M. Palumbi

发表

Identification of novel, selective, and stable inhibitors of class II histone deacetylases. Validation studies of the inhibition of the enzymatic activity of HDAC4 by small molecules as a novel approach for cancer therapy.

S. Altamura, M. Rowley, R. Laufer, 2009, Journal of medicinal chemistry.

2-Trifluoroacetylthiophene oxadiazoles as potent and selective class II human histone deacetylase inhibitors.

S. Altamura, M. Rowley, Philip Jones, 2008, Bioorganic & medicinal chemistry letters.

Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.

Michael Rowley, Michael D. Miller, M. Rowley, 2006, Bioorganic & medicinal chemistry letters.

Identification of aminoethyl pyrrolo dihydroisoquinolinones as novel poly(ADP-ribose) polymerase-1 inhibitors.

Uwe Koch, Michael Rowley, U. Koch, 2009, Bioorganic & medicinal chemistry letters.

Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

C. Toniatti, S. Altamura, M. Rowley, 2009, Journal of medicinal chemistry.

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.

U. Koch, R. De Francesco, P. Baiocco, 2011, Journal of medicinal chemistry.

N-(2-alkylaminoethyl)-4-(1,2,4-oxadiazol-5-yl)piperazine-1-carboxamides as highly potent smoothened antagonists.

M. Rowley, C. Giuliano, Philip Jones, 2011, Bioorganic & medicinal chemistry letters.

Discovery of N-[(1-aryl-1H-indazol-5-yl)methyl]amides derivatives as smoothened antagonists for inhibition of the hedgehog pathway.

M. Rowley, Philip Jones, C. Steinkühler, 2009, Bioorganic & medicinal chemistry letters.

Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant.

M. Rowley, V. Summa, R. Laufer, 2006, Bioorganic & medicinal chemistry letters.

Identification of substituted pyrazolo[1,5-a]quinazolin-5(4H)-one as potent poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors.

U. Koch, C. Toniatti, M. Rowley, 2009, Bioorganic & medicinal chemistry letters.

Inhibitors of the hepatitis C virus NS3 protease with basic amine functionality at the P3-amino acid N-terminus: discovery and optimization of a new series of P2-P4 macrocycles.

S. Harper, N. Liverton, U. Koch, 2009, Journal of medicinal chemistry.

Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.

J. I. Hernando, S. Altamura, M. Rowley, 2011, Bioorganic & medicinal chemistry letters.