Jinlei Bian

发表

Novel biphenyl-based scaffold as potent and selective histone deacetylase 6 (HDAC6) inhibitors: Identification, development and pharmacological evaluation.

Xi Xu, Di Zhang, T. Zhao, 2022, European journal of medicinal chemistry.

Small-molecule degraders of cyclin-dependent kinase protein: a review.

Zhiyu Li, Jinlei Bian, Bin Yu, 2021, Future medicinal chemistry.

Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update.

Zhiyu Li, Jinlei Bian, Tizhi Wu, 2020, Journal of medicinal chemistry.

Janus kinases (JAKs): The efficient therapeutic targets for autoimmune diseases and myeloproliferative disorders.

Qiuyu Chen, Xi Xu, Zhiyu Li, 2020, European journal of medicinal chemistry.

Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion.

Jie Ren, H. Ding, Zhiyu Li, 2020, European journal of medicinal chemistry.

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity.

Yajing Wang, Jie Ren, Xi Xu, 2018, Bioorganic chemistry.

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles.

Xi Xu, Di Zhang, J. Kou, 2022, European journal of medicinal chemistry.

Synthesis, evaluation and quantitative structure-activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents.

Tinghan Li, Zhiyu Li, Jinlei Bian, 2017, Bioorganic & medicinal chemistry letters.

A critical update on the strategies towards small molecule inhibitors targeting Serine/arginine-rich (SR) proteins and Serine/arginine-rich proteins related kinases in alternative splicing.

Zhiyu Li, Jinlei Bian, Liao Zhang, 2022, Bioorganic & medicinal chemistry.

NRF2 promotes breast cancer cell proliferation and metastasis by increasing RhoA/ROCK pathway signal transduction

Lei Wang, Hao-Peng Sun, Chao Zhang, 2016, Oncotarget.

Current knowledge on the nucleotide agonists for the P2Y2 receptor.

Zhiyu Li, Jinlei Bian, Jubo Wang, 2018, Bioorganic & medicinal chemistry.

Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Zhiyu Li, Jinlei Bian, Zhixia Qiu, 2020 .

Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors.

Xi Xu, Zhiyu Li, Jinlei Bian, 2018, The Journal of organic chemistry.

Current Development of ROS-Modulating Agents as Novel Antitumor Therapy.

Q. You, Jinlei Bian, Haopeng Sun, 2017, Current cancer drug targets.

Bioactive modulators targeting STING adaptor in cGAS-STING pathway.

Zhiyu Li, Jinlei Bian, Xi Feng, 2019, Drug discovery today.

Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists.

Xi Xu, Qianming Du, Zhiyu Li, 2020, European journal of medicinal chemistry.

Synthesis and in vivo antitumor evaluation of an orally active potent phosphonamidate derivative targeting IDO1/IDO2/TDO.

Zhiyu Li, Jinlei Bian, Yinuo Wang, 2019, Biochemical pharmacology.

Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo

Q. You, Jinlei Bian, Xiaoli Xu, 2016, Scientific Reports.

Overview of the development of selective androgen receptor modulators (SARMs) as pharmacological treatment for osteoporosis (1998-2021).

R. Chen, Xi Xu, Zhiyu Li, 2022, European journal of medicinal chemistry.

Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors.

C. Luo, H. Ding, Xi Xu, 2019, Journal of medicinal chemistry.

Copper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2-c]coumarin Derivatives and Evaluation for Photophysical Properties.

Zhiyu Li, Jinlei Bian, B. Song, 2021, The Journal of organic chemistry.

Palladium(II)-Catalyzed C-H Bond Activation/C-C Coupling/Intramolecular Tsuji-Trost Reaction Cascade: Facile Access to 2H-Pyranonaphthoquinones.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Organic letters.

NbCl5 mediated biomimetic cascade reaction: efficient and scalable one-pot synthesis of dunnione and nor-β-lapachone

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

Affinity-based small fluorescent probe for NAD(P)H:quinone oxidoreductase 1 (NQO1). Design, synthesis and pharmacological evaluation.

Q. You, Jinlei Bian, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

Novel naphtho[2,1-d]oxazole-4,5-diones as NQO1 substrates with improved aqueous solubility: Design, synthesis, and in vivo antitumor evaluation.

