J. Liou

发表

4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo.

S. Pan, Samir Mehndiratta, Ruei-Shian Wang, 2017, European journal of medicinal chemistry.

Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.

T. Yeh, J. Liou, Jang-Yang Chang, 2014, European journal of medicinal chemistry.

Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents.

Samir Mehndiratta, J. Liou, Jang-Yang Chang, 2014, Bioorganic & medicinal chemistry.

Furanylazaindoles: potent anticancer agents in vitro and in vivo.

Su-Ying Wu, Jian-Sung Wu, S. Pan, 2013, Journal of medicinal chemistry.

Synthesis and biological evaluation of 1-(4'-Indolyl and 6'-Quinolinyl) indoles as a new class of potent anticancer agents.

H. Hsieh, Su-Ying Wu, Jian-Sung Wu, 2011, European journal of medicinal chemistry.

2‐Amino‐3,4,5‐Trimethoxybenzophenones as Potent Tubulin Polymerization Inhibitors

H. Hsieh, J. Liou, Jang-Yang Chang, 2011, ChemMedChem.

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2.

J. Liou, Jang-Yang Chang, C. Kuo, 2011, Journal of medicinal chemistry.

Concise syntheses of N-aryl-5,6,7-trimethoxyindoles as antimitotic and vascular disrupting agents: application of the copper-mediated Ullmann-type arylation.

J. Liou, Jang-Yang Chang, C. Kuo, 2011, Organic & biomolecular chemistry.

Synthesis and biological evaluation of 7-arylindoline-1-benzenesulfonamides as a novel class of potent anticancer agents

Yi-Ting Chang, Yun-Ching Cheng, J. Liou, 2010 .

5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors.

H. Hsieh, Su-Ying Wu, Yuxiang Chen, 2010, Journal of medicinal chemistry.

Synthesis and Structure–Activity Relationships of 1‐Benzyl‐4,5,6‐trimethoxyindoles as a Novel Class of Potent Antimitotic Agents

H. Hsieh, T. Yeh, J. Liou, 2009, ChemMedChem.

Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.

H. Hsieh, Su-Ying Wu, M. Coumar, 2008, Journal of medicinal chemistry.

Concise synthesis and structure-activity relationships of combretastatin A-4 analogues, 1-aroylindoles and 3-aroylindoles, as novel classes of potent antitubulin agents.

H. Hsieh, Shiow-Ju Lee, J. Liou, 2004, Journal of medicinal chemistry.

Effect of 3-subsitution of quinolinehydroxamic acids on selectivity of histone deacetylase isoforms

Samir Mehndiratta, J. Liou, Yuh-Hsuan Chao, 2020, Journal of enzyme inhibition and medicinal chemistry.

Ring-opened tetrahydro-γ-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms.

J. Liou, K. Nepali, Hsueh-Yun Lee, 2017, European journal of medicinal chemistry.

Indole-3-ethylsulfamoylphenylacrylamides: potent histone deacetylase inhibitors with anti-inflammatory activity.

Chia-Ron Yang, C. Teng, Samir Mehndiratta, 2014, European journal of medicinal chemistry.

MPT0B098, a Novel Microtubule Inhibitor That Destabilizes the Hypoxia-Inducible Factor-1α mRNA through Decreasing Nuclear–Cytoplasmic Translocation of RNA-Binding Protein HuR

J. T. Tseng, Yun-Ching Cheng, J. Liou, 2013, Molecular Cancer Therapeutics.

1,4-Naphthoquinones as inhibitors of Itch, a HECT domain-E3 ligase, and tumor growth suppressors in multiple myeloma.

Y. Yen, S. Pan, Han-Li Huang, 2017, European journal of medicinal chemistry.

Suppression of Extracellular Vesicle VEGF-C–mediated Lymphangiogenesis and Pancreatic Cancer Early Dissemination By a Selective HDAC1/2 Inhibitor

Chien-Feng Li, S. Tsai, J. Liou, 2021, Molecular Cancer Therapeutics.

Upregulation of Znf179 acetylation by SAHA protects cells against oxidative stress

T. Su, C. Chuang, Pin-Tse Lee, 2018, Redox biology.

Anti-leukemia effects of the novel synthetic 1-benzylindole derivative 21-900 in vitro and in vivo

Chia-Ron Yang, Yi-Wen Wu, J. Liou, 2017, Scientific Reports.

