Xin Wang

发表

Fragment-based drug discovery of 2-thiazolidinones as inhibitors of the histone reader BRD4 bromodomain.

Yechun Xu, Lele Zhao, Z. Miao, 2013, Journal of medicinal chemistry.

Three-component, one-pot sequential synthesis of functionalized cyclazines: 3H-1,2a1,3-triazaacenaphthylenes.

Jing-kang Shen, Xin Wang, T. Meng, 2012, The Journal of organic chemistry.

Design and Synthesis of 4‐(2,4,5‐Trifluorophenyl)butane‐1,3‐diamines as Dipeptidyl Peptidase IV Inhibitors

B. Xiong, Jing-kang Shen, Xin Wang, 2013, ChemMedChem.

Dual Mechanisms of Novel CD73-Targeted Antibody and Antibody–Drug Conjugate in Inhibiting Lung Tumor Growth and Promoting Antitumor Immune-Effector Function

Jing-kang Shen, Yun Xing, Xin Wang, 2020, Molecular Cancer Therapeutics.

(N,N-Diisopropylcarbamoyloxy)-methyl p-tolyl sulfone: preparation and application for the syntheses of 1,2-diols

Jing-kang Shen, Lin Chen, Xin Wang, 2012 .

Efficient Synthesis of a (Z)-3-Methyleneisoindolin-1-one Library Using Cu(OAc)2•H2O/DBU under Microwave Irradiation

Xin Wang, Li Zhang, Jingkang Shen, 2013, Molecules.

Discovery of potent N-(isoxazol-5-yl)amides as HSP90 inhibitors.

Yechun Xu, Min Huang, M. Geng, 2014, European journal of medicinal chemistry.

Formation of 1,3-diazocine by palladium catalyzed C–H arylation

B. Xiong, Jing-kang Shen, Jingge Ren, 2016 .

Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.

M. Huang, Min Huang, M. Geng, 2019, European journal of medicinal chemistry.

Phage-Display Based Discovery and Characterization of Peptide Ligands against WDR5

B. Xiong, Jing-kang Shen, D. Cao, 2021, Molecules.

Asymmetric synthesis and biological evaluation of N-cyclohexyl-4-[1-(2,4-dichlorophenyl)-1-(p-tolyl)methyl]piperazine-1-carboxamide as hCB1 receptor antagonists.

Jing-kang Shen, Xin Wang, T. Meng, 2011, European journal of medicinal chemistry.

Quinoxalinylurea Derivatives as a Novel Class of JSP‐1 Inhibitors.

B. Xiong, Jing-kang Shen, Xin Wang, 2007 .

Preparation of 6-substituted quinoxaline JSP-1 inhibitors by microwave accelerated nucleophilic substitution.

Jing-kang Shen, Xin Wang, Jingya Li, 2006, Molecules.

Structure-Based Discovery of Potent CARM1 Inhibitors for Solid Tumor and Cancer Immunology Therapy.

Zhuqing Zhang, M. Geng, B. Xiong, 2021, Journal of medicinal chemistry.

Quinoxalinylurea derivatives as a novel class of JSP-1 inhibitors.

B. Xiong, Jing-kang Shen, Xin Wang, 2007, Bioorganic & medicinal chemistry letters.

An efficient synthesis of novel dibenzoxdiazepine-fused heterocycles through a multicomponent reaction

Jing-kang Shen, Xin Wang, T. Meng, 2014 .

Highly Stereoselective Nucleophilic Addition of Difluoromethyl‐2‐pyridyl Sulfone to Sugar Lactones and Efficient Synthesis of Fluorinated 2‐Ketoses

B. Xiong, Jing-kang Shen, Jian Yin, 2014 .

Facile synthesis of new functionalized 3,4-dihydro-2H-pyrroles using 2-isocyanoacetates

Jing-kang Shen, Lin Chen, Xin Wang, 2020 .

Ga(OTf)3-promoted synthesis of functionalized 2-carbonyl-imidazo[1,2-a]pyridines derived from ethyl α-benzotriazolyl-α-morpholinoacetate

Jing-kang Shen, Xin Wang, Lan-ping Ma, 2015 .

Simple and Efficient Copper(I)-Catalyzed Access to Three Versatile Aminocoumarin-Based Scaffolds using Isocyanoacetate

Jing-kang Shen, Xin Wang, D. Hu, 2011 .

Discovery of a series of dihydroquinoxalin-2(1H)-ones as selective BET inhibitors from a dual PLK1-BRD4 inhibitor.

Z. Miao, B. Xiong, Jing-kang Shen, 2017, European journal of medicinal chemistry.

Direct glycosylation of bioactive small molecules with glycosyl iodide and strained olefin as acid scavenger.

B. Xiong, Jing-kang Shen, Xin Wang, 2014, The Journal of organic chemistry.

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors.

Yechun Xu, Li Li, Jian Li, 2013, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase.

Wei Wang, Jingkang Shen, Xin Wang, 2009, Bioorganic & medicinal chemistry.

Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.