Jinlei Bian, Tingting Yang, Jing Gu, 2016, Bioorganic & medicinal chemistry.

2-Substituted 3-methylnaphtho[1,2-b]furan-4,5-diones as novel L-shaped ortho-quinone substrates for NAD(P)H:quinone oxidoreductase (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2014, European journal of medicinal chemistry.

Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

Xi Xu, Zhiyu Li, Jinlei Bian, 2019, Organic Chemistry Frontiers.

Exploring the tetrahydroisoquinoline thiohydantoin scaffold blockade the androgen receptor as potent anti-prostate cancer agents.

Xi Xu, Zhiyu Li, Jinlei Bian, 2018, European journal of medicinal chemistry.

Recent discovery of phosphoinositide 3-kinase γ inhibitors for the treatment of immune diseases and cancers.

Zhiyu Li, Jinlei Bian, Yucheng Tian, 2019, Future medicinal chemistry.

Recent discovery of indoleamine-2,3-dioxygenase 1 inhibitors targeting cancer immunotherapy.

Jinlei Bian, Zhiyu Li, Jinlei Bian, 2018, European journal of medicinal chemistry.

Unconventional Passive Enhancement of Transdermal Drug Delivery: toward a Mechanistic Understanding of Penetration Enhancers Releasing from Acrylic Pressure-Sensitive Adhesive of Patches

Jianping Liu, Jinlei Bian, D. Quan, 2020, Pharmaceutical Research.

Lewis acid mediated highly regioselective intramolecular cyclization for the synthesis of β-lapachone

Q. You, Jinlei Bian, Haopeng Sun, 2014 .

Development of Indoleamine 2,3-Dioxygenase 1 Inhibitors for Cancer Therapy and Beyond: A Recent Perspective.

Zhiyu Li, Jinlei Bian, Xi Feng, 2020, Journal of medicinal chemistry.

Novel natural-product-like caged xanthones with improved druglike properties and in vivo antitumor potency.

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

Discovery and development of small molecule modulators targeting glutamine metabolism.

Xi Xu, Zhiyu Li, Jinlei Bian, 2019, European journal of medicinal chemistry.

Design of wogonin-inspired selective cyclin-dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity.

H. Ding, Tinghan Li, Zhiyu Li, 2019, European journal of medicinal chemistry.

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro.

Xi Xu, Zhiyu Li, Jinlei Bian, 2017, European journal of medicinal chemistry.

The progress and development of GLUT1 inhibitors targeting cancer energy metabolism.

Xi Xu, Zhiyu Li, Jinlei Bian, 2019, Future medicinal chemistry.

A critical update on the strategies towards modulators targeting androgen receptors.

Zhiyu Li, Jinlei Bian, Pengfei Xu, 2020, Bioorganic & medicinal chemistry.

Overview of the Development of Glutaminase Inhibitors: Achievements and Future Directions.

Xi Xu, Zhiyu Li, Jinlei Bian, 2018, Journal of medicinal chemistry.

Design and synthesis of indoline thiohydantoin derivatives based on enzalutamide as antiproliferative agents against prostate cancer.

Xi Xu, Zhiyu Li, Jinlei Bian, 2017, European journal of medicinal chemistry.

Development of Cdc2-like Kinase 2 Inhibitors: Achievements and Future Directions.

Zhiyu Li, Jinlei Bian, Zhen Qin, 2021, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of a novel spiro oxazolidinedione as potent p300/CBP HAT inhibitor for the treatment of ovarian cancer

Kaixian Chen, C. Luo, H. Ding, 2021, Bioorganic & Medicinal Chemistry.

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening.

Kaixian Chen, Hualiang Jiang, C. Luo, 2020, Bioorganic chemistry.

Discovery of phosphonamidate IDO1 inhibitors for the treatment of non-small cell lung cancer.

Xi Xu, Qianming Du, Zhiyu Li, 2019, European journal of medicinal chemistry.

Discovery of cyanopyridine scaffold as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors through virtual screening and preliminary hit optimisation

Yu Cheng, Zhiyu Li, Jie Ren, 2019, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and evaluation of (±)-dunnione and its ortho-quinone analogues as substrates for NAD(P)H:quinone oxidoreductase 1 (NQO1).