A Potent Histone Deacetylase Inhibitor MPT0E028 Mitigates Emphysema Severity via Components of the Hippo Signaling Pathway in an Emphysematous Mouse Model

K. Chung, Chien-Huang Lin, Y. Lo, 2022, Frontiers in Medicine.

A novel HDAC inhibitor suppresses extracellular vesicle VEGF-C-mediated lymphangiogenesis and pancreatic cancer early dissemination

Chien-Feng Li, S. Tsai, J. Liou, 2020 .

MT-4 Suppresses Resistant Ovarian Cancer Growth through Targeting Tubulin and HSP27

C. Teng, S. Pan, J. Liou, 2015, PloS one.

Optimization and Development of Selective Histone Deacetylase Inhibitor (MPT0B291)-Loaded Albumin Nanoparticles for Anticancer Therapy

Athika Darumas Putri, J. Liou, Yu-Lin Su, 2021, Pharmaceutics.

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

Chia-Ron Yang, J. Liou, Fang-I Huang, 2018, Cell Death & Disease.

Combretastatin A4-Induced Differential Cytotoxicity and Reduced Metastatic Ability by Inhibition of AKT Function in Human Gastric Cancer Cells

Li-Hsin Chen, S. Chiou, C. Chi, 2007, Journal of Pharmacology and Experimental Therapeutics.

Cancer Therapy : Preclinical Synergistic Interaction between the HDAC Inhibitor , MPT 0 E 028 , and Sorafenib in Liver Cancer Cells In Vitro and In Vivo

C. Chen, C. Teng, S. Pan, 2014 .

Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo

C. Chen, C. Teng, S. Pan, 2014, Clinical Cancer Research.

Anticancer activity of MPT0G157, a derivative of indolylbenzenesulfonamide, inhibits tumor growth and angiogenesis

Chia-Ron Yang, Samir Mehndiratta, J. Liou, 2015, Oncotarget.

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

C. Teng, S. Pan, J. Liou, 2019, Clinical Epigenetics.

Tubulin inhibitors: a patent review

J. Liou, Hsueh-Yun Lee, Yi-Min Liu, 2014, Expert opinion on therapeutic patents.

An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells

Chia-Ron Yang, C. Teng, Han-Li Huang, 2017, Oncotarget.

A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

J. Liou, Chih-Wei Chen, Tsai-Yun Chen, 2016, Apoptosis.

MPT0B169, a New Tubulin Inhibitor, Inhibits Cell Growth and Induces G2/M Arrest in Nonresistant and Paclitaxel-Resistant Cancer Cells

Wei-Hwa Lee, J. Liou, Jang-Yang Chang, 2013, Pharmacology.

Application of Suzuki arylation, Sonogashira ethynylation and Rosenmund-von Braun cyanation in the exploration of substitution effects on the anticancer activity of 2-aroylquinolines.

J. Liou, Jang-Yang Chang, C. Kuo, 2012, Organic & biomolecular chemistry.

A Novel Oral Indoline-Sulfonamide Agent, N-[1-(4-Methoxybenzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-Isonicotinamide (J30), Exhibits Potent Activity against Human Cancer Cells in Vitro and in Vivo through the Disruption of Microtubule

J. Liou, Jang-Yang Chang, C. Kuo, 2007, Journal of Pharmacology and Experimental Therapeutics.

1-Aroylindoline-hydroxamic acids as anticancer agents, inhibitors of HSP90 and HDAC.

S. Pan, Han-Li Huang, Chih-Jou Su, 2018, European journal of medicinal chemistry.

Androgen attenuates cardiac fibroblasts activations through modulations of transforming growth factor-β and angiotensin II signaling.

Yi‐Jen Chen, J. Liou, Cheng-Chih Chung, 2014, International journal of cardiology.

Anti-Arthritic Effects of Magnolol in Human Interleukin 1β-Stimulated Fibroblast-Like Synoviocytes and in a Rat Arthritis Model

Jyh‐Horng Wang, Chia-Ron Yang, Yi-Wen Wu, 2012, PloS one.

