A. Firulli

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Twist1 Regulates Ifng Expression in Th1 Cells by Interfering with Runx3 Function

Joshua W. Vincentz, M. Kaplan, Duy Pham, 2012, The Journal of Immunology.

D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis.

R. Schulz, E. Olson, B. Lilly, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma

Helena L. Crowell, M. Robinson, J. Huisken, 2020, Nature Communications.

SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects.

S. Ware, A. Firulli, M. Durbin, 2020, Developmental biology.

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability

Joshua W. Vincentz, A. Firulli, B. Firulli, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

Cardiovascular Development and the Colonizing Cardiac Neural Crest Lineage

S. Conway, A. Firulli, Paige L Snider, 2007, TheScientificWorldJournal.

Functional Screening of Intracardiac Cell Transplants Using Two-Photon Fluorescence Microscopy

M. Rubart, Peng-Sheng Chen, W. Shou, 2012, Pediatric Cardiology.

Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development.

Joshua W. Vincentz, A. Firulli, M. Howard, 2010, Developmental biology.

Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification

Jun Yu Li, Bin Zhou, Bin Zhou, 2018, Scientific Reports.

Fkbp 1 a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch 1 activity

R. Schwartz, J. Towbin, Weidong Yong, 2013 .

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity

R. Schwartz, J. Towbin, Weidong Yong, 2013, Development.

The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice

A. Firulli, B. Firulli, Kevin P. Toolan, 2017, Cardiovascular research.

The heart of the neural crest: cardiac neural crest cells in development and regeneration

A. Firulli, Rajani M. George, Gabriel Maldonado-Velez, 2020, Development.

, N early myogenic lineages . MEF 2 B is a potent transactivator expressed in

G. Lyons, N. Jenkins, B. Black, 1996 .

Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart

R. Markwald, R. Hinton, J. Molkentin, 2008, Circulation research.

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra‐embryonic, and lateral mesoderm derivatives

Joshua W. Vincentz, S. Conway, A. Firulli, 2010, Developmental dynamics : an official publication of the American Association of Anatomists.

A comparative molecular analysis of four rat smooth muscle cell lines

E. Olson, S. Schwartz, V. Koteliansky, 1998, In Vitro Cellular & Developmental Biology - Animal.

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function

Joshua W. Vincentz, A. Firulli, Wenjun Zhang, 2017, PLoS genetics.

Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells.

E. Olson, S. Schwartz, J. Miano, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer.

Hongming Zhou, Jian Wang, Rhonda Rogers, 2007, Developmental biology.

Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death.

Joshua W. Vincentz, M. Rubart, A. Firulli, 2014, Developmental biology.

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development

Joshua W. Vincentz, S. Conway, A. Firulli, 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

Evolution of muscle cell diversity through modular enhancers

E. Olson, A. Firulli, 1997 .

The identification of a tandem H-DNA structure in the c-myc nuclease sensitive promoter element.

A. Firulli, A. Kinniburgh, D. Maibenco, 1992, Biochemical and biophysical research communications.

Twist1 Controls a Cell-Specification Switch Governing Cell Fate Decisions within the Cardiac Neural Crest

Joshua W. Vincentz, A. Firulli, B. Firulli, 2013, PLoS genetics.

Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons.

E. Coppola, M. Studer, A. Firulli, 2008, Developmental biology.

Nkx2.5 regulates endothelin converting enzyme‐1 during pharyngeal arch patterning

Kimara L. Targoff, D. Yelon, A. Firulli, 2017, Genesis.

Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease

Joshua W. Vincentz, M. Rubart, A. Firulli, 2012, Pediatric Cardiology.

and man Developmental anatomy of the heart: a tale of mice

Gretchen J. Mahler, Emily J. Farrar, R. Schwartz, 2015 .

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells.

N. Zeleznik-Le, Shubin Zhang, A. Firulli, 2011, Blood.

Overexpression of Foxn 1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD 4 memory T cells

N. Zeleznik-Le, Shubin Zhang, A. Firulli, 2011 .

DEV106336 1..11

D. Yelon, A. Firulli, Jinhu Wang, 2014 .

Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization

A. Robling, A. Firulli, Whitney A Bullock, 2019, International journal of molecular sciences.

Single cell evaluation of endocardial HAND2 gene regulatory networks reveals critical HAND2 dependent pathways impacting cardiac morphogenesis

L. Pennacchio, D. Rusch, Ram Podicheti, 2022, bioRxiv.

Partially Penetrant Cardiac Neural Crest Defects in Hand1 Phosphomutant Mice: Dimer Choice That Is Not So Critical

A. Firulli, B. Firulli, 2019, Pediatric Cardiology.

Cells by Interfering with Runx3 Function Expression in Th1 Ifng Twist1 Regulates

Joshua W. Vincentz, M. Kaplan, Duy Pham, 2012 .

