmental health.

Atopic dermatitis and allergic reactions to individual fragrance chemicals

D. Buckley, D. Basketter, J. Mcfadden, 2009, Allergy.

Why are some proteins allergens?

I Kimber, R J Dearman, I. Kimber, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Assessing the potential to induce respiratory hypersensitivity.

I. Kimber, David R. Jones, M. Selgrade, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses

I Kimber, R J Dearman, D A Basketter, 1999, Journal of applied toxicology : JAT.

The murine local lymph node assay.

J Hilton, I Kimber, I. Kimber, 1995, Methods in molecular biology.

The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions

A. M. Api, I. Kimber, R. Dearman, 2013, Journal of immunotoxicology.

Reactivity of chemical respiratory allergens in the Peroxidase Peptide Reactivity Assay.

I Kimber, A M Api, G F Gerberick, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Assessing the severity of allergic reactions: a regulatory dilemma

D. Basketter, I. Kimber, J. McFadden, 2012, Contact dermatitis.

Vehicle effects on skin sensitizing potency of four chemicals: assessment using the local lymph node assay

I Kimber, I. Kimber, L. Blaikie, 2001, International journal of cosmetic science.

Use of the local lymph node assay for the estimation of relative contact allergenic potency

I. Kimber, D. Basketter, P. Evans, 2000, Contact dermatitis.

Influence of application vehicle on skin sensitization to methylchloroisothiazolinone/methylisothiazolinone: an analysis using the local lymph node assay

D. Basketter, I. Kimber, R. Dearman, 1999, Contact dermatitis.

Assessment of the skin sensitization potential of topical medicaments using the local lymph node assay: an interlaboratory evaluation.

J Hilton, I Kimber, G F Gerberick, 1998, Journal of toxicology and environmental health. Part A.

The effect of ageing on phenotype and function of monocyte-derived Langerhans cells

C. Griffiths, I. Kimber, C. Griffiths, 2011, The British journal of dermatology.

The influence of chemical carcinogens on natural killer cell function in rats. A comparison of 2-acetylaminofluorene with 4-acetylaminofluorene.

I. Kimber, A. Griffin, K. Jones, 1986, Cancer Letters.

A re-appraisal of the skin-sensitizing activity of 2,4-dinitrothiocyanobenzene.

D. Basketter, I. Kimber, R. Dearman, 1997, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Allergic contact dermatitis: a commentary on the relationship between T lymphocytes and skin sensitising potency.

Gavin Maxwell, Ian Kimber, I. Kimber, 2012, Toxicology.

T lymphocyte subpopulations in immunotoxicology

I. Kimber, M. Selgrade, 1998 .

Harnessing co‐operative immune augmentation by contact allergens to enhance the efficacy of viral vaccines

D. Basketter, I. Kimber, I. White, 2020, Contact dermatitis.

The Role of Antibody Density in the Immune Lysis of Sensitised Erythrocytes: A Mathematical Appreciation

T. Bakács, I. Kimber, G. Ringwald, 1989 .

Interactions of IFN-gamma with IL-3 and IL-4 in the regulation of serotonin and arachidonate release from mouse peritoneal mast cells.

I. Kimber, R. Dearman, J. Coleman, 1994, Immunology.

Biomarkers of immunotoxicity in man

I. Kimber, 1995, Human and Experimental Toxicology.

“Omics” Technologies and the Immune System

R. Luebke, G. Ladics, N. Kaminski, 2006, Toxicology mechanisms and methods.

Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation

C. Foradori, R. Handa, I. Kimber, 2017, Regulatory toxicology and pharmacology : RTP.

Extra domain A-positive fibronectin-positive feedback loops and their association with cutaneous inflammatory disease.

D. Basketter, I. Kimber, R. Dearman, 2011, Clinics in dermatology.

Identification of early molecular pathways affected by paraquat in rat lung.

G. Orphanides, J. Moggs, I. Kimber, 2006, Toxicology.

Danger, intracellular signaling, and the orchestration of dendritic cell function in skin sensitization

I. Kimber, R. Dearman, Joseph S. Ainscough, 2013, Journal of immunotoxicology.

Factors influencing the induction phase of skin sensitization.

Ian Kimber, I. Kimber, R. Dearman, 2003, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

What makes a chemical an allergen?

Ian Kimber, I. Kimber, R. Dearman, 2003, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Lower levels of interleukin‐1β gene expression are associated with impaired Langerhans’ cell migration in aged human skin

C. Griffiths, I. Kimber, R. Dearman, 2017, Immunology.

Migration of interleukin-6 producing Langerhans cells to draining lymph nodes following skin sensitization.

S. Hopkins, I. Kimber, J. Hope, 1995, Advances in Experimental Medicine and Biology.

Epidermal cytokines and skin sensitization hazard.

I. Kimber, M. Cumberbatch, 1994, Toxicology in vitro : an international journal published in association with BIBRA.

Dendritic cells and cutaneous immune responses to chemical allergens.