A novel bis-benzylidenecyclopentanone derivative, BPR0Y007, inducing a rapid caspase activation involving upregulation of Fas (CD95/APO-1) and wild-type p53 in human oral epidermoid carcinoma cells.

H. Hsieh, J. Liou, Jang-Yang Chang, 2004, Biochemical pharmacology.

MPT0B002, a novel microtubule inhibitor, downregulates T315I mutant Bcr-Abl and induces apoptosis of imatinib-resistant chronic myeloid leukemia cells

J. Liou, Huei-Mei Huang, Yueh-Lun Lee, 2017, Investigational New Drugs.

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes.

Chia-Ron Yang, T. Yeh, J. Liou, 2018, Journal of medicinal chemistry.

Anticancer Activity of MPT0E028, a Novel Potent Histone Deacetylase Inhibitor, in Human Colorectal Cancer HCT116 Cells In Vitro and In Vivo

C. Teng, S. Pan, Chieh-Yu Peng, 2012, PloS one.

Accommodation of ring C expanded deoxyvasicinone in the HDAC inhibitory pharmacophore culminates into a tractable anti-lung cancer agent and pH-responsive nanocarrier.

Chun-Hsu Pan, S. Guru, Sung-Bau Lee, 2022, European journal of medicinal chemistry.

Early investigational tubulin inhibitors as novel cancer therapeutics

J. Liou, K. Nepali, Hsueh-Yun Lee, 2016, Expert opinion on investigational drugs.

Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenal

J. Liou, K. Nepali, Sachin Sharma, 2022, Journal of biomedical science.

The synergic effect of vincristine and vorinostat in leukemia in vitro and in vivo

C. Teng, S. Pan, Ya-Ling Chang, 2015, Journal of Hematology & Oncology.

Effect of C7-substitution of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indolines on the selectivity towards a subclass of histone deacetylases.

C. Teng, S. Pan, J. Liou, 2014, Organic & biomolecular chemistry.

1‐Arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Chia-Ron Yang, C. Teng, T. Yeh, 2013, Chembiochem : a European journal of chemical biology.

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition.

T. Yeh, J. Liou, Jang-Yang Chang, 2016, Organic & biomolecular chemistry.

Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes.

J. Liou, Jang-Yang Chang, C. Kuo, 2015, Bioorganic & medicinal chemistry.

Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

J. Liou, Jang-Yang Chang, C. Kuo, 2011, Molecules.

Preclinical anti-arthritic study and pharmacokinetic properties of a potent histone deacetylase inhibitor MPT0G009

J. Liou, I-Ni Hsieh, Mei-Jung Lai, 2014, Cell Death and Disease.

Ring-opening of five-membered heterocycles conjugated 4-isopropylresorcinol scaffold-based benzamides as HSP90 inhibitors suppressing tumor growth in vitro and in vivo.

C. Teng, S. Pan, Yi-Wen Wu, 2021, European journal of medicinal chemistry.

Pharmacokinetics and protein binding of MPT0B292

J. Liou, Jang-Yang Chang, Jin‐ding Huang, 2017, Biopharmaceutics & drug disposition.

Novel histone deacetylase inhibitor MPT0G009 induces cell apoptosis and synergistic anticancer activity with tumor necrosis factor-related apoptosis-inducing ligand against human hepatocellular carcinoma

Chia-Ron Yang, C. Teng, J. Liou, 2015, Oncotarget.

A novel histone deacetylase inhibitor MPT0L184 dysregulates cell-cycle checkpoints and initiates unscheduled mitotic signaling.

Y. Yen, S. Pan, Sung-Bau Lee, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.

C. Chen, C. Teng, S. Pan, 2012, Journal of medicinal chemistry.

2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors.

Wei-Chiao Chang, T. Yeh, J. Liou, 2022, European journal of medicinal chemistry.

Denbinobin upregulates miR-146a expression and attenuates IL-1β-induced upregulation of ICAM-1 and VCAM-1 expressions in osteoarthritis fibroblast-like synoviocytes

Jyh‐Horng Wang, Chia-Ron Yang, Yi-Wen Wu, 2014, Journal of Molecular Medicine.

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.

