G. Drummond

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Targeted Delivery of a Heme Oxygenase Inhibitor with a Lyophilized Liposomal Tin Mesoporphyrin Formulation

A. Kappas, J. Cannon, C. Martin, 1993, Pharmaceutical Research.

CD163-Mediated hemoglobin-heme uptake activates macrophage HO-1, providing an antiinflammatory function.

N. Abraham, G. Drummond, 2006, Circulation research.

TIN-PROTOPORPHYRIN AND LONG WAVE LENGTH ULTRAVIOLET LIGHT IN TREATMENT OF PSORIASIS

B. Angelin, A. Kappas, L. Berglund, 1989, The Lancet.

Heme Oxygenase-1 Induction Remodels Adipose Tissue and Improves Insulin Sensitivity in Obesity-Induced Diabetic Rats

V. Positano, A. L'Abbate, L. Rodella, 2009, Hypertension.

Obesity Heme Oxygenase-1 Induction Remodels Adipose Tissue and Improves Insulin Sensitivity in Obesity-Induced Diabetic Rats

V. Positano, A. L'Abbate, L. Rodella, 2009 .

Treatment of Hyperbilirubinemia Pharmacologic Approach SnMP(Tin-Mesoporphyrin)

A. Kappas, G. Drummond, J. Martínez, 2001, Journal of Perinatology.

Physiological significance of heme oxygenase in hypertension.

N. Abraham, G. Drummond, Xiaoying Li, 2009, The international journal of biochemistry & cell biology.

L-4F treatment reduces adiposity, increases adiponectin levels, and improves insulin sensitivity in obese mice** This work was supported by National Institutes of Health Grants DK-068134, HL-55601, and HL-34300. Published, JLR Papers in Press, April 28, 2008.

N. Abraham, Dong Hyun Kim, S. Ikehara, 2008, Journal of Lipid Research.

Heme oxygenase-derived carbon monoxide restores vascular function in type 1 diabetes.

L. Rodella, R. Rezzani, J. Falck, 2008, Drug metabolism letters.

Intestinal heme oxygenase inhibition and increased biliary iron excretion by metalloporphyrins

D. Rosenberg, A. Kappas, G. Drummond, 1992 .

Thyroid hormone regulation of heme synthesis in rat liver.

G. Drummond, T. Smith, 1988, Endocrinology.

The potent heme oxygenase inducing action of arsenic and parasiticidal arsenicals.

S. Sassa, A. Kappas, G. Drummond, 1981, Pharmacology.

Improved myocardial perfusion in chronic diabetic mice by the up‐regulation of pLKB1 and AMPK signaling

A. L'Abbate, N. Abraham, G. Sambuceti, 2010, Journal of cellular biochemistry.

Upregulation of Heme Oxygenase-1 Combined with Increased Adiponectin Lowers Blood Pressure in Diabetic Spontaneously Hypertensive Rats through a Reduction in Endothelial Cell Dysfunction, Apoptosis and Oxidative Stress

S. Omura, G. Drummond, K. Sodhi, 2008, International journal of molecular sciences.

A general method for distinguishing between endo and exo actions of carbohydrases

W. Whelan, E. Smith, G. Drummond, 1971, FEBS letters.

Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity.

N. Abraham, A. Kappas, G. Drummond, 2000, The Journal of pharmacology and experimental therapeutics.

Downregulation of the human heme oxygenase gene by glucocorticoids and identification of 56b regulatory elements.

N. Abraham, G. Drummond, Y. Lavrovsky, 1996, Biochemical and biophysical research communications.

The Biological Significance and Physiological Role of Heme Oxygenase

N. Abraham, A. Kappas, G. Drummond, 1996 .

Heme Oxygenase Inhibitors Transiently Increase Serum Ferritin Concentrations without Altering Other Acute-Phase Reactants in Man

B. Angelin, A. Kappas, L. Berglund, 1999, Pharmacology.

On the specificity of starch debranching enzymes

W. Whelan, E. Smith, G. Drummond, 1970, FEBS letters.

Heme oxygenase -1 gene therapy: recent advances and therapeutic applications.

N. Abraham, G. Drummond, S. Peterson, 2007, Current gene therapy.

Suppression of bilirubin production in the Crigler-Najjar type I syndrome: studies with the heme oxygenase inhibitor tin-mesoporphyrin.

A. Kappas, G. Drummond, R. Galbraith, 1992, Pediatrics.

Control of Heme Oxygenase and Plasma Levels of Bilirubin by a Synthetic Heme Analogue, Tin‐Protoporphyrin

K. Anderson, A. Kappas, G. Drummond, 1984, Hepatology.

Thyroid hormone regulation of heme oxidation in the liver.

