G. Harris

发表

Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.

D. Moller, R. Myers, A. Ogawa, 2003, Bioorganic & medicinal chemistry letters.

Modeling aided design of potent glycogen phosphorylase inhibitors.

R. Myers, B. McKeever, K. Chapman, 2005, Journal of molecular graphics & modelling.

Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation

M. Forrest, G. Harris, C. Freund, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.

Amjad Ali, M. Forrest, G. Harris, 2008, Bioorganic & medicinal chemistry.

Comparison of the effects of new specific azasteroid inhibitors of steroid 5α‐reductase on canine hyperplastic prostate: Suppression of prostatic DHT correlated with prostate regression

S. Cohen, S. Prahalada, T. Nett, 1995, The Prostate.

Steroid 5α-reductase inhibitors in androgen-dependent disorders

J. Kozarich, G. Harris, 1997 .

Enzymatic preparation of high-specific-activity beta-D-[6,6'-3H]fructose-2,6-bisphosphate: Application to a sensitive assay for fructose-2,6-bisphosphatase.

R. Myers, W. Geissler, G. Harris, 2010, Analytical biochemistry.

Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.

D. Zaller, Amjad Ali, Douglas K. Miller, 2004, Journal of medicinal chemistry.

Novel 3,4‐Dihydroquinolin‐2(1H)‐one Inhibitors of Human Glycogen Phosphorylase a.

D. Moller, R. Myers, A. Ogawa, 2004 .

Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions*

W. Geissler, G. Harris, S. Pandit, 2002, The Journal of Biological Chemistry.

Activity of the type 1 5 alpha-reductase exhibits regional differences in isolated sebaceous glands and whole skin.

D. Thiboutot, G. Harris, K. Gilliland, 1995, The Journal of investigative dermatology.

Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride

H. Bull, K. Ellsworth, G. Harris, 1998, The Journal of Steroid Biochemistry and Molecular Biology.

Inhibition of rat α-reductases by finasteride: Evidence for isozyme differences in the mechanism of inhibition

H. Bull, K. Ellsworth, W. Geissler, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

4-Methyl-3-oxo-4-aza-5α-androst-1-ene-17β-N-aryl-carboxamides: an approach to combined androgen blockade [5α-reductase inhibition with androgen receptor binding in vitro]

G. Harris, R. Tolman, R. Bakshi, 1997, The Journal of Steroid Biochemistry and Molecular Biology.

MK386: a potent, selective inhibitor of the human type 1 5α-reductase

H. Bull, K. Ellsworth, G. Harris, 1996, The Journal of Steroid Biochemistry and Molecular Biology.

Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.

D. Zaller, Amjad Ali, Douglas K. Miller, 2005, Bioorganic & Medicinal Chemistry Letters.

Effects of finasteride, a type 2 5-alpha reductase inhibitor, on fetal development in the rhesus monkey (Macaca mulatta).

S. Prahalada, A. Hendrickx, K. Ellsworth, 1997, Teratology.

Glucose-lowering in a db/db mouse model by dihydropyridine diacid glycogen phosphorylase inhibitors.

R. Myers, A. Ogawa, K. Chapman, 2003, Bioorganic & medicinal chemistry letters.

A new class of glycogen phosphorylase inhibitors.

R. Myers, K. Chapman, C. A. Willoughby, 2003, Bioorganic & medicinal chemistry letters.

Design and synthesis of novel antibacterial agents with inhibitory activity against DNA polymerase III.

R. Painter, K. Ellsworth, W. Geissler, 2001, Bioorganic & Medicinal Chemistry Letters.

Selective glucocorticoid receptor nonsteroidal ligands completely antagonize the dexamethasone mediated induction of enzymes involved in gluconeogenesis and glutamine metabolism

Amjad Ali, W. Geissler, G. Harris, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Novel pyrazolo[3,4-d]pyrimidine-based inhibitors of Staphlococcus aureus DNA polymerase III: design, synthesis, and biological evaluation.

Amjad Ali, R. Painter, K. Ellsworth, 2003, Journal of medicinal chemistry.

Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor

R. Myers, M. Garcia-Calvo, J. Kozarich, 1996 .

Identification and selective inhibition of an isozyme of steroid 5 alpha-reductase in human scalp.

C. Raetz, K. Ellsworth, G. Harris, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.

D. Zaller, Amjad Ali, Douglas K. Miller, 2007, Bioorganic & medicinal chemistry letters.

Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.

Scott K. Smith, D. Zaller, Amjad Ali, 2005, Bioorganic & Medicinal Chemistry Letters.

Colorimetric detection of glutamine synthetase-catalyzed transferase activity in glucocorticoid-treated skeletal muscle cells.

G. Harris, J. Santoro, A. Sitlani, 2001, Analytical biochemistry.

4,7 beta-Dimethyl-4-azacholestan-3-one (MK-386) and related 4-azasteroids as selective inhibitors of human type 1 5 alpha-reductase.

H. Bull, K. Ellsworth, G. Harris, 1994, Journal of medicinal chemistry.

Immunohistochemical localization of types 1 and 2 5alpha-reductase in human scalp.

D. Thiboutot, D. Whiting, G. Harris, 1999, British Journal of Dermatology.

4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.

K. Ellsworth, G. Harris, R. Mosley, 1995, Journal of medicinal chemistry.

Immunohistochemical localization of types 1 and 2 5α‐reductase in human scalp

Harris, J. Flanagan, D. Thiboutot, 1999, The British journal of dermatology.

Expression of the Type 1 and Type 2 Steroid 5α-Reductases in Human Fetal Tissues

K. Ellsworth, G. Harris, 1995 .