H. Hsieh, Jen‐Shin Song, Chung-Ming Chang, 2002, Journal of medicinal chemistry.

2-(Phenylsulfonyl)quinoline N-hydroxyacrylamides as potent anticancer agents inhibiting histone deacetylase.

Chia-Ron Yang, Samir Mehndiratta, Han-Li Huang, 2016, European journal of medicinal chemistry.

Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects.

J. Liou, K. Nepali, J. Chuang, 2023, European journal of medicinal chemistry.

2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.

J. Liou, Jang-Yang Chang, C. Kuo, 2006, Journal of medicinal chemistry.

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

H. Hsieh, C. Liao, Su-Ying Wu, 2011, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of 3-aminobenzophenones as antimitotic agents.

H. Hsieh, N. Mahindroo, J. Liou, 2004, Journal of medicinal chemistry.

Pharmaceutical design of antimitotic agents based on combretastatins.

H. Hsieh, N. Mahindroo, J. Liou, 2005, Current pharmaceutical design.

Nitro-Group-Containing Drugs.

J. Liou, K. Nepali, Hsueh-Yun Lee, 2018, Journal of medicinal chemistry.

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

H. Hsieh, C. Chen, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Novel radical synthesis of morphine fragments spiro[benzofuran-3(2H),4′-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline

J. Liou, L. Hsin, Chen‐Yu Cheng, 1996 .

4- and 5-aroylindoles as novel classes of potent antitubulin agents.

H. Hsieh, J. Liou, Jang-Yang Chang, 2007, Journal of medicinal chemistry.

Antitubulin agents for the treatment of cancer – a medicinal chemistry update

H. Hsieh, N. Mahindroo, J. Liou, 2006 .

Total synthesis of (±)-desoxycodeine-d: a novel route to the morphine skeleton

J. Liou, Chen‐Yu Cheng, C. Cheng, 2000 .

Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents

Yi-Wei Chang, Hsing-Pang Hsieh, Uan-Kang Tan, 2006, ChemMedChem.

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

H. Hsieh, J. Liou, Jang-Yang Chang, 2008, Journal of medicinal chemistry.

Synthesis of morphine fragments spiro[benzofuran-3(2H),4′-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline by intramolecular Heck reaction

J. Liou, Chen‐Yu Cheng, M.‐J. Lee, 1997 .

A concise synthesis of denbinobin

Chien-Huang Lin, J. Liou, Chi Ming Chen, 2005 .

Total Synthesis of Two Glycosylated Stilbenes, Oxyresveratrol 2-O-β-d-Glucopyranoside and 2,3,5,4'-Tetrahydroxystilbene 2-O-β-d-Glucopyranoside.

J. Liou, Sunil Kumar, Hsueh-Yun Lee, 2017, Journal of natural products.

Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye.

J. Liou, K. Nepali, Chien-Ming Hsieh, 2020, Journal of medicinal chemistry.

Idiopathic Pulmonary Fibrosis: Current Status, Recent Progress, and Emerging Targets.

J. Liou, K. Nepali, Yi-Min Liu, 2017, Journal of medicinal chemistry.

Structure-activity and crystallographic analysis of benzophenone derivatives-the potential anticancer agents.

Chi-Hung Lin, Ying-Ting Lin, H. Hsieh, 2003, Bioorganic & medicinal chemistry letters.

7-Aroyl-aminoindoline-1-sulfonamides as a novel class of potent antitubulin agents.

H. Hsieh, J. Liou, Jang-Yang Chang, 2006, Journal of medicinal chemistry.

BPR0L075, a Novel Synthetic Indole Compound with Antimitotic Activity in Human Cancer Cells, Exerts Effective Antitumoral Activity in Vivo

H. Hsieh, C. Chen, Shiow-Ju Lee, 2004, Cancer Research.

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent.

H. Hsieh, Jen‐Shin Song, J. Liou, 2003, Biochemical pharmacology.

A novel class I HDAC inhibitor, MPT0G030, induces cell apoptosis and differentiation in human colorectal cancer cells via HDAC1/PKCδ and E-cadherin

C. Teng, S. Pan, J. Liou, 2014, Oncotarget.

Histone lysine specific demethylase 1 inhibitors.

Samir Mehndiratta, J. Liou, 2020, RSC medicinal chemistry.