I Kimber, I. Kimber, M. Cumberbatch, 1992, Toxicology and applied pharmacology.

Epidermal cytokines in contact hypersensitivity: Immunological roles and practical applications.

I. Kimber, Ian Kimber, 1993, Toxicology in vitro : an international journal published in association with BIBRA.

Classification of contact allergens according to potency: proposals.

I Kimber, G F Gerberick, D A Basketter, 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The local lymph node assay: past, present and future

Ian Kimber, D. Basketter, I. Kimber, 2002, Contact dermatitis.

Local lymph node assay responses to paraphenylenediamine: intra‐ and inter‐laboratory evaluations

I. Kimber, D. Basketter, I. Kimber, 1999, Journal of applied toxicology : JAT.

Temporal stability of local lymph node assay responses to hexyl cinnamic aldehyde

Ian Kimber, D. Basketter, P. Evans, 1998, Journal of applied toxicology : JAT.

Development of a murine local lymph node assay for the determination of sensitizing potential

I. Kimber, J. Mitchell, A. Griffin, 1986 .

Comparison between the phenotype and function of maturing dendritic cells from spleen and lymph nodes

S. Rowland, I. Kimber, S. Knight, 1996, Immunology.

Impact of Cutaneous IL-10 on Resident Epidermal Langerhans’ Cells and the Development of Polarized Immune Responses

Ian Kimber, I. Kimber, Kirsty Clelland, 2005, The Journal of Immunology.

Thalidomide: lack of mutagenic activity across phyla and genetic endpoints.

J. Ashby, J. Parry, R. Hill, 1997, Mutation research.

Interleukin-6 production by draining lymph node cells following primary contact sensitisation of mice: relationship to the proliferative response.

S. Hopkins, I. Kimber, J. Hope, 1994, International archives of allergy and immunology.

Production of interleukin-1 by draining lymph node cells during the induction phase of contact sensitization in mice.

D. Jones, S. Hopkins, I. Kimber, 1990, Immunology.

Characterization of a monoclonal antibody to cis-urocanic acid: detection of cis-urocanic acid in the serum of irradiated mice by immunoassay.

M. Norval, I. Kimber, T. J. Simpson, 1993, Immunology.

Further evaluation of the local lymph node assay in the final phase of an international collaborative trial.

J Hilton, I Kimber, G F Gerberick, 1996, Toxicology.

Assessment of Allergic Potential

I. Kimber, 1996 .

Antigen-bearing dendritic cells in the draining lymph nodes of contact sensitized mice: cluster formation with lymphocytes.

I. Kimber, M. Cumberbatch, I. Illingworth, 1991, Immunology.

Assessment of the functional activity of antigen-bearing dendritic cells isolated from the lymph nodes of contact-sensitized mice.

D. Jones, I. Kimber, A. Morris, 1989, International archives of allergy and applied immunology.

Differential function ofdendritic cells isolated frombloodandlymphnodes

I. Kimber, 1994 .

Migration of dendritic cells during contact sensitization.

I. Kimber, S. Knight, S. Griffiths, 1993, Advances in experimental medicine and biology.

Antigenic competition incontactsensitivity. Evidence forchanges indendritic cellmigration andantigen handling

I. Kimber, J. Mitchell, S. Knight, 1990 .

Investigation of induced changes in interleukin 1beta mRNA expression by cultured human dendritic cells as an in vitro approach to skin sensitization testing.

I Kimber, D A Basketter, Dearman, 2000, Toxicology in vitro : an international journal published in association with BIBRA.

Antigen-specific regulation of T lymphocyte proliferative responses to contact-sensitizing chemicals in the guinea pig.

D. Baker, I. Kimber, J. Turk, 1989, Cellular immunology.

The murine local lymph node assay: a commentary on collaborative studies and new directions.

I Kimber, D A Basketter, D. Basketter, 1992, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Contact-sensitizing and tolerogenic properties of 2,4-dinitrothiocyanobenzene.

P. Botham, I. Kimber, N. J. Rattray, 1986, International archives of allergy and applied immunology.

Differential function of dendritic cells isolated from blood and lymph nodes.

I. Kimber, J. Coates, S. Knight, 1994, Immunology.

Enumeration of the frequency of Langerhans cells in epidermis: reply from authors

I. Kimber, M. Cumberbatch, R. Dearman, 2002 .

Differential effects of UVA1 and UVB radiation on Langerhans cell migration in mice.

M. Norval, I. Kimber, R. Dearman, 2000, Journal of photochemistry and photobiology. B, Biology.

Leukocyte migration inhibition in human pulmonary neoplasia.

I. Kimber, M. Moore, B. Vose, 1977, Journal of the National Cancer Institute.

Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity.

I. Kimber, Stefan F. Martin, P. Esser, 2014, Experientia supplementum.

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.

