Yong Li

发表

Discovery of 1,2,4-oxadiazole-Containing hydroxamic acid derivatives as histone deacetylase inhibitors potential application in cancer therapy.

M. Shen, Zhuang Yang, Ming-hai Tang, 2019, European journal of medicinal chemistry.

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

Yuquan Wei, Dingguo Xu, L. Ouyang, 2021, bioRxiv.

The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation

Yong Li, Lijuan Chen, Wei-Qun Yan, 2019, Molecular Pharmacology.

Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.

Yan Liu, Zhuang Yang, Ming-hai Tang, 2022, Journal of medicinal chemistry.

Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.

Dingguo Xu, L. Ouyang, Heying Pei, 2022, Journal of medicinal chemistry.

Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation

Yong Li, Lijuan Chen, Weimin Li, 2019, The Journal of Biological Chemistry.

Crystal structure of tubulin-barbigerone complex enables rational design of potent anticancer agents with isoflavone skeleton.

Yan Liu, Heying Pei, Yong Li, 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Structure-Kinetic Relationship Studies for the Development of Long Residence Time LpxC Inhibitors.

P. Tonge, Yong Li, F. Daryaee, 2022, Journal of medicinal chemistry.

Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance.

Zhuang Yang, Ming-hai Tang, Yong Li, 2018, European journal of medicinal chemistry.

Structurally various p-terphenyls with neuraminidase inhibitory from a sponge derived fungus Aspergillus sp. SCSIO41315.

Shuwen Liu, Jie Yang, Yong Li, 2023, Bioorganic chemistry.

Design, synthesis and anti‐inflammatory study of novel N‐heterocyclic substituted Aloe‐emodin derivatives

Zhuang Yang, Heying Pei, Yong Li, 2020, Chemical biology & drug design.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Yuquan Wei, L. Ouyang, Zhuang Yang, 2020, Science Advances.

Discovery of 3-(4-(2-((1H-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease.

Mingli Xiang, Ming-hai Tang, Yong Li, 2021, Journal of medicinal chemistry.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin and provides insights into microtubule dynamic instability

Yuquan Wei, L. Ouyang, Zhuang Yang, 2020, bioRxiv.

Recent Progress on Microtubule Degradation Agents.

Yong Li, Chufeng Zhang, Min Zhao, 2023, Journal of medicinal chemistry.

Fragment growth-based discovery of novel TNIK inhibitors for the treatment of colorectal cancer

Xue Cui, Yong Li, Chufeng Zhang, 2024, European Journal of Medicinal Chemistry.

Structure-based design and synthesis of BML284 derivatives: A novel class of colchicine-site noncovalent tubulin degradation agents.

Yong Li, Chufeng Zhang, Min Zhao, 2024, European journal of medicinal chemistry.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Yuquan Wei, Zhuang Yang, Ming-hai Tang, 2021, Science Advances.

Discovery of 4-amino-1,6-dihydro-7H-pyrrolo[2,3-d]pyridazin-7-one derivatives as potential receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitors.

Yong Li, Dexin Deng, Chufeng Zhang, 2023, European journal of medicinal chemistry.