Combretastatin A 4-Induced Differential Cytotoxicity and Reduced Metastatic Ability by Inhibition of AKT Function in Human Gastric Cancer Cells

Li-Hsin Chen, S. Chiou, C. Chi, 2007 .

Specificity protein 1-modulated superoxide dismutase 2 enhances temozolomide resistance in glioblastoma, which is independent of O6-methylguanine-DNA methyltransferase

J. Hung, C. Chuang, Wen-Chang Chang, 2017, Redox biology.

Histone deacetylase 6 acts upstream of DNA damage response activation to support the survival of glioblastoma cells

U. Kikkawa, Ruei-Ming Chen, Wen-Chang Chang, 2021, Cell Death & Disease.

HDAC6 involves in regulating the lncRNA-microRNA-mRNA network to promote the proliferation of glioblastoma cells

U. Kikkawa, Chih-Yang Wang, Wen-Chang Chang, 2022, Journal of Experimental & Clinical Cancer Research.

Pyrimidinedione-mediated selective histone deacetylase 6 inhibitors with antitumor activity in colorectal cancer HCT116 cells.

S. Pan, J. Liou, Hsueh-Yun Lee, 2015, Organic & biomolecular chemistry.

Glioblastoma: Current Status, Emerging Targets, and Recent Advances

B. Malik, J. Liou, K. Nepali, 2022, Journal of medicinal chemistry.

Targeting Autophagy by MPT0L145, a Highly Potent PIK3C3 Inhibitor, Provides Synergistic Interaction to Targeted or Chemotherapeutic Agents in Cancer Cells

Y. Yen, Tsung-Han Hsieh, Yun-Ru Liu, 2019, Cancers.

A novel dual HDAC and HSP90 inhibitor, MPT0G449, downregulates oncogenic pathways in human acute leukemia in vitro and in vivo

Chia-Ron Yang, S. Pan, Yi-Wen Wu, 2021, Oncogenesis.

Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib

J. Chang, C. Teng, J. Liou, 2014, Cell Death and Disease.

Design, synthesis, and evaluation of N-phenyl-4-(2-phenylsulfonamido)-benzamides as microtubule-targeting agents in drug-resistant cancer cells, displaying HDAC inhibitory response.

J. Liou, Wei-Cheng Wu, Mei-Hsiang Lin, 2020, European journal of medicinal chemistry.

Azatyrosinamides: novel RAS-related anticancer agents.

C. Teng, S. Pan, Chiu-Fen Huang, 2013, Anticancer research.

Hypoxia-Induced Downregulation of DUSP-2 Phosphatase Drives Colon Cancer Stemness.

S. Tsai, H. Sun, J. Liou, 2017, Cancer research.

The HDAC inhibitor, MPT0E028, enhances erlotinib-induced cell death in EGFR-TKI-resistant NSCLC cells

C. Teng, S. Pan, J. Liou, 2013, Cell Death and Disease.

MPT0G612, a Novel HDAC6 Inhibitor, Induces Apoptosis and Suppresses IFN-γ-Induced Programmed Death-Ligand 1 in Human Colorectal Carcinoma Cells

Yu-chen Lin, J. Liou, Chun-Han Chen, 2019, Cancers.

Novel oral histone deacetylase inhibitor, MPT0E028, displays potent growth-inhibitory activity against human B-cell lymphoma in vitro and in vivo

C. Teng, S. Pan, Chieh-Yu Peng, 2014, Oncotarget.

MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation

J. Liou, Huei-Mei Huang, Yueh-Lun Lee, 2016, Tumor Biology.

Histone deacetylase inhibition improved cardiac functions with direct antifibrotic activity in heart failure.

Shih-Ann Chen, Yu-Hsun Kao, Yi-Jen Chen, 2013, International journal of cardiology.