B. K. Park, D. Naisbitt, N. Humphreys, 2005, Toxicology.

Cytokine endpoints for the local lymph node assay: consideration of interferon‐γ and interleukin 12

I. Kimber, D. Basketter, I. Kimber, 1999, Journal of applied toxicology : JAT.

Regulation ofnatural andantibody-dependent cellular cytotoxicity bystaphylococcal enterotoxin A

I. Kimber, M. Moore, T. BAKACSt, 1983 .

Surrogate CD16‐expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies

M. Wadhwa, R. Thorpe, J. Derrick, 2017, Journal of pharmaceutical and biomedical analysis.

Gene regulation by IL‐1β independent of IL‐1R1 in the mouse brain

N. Rothwell, J. Moggs, I. Kimber, 2006, Glia.

The rapid rejection of allogeneic lymphocytes by a non-adaptive, cell-mediated mechanism (NK activity).

H. Bazin, I. Kimber, W. L. Ford, 1985, Immunology.

Chemical allergy: considerations for the practical application of cytokine profiling.

Neil Humphreys, Ian Kimber, David A Basketter, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Impact of environmental pollution on respiratory sensitization and asthma.

I. Kimber, 1996, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Approaches to the identification and classification of chemical allergens in mice.

I. Kimber, R. Dearman, 1993, Journal of pharmacological and toxicological methods.

T lymphocyte phenotype of contact‐allergic patients: experience with nickel and p‐phenylenediamine

J. P. Gosling, C. Stretton, I. Kimber, 2019, Contact dermatitis.

Concepts in psoriasis: psoriasis and the extracellular matrix

I. Kimber, L. Fry, J. McFadden, 2012, The British journal of dermatology.

Selective Haptenation of Cellular or Extracellular Protein by Chemical Allergens: Association with Cytokine Polarization

N. Kitteringham, B. K. Park, D. Naisbitt, 2005 .

Toxicogenetics: applications and opportunities.

G. Orphanides, I. Kimber, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

REVIEW Toxicogenetics: Applications and Opportunities

G. Orphanides, I. Kimber, 2003 .

The Aryl Hydrocarbon Receptor: Differential Contribution to T Helper 17 and T Cytotoxic 17 Cell Development

Andrew G Smith, I. Kimber, R. Dearman, 2014, PloS one.

Downregulation of Lactoferrin by PPARα Ligands: Role in Perturbation of Hepatocyte Proliferation and Apoptosis

G. Orphanides, W. Pennie, R. Roberts, 2002 .

Investigation of lymph node cell proliferation as a possible immunological correlate of contact sensitizing potential.

I Kimber, R J Dearman, I. Kimber, 1991, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Stimulation of Langerhans cell migration in mice by tumour necrosis factor alpha and interleukin 1 beta.

I. Kimber, R. Dearman, M. Cumberbatch, 1997, Advances in experimental medicine and biology.

Developing a framework for assessing chemical respiratory sensitization: A workshop report.

Janine Ezendam, Ian Kimber, Antti Karjalainen, 2016, Regulatory toxicology and pharmacology : RTP.

Respiratory Allergy: Hazard Identification and Risk Assessment

J. Pauluhn, I. Kimber, T. Hofmann, 1994 .

Workshop overview. Identification of respiratory allergens.

I. Bernstein, I. Kimber, M. Karol, 1996, Fundamental and Applied Toxicology.

Thresholds in chemical respiratory sensitisation.

A. Poole, I. Kimber, J. Arts, 2015, Toxicology.

Critical evaluation of low-molecular weight respiratory sensitizers and their protein reactivity potential towards lysine residues.

Nora L. Krutz, I. Kimber, C. Ryan, 2021, Toxicological sciences : an official journal of the Society of Toxicology.

Azodicarbonamide (ADCA): A reconsideration of classification as a respiratory sensitiser.

I. Kimber, J. Arts, 2018, Regulatory toxicology and pharmacology : RTP.

Chemical allergens--what are the issues?

D. Basketter, I. Kimber, R. Dearman, 2010, Toxicology.

Structure activity relationships in skin sensitization using the murine local lymph node assay.

I Kimber, D A Basketter, J Ashby, 1995, Toxicology.

Pathology considerations for, and subsequent risk assessment of, chemicals identified as immunosuppressive in routine toxicology.

D. Basketter, I. Kimber, D. A. Stringer, 1995, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The role of the skin in the development of chemical respiratory hypersensitivity.

I Kimber, I. Kimber, 1996, Toxicology letters.

Updating the skin sensitization in vitro data assessment paradigm in 2009

Ian Kimber, D. Basketter, I. Kimber, 2009, Journal of applied toxicology : JAT.

An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential

G Patlewicz, I Kimber, A O Aptula, 2007, SAR and QSAR in environmental research.

The Local Lymph Node Assay: Current Position in the Regulatory Classification of Skin Sensitizing Chemicals

G Frank Gerberick, Ian Kimber, David A Basketter, 2007, Cutaneous and ocular toxicology.

A future approach to measuring relative skin sensitising potency: a proposal

Carl Westmoreland, Ian Kimber, David A Basketter, 2006, Journal of applied toxicology : JAT.

