C. Sorbi

发表

Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs).

G. Rastelli, L. Altucci, S. Franchini, 2020, Bioorganic chemistry.

1,3‐Dioxolane‐Based Ligands as Rigid Analogues of Naftopidil: Structure–Affinity/Activity Relationships at α1 and 5‐HT1A Receptors

Silvia Franchini, A. Prandi, S. Franchini, 2009, ChemMedChem.

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.

S. Franchini, M. Buccioni, A. Cilia, 2019, European journal of medicinal chemistry.

1,4-Dioxolane-triazaspirodecanone derivatives as nociceptin/orphanin FQ receptor ligands

L. Brasili, G. Calo’, C. Sorbi, 2014, Medicinal Chemistry Research.

Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands

S. Franchini, M. Buccioni, A. Cilia, 2022, Results in Chemistry.

Spiroxatrine derivatives towards 5-HT1A receptor selectivity

L. Brasili, C. Sorbi, U. Battisti, 2020, Pharmacological Reports.

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

L. Brasili, G. Calo’, C. Sorbi, 2014 .

1,4-Dioxolane-triazaspirodecanone derivatives as nociceptin/orphanin FQ receptor ligands

L. Brasili, G. Calo’, C. Sorbi, 2014, Medicinal Chemistry Research.

Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides

S. Franchini, L. Brasili, Sang Kook Lee, 2017, Archives of pharmacal research.

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.

Silvia Franchini, Paola Fossa, Elena Cichero, 2010, European journal of medicinal chemistry.

Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides

S. Franchini, L. Brasili, L. Jeong, 2016, Archives of Pharmacal Research.

Diastereoselective Synthesis of (1,3‐Dioxan‐4‐yl)pyrimidine and Purin Nucleoside Analogues

S. Franchini, L. Brasili, L. Jeong, 2015 .

Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane

S. Franchini, L. Brasili, C. Sorbi, 2014, Synthesis.

Structure–Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

S. Franchini, P. Fossa, E. Cichero, 2017, ChemMedChem.

Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline.

S. Franchini, G. Marucci, L. Brasili, 2000, Bioorganic & medicinal chemistry.

On the presence of H1-receptors in various sections of guinea-pig heart: A correlation between binding and functional studies

R. Matucci, A. Mugelli, F. Ledda, 1984, Agents and Actions.

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

G. Rastelli, L. Altucci, S. Franchini, 2021, Journal of enzyme inhibition and medicinal chemistry.

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study

S. Franchini, E. Cichero, A. Cilia, 2015 .

Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.

A. Tesei, S. Franchini, D. Rossi, 2023, European journal of medicinal chemistry.

Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain.

S. Franchini, P. Fossa, E. Cichero, 2018, Future medicinal chemistry.

Discovery of a new series of 5-HT1A receptor agonists.

Silvia Franchini, Paola Fossa, A. Prandi, 2010, Bioorganic & medicinal chemistry letters.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

Identification of a Potent and Selective 5-HT1A Receptor Agonist with In Vitro and In Vivo Antinociceptive Activity

S. Franchini, P. Fossa, E. Cichero, 2020, ACS chemical neuroscience.

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status

G. Rastelli, S. Franchini, C. Sorbi, 2023, Molecules.

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.

A. Prandi, S. Franchini, P. Fossa, 2014, European journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.

S. Franchini, Leda Ivanova Manasieva, P. Fossa, 2017, European journal of medicinal chemistry.

BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting

S. Franchini, L. Brasili, C. Imbriano, 2023, International journal of molecular sciences.

A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists

R. Gainetdinov, S. Franchini, P. Fossa, 2016 .

Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer.

G. Rastelli, S. Franchini, C. Imbriano, 2023, European journal of medicinal chemistry.

Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents.

S. Franchini, L. Brasili, R. Iacobazzi, 2020, ACS medicinal chemistry letters.

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.

S. Franchini, G. Marucci, M. Buccioni, 2001, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

S. Franchini, P. Fossa, E. Cichero, 2017, ChemMedChem.

Synthesis and Structure–Activity Relationships of Triazaspirodecanone Derivatives as Nociceptin/Orphanin FQ Receptor Ligands

L. Brasili, G. Calo’, C. Sorbi, 2015, Chemical biology & drug design.

Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands

S. Franchini, P. Fossa, E. Cichero, 2017, Journal of enzyme inhibition and medicinal chemistry.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

1,3-dioxolane-based ligands as a novel class of alpha1-adrenoceptor antagonists.

S. Franchini, G. Marucci, L. Brasili, 2003, Journal of medicinal chemistry.