Zhiqing Liu

发表

Drug Discovery Targeting Bromodomain-Containing Protein 4

A. Brasier, B. Tian, Zhiqing Liu, 2017, Journal of medicinal chemistry.

Direct Activation of Bax Protein for Cancer Therapy

Na Ye, Zhiqing Liu, Haiying Chen, 2016, Medicinal research reviews.

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function

S. Snyder, J. Barrow, N. Wei, 2016, Proceedings of the National Academy of Sciences.

Efficacy of Novel Highly Specific Bromodomain‐Containing Protein 4 Inhibitors in Innate Inflammation‐Driven Airway Remodeling

B. Ameredes, M. Motamedi, M. Jamaluddin, 2019, American journal of respiratory cell and molecular biology.

Exchange proteins directly activated by cAMP (EPACs): Emerging therapeutic targets

Na Ye, Xiaodong Cheng, Zhiqing Liu, 2017, Bioorganic & Medicinal Chemistry Letters.

A Bromodomain-Containing Protein 4 (BRD4) Inhibitor Suppresses Angiogenesis by Regulating AP-1 Expression

Zhiqing Liu, Jia Zhou, Jian Chen, 2020, Frontiers in Pharmacology.

Selective Antagonists of the Bronchiolar Epithelial NF-κB-Bromodomain-Containing Protein 4 Pathway in Viral-Induced Airway Inflammation.

A. Brasier, B. Tian, Yingxin Zhao, 2018, Cell reports.

Selective Molecular Antagonists of the Bronchiolar Epithelial NF κ B-Bromodomain-Containing Protein 4 (BRD4) Pathway in Viral-induced Airway Inflammation

A. Brasier, B. Tian, Yingxin Zhao, 2018 .

Target-Based Small Molecule Drug Discovery Towards Novel Therapeutics for Inflammatory Bowel Diseases.

I. Pinchuk, A. Brasier, B. Tian, 2021, Inflammatory bowel diseases.

Discovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site.

Shwu‐Yuan Wu, C. Chiang, A. Brasier, 2022, Journal of medicinal chemistry.

Apelin-mediated deamidation modification of HMGA1 promotes tumorigenesis by enhancing SRBEP1 activity and Lipid Synthesis

Zhiqing Liu, Mufeng Li, Tingting Guo, 2020 .

Structure-Activity Relationship Studies of Substituted 2-(Isoxazol-3-yl)-2-oxo-N'-phenyl-acetohydrazonoyl Cyanide Analogues: Identification of Potent Exchange Proteins Directly Activated by cAMP (EPAC) Antagonists.

Na Ye, Xiaodong Cheng, Zhiqing Liu, 2015, Journal of medicinal chemistry.

Mucosal bromodomain‐containing protein 4 mediates aeroallergen‐induced inflammation and remodeling

W. Calhoun, A. Brasier, B. Tian, 2019, The Journal of allergy and clinical immunology.

Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffolding Hopping, Optimization and Pharmacological Evaluation.

A. Brasier, B. Tian, P. Leonard, 2020, Journal of medicinal chemistry.

Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.

A. Brasier, B. Tian, Zhiqing Liu, 2018, European journal of medicinal chemistry.

Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection

Jian-xun Luo, Zhiqing Liu, Jia Zhou, 2021, bioRxiv.

BH4 domain of Bcl-2 as a novel target for cancer therapy.

Na Ye, Zhiqing Liu, Haiying Chen, 2016, Drug discovery today.

Identification of peptidomimetics as novel chemical probes modulating fibroblast growth factor 14 (FGF14) and voltage-gated sodium channel 1.6 (Nav1.6) protein-protein interactions.

Syed R Ali, A. Singh, F. Laezza, 2019, Bioorganic & medicinal chemistry letters.

Regio- and Stereospecific Synthesis of Oridonin D-Ring Aziridinated Analogues for the Treatment of Triple-Negative Breast Cancer via Mediated Irreversible Covalent Warheads.

Na Ye, Deng-feng Li, Q. Shen, 2018, Journal of medicinal chemistry.