A glimpse of Cre-mediated controversies in epicardial signalling.

W. Shou, A. Firulli, Wenjun Zhang, 2013, Cardiovascular research.

Epigenetics and Heart Development

A. Firulli, Rajani M. George, 2021, Frontiers in Cell and Developmental Biology.

DNA triplexes and regulation of the c-myc gene.

A. Firulli, A. Kinniburgh, R. Kolluri, 1994, Gene.

Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene.

A. Firulli, A. Kinniburgh, T. L. Davis, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The Cardiac Neural Crest and Their Role in Development and Disease

Joshua W. Vincentz, A. Firulli, 2014 .

Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification.

Jian Li, Bin Zhou, R. Schwartz, 2016, Cell reports.

Combinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation.

S. Conway, A. Firulli, 2004, Birth defects research. Part C, Embryo today : reviews.

Phosphoregulation of Twist1 Provides a Mechanism of Cell Fate Control

S. Conway, A. Firulli, 2008, Current medicinal chemistry.

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

P. Tran, T. Burns, E. Fertig, 2015, Neoplasia.

Structure-Function Studies of the bHLH Phosphorylation Domain of TWIST1 in Prostate Cancer Cells

P. Tran, T. Burns, E. Fertig, 2015, Neoplasia.

Modular regulation of muscle gene transcription: a mechanism for muscle cell diversity.

E. Olson, A. Firulli, A B Firulli, 1997, Trends in genetics : TIG.

Myocyte enhancer binding factor-2 expression and activity in vascular smooth muscle cells. Association with the activated phenotype.

E. Olson, W. Casscells, J. Miano, 1996, Circulation research.

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

V. Centonze, E. Laufer, D. Virshup, 2005, Nature Genetics.

The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene.

A. Firulli, B. Thattaliyath, B. Firulli, 2002, Journal of molecular and cellular cardiology.

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1

D. Srivastava, E. Olson, D. McFadden, 1998, Nature Genetics.

Hand2 Loss-of-Function in Hand1-Expressing Cells Reveals Distinct Roles in Epicardial and Coronary Vessel Development

Joshua W. Vincentz, S. Conway, A. Firulli, 2011, Circulation research.

MEF2B is a potent transactivator expressed in early myogenic lineages

G. Lyons, N. Jenkins, J. Martín, 1996, Molecular and cellular biology.

Deletion of a Hand1 lncRNA-Containing Septum Transversum Enhancer Alters lncRNA Expression but Is Not Required for Hand1 Expression

A. Firulli, Rajani M. George, 2021, Journal of cardiovascular development and disease.

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function.

Joshua W. Vincentz, D. Arking, N. Sotoodehnia, 2019, Circulation research.

Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap

Jun Wang, Jianwen Que, Joshua W. Vincentz, 2016, Proceedings of the National Academy of Sciences.

Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium.

Joshua W. Vincentz, R. Zeller, J. Lopez-Rios, 2014, Cell reports.

A Phox2- and Hand2-Dependent Hand1 cis-Regulatory Element Reveals a Unique Gene Dosage Requirement for Hand2 during Sympathetic Neurogenesis

Joshua W. Vincentz, M. Rubart, A. Firulli, 2012, The Journal of Neuroscience.

A twist of insight - the role of Twist-family bHLH factors in development.

A. Firulli, Ralston M. Barnes, 2009, The International journal of developmental biology.

Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart.

A. Firulli, Nathan J. VanDusen, 2012, Differentiation; research in biological diversity.

A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors.

A. Firulli, 2003, Gene.

A GATA-dependent right ventricular enhancer controls dHAND transcription in the developing heart.

D. Srivastava, E. Olson, J. Richardson, 2000, Development.

Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects.

Joshua W. Vincentz, A. Firulli, Ralston M. Barnes, 2011, Birth defects research. Part A, Clinical and molecular teratology.

Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart.

A. Firulli, B. Thattaliyath, Bijoy Thattaliyath, 2002, International review of cytology.

HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a.

A. Firulli, M. Howard, Xiaotong Zhang, 2003, Developmental biology.

Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis

Joshua W. Vincentz, A. Firulli, D. Clouthier, 2014, Development.

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis.

Joshua W. Vincentz, S. Conway, A. Firulli, 2008, Developmental biology.