The local lymph node assay and skin sensitization: a cut‐down screen to reduce animal requirements?

Petra S Kern, G Frank Gerberick, Ian Kimber, 2006, Contact dermatitis.

Chemical respiratory allergy. Toxicological and occupational health issues

I. Kimber, M.F. Wilks, 1995, Human & experimental toxicology.

Evaluation of the skin sensitizing potency of chemicals by using the existing methods and considerations of relevance for elicitation

David A. Basketter, Klaus E. Andersen, Carola Liden, 2005, Contact dermatitis.

Respiratory allergy: hazard identification and risk assessment.

J. Pauluhn, I. Kimber, T. Hofmann, 1994, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Identification of Respiratory Allergens

I. Bernstein, I. Kimber, M. Karol, 1996 .

Differential cytokine production following chronic exposure of mice to chemical respiratory and contact allergens.

D. Basketter, I. Kimber, R. Dearman, 1995, Immunology.

Inhalation Exposure to Methylene Chloride Does Not Induce Systemic Immunotoxicity in Rats

I. Kimber, P. Dugard, R. Dearman, 2003, Journal of toxicology and environmental health. Part A.

The identification of chemicals with sensitizing or immunosuppressive properties in routine toxicology.

I Kimber, D A Basketter, D. Basketter, 1994, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Rethinking agrochemical safety assessment: A perspective.

I. Kimber, C. Terry, F. Sewell, 2021, Regulatory toxicology and pharmacology : RTP.

Toll‐like receptor ligand activation of murine bone marrow‐derived dendritic cells

Gavin Maxwell, Ian Kimber, D. Basketter, 2009, Immunology.

Use of the kinetically-derived maximum tolerated dose: Opportunities for delivering 3Rs benefits.

A. Boobis, I. Kimber, F. Sewell, 2020, Regulatory toxicology and pharmacology : RTP.

Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals.

W. Casey, M. Whelan, I. Kimber, 2019, Regulatory toxicology and pharmacology : RTP.

Adverse Outcome Pathways can drive non-animal approaches for safety assessment

Melvin E Andersen, Alan Boobis, Fiona Sewell, 2015, Journal of applied toxicology : JAT.

Skin Sensitisation and Epidermal Disposition: The Relevance of Epidermal Disposition for Sensitisation Hazard Identification and Risk Assessment

Silvia Casati, Thomas Hartung, David Basketter, 2007, Alternatives to laboratory animals : ATLA.

Allergic Sensitization to Nickel and Implanted Metal Devices: A Perspective

D. Basketter, I. Kimber, 2021, Dermatitis : contact, atopic, occupational, drug.

A primer on systematic reviews in toxicology

M. Lalu, T. Hartung, M. Stephens, 2017, Archives of Toxicology.

Integrating asthma hazard characterization methods for consumer products.

P. Dalton, A. Maier, M. Vincent, 2014, Regulatory toxicology and pharmacology : RTP.

Categorisation of protein respiratory allergens: the case of Subtilisin.

D. Basketter, I. Kimber, 2014, Regulatory toxicology and pharmacology : RTP.

Inhalation exposure of mice to trimellitic anhydride induces both IgG and IgE anti-hapten antibody.

I. Kimber, R. Dearman, J. M. Hegarty, 1991, International archives of allergy and applied immunology.

Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects

A. M. Api, H. Maibach, A. Schnuch, 2011, Cellular and Molecular Life Sciences.

Identification of a truncated IL-18Rβ mRNA: a putative regulator of IL-18 expressed in rat brain

N. Rothwell, S. Pickering-Brown, I. Kimber, 2003, Journal of Neuroimmunology.

Selective impairment of T lymphocyte activation following contact sensitization with oxazolone.

I. Kimber, J. Turk, J. Foster, 1991, International archives of allergy and applied immunology.

How Reaction Severity Is Affected By Cofactors And Repeat Challenges: A Prospective Study Of Peanut Allergic Adults

J. Wason, C. Mills, S. Durham, 2020 .

The Need to Decide If All Estrogens Are Intrinsically Similar

G. Orphanides, J. Ashby, J. Moggs, 2004, Environmental health perspectives.

Skin sensitization

I Kimber, D A Basketter, D. Basketter, 2015, Human & experimental toxicology.

Nothing is perfect, not even the local lymph node assay: a commentary and the implications for REACH

Frank Gerberick, Amanda Cockshott, Ian Kimber, 2009, Contact dermatitis.

Local lymph node assay: validation assessment for regulatory purposes.

I Kimber, G F Gerberick, R J Dearman, 2000, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Allergic contact dermatitis: is the reactive chemistry of skin sensitizers the whole story?

D. Basketter, I. Kimber, 2013, Contact dermatitis.

Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation.

D. Basketter, I. Kimber, R. Dearman, 2008, Toxicology in vitro : an international journal published in association with BIBRA.

The principles and practice of toxigenomics: applications and opportunities.

