D. Dambach

发表

New Technologies and Screening Strategies for Hepatotoxicity: Use of In Vitro Models

B. Andrews, D. Dambach, F. Moulin, 2005, Toxicologic pathology.

Dilated Cardiomyopathy in Juvenile Portuguese Water Dogs

P. Henthorn, D. Dambach, M. Sleeper, 2002, Journal of veterinary internal medicine.

D. Dambach, H. Uppal, 2012, Science Translational Medicine.

Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.

Kevin A Ford, D. Sutherlin, M. Merchant, 2013, Toxicology and applied pharmacology.

Role of p55 tumor necrosis factor receptor 1 in acetaminophen-induced antioxidant defense.

D. Laskin, J. Laskin, D. Dambach, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor receptor-1. Potential role of inflammatory mediators.

D. Laskin, J. Laskin, D. Dambach, 2003, Toxicology and applied pharmacology.

Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications

Gregory A. Ryslik, Kevin A Ford, D. Dambach, 2015, Drug metabolism reviews.

Role of CCR2 in macrophage migration into the liver during acetaminophen‐induced hepatotoxicity in the mouse

D. Laskin, D. Dambach, S. Durham, 2002, Hepatology.

Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.

Adam R. Johnson, C. Eigenbrot, J. Lubach, 2016, Bioorganic & medicinal chemistry letters.

Therapeutic Antibody-Induced Vascular Toxicity Due to Off-Target Activation of Nitric Oxide in Cynomolgus Monkeys.

Anu V. Connor, Hong Wang, D. Danilenko, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Antibody-mediated inhibition of fibroblast growth factor 19 results in increased bile acids synthesis and ileal malabsorption of bile acids in cynomolgus monkeys.

J. Ware, K. Hotzel, K. Setchell, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Drug‐Induced Hepatotoxicity: Advances in Preclinical Predictive Strategies and Tools

D. Dambach, 2014 .

Functional Redundancy of the Nuclear Factor k B Inhibitors I k B a and I k B b

R. Bravo, R. Attar, D. Dambach, 1998 .

Captopril prevents nephropathy in HIV-transgenic mice.

J. Kopp, D. Dambach, M. Mózes, 1998, Journal of the American Society of Nephrology : JASN.

BTK small molecule inhibitors induce a distinct pancreatic toxicity in rats

Adam R. Johnson, Li-chuan, M. Hedehus, 2016 .

Chronic Inﬂammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF- (cid:107) B1) but Expressing p50

R. Bravo, H. Ishikawa, D. Dambach, 1998 .

A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice.

K. McIntyre, D. Shuster, D. Dambach, 2003, Arthritis and rheumatism.

Distinct roles of NF-kappaB p50 in the regulation of acetaminophen-induced inflammatory mediator production and hepatotoxicity.

D. Laskin, J. Laskin, D. Dambach, 2006, Toxicology and applied pharmacology.

Morphologic, Immunohistochemical, and Ultrastructural Characterization of a Distinctive Renal Lesion in Dogs Putatively Associated with Borrelia burgdorferi Infection: 49 Cases (1987-1992)

D. Dambach, T. V. Van Winkle, R. Lewis, 1997, Veterinary pathology.

Cloning, expression and characterization of monkey (Macaca fascicularis) CD137.

L. Hefta, W. Foster, Shenjue Chen, 2008, Veterinary immunology and immunopathology.

Identification and Use of Biomarkers in Preclinical Toxicologic Safety Assessment

D. Dambach, J. Gautier, 2006 .

Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures☆

D. Silberberg, S. Weiss, E. Lavi, 1987, Microbial Pathogenesis.

Familial dilated cardiomyopathy of young Portuguese water dogs.

D. Dambach, M. Sleeper, A. Lannon, 1999, Journal of veterinary internal medicine.

Bruton’s Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats

Adam R. Johnson, M. Hedehus, R. Carano, 2017, The Journal of Pharmacology and Experimental Therapeutics.

An inhibitor of IκB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice

D. Dambach, Y. Qiu, D. Lee, 2003, Inflammation Research.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Ping Chen, Henry H. Gu, E. Iwanowicz, 2007, Journal of medicinal chemistry.

An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice.

D. Dambach, D. Lee, J. Burke, 2003, Inflammation research : official journal of the European Histamine Research Society ... [et al.].

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats

G. Cain, D. Dambach, N. La, 2017, Toxicologic pathology.

Current nonclinical testing paradigm enables safe entry to First‐In‐Human clinical trials: The IQ consortium nonclinical to clinical translational database

T. Monticello, D. Dambach, D. Keller, 2017, Toxicology and applied pharmacology.

Familial Glomerulonephropathy in the Bullmastiff

P. Henthorn, D. Dambach, M. Casal, 2004, Veterinary pathology.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

Philip Hewitt, Richard J Weaver, Yvonne Will, 2016, BioMed research international.

