Zhuang Yang

发表

Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.

M. Shen, Zhuang Yang, Ming-hai Tang, 2019, European journal of medicinal chemistry.

Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.

Fang Wang, Zhuang Yang, Taijin Wang, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents.

X. Liang, Mingli Xiang, Liang Ma, 2013, European journal of medicinal chemistry.

Purinostat Mesylate Is a Uniquely Potent and Selective Inhibitor of HDACs for the Treatment of BCR-ABL–Induced B-Cell Acute Lymphoblastic Leukemia

Fang Wang, Yiguo Hu, Zhuang Yang, 2019, Clinical Cancer Research.

From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.

Zhuang Yang, Linyu Yang, X. Qiu, 2021, Bioorganic & medicinal chemistry.

Discovery of a potent microtubule-targeting agent: Synthesis and biological evaluation of water-soluble amino acid prodrug of combretastatin A-4 derivatives.

Chunlai Nie, F. Wang, Zhuang Yang, 2015, Bioorganic & medicinal chemistry letters.

Design, synthesis and discovery of 2(1H)-quinolone derivatives for the treatment of pulmonary fibrosis through inhibition of TGF-β/smad dependent and independent pathway.

Zhuang Yang, Ming-hai Tang, Heying Pei, 2020, European journal of medicinal chemistry.

Synthesis and biological evaluation of 4-oxoquinoline-3-carboxamides derivatives as potent anti-fibrosis agents.

Yuquan Wei, Mingli Xiang, Liang Ma, 2014, Bioorganic & medicinal chemistry letters.

Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms

T. Yang, Zhuang Yang, Ming-hai Tang, 2022, Blood Cancer Journal.

Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents.

Yuquan Wei, F. Wang, Mingli Xiang, 2014, Bioorganic & medicinal chemistry letters.

Identification of a Novel 2,8-Diazaspiro[4.5]decan-1-one Derivative as a Potent and Selective Dual TYK2/JAK1 Inhibitor for the Treatment of Inflammatory Bowel Disease.

T. Yang, Zhuang Yang, Ming-hai Tang, 2022, Journal of medicinal chemistry.

Studies on the anti-psoriasis effects and its mechanism of a dual JAK2/FLT3 inhibitor flonoltinib maleate.

P. Lin, Zhuang Yang, Ming-hai Tang, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.

Yan Liu, Zhuang Yang, Ming-hai Tang, 2022, Journal of medicinal chemistry.

Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity.

Yan Liu, Zhuang Yang, Ming-hai Tang, 2021, Journal of medicinal chemistry.

Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.

Chunyu Wang, F. Wang, Liang Ma, 2016, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.

Yuquan Wei, X. Liang, F. Wang, 2014, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors.

Mingli Xiang, F. Wang, Liang Ma, 2014, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents.

Yuquan Wei, X. Liang, Liang Ma, 2012, European journal of medicinal chemistry.

Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis

Sheng-yong Yang, Mingli Xiang, Zhuang Yang, 2018, Scientific Reports.

Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.

M. Shen, F. Wang, Zhuang Yang, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis.

Zhuang Yang, Ming-hai Tang, Heying Pei, 2019, European journal of medicinal chemistry.

Molecular Docking, Molecular Dynamics Simulations, and Free Energy Calculation Insights into the Binding Mechanism between VS-4718 and Focal Adhesion Kinase

Yan Liu, Zhuang Yang, Lijuan Chen, 2022, ACS omega.

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.

F. Wang, Hang Song, Zhuang Yang, 2016, Journal of medicinal chemistry.

ISG20L2 suppresses bortezomib antimyeloma activity by attenuating bortezomib binding to PSMB5

Yan Yang, Zhuang Yang, Yuhuan Zheng, 2022, JCI insight.

Synthesis and Biological Evaluation of 5‐Nitropyrimidine‐2,4‐dione Analogues as Inhibitors of Nitric Oxide and iNOS Activity

X. Liang, Liang Ma, Zhuang Yang, 2015, Chemical biology & drug design.

Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms.

Mingli Xiang, Zhuang Yang, Ming-hai Tang, 2019, Journal of medicinal chemistry.

Design, synthesis, and pharmacological evaluation of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol analogs as novel glutaminase 1 inhibitors.