A. Kappas, G. Drummond, T. Smith, 1982, Proceedings of the National Academy of Sciences of the United States of America.

ORIGINAL RESEARCH—BASIC SCIENCE: Effect of Hemin and Carbon Monoxide Releasing Molecule (CORM-3) on cGMP in Rat Penile Tissue

D. Sabry, L. Rashed, R. Olszanecki, 2008 .

Mechanism of action of pullulanase

W. Whelan, E. Smith, G. Drummond, 1969, FEBS letters.

Zinc porphyrins: potent inhibitors of hematopoieses in animal and human bone marrow.

N. Abraham, A. Kappas, G. Drummond, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Disposition of tin‐protoporphyrin and suppression of hyperbilirubinemia in humans

K. Anderson, A. Kappas, G. Drummond, 1986, Clinical pharmacology and therapeutics.

Direct in vitro effects of bis(tri-n-butyltin)oxide on hepatic cytochrome P-450.

D. Rosenberg, G. Drummond, D. Rosenberg, 1983, Biochemical pharmacology.

Studies on the mechanism of Sn-protoporphyrin suppression of hyperbilirubinemia. Inhibition of heme oxidation and bilirubin production.

K. Anderson, A. Kappas, G. Drummond, 1985, The Journal of clinical investigation.

Tissue distribution and disposition of tin-protoporphyrin, a potent competitive inhibitor of heme oxygenase.

K. Anderson, A. Kappas, G. Drummond, 1984, The Journal of pharmacology and experimental therapeutics.

Porphyrogenic effects and induction of heme oxygenase in vivo by δ-aminolevulinic acid

S. Sassa, G. Drummond, K. Andersson, 1981 .

Proof that Sn-protoporphyrin inhibits the enzymatic catabolism of heme in vivo. Suppression of 14CO generation from radiolabeled endogenous and exogenous heme sources

S. Sassa, A. Kappas, S. Landaw, 1987, The Journal of experimental medicine.

Impact of silencing HO‐2 on EC‐SOD and the mitochondrial signaling pathway

L. Rodella, R. Rezzani, N. Abraham, 2007, Journal of cellular biochemistry.

HO-1 overexpression and underexpression: Clinical implications.

N. Abraham, G. Drummond, D. Lewis, 2019, Archives of biochemistry and biophysics.

Purification and properties of potato -1,4-glucan. -1,4-Glucan 6-glycosyltransferase (Q-enzyme).

W. Whelan, E. Smith, G. Drummond, 1972, European journal of biochemistry.

Heme oxygenase: a target gene for anti-diabetic and obesity.

N. Abraham, G. Drummond, J. McClung, 2008, Current pharmaceutical design.

Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway.

L. Rodella, R. Rezzani, N. Abraham, 2007, American journal of physiology. Renal physiology.

Chemoprevention of severe neonatal hyperbilirubinemia.

A. Kappas, G. Drummond, 2004, Seminars in perinatology.

Porphyrogenic effects and induction of heme oxygenase in vivo by delta-aminolevulinic acid.

K. Anderson, S. Sassa, G. Drummond, 1981, Biochimica et biophysica acta.

Pharmacologic Effects of the Red Blood Cell Substitutes Cross-Linked and Non-Cross-Linked Hemoglobins on Hematopoiesis in Rabbits

N. Abraham, A. Kappas, G. Drummond, 1999, Pharmacology.

Depletion of cytochrome P-450 by thyroid hormone and cobalt-protoporphyrin IX in rat liver: evidence that susceptibility varies among forms of the heme protein.

D. Rosenberg, G. Drummond, T. Smith, 1995, Pharmacology.

Heme oxygenase: the key to renal function regulation.

N. Abraham, G. Drummond, Xiaoying Li, 2009, American journal of physiology. Renal physiology.

Translational Significance of Heme Oxygenase in Obesity and Metabolic Syndrome.

N. Abraham, G. Drummond, Joshua M Junge, 2016, Trends in pharmacological sciences.

Upregulating Heme Oxygenase-1 Via a Nuclear Factor-{kappa}B-Dependent Pathway Gene Transfer of Inducible Nitric Oxide Synthase Affords Cardioprotection by

V. Positano, D. Neglia, R. Bolli, 2009 .

Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats.

D. Neglia, A. L'Abbate, N. Abraham, 2007, American journal of physiology. Heart and circulatory physiology.

Control of Severe Hyperbilirubinemia in Full-term Newborns With the Inhibitor of Bilirubin Production Sn-Mesoporphyrin

A. Kappas, G. Drummond, J. Martínez, 1999, Pediatrics.

Diabetes Impairs the Vascular Recruitment of Normal Stem Cells by Oxidant Damage, Reversed by Increases in pAMPK, Heme Oxygenase-1, and Adiponectin

A. L'Abbate, L. Rodella, N. Abraham, 2009, Stem cells.

Retinoic acid can enhance the stimulation by thyroid hormone of heme oxygenase activity in the liver of thyroidectomized rats.