W. Pennie, I. Kimber, J. Tugwood, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Human K cell-mediated haemolysis: determination of the cytotoxic capacity and antibody sensitization requirements of T lymphocyte enriched and depleted populations.

T. Bakács, I. Kimber, M. Moore, 1983, Journal of clinical & laboratory immunology.

Fragrance inhalation and adverse health effects: The question of causation

D. Basketter, I. Kimber, J. Huggard, 2019, Regulatory toxicology and pharmacology : RTP.

Contact sensitization of mice to nickel sulphate and potassium dichromate

I. Kimber, J. Hilton, A. Bentley, 1990, Contact dermatitis.

Contact hypersensitivity induces plasma interleukin 6.

S. Hopkins, I. Kimber, M. Cumberbatch, 1990, International archives of allergy and applied immunology.

Functional dichotomy of dendritic cells isolated from blood and lymph nodes.

I. Kimber, J. Coates, S. Knight, 1995, Advances in experimental medicine and biology.

Langerhans cell mobilization distinguishes between early-onset and late-onset psoriasis.

C. Griffiths, I. Kimber, C. E. Kleyn, 2010, The Journal of investigative dermatology.

Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization.

N. Kitteringham, B. K. Park, D. Naisbitt, 2005, Chemical research in toxicology.

Allergen‐induced changes in interleukin 1β (iL‐1β) mRNA expression by human blood‐derived dendritic cells: inter‐individual differences and relevance for sensitization testing

I Kimber, R J Dearman, D A Basketter, 2001, Journal of applied toxicology : JAT.

Analysis of cytokine mRNA expression following repeated exposure of mice to chemical contact and respiratory allergens

D. Basketter, I. Kimber, G. Gerberick, 1998, Journal of applied toxicology : JAT.

Influence of topical exposure to chemical allergens on murine Langerhans cells. Comparison of 2,4-dinitrochlorobenzene with trimellitic anhydride.

S. Gould, D. Basketter, I. Kimber, 1992, Journal of clinical & laboratory immunology.

Effects of exercise and sleep deprivation on reaction severity during oral peanut challenge: a randomised controlled trial.

J. Wason, C. Mills, S. Durham, 2022, The journal of allergy and clinical immunology. In practice.

Chemicals in moisturizers may promote type 2 inflammation and food allergy.

J. Thyssen, I. Kimber, J. McFadden, 2021, The Journal of allergy and clinical immunology.

Identification of dendritic cells as a major source of interleukin-6 in draining lymph nodes following skin sensitization of mice.

S. Hopkins, I. Kimber, J. Hope, 1995, Immunology.

The role of cis-urocanic acid in UVB-induced immunosuppression.

M. Norval, I. Kimber, A. El-Ghorr, 1995, Advances in experimental medicine and biology.

The T Cell Response to the Contact Sensitizer Paraphenylenediamine Is Characterized by a Polyclonal Diverse Repertoire of Antigen-Specific Receptors

K. Best, B. Chain, J. Heather, 2017, Front. Immunol..

Influence of Escherichia coli chaperone DnaK on protein immunogenicity

M. Wadhwa, R. Thorpe, J. Derrick, 2016, Immunology.

Challenges in the classification of chemical respiratory allergens based on human data: Case studies of 2-hydroxyethylmethacrylate (HEMA) and 2-hydroxypropylmethacrylate (HPMA).

M. Pemberton, I. Kimber, K. Kreuzer, 2023, Regulatory toxicology and pharmacology : RTP.

Chemical reactivity measurement and the predicitve identification of skin sensitisers. The report and recommendations of ECVAM Workshop 64.

Silvia Casati, David Basketter, Petra Kern, 2008, Alternatives to laboratory animals : ATLA.

Estimation of relative skin sensitizing potency using the local lymph node assay: a comparison of formaldehyde with glutaraldehyde.

D. Basketter, P. Evans, I. Kimber, 1998, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Toxicology of Chemical Respiratory Hypersensitivity

I. Kimber, R. Dearman, 1997 .

The Mouse IgE Test for the Identification of Potential Chemical Respiratory Allergens: Considerations of Stability and Controls

D. Basketter, I. Kimber, R. Dearman, 1996, Journal of applied toxicology : JAT.

Inducible interleukin-4-secreting cells provoked in mice during chemical sensitization.

D. Basketter, I. Kimber, R. Dearman, 1994, Immunology.

Prediction of rodent nongenotoxic carcinogenesis: evaluation of biochemical and tissue changes in rodents following exposure to nine nongenotoxic NTP carcinogens.

J. Ashby, C. Elcombe, J. Odum, 2002, Environmental health perspectives.

Downregulation of lactoferrin by PPARalpha ligands: role in perturbation of hepatocyte proliferation and apoptosis.

G. Orphanides, W. Pennie, R. Roberts, 2002, Toxicological Sciences.

Specificity of the local lymph node assay (LLNA) for skin sensitisation.