The Basic Helix-Loop-Helix Transcription factorsdHAND and eHAND Exhibit Dimerization Characteristics That Suggest Complex Regulation of Function*

A. Firulli, B. Firulli, J. McDaid, 2000, The Journal of Biological Chemistry.

Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration

D. Yelon, A. Firulli, Jinhu Wang, 2014, Development.

PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.

V. Centonze, D. Virshup, K. Dionne, 2003, Molecular cell.

Mechanisms Underlying Cardiomyocyte Development: Can We Exploit Them to Regenerate the Heart?

A. Firulli, Gabriel Maldonado-Velez, 2021, Current Cardiology Reports.

Mutations within Helix I of Twist1 Result in Distinct Limb Defects and Variation of DNA Binding Affinities*

S. Conway, A. Firulli, B. Firulli, 2007, Journal of Biological Chemistry.

Hand Factors in Cardiac Development

A. Firulli, Rajani M. George, 2018, Anatomical record.

Recombinant Neuregulin 1 Does Not Activate Cardiomyocyte DNA Synthesis in Normal or Infarcted Adult Mice

Anthony B. Firulli, M. Soonpaa, L. Field, 2014, PloS one.

HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy.

C. Livi, A. Firulli, G. Toney, 2002, Biochemical and biophysical research communications.

The Transcription Factor Twist1 Limits T Helper 17 and T Follicular Helper Cell Development by Repressing the Gene Encoding the Interleukin-6 Receptor α Chain*

M. Kaplan, A. Dent, C. Walline, 2013, The Journal of Biological Chemistry.

Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes

Joshua W. Vincentz, A. Firulli, D. Clouthier, 2020, Journal of cardiovascular development and disease.

GATA3 is essential for separating patterning domains during facial morphogenesis.

J. D. Engel, T. Cox, K. Lim, 2021, Development.

A bHLH Code for Cardiac Morphogenesis

S. Conway, A. Firulli, B. Firulli, 2009, Pediatric Cardiology.

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.

W. Shou, L. Field, A. Firulli, 2019, Cardiovascular research.

HAND transcription factors cooperatively specify the aorta and pulmonary trunk.

Joshua W. Vincentz, L. Pennacchio, A. Firulli, 2021, Developmental biology.

Triplex forming ability of a c-myc promoter element predicts promoter strength.

A. Firulli, A. Kinniburgh, D. Maibenco, 1994, Archives of biochemistry and biophysics.

Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells

P. Tran, T. Burns, E. Fertig, 2015 .

Gene Replacement Strategies to Test the Functional Redundancy of Basic Helix–Loop–Helix Transcription Factor

S. Conway, A. Firulli, Jian Wang, 2010, Pediatric Cardiology.

Fluorescence Resonance Energy Transfer (FRET) as a method to calculate the dimerization strength of basic Helix-Loop-Helix (bHLH) proteins

V. Centonze, A. Firulli, B. Firulli, 2004, Biological Procedures Online.

Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines

D. Virshup, A. Firulli, B. Firulli, 2004, Biological Procedures Online.

GATA3 is essential for separating patterning domains during facial morphogenesis

J. D. Engel, T. Cox, K. Lim, 2021, bioRxiv.

Hand 2 elevates cardiomyocyte production during zebrafish heart development and regeneration

D. Yelon, A. Firulli, Jinhu Wang, 2014 .

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis

A. Robling, A. Firulli, R. Fuchs, 2017, Development.

Another hat for myocardin.

A. Firulli, 2002, Journal of molecular and cellular cardiology.

The Transcription Factor Twist1 Limits T Helper 17 and T Follicular Helper Cell Development by Repressing the Gene Encoding the Interleukin-6 Receptor α Chain*

M. Kaplan, A. Dent, J. Blum, 2013, The Journal of Biological Chemistry.

Single-Cell Lineage Tracin g Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification Graphical Abstract Highlights

R. Schwartz, H. Singer, A. Firulli, 2016 .

Periostin Is Required for Maturation and Extracellular Matrix Stabilization of Noncardiomyocyte Lineages of the Heart

R. Markwald, R. Hinton, J. Molkentin, 2008, Circulation research.

Single cell evaluation of endocardial HAND2 gene regulatory networks reveals critical HAND2 dependent pathways impacting cardiac morphogenesis.

L. Pennacchio, D. Rusch, Ram Podicheti, 2022 .

Defective Hand 1 phosphoregulation uncovers essential roles for Hand 1 in limb morphogenesis

A. Robling, A. Firulli, R. Fuchs, 2017 .