Takeshi Takahashi

发表

Homeostatic Proliferation of Naive CD4+ T Cells in Mesenteric Lymph Nodes Generates Gut-Tropic Th17 Cells

T. So, T. Kawabe, Shu-lan Sun, 2013, The Journal of Immunology.

Dendritic Discrimination of Temporal Input Sequences in Cortical Neurons

Bruce R. Blazar, Shimon Sakaguchi, Michael A. Farrar, 2010 .

Development of a novel humanized mouse model for improved evaluation of in vivo anti-cancer effects of anti-PD-1 antibody

K. Kawai, R. Ito, Takeshi Takahashi, 2021, Scientific Reports.

Improved Detection of in vivo Human NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Using a Novel NOG-FcγR-Deficient Human IL-15 Transgenic Mouse

R. Ito, K. Kawai, Takeshi Takahashi, 2020, Frontiers in Immunology.

Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease

M. Takei, Mamoru Ito, Y. Nagatsuka, 2021, Heliyon.

Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice.

H. Suemizu, Mamoru Ito, R. Ito, 2020, International immunology.

Spontaneous rejection of intradermally transplanted non‐engineered tumor cells by neutrophils and macrophages from syngeneic strains of mice

Takeshi Takahashi, Tetsunosuke Shimizu, Minenori Ibata, 2011, Microbiology and immunology.

Evaluation of immunosuppression protocols for MHC-matched allogeneic iPS cell-based transplantation using a mouse skin transplantation model

H. Taniguchi, S. Murata, Takeshi Takahashi, 2022, Inflammation and Regeneration.

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse.

Mamoru Ito, K. Sugamura, H. Harigae, 2012, International immunology.

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

H. Suemizu, Mamoru Ito, Y. Kawakami, 2017, Scientific Reports.

A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis.

Mamoru Ito, Y. Okayama, K. Izuhara, 2018, JCI insight.

OX40 Costimulatory Signals Potentiate the Memory Commitment of Effector CD8+ T Cells1

K. Sugamura, J. Borst, Y. Yoshikai, 2008, The Journal of Immunology.

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice1

T. Nomura, N. Ishimaru, Y. Hayashi, 2005, The Journal of Immunology.

Gut-Tropic Th17 Cells Cells in Mesenteric Lymph Nodes Generates T + Homeostatic Proliferation of Naive CD4

T. So, T. Kawabe, Shu-lan Sun, 2013 .

Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice

T. Nomura, S. Yamazaki, S. Sakaguchi, 2003, Nature.

Costimulation via Glucocorticoid-Induced TNF Receptor in Both Conventional and CD25+ Regulatory CD4+ T Cells1

I. Ishikawa, S. Sakaguchi, M. Azuma, 2004, The Journal of Immunology.

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

H. Suemizu, Mamoru Ito, Y. Kawakami, 2018, Front. Immunol..

Recent Advances in Allergy Research Using Humanized Mice

Mamoru Ito, K. Izuhara, R. Ito, 2019, International journal of molecular sciences.

OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.

K. Sugamura, Takeshi Takahashi, N. Ishii, 2010, Advances in immunology.

Novel reporter and deleter mouse strains generated using VCre/VloxP and SCre/SloxP systems, and their system specificity in mice

Mamoru Ito, T. Eto, K. Kawai, 2018, Transgenic Research.

In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice.

Mamoru Ito, K. Sugamura, Shoichi Kita, 2010, Biochemical and biophysical research communications.

Breaking Immunological Tolerance to Tumor Cells as a Novel Immunotherapy for Cancer

J. Shimizu, S. Sakaguchi, Takeshi Takahashi, 2000 .

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice).

Mamoru Ito, K. Sugamura, M. Minegishi, 2009, International immunology.

Co‐inhibitory roles for glucocorticoid‐induced TNF receptor in CD1d‐dependent natural killer T cells

P. Pandolfi, K. Sugamura, C. Riccardi, 2008, European journal of immunology.

Thymic generation and selection of CD25+CD4+ regulatory T cells: implications of their broad repertoire and high self-reactivity for the maintenance of immunological self-tolerance.

