J. Gale

发表

Amino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors.

Mehul M. Patel, S. Thrall, D. Tew, 2008, Bioorganic & medicinal chemistry letters.

Class I HDAC imaging using [3H]CI-994 autoradiography

S. Haggarty, Anna Cha, E. Holson, 2013, Epigenetics.

Discovery of the first histone deacetylase 6/8 dual inhibitors.

D. E. Olson, M. Weïwer, E. Holson, 2013, Journal of medicinal chemistry.

Conservation of the structure and function of bacterial tryptophan synthases

A. Joachimiak, M. Endres, B. Nocek, 2019, IUCrJ.

PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat

F. A. Schroeder, S. Haggarty, H. Wey, 2014, ACS chemical neuroscience.

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

F. A. Schroeder, S. Haggarty, Wen-Ning Zhao, 2013, PloS one.

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition

Sama F. Sleiman, D. E. Olson, G. Coppola, 2014, The Journal of Neuroscience.

Virtual screening for small molecule pathway regulators by image profile matching

Anne E Carpenter, Ashley M. Fuller, R. Derynck, 2021, bioRxiv.

Synthesis and structure-activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a.

Mehul M. Patel, K. Evans, T. Graybill, 2006, Bioorganic & medicinal chemistry letters.

An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8

Ted Natoli, Aravind Subramanian, Carol A. Fierke, 2014, ACS chemical biology.

Hydroxamate-based histone deacetylase inhibitors can protect neurons from oxidative stress via a histone deacetylase-independent catalase-like mechanism.

Sama F. Sleiman, D. E. Olson, R. Ratan, 2015, Chemistry & biology.

Hydroxamate-based Histone Deacetylase Inhibitors Can Protect Neurons from Oxidative Stress via an HDAC-independent Catalase-like Mechanism

Sama F. Sleiman, D. E. Olson, R. Ratan, 2015 .

Title: Virtual screening for small molecule pathway regulators by image profile matching of hits modulating the p38ɑ Discovery of hits impacting PPARGC1A (PGC-1α) overexpression phenotypes

Anne E Carpenter, Ashley M. Fuller, R. Derynck, 2021 .

Dysfunction of D2 dopamine receptor expressing neurons underlies manic-like behaviors in mice modeling SHANK3 duplication disorder

Zhandong Liu, H. Zoghbi, D. Standaert, 2021 .

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects.

Jen Q. Pan, D. E. Olson, S. Haggarty, 2016, ACS chemical biology.

Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

Patrick W. Faloon, Jen Q. Pan, F. A. Schroeder, 2018, ACS chemical biology.

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

Jen Q. Pan, K. Stegmaier, E. Scolnick, 2018, Science Translational Medicine.

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

Joshua A. Bittker, Carol A. Mulrooney, S. Schreiber, 2018, ACS Infectious Diseases.

High throughput screen identifies IFN-γ-dependent inhibitors of Toxoplasma gondii growth

Joshua A. Bittker, Carol A. Mulrooney, S. Schreiber, 2018, bioRxiv.

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection.

B. Wagner, N. Morgan, S. Richardson, 2016, ACS chemical biology.

Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection

Amy S. Espeseth, A. Espeseth, D. Margolis, 2014, PloS one.

Novel Fluorescence-Based High-Throughput FLIPR Assay Utilizing Membrane-Tethered Genetic Calcium Sensors to Identify T-Type Calcium Channel Modulators

Jen Q. Pan, S. P. Moran, M. Weïwer, 2022, ACS pharmacology & translational science.

Discovery of Potent and Highly Selective Inhibitors of GSK3b

Jen Q. Pan, S. Haggarty, S. Schreiber, 2014 .

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

S. Haggarty, E. Scolnick, P. McCarren, 2014, Chemical science.

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors

Colin M. Wilson, F. A. Schroeder, S. Haggarty, 2013, Neuroscience Letters.

Kinetic and structural insights into the binding of histone deacetylase 1 and 2 (HDAC1, 2) inhibitors.

S. Steinbacher, P. Reinemer, S. Haggarty, 2016, Bioorganic & medicinal chemistry.

Cloning and functional expression of the small subunit of acetolactate synthase from Nicotiana plumbaginifolia

L. Abell, J. Gale, H. Hershey, 1999, Plant Molecular Biology.

Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif.

D. E. Olson, M. Weïwer, E. Holson, 2013, Journal of medicinal chemistry.

Title: Virtual screening for small molecule pathway regulators by image profile matching of hits modulating the p38ɑ Discovery of hits impacting PPARGC1A (PGC-1α) overexpression phenotypes

Anne E Carpenter, Ashley M. Fuller, Shantanu Singh, 2021 .

Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Hydroxamic Acid-Based Histone Deacetylase (HDAC) Inhibitors Can Mediate Neuroprotection Independent of HDAC Inhibition Can Mediate Neuroprotection Independent of HDAC Inhibition

Sama F. Sleiman, D. E. Olson, R. Ratan, 2020 .

Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers

S. Haggarty, L. Tsai, E. Scolnick, 2014, Chemical science.

A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests

S. Haggarty, Wen-Ning Zhao, T. Petryshen, 2013, PloS one.