Carcinogenicity assessment of the Hedgehog pathway inhibitor, vismodegib in Tg.rasH2 mice and Sprague‐Dawley rats

S. Gould, D. Dambach, N. Dybdal, 2018, Regulatory toxicology and pharmacology : RTP.

Potential Mechanisms for Thrombocytopenia Development with Trastuzumab Emtansine (T-DM1)

M. Sliwkowski, S. Girish, V. Ramakrishnan, 2014, Clinical Cancer Research.

9. Utilization of In Vitro Neurotoxicity Models in Pre-Clinical Toxicity Assessment

D. Dambach, D. Misner, K. Staflin, 2016 .

Extraskeletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996).

D. Dambach, M. Anderson, K. Sorenmo, 1998, Journal of the American Animal Hospital Association.

Sry-negative XX sex reversal in a family of Norwegian Elkhounds.

U. Giger, P. Henthorn, D. Dambach, 1999, Journal of veterinary internal medicine.

Functional Redundancy of the Nuclear Factor κB Inhibitors IκBα and IκBβ

R. Bravo, R. Attar, D. Dambach, 1998, The Journal of experimental medicine.

Mitigation of opioid off-target effects and identification of structural drivers of opioid receptor engagement for BACE-1 small molecule inhibitors

Xingrong Liu, J. Lyssikatos, D. Dambach, 2015, Toxicology mechanisms and methods.

Familial protein-losing enteropathy and protein-losing nephropathy in Soft Coated Wheaten Terriers: 222 cases (1983-1997).

U. Giger, D. Dambach, Shelly L Vaden, 2000, Journal of veterinary internal medicine.

Ascites, premature emergence, increased gonadal cell apoptosis, and cytochrome P4501A induction in pink salmon larvae continuously exposed to oil-contaminated gravel during development

R. Heintz, J. Stegeman, S. Rice, 1997 .

Chronic Inflammation and Susceptibility to Bacterial Infections in Mice Lacking the Polypeptide (p)105 Precursor (NF-κB1) but Expressing p50

Hideaki Ishikawa, R. Bravo, H. Ishikawa, 1998, The Journal of experimental medicine.

Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases.

D. Dambach, 2005, Current topics in medicinal chemistry.

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.

W. Fairbrother, K. Amemiya, H. Wong, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Role of tumor necrosis factor receptor 1 (p55) in hepatocyte proliferation during acetaminophen-induced toxicity in mice.

D. Laskin, J. Laskin, D. Dambach, 2003, Toxicology and applied pharmacology.

Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.

S. Hymowitz, J. Lubach, K. Reif, 2015, Bioorganic & medicinal chemistry letters.

Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: potential role of tumor necrosis factor-alpha and interleukin-10.

Steven D. Cohen, D. Laskin, J. Laskin, 2002, Toxicology and Applied Pharmacology.

Identification of in vitro protein biomarkers of idiosyncratic liver toxicity.

G. Opiteck, D. Dambach, F. Moulin, 2004, Toxicology in vitro : an international journal published in association with BIBRA.

A Retrospective Analysis of Toxicogenomics in the Safety Assessment of Drug Candidates

Aiqing He, Lois D Lehman-McKeeman, Amy Truong, 2007, Toxicologic pathology.

Integrated risk assessment of suicidal ideation and behavior in drug development.

L. Urban, D. Dambach, B. Gemzik, 2015, Drug discovery today.

Preclinical models of nicotinamide phosphoribosyltransferase inhibitor-mediated hematotoxicity and mitigation by co-treatment with nicotinic acid

Dolores Diaz, Deepak Sampath, Hirdesh Uppal, 2015, Toxicology mechanisms and methods.

Biomarker discovery in biological fluids.

G. Opiteck, D. Dambach, A. Dongre, 2005, Methods.

Abstract A135: T-DM1-induced thrombocytopenia results from impaired platelet production in a HER2-independent manner.

M. Sliwkowski, S. Girish, V. Ramakrishnan, 2011 .

A MURINE MODEL OF CIGARETTE SMOKE-INDUCED PULMONARY INFLAMMATION USING INTRANASALLY ADMINISTERED SMOKE-CONDITIONED MEDIUM

D. Dambach, L. Killar, M. Mckinnon, 2002, Experimental lung research.

Aggressive, undifferentiated sarcoma with widespread metastasis in a six-month-old Neopolitan mastiff.

D. Dambach, R. Kerlin, N. Sanders, 1996, Journal of the American Animal Hospital Association.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

Dolores Diaz, Cleopatra Kozlowski, Donna M Dambach, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Using Genetically Modified Rodent Models in Drug Development to Explore Target Physiology and Potential Drug Effects

D. Dambach, Yu Zhong, J. Maher, 2018, Veterinary pathology.

Small‐Molecule Safety Lead Optimization

D. Dambach, 2016 .

An algorithm for evaluating potential tissue drug distribution in toxicology studies from readily available pharmacokinetic parameters.

Dolores Diaz, Brian Dean, Donna M Dambach, 2013, Journal of pharmaceutical sciences.

Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney.

G. Cain, Cleopatra Kozlowski, D. Dambach, 2012, Toxicological Sciences.

MEK and ERK Kinase Inhibitors Increase Circulating Ceruloplasmin and Cause Green Serum in Rats

G. Cain, D. Dambach, N. La, 2017, Toxicologic pathology.