T. Sasazuki, S. Hori, S. Sakaguchi, 2003, Novartis Foundation symposium.

Y Chromosome–Linked B and NK Cell Deficiency in Mice

K. Nakayama, N. Matsumoto, T. So, 2013, The Journal of Immunology.

Enhanced Antibody Responses in a Novel NOG Transgenic Mouse with Restored Lymph Node Organogenesis

Mamoru Ito, F. Sugiyama, S. Mizuno, 2018, Front. Immunol..

Establishment of a Human Allergy Model Using Human IL-3/GM-CSF–Transgenic NOG Mice

H. Suemizu, Mamoru Ito, A. Mori, 2013, The Journal of Immunology.

Exacerbation of pathogenic Th17-cell-mediated cutaneous graft-versus-host-disease in human IL-1β and IL-23 transgenic humanized mice.

Mamoru Ito, R. Ito, K. Kawai, 2019, Biochemical and biophysical research communications.

NOD-Rag2null IL-2Rγnull Mice: An Alternative to NOG Mice for Generation of Humanized Mice

H. Suemizu, Mamoru Ito, Y. Kawakami, 2014, Experimental animals.

Immunological responses against hepatitis B virus in human peripheral blood mononuclear cell-engrafted mice.

H. Suemizu, T. Kodama, Teppei Yoshioka, 2018, Biochemical and biophysical research communications.

Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver

H. Eguchi, H. Suemizu, N. Hiramatsu, 2016, Scientific Reports.

Predominant Development of Mature and Functional Human NK Cells in a Novel Human IL-2–Producing Transgenic NOG Mouse

H. Suemizu, Mamoru Ito, Y. Kawakami, 2015, The Journal of Immunology.

Formation of lipid droplets induced by 2,3-dihydrogeranylgeranoic acid distinct from geranylgeranoic acid.

Y. Matsumura, Takeshi Takahashi, Y. Shidoji, 2007, Acta biochimica Polonica.

Experimental autoimmune uveoretinitis initiated by non‐phagocytic destruction of inner segments of photoreceptor cells by Mac‐1+ mononuclear cells

Takeshi Takahashi, Tetsunosuke Shimizu, T. Sugiyama, 2008, Microbiology and immunology.

Control of autoimmunity by naturally arising regulatory CD4+ T cells.

S. Hori, S. Sakaguchi, Takeshi Takahashi, 2003, Advances in immunology.

Visualization of the human CD4⁺ T-cell response in humanized HLA-DR4-expressing NOD/Shi-scid/γc(null) (NOG) mice by retrogenic expression of the human TCR gene.

Mamoru Ito, R. Ito, Takeshi Takahashi, 2015, Biochemical and biophysical research communications.

The Analysis of the Functions of Human B and T Cells in Humanized NOG Mice

Takeshi Takahashi, 2014 .

Regulation of Hair Regrowth in Alopecic Site of IFN-γ−/− Mice by Macrophages Infiltrating into Allograft in IFN-γ+/+ Mice

Takeshi Takahashi, Yumiko Yamamoto, J. Tashiro-Yamaji, 2005 .

The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice

A. Ryo, H. Suemizu, N. Hiramatsu, 2015, PloS one.

Perforin/Fas Ligand Double-Deficient Mice CTL-Susceptible Leukemia Cells from Acute Rejection of Allografted

Takeshi Takahashi, H. Azuma, Y. Katsuoka, 2007 .

TNF Receptor in Both Conventional and Costimulation via Glucocorticoid-Induced

I. Ishikawa, M. Azuma, Takeshi Takahashi, 2013 .

Establishment of Human Leukocyte Antigen-Mismatched Immune Responses after Transplantation of Human Liver Bud in Humanized Mouse Models

H. Taniguchi, S. Okamoto, S. Murata, 2021, Cells.

Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease.