D. Basketter, I. Kimber, D. Roberts, 2023, Regulatory toxicology and pharmacology : RTP.

Interleukin 1 beta and the stimulation of Langerhans cell migration: comparisons with tumour necrosis factor alpha.

I. Kimber, R. Dearman, M. Cumberbatch, 1997, Archives of dermatological research.

Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies

S. Uddin, J. Derrick, A. Pluen, 2019, Pharmaceutical Research.

Local lymph node assay - validation, conduct and use in practice.

R J Fielder, I Kimber, G F Gerberick, 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The kinetics of cytokine production by draining lymph node cells following primary exposure of mice to chemical allergens.

S. Hopkins, I. Kimber, J. Hope, 1994, Immunology.

Blocking Antibodies: Relationship between IgG4-associated Inhibitory Activity and Clinical Response to Grass-Pollen Immunotherapy

S. Durham, M. Shamji, I. Kimber, 2010 .

Information derived from sensitization test methods: test sensitivity, false positives and false negatives

Ian Kimber, David A Basketter, D. Basketter, 2007, Contact dermatitis.

Olive oil: suitability for use as a vehicle in the local lymph node assay

D. Basketter, I. Kimber, 1996, Contact dermatitis.

Sulphanilic acid: divergent results in the guinea pig maximization test and the local lymph node assay

I. Kimber, D. Basketter, I. Kimber, 1992, Contact dermatitis.

Draining lymph node cell activation in guinea pigs: comparisons with the murine local lymph node assay.

I. Kimber, T. Maurer, 1991, Toxicology.

Quantitative risk assessment for skin sensitisation: consideration of a simplified approach for hair dye ingredients.

A. Schnuch, C. Goebel, James S. Taylor, 2012, Regulatory toxicology and pharmacology : RTP.

Immunoglobulin G1 and immunoglobulin G4 antibodies in multiple sclerosis patients treated with IFNβ interact with the endogenous cytokine and activate complement☆

M. Pirmohamed, M. Wadhwa, S. Sethu, 2013, Clinical immunology.

Characterization of skin sensitizing chemicals: A lesson learnt from nickel allergy

Ian Kimber, David A Basketter, D. Basketter, 2011, Journal of immunotoxicology.

Aligning the 3Rs with new paradigms in the safety assessment of chemicals.

Catherine Mahony, Natalie Burden, Ian Kimber, 2015, Toxicology.

Epidermal Langerhans cell migration: signals and mechanisms.

I. Kimber, M. Cumberbatch, I. Fielding, 1995, Advances in Experimental Medicine and Biology.

In vivo assays of langerhans cell migration.

I. Kimber, R. Dearman, M. Cumberbatch, 2001, Methods in molecular medicine.

Interleukin 6 (IL-6) Production by Lymph Node Cells: An Alternative Endpoint for the Murine Local Lymph Node Assay

Ian Kimber, S. Hopkins, I. Kimber, 1993 .

The Application of Genomics and Proteomics to Toxicological Sciences

W. Pennie, I. Kimber, S. Chevalier, 2003 .

Skin sensitization, false positives and false negatives: experience with guinea pig assays

Ian Kimber, David A Basketter, D. Basketter, 2010, Journal of applied toxicology : JAT.

The local lymph node assay in practice: a current regulatory perspective

I Kimber, G F Gerberick, R J Dearman, 2006, Human & experimental toxicology.

Measurement of allergenic potency using the local lymph node assay.

I Kimber, G F Gerberick, D A Basketter, 2001, Trends in pharmacological sciences.

Failure of vehicle to influence local lymph node assay response to benzocaine.

I Kimber, R J Dearman, D A Basketter, 2000, Contact dermatitis.

Influence of 12‐o‐tetradecanoylphorbol‐13‐acetate (TPA) on the susceptibility of K562 to natural cytotoxicity: Evidence for clonal variation in differentiation‐induced changes of lytic sensitivity

C. Harrison, I. Kimber, M. Moore, 1984, International journal of cancer.

Regulation of lymphocyte proliferation in contact sensitivity: homeostatic mechanisms and a possible explanation of antigenic competition.

I. Kimber, J. Turk, J. Mitchell, 1989, Immunology.

The local lymph node assay: Results of a final inter‐laboratory validation under field conditions

I. Kimber, D. Basketter, I. Kimber, 1992, Journal of applied toxicology : JAT.

Serum histamine and the elicitation of murine contact sensitivity

I. Kimber, M. Cumberbatch, J. Coleman, 1991, Journal of applied toxicology : JAT.

Interlaboratory Evaluation of the Local Lymph Node Assay with 25 Chemicals and Comparison with Guinea Pig Test Data

D. Basketter, P. Botham, I. Kimber, 1991 .

Immunotoxicology and Allergy: Options for Ex Vivo and In Vitro Experimentation

P. Botham, I. Kimber, 1991 .

Variance in resistance to natural and antibody‐dependent cellular cytotoxicity and to complement‐mediated lysis among K562 lines

I. Kimber, M. Moore, K. Roberts, 1983, International journal of cancer.

Depression of lymph node cell proliferation induced by oxazolone.