2‐Methoxyestradiol attenuates phosphatidylinositol 3‐kinase/Akt pathway‐mediated metastasis of gastric cancer

S. Chiou, C. Chi, Yi-ping Yang, 2007, International journal of cancer.

Recent Update of HDAC Inhibitors in Lymphoma

J. Liou, Bidyadhar Sethy, I-Chung Chen, 2020, Frontiers in Cell and Developmental Biology.

Recent developments in epigenetic cancer therapeutics: clinical advancement and emerging trends

J. Liou, K. Nepali, 2021, Journal of Biomedical Science.

Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status

C. Teng, S. Pan, J. Liou, 2019, Clinical epigenetics.

Trichlorobenzene-substituted azaaryl compounds as novel FGFR inhibitors exhibiting potent antitumor activity in bladder cancer cells in vitro and in vivo

Y. Yen, Yun-Ru Liu, S. Pan, 2016, Oncotarget.

LTP-1, a novel antimitotic agent and Stat3 inhibitor, inhibits human pancreatic carcinomas in vitro and in vivo

C. Teng, S. Pan, Han-Li Huang, 2016, Scientific Reports.

Dual Inhibition of PIK3C3 and FGFR as a New Therapeutic Approach to Treat Bladder Cancer

Y. Yen, Cheng-Ying Chu, Tsung-Han Hsieh, 2017, Clinical Cancer Research.

MPT0B098, a Microtubule Inhibitor, Suppresses JAK2/STAT3 Signaling Pathway through Modulation of SOCS3 Stability in Oral Squamous Cell Carcinoma

Hsuan-Yu Peng, Shiow-Lian Catherine Jin, J. Liou, 2016, PloS one.

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

J. Liou, Jang-Yang Chang, C. Kuo, 2018, Journal of Biomedical Science.

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

H. Hsieh, C. Chen, Y. Chao, 2010, Anticancer research.

Suberoylanilide hydroxamic acid represses glioma stem-like cells

J. Liou, Shiu-Hwa Yeh, Kwang-Yu Chang, 2016, Journal of Biomedical Science.

Histone deacetylase inhibitor MPT0B291 suppresses Glioma Growth in vitro and in vivo partially through acetylation of p53

Ruei-Ming Chen, J. Liou, Y. Chiang, 2020, International journal of biological sciences.

Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2

D. Ann, J. Liou, Chun-Ting Cheng, 2014, PloS one.

N-alkyl-hydroxybenzoyl anilide hydroxamates as dual inhibitors of HDAC and HSP90, downregulating IFN-γ induced PD-L1 expression.

S. Pan, Samir Mehndiratta, Yi-Wen Wu, 2019, European journal of medicinal chemistry.

TIMP3 expression associates with prognosis in colorectal cancer and its novel arylsulfonamide inducer, MPT0B390, inhibits tumor growth, metastasis and angiogenesis

Ya‐Wen Cheng, S. Pan, Tsui-Chin Huang, 2019, Theranostics.

Isoindoline scaffold-based dual inhibitors of HDAC6 and HSP90 suppressing the growth of lung cancer in vitro and in vivo.

S. Pan, Han-Li Huang, J. Liou, 2020, European journal of medicinal chemistry.

Amide-tethered quinoline-resorcinol conjugates as a new class of HSP90 inhibitors suppressing the growth of prostate cancer cells.

S. Pan, J. Liou, Min-Wu Chao, 2019, Bioorganic chemistry.

Pragmatic recruitment of memantine as the capping group for the design of HDAC inhibitors: A preliminary attempt to unravel the enigma of glioblastoma.

J. Liou, K. Nepali, K. Hsu, 2021, European journal of medicinal chemistry.

N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling.

C. Teng, S. Pan, Samir Mehndiratta, 2015, Journal of medicinal chemistry.

Total Synthesis of Denbinobin.

J. Liou, Sunil Kumar, Hsueh-Yun Lee, 2016, Journal of natural products.

CAP rigidification of MS-275 and chidamide leads to enhanced antiproliferative effects mediated through HDAC1, 2 and tubulin polymerization inhibition.

Y. Yen, Sung-Bau Lee, J. Liou, 2021, European journal of medicinal chemistry.

Purine/purine isoster based scaffolds as new derivatives of benzamide class of HDAC inhibitors.

Y. Yen, Sung-Bau Lee, J. Liou, 2020, European journal of medicinal chemistry.

Synthesis and biological evaluation of 2-quinolineacrylamides.

J. Liou, Shih-Wei Wang, Mei-Hsiang Lin, 2019, Bioorganic & medicinal chemistry.

3-Aroylindoles display antitumor activity in vitro and in vivo: Effects of N1-substituents on biological activity.

