David A. Close

发表

Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation.

S. Sant, P. Johnston, Manjulata Singh, 2015, Assay and drug development technologies.

The Generation of Three-Dimensional Head and Neck Cancer Models for Drug Discovery in 384-Well Ultra-Low Attachment Microplates.

P. Johnston, David A. Close, D. Camarco, 2018, Methods in molecular biology.

A Target-Based High Throughput Screen Yields Trypanosoma brucei Hexokinase Small Molecule Inhibitors with Antiparasitic Activity

G. Mustata, J. Lazo, K. Lee, 2010, PLoS neglected tropical diseases.

Implementation of the NCI-60 Human Tumor Cell Line Panel to Screen 2260 Cancer Drug Combinations to Generate >3 Million Data Points Used to Populate a Large Matrix of Anti-Neoplastic Agent Combinations (ALMANAC) Database

P. Johnston, T. Shun, David A. Close, 2018, SLAS discovery : advancing life sciences R & D.

Discovery of Non-peptide Small Molecule Allosteric Modulators of the Src-family Kinase, Hck

C. Camacho, T. Smithgall, P. Johnston, 2019, Front. Chem..

Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen

John S. Lazo, Peter Wipf, Elizabeth R. Sharlow, 2009, PLoS neglected tropical diseases.

Detection and impact of hypoxic regions in multicellular tumor spheroid cultures formed by head and neck squamous cell carcinoma cells lines.

P. Johnston, David A. Close, 2021, SLAS discovery : advancing life sciences R & D.

High Content Screening Characterization of Head and Neck Squamous Cell Carcinoma Multicellular Tumor Spheroid Cultures Generated in 384-Well Ultra-Low Attachment Plates to Screen for Better Cancer Drug Leads.

P. Johnston, David A. Close, Stanton J Kochanek, 2019, Assay and drug development technologies.

Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines

P. Wipf, J. Grandis, D. Huryn, 2017, Journal of chemical biology.

Genomic Correlate of Exceptional Erlotinib Response in Head and Neck Squamous Cell Carcinoma.

Simion I. Chiosea, Kelsey P. Pendleton, A. McKenna, 2015, JAMA oncology.

Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury.

D. Huryn, N. Hukriede, M. D. de Caestecker, 2022, ACS pharmacology & translational science.

High-Content Screening Campaign to Identify Compounds That Inhibit or Disrupt Androgen Receptor-Transcriptional Intermediary Factor 2 Protein-Protein Interactions for the Treatment of Prostate Cancer.

C. Strock, P. Johnston, Yun Hua, 2018, Assay and drug development technologies.

Reconfiguring the AR-TIF2 Protein-Protein Interaction HCS Assay in Prostate Cancer Cells and Characterizing the Hits from a LOPAC Screen.

C. Strock, P. Johnston, Yun Hua, 2016, Assay and drug development technologies.

Unbiased High-Throughput Drug Combination Pilot Screening Identifies Synergistic Drug Combinations Effective against Patient-Derived and Drug-Resistant Melanoma Cell Lines

J. Kirkwood, P. Johnston, David A. Close, 2020, SLAS discovery : advancing life sciences R & D.

Maximizing the Value of Cancer Drug Screening in Multicellular Tumor Spheroid Cultures: A Case Study in Five Head and Neck Squamous Cell Carcinoma Cell Lines

P. Johnston, David A. Close, Stanton J Kochanek, 2020, SLAS discovery : advancing life sciences R & D.

Confirmation of Selected Synergistic Cancer Drug Combinations Identified in an HTS Campaign and Exploration of Drug Efflux Transporter Contributions to the Mode of Synergy

P. Empey, P. Johnston, T. Shun, 2019, SLAS discovery : advancing life sciences R & D.

High-Content Screening Comparison of Cancer Drug Accumulation and Distribution in Two-Dimensional and Three-Dimensional Culture Models of Head and Neck Cancer.

P. Johnston, David A. Close, Feng Shan, 2017, Assay and drug development technologies.

Selecting a minimal set of androgen receptor assays for screening chemicals

R. Judson, K. Houck, K. Mansouri, 2020, Regulatory toxicology and pharmacology : RTP.

Discovery of Diverse Small Molecule Chemotypes with Cell-Based PKD1 Inhibitory Activity

P. Wipf, J. Lazo, T. Shun, 2011, PloS one.

Design and activity of AP endonuclease-1 inhibitors

Zhiwei Feng, Xiang-Qun Xie, Paul A Johnston, 2015, Journal of chemical biology.

Auranofin is an apoptosis-simulating agent with in vitro and in vivo anti-leishmanial activity.

J. Lazo, M. Hickman, David A. Close, 2014, ACS chemical biology.

Characterization of Allosteric Modulators that Disrupt Androgen Receptor Co-activator Protein-Protein Interactions to Alter Transactivation - Drug Leads for Metastatic Castration Resistant Prostate Cancer.

C. Camacho, C. Strock, Wei Xu, 2023, SLAS discovery : advancing life sciences R & D.

Replacement of the hydroxamic acid group in the selective HDAC8 inhibitor PCI-34051.

D. Huryn, David A. Close, Keith Long, 2024, Bioorganic & medicinal chemistry letters.