S. Sakaguchi, Takeshi Takahashi, 2003, Current molecular medicine.

Current advances in humanized mouse models

Mamoru Ito, R. Ito, Takeshi Takahashi, 2012, Cellular and Molecular Immunology.

Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

Shimon Sakaguchi, Masahiro Ono, Shohei Hori, 2006, Immunological reviews.

Long-term maintenance of peripheral blood derived human NK cells in a novel human IL-15- transgenic NOG mouse

H. Suemizu, Mamoru Ito, Y. Kawakami, 2017, Scientific Reports.

Generation of Novel Human Red Blood Cell-Bearing Humanized Mouse Models Based on C3-Deficient NOG Mice

R. Ito, Takeshi Takahashi, I. Katano, 2021, Frontiers in Immunology.

Efficient differentiation of human neutrophils with recapitulation of emergency granulopoiesis in human G-CSF knockin humanized mice.

Mamoru Ito, Immanuel Kwok, L. Ng, 2022, Cell reports.

Immunologic tolerance maintained by CD25+ CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

Sayuri Yamazaki, Masaaki Toda, Shimon Sakaguchi, 2001, Immunological reviews.

Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

A. Ryo, H. Suemizu, Y. Kondo, 2020, Scientific Reports.

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

T. Mak, J. Shimizu, S. Yamazaki, 2000, The Journal of experimental medicine.

Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

J. Shimizu, S. Yamazaki, S. Sakaguchi, 2002, Nature Immunology.

Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor.

S. Sakaguchi, Tomoyuki Yamaguchi, Takeshi Takahashi, 2007, Immunity.

IL‐4‐dependent induction of IgE+ basophils in peripheral blood and IgE+ B cells in spleen as respective indicators of allergen sensitization and a precursor of cells secreting allergen‐specific IgE antibody

Takeshi Takahashi, H. Takenaka, J. Tashiro-Yamaji, 2009, Microbiology and immunology.

Generation of a Nonhuman Primate Model of Severe Combined Immunodeficiency Using Highly Efficient Genome Editing.

Tetsushi Sakuma, Hideyuki Okano, Yasubumi Sakakibara, 2016, Cell stem cell.

Homeostatic maintenance of natural Foxp3 + CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization

Shimon Sakaguchi, Shohei Hori, Ruka Setoguchi, 2005, The Journal of experimental medicine.

Spontaneous development of autoimmune arthritis due to genetic anomaly of T cell signal transduction: Part 1.

T. Nomura, S. Sakaguchi, Takeshi Takahashi, 2006, Seminars in immunology.

Humanized mouse models: Application to human diseases

Mamoru Ito, R. Ito, Takeshi Takahashi, 2018, Journal of cellular physiology.

IL‐2 induces in vivo suppression by CD4+CD25+Foxp3+ regulatory T cells

A. Scheffold, Takeshi Takahashi, G. Karsten, 2008, European journal of immunology.

The role of regulatory T cells in controlling immunologic self-tolerance.

S. Sakaguchi, Takeshi Takahashi, 2003, International review of cytology.

Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma

K. Takata, T. Miyata‐Takata, T. Yoshino, 2015, Scientific Reports.

SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells

T. Nomura, S. Sakaguchi, Takeshi Takahashi, 2006 .

Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis

Elaine Y. Cao, John F. Ouyang, F. Chong, 2023, Nature Communications.

Immunologic self-tolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state.

M. Toda, J. Shimizu, S. Sakaguchi, 1998, International immunology.

Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance.

F. Otsuka, J. Shimizu, S. Sakaguchi, 1999, Journal of immunology.

Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway

A. Ryo, H. Suemizu, Y. Kondo, 2020, Scientific Reports.

Rejection of intradermally injected syngeneic tumor cells from mice by specific elimination of tumor-associated macrophages with liposome-encapsulated dichloromethylene diphosphonate, followed by induction of CD11b+/CCR3−/Gr-1− cells cytotoxic against the tumor cells

Y. Shikama, Zhiqian Yu, Takeshi Takahashi, 2009, Cancer Immunology, Immunotherapy.