Jia Li

发表

Design, Synthesis, and Biological Evaluation of HDAC Degraders with CRBN E3 Ligase Ligands

Yu-bo Zhou, Yingxin Lu, Danwen Sun, 2021, Molecules.

Discovery of toxoflavin, a potent IRE1α inhibitor acting through structure-dependent oxidative inhibition

Yu-bo Zhou, Jia Li, Lei Xu, 2022, Acta Pharmacologica Sinica.

Structure-based rational design enables efficient discovery of a new selective and potent AKT PROTAC degrader.

Xiaowu Dong, Yizhe Wu, J. Che, 2022, European journal of medicinal chemistry.

Metabolism guided optimization of peptidomimetics as non-covalent proteasome inhibitors for cancer treatment.

Yu-bo Zhou, Jia Li, Qian Yu, 2022, European journal of medicinal chemistry.

Design, synthesis, and biological evaluation of Wee1 kinase degraders.

Yu-bo Zhou, Jingkun Ma, Donghuai Xiao, 2022, European journal of medicinal chemistry.

Triazine-Based Covalent DNA-Encoded Libraries for Discovery of Covalent Inhibitors of Target Proteins.

Yu-bo Zhou, Jia Li, Jiaxiang Liu, 2022, ACS medicinal chemistry letters.

Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma

Jia Li, Yifan Zhang, An-hui Gao, 2021, Acta pharmacologica Sinica.

Discovery of Novel N-(5-(Pyridin-3-yl)-1H-indazol-3-yl)benzamide Derivatives as Potent Cyclin-Dependent Kinase 7 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease.

Tongchao Liu, Yu-bo Zhou, B. Xiong, 2022, Journal of medicinal chemistry.

Synthesis and Evaluation of 3‐(furo[2,3‐b]pyridin‐3‐yl)‐4‐(1H‐indol‐3‐yl)‐maleimides as Novel GSK‐3β Inhibitors and Anti‐Ischemic Agents

Luyong Zhang, Jian-rong Gao, Jia Li, 2015, Chemical biology & drug design.

Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma.

Xiaowu Dong, Yizhe Wu, J. Che, 2022, Journal of medicinal chemistry.

Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT.

Xiaowu Dong, Jia Li, Tao Liu, 2022, Journal of medicinal chemistry.

Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents.

Hang Du, Danwen Sun, Jia Li, 2019, European journal of medicinal chemistry.

Dual inhibition of CHK1/FLT3 enhances cytotoxicity and overcomes adaptive and acquired resistance in FLT3-ITD acute myeloid leukemia

Jianmin Yang, Jia Li, Yubing Han, 2022, Leukemia.

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

W. Jia, Yu-bo Zhou, L. Rui, 2014, Nature Communications.

Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors

Tingjun Hou, Jia Li, Qianwen Mu, 2022, Chinese Chemical Letters.

Structure-Activity Relationship Study of Indolin-5-yl-cyclopropanamine Derivatives as Selective Lysine Specific Demethylase 1 (LSD1) Inhibitors.

F. Gao, Hong Liu, Chunpu Li, 2022, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 2‐Aminothiazole Derivatives as Novel Checkpoint Kinase 1 (CHK1) Inhibitors

T. Liu, Minjie Deng, Jia Li, 2023, ChemMedChem.

Exploration of novel four-membered-heterocycle constructed peptidyl proteasome inhibitors with improved metabolic stability for cancer treatment.

G. Wei, Jia Li, Li-xin Gao, 2023, Bioorganic chemistry.

Downregulation of c-Myc expression confers sensitivity to CHK1 inhibitors in hematologic malignancies

Yongzhou Hu, Tao Wang, Jianwei Yang, 2021, Acta pharmacologica Sinica.

Selective Late‐Stage Oxygenation of Sulfides with Ground‐State Oxygen by Uranyl Photocatalysis

Danwen Sun, Jia Li, An-hui Gao, 2019, Angewandte Chemie.

Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study.

Jia Li, Li-xin Gao, Chun Zhang, 2023, Journal of molecular graphics & modelling.

Synthesis and Biological Evaluation of 3-Amino-4,4-Dimethyl Lithocholic Acid Derivatives as Novel, Selective, and Cellularly Active Allosteric SHP1 Activators

Jia Li, Jie Tang, Li-xin Gao, 2023, Molecules.

Discovery of a Potent and Selective Degrader for USP7.

Jia Li, Bing Zhou, Ya-xi Yang, 2022, Angewandte Chemie.

Photophysical Exploration of Alectinib and Rilpivirine: Insights from Theory and Experiment

Jia Li, Aimin Ren, Chun Zhang, 2023, Molecules.

Discovery of 2-Aminopyrimidine Derivatives as Potent Dual FLT3/CHK1 Inhibitors with Significantly Reduced hERG Inhibitory Activities.

T. Liu, Jia Li, Peipei Wang, 2023, Journal of medicinal chemistry.