B. Xiong, Jing-kang Shen, Xin Wang, 2008, Bioorganic & medicinal chemistry.

Microwave-assisted rapid and straightforward synthesis of 2-aryl-4-quinolones from acylated 2′-aminoacetophenones

Jing-kang Shen, Xin Wang, Yongli Du, 2006 .

Soluble polymer-supported synthesis of 5-arylidene thiazolidinones and pyrimidinones using a novel traceless linker strategy.

Wei Zhang, Jing-kang Shen, Xin Wang, 2008, Journal of combinatorial chemistry.

Design and optimization of a series of 1-sulfonylpyrazolo[4,3-b]pyridines as selective c-Met inhibitors.

Jian Ding, M. Geng, B. Xiong, 2015, Journal of medicinal chemistry.

Synthesis of pyrrolidine analogues of solamin

L. Lou, Jing-kang Shen, Xin Wang, 2005 .

Design and Synthesis of Potent, Selective Inhibitors of Protein Arginine Methyltransferase 4 against Acute Myeloid Leukemia.

Zhuqing Zhang, Jian Ding, M. Geng, 2019, Journal of medicinal chemistry.

1,2-Tans-1-dihydroxyboryl benzyl S-glycoside as glycosyl donor.

B. Xiong, Jing-kang Shen, Xin Wang, 2014, Carbohydrate research.

Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer

Jing-kang Shen, Xin Wang, Lan-ping Ma, 2016, Oncotarget.

Synthesis and LAR inhibition of 7-alkoxy analogues of illudalic acid.

B. Xiong, Jing-kang Shen, Xin Wang, 2010, Yao xue xue bao = Acta pharmaceutica Sinica.

Total Synthesis and Antidepressant Activities of Laetispicine and Its Derivatives

Jing-kang Shen, Xin Wang, T. Meng, 2012, Molecules.

Aromatic beta-amino-ketone derivatives as novel selective non-steroidal progesterone receptor antagonists.

B. Xiong, Jing-kang Shen, Qunyi Li, 2010, Bioorganic & medicinal chemistry.

Structure-based optimization of a series of selective BET inhibitors containing aniline or indoline groups.

Z. Miao, Jian Li, B. Xiong, 2018, European journal of medicinal chemistry.

Design and discovery of new pyrimidine coupled nitrogen aromatic rings as chelating groups of JMJD3 inhibitors.

Min Huang, Jian-Ping Zuo, Rongfeng Liu, 2016, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of bivalent ligands against A1–D1 receptor heteromers

Ye-chun Xu, Jing-kang Shen, Xin Wang, 2013, Acta Pharmacologica Sinica.

Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma.

M. Geng, B. Xiong, Yuchen Jiang, 2019, European journal of medicinal chemistry.

Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells.

Xin Wang, T. Meng, D. Ding, 2011, Organic & biomolecular chemistry.

Three-component combinatorial synthesis of a substituted 6H-pyrido[2',1':2,3]imidazo- [4,5-c]isoquinolin-5(6H)-one library with cytotoxic activity.

Jian Ding, Xin Wang, D. Hu, 2007, Journal of combinatorial chemistry.

Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors

Yechun Xu, Jian Ding, Qiu-feng Liu, 2018, Molecules.

Structure-based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.

Z. Miao, Jian Li, B. Xiong, 2019, Journal of medicinal chemistry.

Fragment-based drug discovery of 2-thiazolidinones as BRD4 inhibitors: 2. Structure-based optimization.

Yechun Xu, Lele Zhao, Z. Miao, 2015, Journal of medicinal chemistry.

Synthesis and bioassay of β-(1,4)-D-mannans as potential agents against Alzheimer's disease

M. Geng, Ding-yu Hu, Xin Wang, 2013, Acta Pharmacologica Sinica.

Rational Design and Evaluation of 6-(Pyrimidin-2-ylamino)-3,4-dihydroquinoxalin-2(1H)-ones as Polypharmacological Inhibitors of BET and Kinases.

B. Xiong, D. Pei, D. Cao, 2020, Journal of medicinal chemistry.

Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

B. Xiong, Xin Wang, Hai-Yan Zhang, 2009, Acta Pharmacologica Sinica.

Design, synthesis, and evaluation of Leu*Ala hydroxyethylene-based non-peptide beta-secretase (BACE) inhibitors.

Xin Wang, Jia Li, D. Hu, 2006, Bioorganic & medicinal chemistry.

Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E–based Antibody–Drug Conjugate for Treatment of Nectin-4–expressing Cancers

Wei Zhou, L. Lou, P. Fang, 2023, Molecular cancer therapeutics.

Synthesis of novel substituted benzimidazo[1,2-a]quinoxalin-6(5H)-ones via an intramolecular Goldberg reaction.

Xin Wang, T. Meng, Yongliang Zhang, 2010, Journal of combinatorial chemistry.

Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors.

Tongchao Liu, Z. Miao, B. Xiong, 2020, Bioorganic & medicinal chemistry letters.

Energetic factors determining the binding of type I inhibitors to c-Met kinase: experimental studies and quantum mechanical calculations

Bing Xiong, Xin Wang, Jing Ai, 2013, Acta Pharmacologica Sinica.