Chia-Ron Yang, Yi-Wen Wu, J. Liou, 2017, European journal of medicinal chemistry.

Anaplastic lymphoma kinase inhibitors: an updated patent review (2014–2018)

J. Liou, Yi-Min Liu, Chun-Nan Kuo, 2020, Expert opinion on therapeutic patents.

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Chia-Ron Yang, S. Pan, Yi-Wen Wu, 2018, Clinical Epigenetics.

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.

S. Pan, T. Yeh, J. Liou, 2014, Journal of medicinal chemistry.

Installation of Pargyline, a LSD1 Inhibitor, in the HDAC Inhibitory Template Culminated in the Identification of a Tractable Antiprostate Cancer Agent.

S. Pan, J. Liou, K. Nepali, 2021, Journal of medicinal chemistry.

HDAC inhibitor protects chronic cerebral hypoperfusion and oxygen‐glucose deprivation injuries via H3K14 and H4K5 acetylation‐mediated BDNF expression

L. Chan, J. Liou, Chaur-Jong Hu, 2020, Journal of cellular and molecular medicine.

Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents.

T. Yeh, J. Liou, Yi-Min Liu, 2019, Future medicinal chemistry.

Anti-metastatic activity of MPT0G211, a novel HDAC6 inhibitor, in human breast cancer cells in vitro and in vivo.

Chia-Ron Yang, S. Pan, J. Liou, 2019, Biochimica et biophysica acta. Molecular cell research.

Fluoropyrimidin-2,4-dihydroxy-5-isopropylbenzamides as antitumor agents against CRC and NSCLC cancer cells.

S. Pan, J. Liou, Wei-Cheng Wu, 2020, European journal of medicinal chemistry.

A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

J. Liou, Chih-Wei Chen, Tsai-Yun Chen, 2016, Apoptosis.

A Novel Dual HDAC6 and Tubulin Inhibitor, MPT0B451, Displays Anti-tumor Ability in Human Cancer Cells in Vitro and in Vivo

S. Pan, Tsui-Chin Huang, W. Hwang-Verslues, 2018, Front. Pharmacol..

CK1δ as a potential therapeutic target to treat bladder cancer

Tsung-Han Hsieh, Yu-chen Lin, J. Liou, 2020, Aging.

MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells

Chia-Ron Yang, S. Pan, Yi-Wen Wu, 2019, Front. Oncol..

(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.

Chia-Ron Yang, J. Liou, K. Nepali, 2018, Journal of medicinal chemistry.

The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model

Chia-Ron Yang, J. Liou, Fang-I Huang, 2018, Cell Death & Disease.

1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells.

S. Pan, T. Yeh, J. Liou, 2015, European journal of medicinal chemistry.

The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells

Chia-Ron Yang, S. Pan, Yi-Wen Wu, 2018, Clinical Epigenetics.

1-Arylsulfonyl indoline-benzamides as a new antitubulin agents, with inhibition of histone deacetylase.

J. Liou, Jang-Yang Chang, K. Nepali, 2019, European journal of medicinal chemistry.

In vitro and in vivo anti‐tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non‐small‐cell lung cancer cells

C. Teng, S. Pan, J. Liou, 2014, British journal of pharmacology.

A Novel Synthetic Microtubule Inhibitor, MPT0B214 Exhibits Antitumor Activity in Human Tumor Cells through Mitochondria-Dependent Intrinsic Pathway

J. Liou, Jang-Yang Chang, C. Kuo, 2013, PloS one.

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment.

L. Chan, T. Yeh, J. Liou, 2019, European journal of medicinal chemistry.

Novel microtubule inhibitor MPT0B098 inhibits hypoxia-induced epithelial-to-mesenchymal transition in head and neck squamous cell carcinoma

J. Liou, Jang-Yang Chang, C. Kuo, 2018, Journal of Biomedical Science.

MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer

C. Teng, S. Pan, Han-Li Huang, 2016, Scientific Reports.

Erratum to: A novel tubulin polymerization inhibitor, MPT0B206, downregulates Bcr-Abl expression and induces apoptosis in imatinib-sensitive and imatinib-resistant CML cells

J. Liou, Chih-Wei Chen, Tsai-Yun Chen, 2017, Apoptosis.

Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma.