I. Kimber, J. Mitchell, A. Kinnaird, 1987, International archives of allergy and applied immunology.

Response

G. Ladics, C. Burns, I. Kimber, 1998, Environmental Health Perspectives.

IL-1beta-induced Langerhans' cell migration and TNF-alpha production in human skin: regulation by lactoferrin.

C. Griffiths, I. Kimber, R. Dearman, 2003, Clinical and experimental immunology.

Local Lymph Node Data for the Evaluation of Skin Sensitization Alternatives: A Second Compilation

Aynur Aptula, Ian Kimber, David A. Basketter, 2010, Dermatitis : contact, atopic, occupational, drug.

Workshop overview: approaches to the assessment of the allergenic potential of food from genetically modified crops.

R. Helm, G. Ladics, I. Kimber, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Stimulation of Langerhans cell migration by tumor necrosis factor alpha (TNF-alpha).

I. Kimber, M. Cumberbatch, 1992, The Journal of investigative dermatology.

Transcript Profiling of T Lymphocytes and Dendritic Cells in a Co–culture System Using Anti‐CD3 and Allergen Activation

I. Kimber, C. Ryan, R. Dearman, 2004 .

A chemical dataset for evaluation of alternative approaches to skin‐sensitization testing

Ian Kimber, G. Patlewicz, D. Basketter, 2004, Contact dermatitis.

The use of T cells in hazard characterization of chemical and drug allergens and integration in testing strategies. Foreword.

M. Pallardy, I. Kimber, 2014, Experientia supplementum.

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages

D. Brough, A. Verkhratsky, Pavlos C. Englezou, 2015, Cytokine.

Extrapolating Local Lymph Node Assay EC3 Values To Estimate Relative Sensitizing Potency

Ian Kimber, David A. Basketter, Petra S. Kern, 2007, Cutaneous and ocular toxicology.

Langerhans cells express human β‐defensin 3: relevance for immunity during skin ageing

C. Griffiths, I. Kimber, R. Dearman, 2018, The British journal of dermatology.

Mechanism and regulation of natural cytotoxicity. Minireview on cancer research.

I. Kimber, M. Moore, 1985, Experimental cell biology.

Characterization in mice of the immunological properties of five allergenic acid anhydrides

I. Humphreys, I. Kimber, R. Dearman, 2000, Journal of applied toxicology : JAT.

IDENTIFICATION OF CHEMICAL RESPIRATORY ALLERGENS

Ige, N. Humphreys, I. Kimber, 2003 .

A comparison of statistical approaches to the derivation of EC3 values from local lymph node assay dose responses

D. Basketter, I. Kimber, R. Dearman, 1999, Journal of applied toxicology : JAT.

Cytokine endpoints for the local lymph node assay: consideration of interferon‐γ and interleukin 12

D. Basketter, I. Kimber, R. Dearman, 1999, Journal of applied toxicology : JAT.

Differential susceptibility of haemolysin-sensitized erythrocytes to complement-mediated cytotoxicity: a biological manifestation of the relationship between antibody availability and complement fixation.

T. Bakács, I. Kimber, G. Ringwald, 1989, Journal of clinical & laboratory immunology.

International Collaborative Studies on the Detection of Immunotoxicity

R. Smialowicz, H. Loveren, I. Kimber, 2013 .

The effects of ultraviolet radiation on the human immune system

Kimber, M. Norval, Norval, 1999, The British journal of dermatology.

The future trajectory of adverse outcome pathways: a commentary

G. Whale, M. Jacobs, I. Kimber, 2018, Archives of Toxicology.

TITLE : Developing a Framework for Assessing Respiratory Sensitization : A Workshop Report

S. Tarlo, S. Enoch, C. North, 2018 .

Developing a framework for assessing respiratory sensitization: A workshop report

S. Tarlo, S. Enoch, C. North, 2016 .

Selectivity of IgE responses, mast cell sensitization, and cytokine expression in the immune response of Brown Norway rats to chemical allergens.

D. Basketter, I. Kimber, R. Dearman, 1996, Cellular immunology.

Key issues for the assessment of the allergenic potential of genetically modified foods: breakout group reports.

L. Goldman, D. Germolec, I. Kimber, 2002, Environmental health perspectives.

The Local Lymph Node Assay

G. Frank Gerberick, Ian Kimber, David A. Basketter, 2017 .

Preliminary assessment of the skin sensitizing activity of selected rodent carcinogens using the local lymph node assay.

I Kimber, R J Dearman, J Ashby, 2001, Toxicology.

Streptozotocin: inherent but not expressed skin sensitizing activity

J. Ashby, I. Kimber, R. Dearman, 1995, Contact dermatitis.

Management of an Integrated Project (Sens-it-iv) to Develop In Vitro Tests to Assess Sensitisation

Silvia Casati, David Basketter, Irene Manou, 2007, Alternatives to laboratory animals : ATLA.