G. Drummond, T. Smith, 1991, Biochimica et biophysica acta.

Tryptophan pyrrolase in heme metabolism. Comparative actions of inorganic tin and cobalt and their protoporphyrin chelates on tryptophan pyrrolase in liver.

G. Drummond, M. Sardana, 1986, Biochemical pharmacology.

pathwayby an increase in the antiapoptotic signaling Genetic suppression of HO-1 exacerbates renal damage:

L. Rodella, R. Rezzani, N. Abraham, 2016 .

Dual role of heme oxygenase in epithelial cell injury: contrasting effects of short-term and long-term exposure to oxidant stress.

M. Goligorsky, N. Abraham, B. Escalante, 1996, The Journal of laboratory and clinical medicine.

Prolonged clinical use of a heme oxygenase inhibitor: hematological evidence for an inducible but reversible iron-deficiency state.

G. Drummond, A. Kappas, R. Galbraith, 1993, Pediatrics.

Comparative Pharmacology of Zinc Mesoporphyrin and Tin Mesoporphyrin: Toxic Actions of Zinc Mesoporphyrin on Hematopoiesis and Progenitor Cell Mobilization

N. Abraham, A. Kappas, G. Drummond, 1998, Pharmacology.

Sn-mesoporphyrin Suppression of Hyperbilirubinemia in EHBR/Eis Rats, an Animal Model of Dubin-Johnson Syndrome

A. Kappas, G. Drummond, 1998, Pharmacology.

Control of bilirubin production by synthetic heme analogs: pharmacologic and toxicologic considerations.

A. Kappas, G. Drummond, T. Valaes, 1996, Journal of perinatology : official journal of the California Perinatal Association.

The liver excretes large amounts of heme into bile when heme oxygenase is inhibited competitively by Sn-protoporphyrin.

K. Anderson, S. Sassa, A. Kappas, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Sn‐protoporphyrin lowers serum bilirubin levels, decreases biliary bilirubin output, enhances biliary heme excretion and potently inhibits hepatic heme oxygenase activity in normal human subjects

B. Angelin, A. Kappas, L. Berglund, 1988, Hepatology.

Induction of heme oxygenase mRNA by cobalt protoporphyrin in rat liver.

G. Drummond, T. Smith, S. Haque, 1991, Biochimica et biophysica acta.

Synthetic metalloporphyrins: A class of compounds of pharmacological interest

A. Kappas, G. Drummond, 1985, BioEssays : news and reviews in molecular, cellular and developmental biology.

A single dose of Sn-mesoporphyrin prevents development of severe hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns.

A. Kappas, G. Drummond, T. Valaes, 2001, Pediatrics.

Sn-protoporphyrin use in the management of hyperbilirubinemia in term newborns with direct Coombs-positive ABO incompatibility.

A. Kappas, G. Drummond, T. Valaes, 1988, Pediatrics.

Reduction of the C2 and C4 vinyl groups of Sn-protoporphyrin to form Sn-mesoporphyrin markedly enhances the ability of the metalloporphyrin to inhibit in vivo heme catabolism.

A. Kappas, G. Drummond, M. Sardana, 1987, Archives of biochemistry and biophysics.

Fluorometric measurement of tin-protoporphyrin in biological samples.

K. Anderson, S. Sassa, A. Kappas, 1984, Analytical Biochemistry.

Control of Heme Metabolism by Synthetic Metalloporphyrins a

G. Drummond, 1987, Annals of the New York Academy of Sciences.

Tin-mesoporphyrin inhibits heme oxygenase activity and heme-iron absorption in the intestine.

A. Kappas, G. Drummond, G. Drummond, 1993, Pharmacology.

Sn-Mesoporphyrin interdiction of severe hyperbilirubinemia in Jehovah's Witness newborns as an alternative to exchange transfusion.

G. Drummond, D. Munson, G. Drummond, 2001, Pediatrics.

Control of hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient newborns using an inhibitor of bilirubin production, Sn-mesoporphyrin.

A. Kappas, G. Drummond, T. Valaes, 1998, Pediatrics.

Control of jaundice in preterm newborns by an inhibitor of bilirubin production: studies with tin-mesoporphyrin.

C. Henschke, A. Kappas, G. Drummond, 1994, Pediatrics.

Direct comparison of Sn-mesoporphyrin, an inhibitor of bilirubin production, and phototherapy in controlling hyperbilirubinemia in term and near-term newborns.

C. Henschke, A. Kappas, G. Drummond, 1995, Pediatrics.