Zhen Wang

发表

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning.

Hualiang Jiang, M. Zheng, Xutong Li, 2020, European journal of medicinal chemistry.

Utilization of halogen bond in lead optimization: a case study of rational design of potent phosphodiesterase type 5 (PDE5) inhibitors.

Weiliang Zhu, Kaixian Chen, Hualiang Jiang, 2011, Journal of medicinal chemistry.

Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.

Hualiang Jiang, Yechun Xu, M. Zheng, 2012, Journal of medicinal chemistry.

Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics.

Xiangrui Jiang, Yang He, Qingjie Zhao, 2017, Bioorganic & medicinal chemistry.

TPN672: A Novel Serotonin-Dopamine Activity Modulator for the Treatment of Schizophrenia

Linyin Feng, Yang He, Feipu Yang, 2021 .

Optimization of permethyl ningalin B analogs as P-glycoprotein inhibitors.

Chao Yang, L. Chow, Zhen Wang, 2015, Bioorganic & medicinal chemistry.

2-Phenylquinazolin-4(3H)-one, a class of potent PDE5 inhibitors with high selectivity versus PDE6.

Zhen Wang, Zheng Liu, Guanghui Tian, 2009, Bioorganic & medicinal chemistry letters.

A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects

Jingshan Shen, Zhen Wang, Guanghui Tian, 2021, Drug design, development and therapy.

TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats.

Qianbin Li, Chunhui Wu, Jingshan Shen, 2022, Vascular pharmacology.

The selectivity and potency of the new PDE5 inhibitor TPN729MA.

Qiaojun He, Bo Yang, Xiangrui Jiang, 2013, The journal of sexual medicine.

Liquid chromatography-tandem mass spectrometric assay for TPN171 in human plasma.

Jingshan Shen, Zhen Wang, Gang-yi Liu, 2020, Journal of pharmaceutical and biomedical analysis.

Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics.

Yang He, Feipu Yang, Chunhui Wu, 2020, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Pharmacological Evaluation of Highly Potent and Selective Dipeptidyl Peptidase‐4 Inhibitors

Weiliang Zhu, Qiang Shao, Xiangrui Jiang, 2015, Archiv der Pharmazie.

Design, Synthesis, and Pharmacological Evaluation of Fused β-Homophenylalanine Derivatives as Potent DPP-4 Inhibitors.

Weiliang Zhu, Kaixian Chen, Hualiang Jiang, 2015, ACS medicinal chemistry letters.

Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives.

Xiangrui Jiang, Qingjie Zhao, Jingshan Shen, 2020, Journal of medicinal chemistry.

Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs.

Hualiang Jiang, Xiangrui Jiang, Yang He, 2018, Bioorganic & medicinal chemistry letters.

Synthesis, structure-activity relationships, and biological evaluation of a series of benzamides as potential multireceptor antipsychotics.

Xiangrui Jiang, Yang He, Qingjie Zhao, 2016, Bioorganic & medicinal chemistry letters.

[Research progress of antipsychotics].

Yang He, Jingshan Shen, Zhen Wang, 2016, Yao xue xue bao = Acta pharmaceutica Sinica.

Pharmacokinetics-Driven Optimization of 4(3 H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension.

Weiliang Zhu, Hualiang Jiang, Yechun Xu, 2019, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of Five‐Atom‐Linker‐Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile

Yang He, Feipu Yang, Chunhui Wu, 2019, ChemMedChem.

Continuation of structure–activity relationship study of novel benzamide derivatives as potential antipsychotics

Xiangrui Jiang, Yang He, Qingjie Zhao, 2019, Archiv der Pharmazie.

Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect.

Hualiang Jiang, Xiangrui Jiang, Yang He, 2018, European journal of medicinal chemistry.

Automated design and optimization of multitarget schizophrenia drug candidates by deep learning

Chen Cui, Zhaojun Li, Yang He, 2020, bioRxiv.

Thermodynamic and structural characterization of halogen bonding in protein-ligand interactions: a case study of PDE5 and its inhibitors.

Guan Wang, Weiliang Zhu, Zhijian Xu, 2014, Journal of medicinal chemistry.

Preventive and therapeutic benefits of nelfinavir in rhesus macaques and human beings infected with SARS-CoV-2

Weiliang Zhu, H. Yao, N. Wu, 2023, Signal transduction and targeted therapy.

Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

Xiaoyan Chen, D. Zhong, Xiangrui Jiang, 2019, Journal of pharmaceutical and biomedical analysis.

Sub-anesthetic and anesthetic ketamine produce different long-lasting behavioral phenotypes (24 h post-treatment) via inducing different brain-derived neurotrophic factor (BDNF) expression level in the hippocampus

Song Wu, Yang He, Chunhui Wu, 2019, Neurobiology of Learning and Memory.

Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.

Hualiang Jiang, Yechun Xu, Jingge Ren, 2013, Bioorganic & medicinal chemistry letters.

Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity

Zhi Chen, Zhen Wang, Weiliang Zhu, 2010, J. Chem. Inf. Model..