Reprint of: Characterising hepatic mitochondrial function as a model for systemic toxicity: a commentary.

A. Leach, G. Daston, M. Whelan, 2012, Toxicology.

Computational chemistry, systems biology and toxicology. Harnessing the chemistry of life: revolutionizing toxicology. A commentary

Irene Manou, Ian Kimber, Nathalie Alepee, 2011, Journal of applied toxicology : JAT.

Toxic shock syndrome: characterization of human immune responses to TSST-1 and evidence for sensitivity thresholds.

R. Goering, M. Kotb, J. Parsonnet, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

The suitability of hexyl cinnamic aldehyde as a calibrant for the murine local lymph node assay

Ian Kimber, D. Basketter, I. Kimber, 2001, Contact dermatitis.

Keratinocytes derived from late‐onset‐psoriasis skin do not impair Langerhans cell migration

C. Griffiths, I. Kimber, R. Dearman, 2018, The British journal of dermatology.

Butyl benzyl phthalate: effects on immune responses to ovalbumin in mice

I. Kimber, R. Dearman, C. Betts, 2009, Journal of applied toxicology : JAT.

Reciprocal effects of interleukin‐4 and interferon‐γ on immunoglobulin E‐mediated mast cell degranulation: a role for nitric oxide but not peroxynitrite or cyclic guanosine monophosphate

Kimber, Dearman, D. Basketter, 1999, Immunology.

The lymphocyte transformation test in allergic contact dermatitis: New opportunities

I. Kimber, R. Dearman, N. Gellatly, 2016, Journal of immunotoxicology.

α6 Integrins Are Required for Langerhans Cell Migration from the Epidermis

I. Kimber, M. Cumberbatch, A. Ager, 1997, The Journal of experimental medicine.

Danger, intracellular signaling, and the orchestration of dendritic cell function in skin sensitization

I. Kimber, R. Dearman, Joseph S. Ainscough, 2013, Journal of immunotoxicology.

The effects of acute social stress on epidermal Langerhans' cell frequency and expression of cutaneous neuropeptides.

H. Richards, C. Griffiths, I. Kimber, 2008, The Journal of investigative dermatology.

Lack of association between interleukin-6 production by contact allergen-activated draining lymph node cells and lymphoproliferative activity.

M. Norval, I. Kimber, R. Dearman, 1998, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

Antigen-induced unresponsiveness in contact sensitivity: association of depressed T lymphocyte proliferative responses with decreased interleukin 6 secretion.

S. Hopkins, I. Kimber, J. Hope, 1996, Immunology letters.

Chemical allergen induced perturbations of the mouse lymph node DNA methylome.

J. Moggs, I. Kimber, R. Terranova, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Tumour necrosis factor‐α induces Langerhans cell migration in humans

Griffiths, Kimber, Dearman, 1999, The British journal of dermatology.

Dose metrics in the acquisition of skin sensitization: thresholds and importance of dose per unit area.

A. M. Api, D. Basketter, I. Kimber, 2008, Regulatory toxicology and pharmacology : RTP.

Differential effect of thalidomide and dexamethasone on the transcription factor NF-kappa B.

J. Deighton, I. Kimber, P. Ewan, 2001, International immunopharmacology.

11.26 – Contact Hypersensitivity☆

D. Basketter, I. Kimber, S. Kolle, 2018 .

Integration of Consortia Recommendations for Justification of Animal Use Within Current and Future Drug Development Paradigms

T. Monticello, I. Kimber, F. Brennan, 2019, International journal of toxicology.

Allergic contact dermatitis: a commentary on the relationship between T lymphocytes and skin sensitising potency.

I. Kimber, R. Dearman, Stefan F. Martin, 2012, Toxicology.

INFLUENCE OF 12-0-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON THE SUSCEPTIBILITY OF K562 TO NATURAL CYTOTOXICITY: CHANGES OF LYTIC SENSITIVITY EVIDENCE FOR CLONAL VARIATION IN DIFFERENTIATION-INDUCED

I. Kimber, M. Moore, ON ChristineJ.HARRIS, 2006 .

Selection of Chemicals for the Development and Evaluation of In Vitro Methods for Skin Sensitisation Testing

Silvia Casati, Gavin Maxwell, Costanza Rovida, 2009 .

Dendritic cell research projects.

D. Basketter, I. Kimber, F. Gerberick, 2006 .

Immunologic basis for autoimmunity and the potential influences of xenobiotics.

I. Kimber, R. Dearman, 2002, Toxicology letters.

Oxidised adenosine 5′-triphosphate, a P2X7 antagonist, is toxic to rat cerebellar granule neurones in vitro

N. Rothwell, M. Craighead, I. Kimber, 2001, Neuroscience Letters.

Food allergy--science and policy needs--The UK Food Standards Agency Research Programme.

I. Kimber, S. Hattersley, J. Buck, 2010, Toxicology.