J. Shih, J. Liou, Kuo-Hsiang Chuang, 2023, European journal of medicinal chemistry.

Curcumin Suppress Cardiac Fibroblasts Activities by Regulating Proliferation, Migration, and the Extracellular Matrix.

Yi‐Jen Chen, J. Liou, Cheng-Chih Chung, 2014, Acta Cardiologica Sinica.

Suberoylanilide hydroxamic acid represses glioma stem-like cells

Wen-Chang Chang, J. Liou, Shiu-Hwa Yeh, 2016, Journal of Biomedical Science.

6-Regioisomeric 5,8-quinolinediones as potent CDC25 inhibitors against colorectal cancers.

Sung-Bau Lee, J. Liou, Hsueh-Yun Lee, 2023, European journal of medicinal chemistry.

Identification of 7-(4′-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells

J. Liou, Chung-Kuang Lu, Ting-Yu Cho, 2017, Scientific Reports.

Molecular mechanisms underlying the antitumor activity of (E)-N-hydroxy-3-(1-(4-methoxyphenylsulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl)acrylamide in human colorectal cancer cells in vitro and in vivo

C. Teng, S. Pan, Chia-Hwa Lee, 2015, Oncotarget.

Combining an Autophagy Inhibitor, MPT0L145, with Abemaciclib Is a New Therapeutic Strategy in GBM Treatment

Y. Yen, Tsung-Han Hsieh, Yu-chen Lin, 2021, Cancers.

A novel action mechanism for MPT0G013, a derivative of arylsulfonamide, inhibits tumor angiogenesis through up-regulation of TIMP3 expression

C. Teng, S. Pan, J. Liou, 2014, Oncotarget.

Prudent tactics to sail the boat of PARP inhibitors as therapeutics for diverse malignancies

Sung-Bau Lee, J. Liou, K. Nepali, 2023, Expert opinion on drug discovery.

Structural compositions and biological activities of cell wall polysaccharides in the rhizome, stem, and leaf of Polygonatum odoratum (Mill.) Druce.

S. Kwon, Xiaohui Xing, D. W. Abbott, 2022, Carbohydrate Research.

The complex role of eicosanoids in the brain: Implications for brain tumor development and therapeutic opportunities.

J. Liou, Kwang-Yu Chang, T. Hsu, 2023, Biochimica et biophysica acta. Reviews on cancer.

Erratum: Structure-activity and crystallographic analysis of benzophenone derivatives - The potential anticancer agents (Bioorganic and Medicinal Chemistry Letters (2003) 13 (101) PII S0960894X02008508)

Chi-Hung Lin, Ying-Ting Lin, H. Hsieh, 2003 .

Identification of 7-(4′-Cyanophenyl)indoline-1-benzenesulfonamide as a mitotic inhibitor to induce apoptotic cell death and inhibit autophagy in human colorectal cancer cells

J. Liou, Chung-Kuang Lu, Ting-Yu Cho, 2017, Scientific Reports.

Curcumin Suppress Cardiac Fibroblasts Activities by Regulating Proliferation, Migration, and the Extracellular Matrix.

Yi‐Jen Chen, J. Liou, Cheng-Chih Chung, 2014, Acta Cardiologica Sinica.

Anticancer Study of a Novel Pan-HDAC Inhibitor MPT0G236 in Colorectal Cancer Cells

Chia-Ron Yang, S. Pan, Han-Li Huang, 2023, International journal of molecular sciences.

An updated patent review of histone deacetylase (HDAC) inhibitors in cancer (2020 – present)

J. Liou, Yi-Min Liu, 2023, Expert opinion on therapeutic patents.

Androgen attenuates cardiac fibroblasts activations through modulations of transforming growth factor-β and angiotensin II signaling.

Yi‐Jen Chen, J. Liou, Cheng-Chih Chung, 2014, International journal of cardiology.

N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment.

J. Shih, Samir Mehndiratta, J. Liou, 2022, Journal of medicinal chemistry.

Chia-Ron Yang, C. Teng, J. Liou, 2015, Oncotarget.