Q. You, Jinlei Bian, Haopeng Sun, 2015, Bioorganic & medicinal chemistry letters.

A review on flavones targeting serine/threonine protein kinases for potential anticancer drugs.

Zhiyu Li, Jinlei Bian, Yifan Feng, 2019, Bioorganic & medicinal chemistry.

Discovery of novel chemical scaffolds as RhoA inhibitors using virtual screening, synthesis, and bioactivity evaluation

Q. You, Jinlei Bian, Xiaoli Xu, 2016 .

Discovery of imidazopyrrolopyridines derivatives as novel and selective inhibitors of JAK2.

Jie Ren, Zhiyu Li, Jinlei Bian, 2021, European journal of medicinal chemistry.

Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site.

Xi Xu, J. Kou, Zhiyu Li, 2021, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group.

Xi Xu, Di Zhang, Jinlei Bian, 2023, European journal of medicinal chemistry.

Discovery of quinone-directed antitumor agents selectively bioactivated by NQO1 over CPR with improved safety profile.

Q. You, Jinlei Bian, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

An updated patent review of glutaminase inhibitors (2019–2022)

Zhiyu Li, Jinlei Bian, Danni Wang, 2023, Expert opinion on therapeutic patents.

Discovery of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with novel chemical scaffolds by shape-based virtual screening combined with cascade docking

Q. You, Jinlei Bian, Haopeng Sun, 2015 .

2-Substituted 3,7,8-trimethylnaphtho[1,2-b]furan-4,5-diones as specific L-shaped NQO1-mediated redox modulators for the treatment of non-small cell lung cancer.

Q. You, Jinlei Bian, Xiaojin Zhang, 2017, European journal of medicinal chemistry.

Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT.

Dalei Wu, C. Luo, H. Ding, 2023, Bioorganic chemistry.

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

Zhiyu Li, Jinlei Bian, Dechun Huang, 2021, Acta Pharmaceutica Sinica B.

Microwave-assisted unprotected Sonogashira reaction in water for the synthesis of polysubstituted aromatic acetylene compounds

Zhiyu Li, Jinlei Bian, Tizhi Wu, 2020 .

A patent review of selective CDK9 inhibitors in treating cancer

R. Chen, Zhiyu Li, Jinlei Bian, 2023, Expert opinion on therapeutic patents.

Identification of novel androgen receptor degrading agents to treat advanced prostate cancer.

Jie Ren, Zhiyu Li, Jinlei Bian, 2021, European journal of medicinal chemistry.

Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors.

Q. You, Xi Xu, Zhiyu Li, 2019, Bioorganic chemistry.

DNA framework-engineered chimeras platform enables selectively targeted protein degradation

R. Chen, Yueqing Gu, Ting Yu, 2023, Nature Communications.

Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia.

Ting Yu, Jing Zhang, Zhiyu Li, 2023, European journal of medicinal chemistry.

Reversal of hepatic fibrosis by the co-delivery of drug and ribonucleoprotein-based genome editor.

Juanjuan Peng, Lingzhi Zhao, Shu Xu, 2023, Biomaterials.

Nano-genome editors accelerate mRNA cleavage through spatial con nement effect and reverse liver brosis by chemogene therapy

K. Tian, Jinlei Bian, Jingfang Sun, 2022 .

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

Xi Xu, Jinlei Bian, Jubo Wang, 2024, Medicinal research reviews.

Opportunities and Challenges for Inhibitors Targeting Citrate Transport and Metabolism in Drug Discovery.

Zhiyu Li, Jinlei Bian, Zhixia Qiu, 2023, Journal of medicinal chemistry.

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy.

Xi Xu, Jinlei Bian, Zekun Du, 2023, European journal of medicinal chemistry.

Discovery of Selenium-Containing STING Agonists as Orally Available Antitumor Agents.

Zhe Wang, Yi Ma, Xi Xu, 2022, Journal of medicinal chemistry.

Design strategies and recent development of bioactive modulators for glutamine transporters.

Jinlei Bian, Yezhi Wang, Guangyue Gong, 2024, Drug discovery today.