T. Yang, Zhuang Yang, Ming-hai Tang, 2022, European journal of medicinal chemistry.

Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance.

Zhuang Yang, Ming-hai Tang, Yong Li, 2018, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes.

Yuquan Wei, Tao Chen, X. Liang, 2012, European journal of medicinal chemistry.

Design, synthesis and anti‐inflammatory study of novel N‐heterocyclic substituted Aloe‐emodin derivatives

Zhuang Yang, Heying Pei, Yong Li, 2020, Chemical biology & drug design.

Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.

Yuquan Wei, X. Liang, Mingli Xiang, 2012, European journal of medicinal chemistry.

Rational design and appraisal of selective Cdc2-Like kinase 1 (Clk1) inhibitors as novel autophagy inducers for the treatment of acute liver injury (ALI).

T. Yang, Zhuang Yang, Ming-hai Tang, 2023, European journal of medicinal chemistry.

Correction to "Discovery of Potent and Orally Effective Dual Janus Kinase 2/FLT3 Inhibitors for the Treatment of Acute Myelogenous Leukemia and Myeloproliferative Neoplasms".

Mingli Xiang, Zhuang Yang, Ming-hai Tang, 2020, Journal of medicinal chemistry.

Therapeutic efficacy of an injectable formulation of purinostat mesylate in SU-DHL-6 tumour model

Zhuang Yang, Ming-hai Tang, Heying Pei, 2022, Annals of medicine.

Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors.

T. Yang, Zhuang Yang, Ming-hai Tang, 2022, Bioorganic chemistry.

SKLB-M8 induces apoptosis through the AKT/mTOR signaling pathway in melanoma models and inhibits angiogenesis with decrease of ERK1/2 phosphorylation.

F. Wang, Chunlai Nie, Feng Ma, 2014, Journal of pharmacological sciences.

Synthesis and Biological Evaluation of Novel Substituted 4‐Anilinoquinazolines as Antitumor Agents

Liang Ma, Zhuang Yang, Lijuan Chen, 2020, Chemical biology & drug design.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Yuquan Wei, L. Ouyang, Zhuang Yang, 2020, Science Advances.

HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells

Fang Wang, Zhuang Yang, Ming-hai Tang, 2022, Bioactive materials.

Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases.

Zhuang Yang, Ming-hai Tang, Lijuan Chen, 2021, Journal of medicinal chemistry.

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.

F. Wang, Liang Ma, Zhuang Yang, 2016, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.

M. Shen, F. Wang, Zhuang Yang, 2017, European journal of medicinal chemistry.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin and provides insights into microtubule dynamic instability

Yuquan Wei, L. Ouyang, Zhuang Yang, 2020, bioRxiv.

N-(Pyrimidin-2-yl)-1,2,3,4-tetrahydroisoquinolin-6-amine Derivatives as Selective Janus Kinase 2 Inhibitors for the Treatment of Myeloproliferative Neoplasms.

Mingli Xiang, Zhuang Yang, Ming-hai Tang, 2020, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.

Yuquan Wei, Mingli Xiang, Liang Ma, 2013, Bioorganic & medicinal chemistry.

UPLC-MS/MS method development and application to pharmacokinetic study in rats and dogs of Flonoltinib Maleat.

Zhuang Yang, Qianlun Pu, Yanting Zhou, 2023, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.

F. Wang, Chunlai Nie, Liang Ma, 2015, Bioorganic & medicinal chemistry.

SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

Yuquan Wei, Yiguo Hu, F. Wang, 2018, Molecular Cancer Therapeutics.

SKLB-14b, a novel oral microtubule-destabilizing agent based on hydroxamic acid with potent anti-tumor and anti-multidrug resistance activities.

Zhuang Yang, Ming-hai Tang, Wanhua Zhang, 2022, Bioorganic chemistry.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Yuquan Wei, Zhuang Yang, Ming-hai Tang, 2021, Science Advances.

Discovery, Optimization, and Evaluation of Potent and Selective DNA-PK Inhibitors in Combination with Chemotherapy or Radiotherapy for the Treatment of Malignancies.

Zhuang Yang, Yong Chen, Dexin Deng, 2023, Journal of medicinal chemistry.

Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease.

Zhuang Yang, Xue Cui, Heying Pei, 2023, International immunopharmacology.