K. Ellsworth

发表

Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

D. Moller, R. Myers, A. Ogawa, 2003, Bioorganic & medicinal chemistry letters.

Modeling aided design of potent glycogen phosphorylase inhibitors.

R. Myers, B. McKeever, K. Chapman, 2005, Journal of molecular graphics & modelling.

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

Margaret S. Wu, Michael E. Lassman, M. Tota, 2011, Proceedings of the National Academy of Sciences.

Development of a novel tricyclic class of potent and selective FIXa inhibitors.

J. Metzger, R. Berger, Hong Li, 2015, Bioorganic & medicinal chemistry letters.

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

Margaret S. Wu, T. Doebber, D. Szalkowski, 2005, The Journal of clinical investigation.

Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.

I. Wang, J. Berger, P. Lu, 2009, European Journal of Pharmacology.

Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.

Margaret S. Wu, I. Wang, J. Berger, 2009, European journal of pharmacology.

Novel 3,4‐Dihydroquinolin‐2(1H)‐one Inhibitors of Human Glycogen Phosphorylase a.

D. Moller, R. Myers, A. Ogawa, 2004 .

Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride

H. Bull, K. Ellsworth, G. Harris, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition

H. Bull, K. Ellsworth, W. Geissler, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

MK386: a potent, selective inhibitor of the human type 1 5α-reductase

H. Bull, K. Ellsworth, G. Harris, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of Factor XIa Reduces the Frequency of Cerebral Microembolic Signals Derived from Carotid Arterial Thrombosis in Rabbits

M. Erion, D. Seiffert, K. Ellsworth, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta).

S. Prahalada, A. Hendrickx, K. Ellsworth, 1997, Teratology.

Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.

Margaret S. Wu, Michael E. Lassman, J. Berger, 2010, Bioorganic & medicinal chemistry letters.

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.

R. Myers, A. Ogawa, K. Chapman, 2003, Bioorganic & medicinal chemistry letters.

A new class of glycogen phosphorylase inhibitors.

R. Myers, K. Chapman, C. A. Willoughby, 2003, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

R. Painter, K. Ellsworth, W. Geissler, 2001, Bioorganic & Medicinal Chemistry Letters.

Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation.

Amjad Ali, R. Painter, K. Ellsworth, 2003, Journal of medicinal chemistry.

Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.

C. Raetz, K. Ellsworth, G. Harris, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Definitive Metabolite Identification Coupled with Automated Ligand Identification System (ALIS) Technology: A Novel Approach to Uncover Structure-Activity Relationships and Guide Drug Design in a Factor IXa Inhibitor Program.

Y. Liu, S. Hill, E. Sherer, 2016, Journal of medicinal chemistry.

Rapid development of two factor IXa inhibitors from hit to lead.

W. Greenlee, R. Berger, E. Sherer, 2015, Bioorganic & medicinal chemistry letters.

4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.

H. Bull, K. Ellsworth, G. Harris, 1994, Journal of medicinal chemistry.

4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.

K. Ellsworth, G. Harris, R. Mosley, 1995, Journal of medicinal chemistry.

Development of a novel class of potent and selective FIXa inhibitors.

E. Sherer, K. Ellsworth, W. Geissler, 2015, Bioorganic & medicinal chemistry letters.

Improved Stability of Proline-Derived Direct Thrombin Inhibitors through Hydroxyl to Heterocycle Replacement.

L. Mitnaul, B. Hawes, K. O'neill, 2015, ACS medicinal chemistry letters.

Prevention of obesity in mice by antisense oligonucleotide inhibitors of stearoyl-CoA desaturase-1.

Margaret S. Wu, T. Doebber, D. Szalkowski, 2005, The Journal of clinical investigation.

Evidence that inhibition of insulin receptor signaling activity by PC-1/ENPP1 is dependent on its enzyme activity.

I. Wang, J. Berger, P. Lu, 2009, European journal of pharmacology.

Expression of the Type 1 and Type 2 Steroid 5α-Reductases in Human Fetal Tissues

K. Ellsworth, G. Harris, 1995 .