Discovery and development of natural product oridonin-inspired anticancer agents.

Jia Zhou, Qiang Shen, Ye Ding, 2016, European journal of medicinal chemistry.

Discovery and Development of Natural Product Oridonin‐Inspired Anticancer Agents

Jia Zhou, Qiang Shen, Ye Ding, 2016 .

Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic.

Syed R Ali, Neli I Panova-Elektronova, A. Singh, 2018, ACS chemical neuroscience.

Design, Synthesis, and Pharmacological Evaluation of Analogues Derived from the PLEV Tetrapeptide as Protein-Protein Interaction Modulators of Voltage-Gated Sodium Channel 1.6.

A. Singh, F. Laezza, Zhiqing Liu, 2020, Journal of medicinal chemistry.

Small-Molecule Inhibitors Targeting the Canonical WNT Signaling Pathway for the Treatment of Cancer.

Zhiqing Liu, Pingyuan Wang, E. Wold, 2021, Journal of medicinal chemistry.

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

Na Ye, Xiaodong Cheng, Zhiqing Liu, 2017, European journal of medicinal chemistry.

Structure-guided drug design identifies a BRD4-selective small molecule that suppresses HIV.

Jerome H. Kim, J. Ananworanich, M. Robb, 2019, The Journal of clinical investigation.

Scaffold repurposing of fendiline: Identification of potent KRAS plasma membrane localization inhibitors.

J. Frost, Na Ye, Dharini van der Hoeven, 2021, European journal of medicinal chemistry.

Semi-Synthesis and Biological Evaluation of 25(R)-26-Acetoxy-3β,5α-Dihydroxycholest-6-One

Zhiqing Liu, Pingyuan Wang, Xin Li, 2023, Marine drugs.

Pharmacoproteomics reveal novel protective activity of bromodomain containing 4 inhibitors on vascular homeostasis in TLR3-mediated airway remodeling.

W. Calhoun, M. Motamedi, A. Brasier, 2019, Journal of proteomics.

Identification of marine natural product Pretrichodermamide B as a STAT3 inhibitor for efficient anticancer therapy

Rui Li, Xinxin Zhang, Jieyu Liu, 2023, Marine Life Science & Technology.

Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities.

Yan Huang, Yanfeng Sun, C. Xue, 2023, European journal of medicinal chemistry.

Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP.

Zhiqing Liu, Huaxuan Li, Yi Zhang, 2023, Journal of medicinal chemistry.

Epigenetic Suppression of HIV in Myeloid Cells by the BRD4-Selective Small Molecule Modulator ZL0580

B. Gelman, Zhiqing Liu, Jia Zhou, 2020, Journal of Virology.

Synthesis and Biochemical Evaluation of Non-Cyclic Nucleotide Exchange Protein Directly Activated by cAMP 1 (EPAC1) Regulators.

H. Rehmann, Zhiqing Liu, Pingyuan Wang, 2020, Journal of medicinal chemistry.

Structure-activity relationships of 2-substituted phenyl-N-phenyl-2-oxoacetohydrazonoyl cyanides as novel antagonists of exchange proteins directly activated by cAMP (EPACs).

Na Ye, Xiaodong Cheng, Zhiqing Liu, 2017, Bioorganic & medicinal chemistry letters.

Discovery of phenanthridine analogues as novel chemical probes disrupting the binding of DNA to ΔFosB homodimers and ΔFosB/JunD heterodimers.

G. Rudenko, Zhiqing Liu, Haiying Chen, 2020, Bioorganic & medicinal chemistry letters.

Direct Activation of Bax Protein for Cancer Therapy

Na Ye, Zhiqing Liu, Haiying Chen, 2016, Medicinal research reviews.

Identification of novel 2-(benzo[d]isoxazol-3-yl)-2-oxo-N-phenylacetohydrazonoyl cyanide analoguesas potent EPAC antagonists.

Na Ye, Xiaodong Cheng, Zhiqing Liu, 2017, European journal of medicinal chemistry.